William G. Fairbrother

Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 
"William Fairbrother"
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Buerer L, Clark N, Welch A, et al. (2023) The debranching enzyme Dbr1 regulates lariat turnover and intron splicing. Research Square
Townley BA, Buerer L, Tsao N, et al. (2023) A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy. Molecular Cell
Rong S, Neil CR, Welch A, et al. (2023) Large-scale functional screen identifies genetic variants with splicing effects in modern and archaic humans. Proceedings of the National Academy of Sciences of the United States of America. 120: e2218308120
Fredericks AM, East KW, Shi Y, et al. (2022) Identification and mechanistic basis of non-ACE2 blocking neutralizing antibodies from COVID-19 patients with deep RNA sequencing and molecular dynamics simulations. Frontiers in Molecular Biosciences. 9: 1080964
Rhine CL, Neil C, Wang J, et al. (2022) Massively parallel reporter assays discover de novo exonic splicing mutants in paralogs of Autism genes. Plos Genetics. 18: e1009884
Glidden DT, Buerer JL, Saueressig CF, et al. (2021) Hotspot exons are common targets of splicing perturbations. Nature Communications. 12: 2756
Rong S, Buerer L, Rhine CL, et al. (2020) Mutational bias and the protein code shape the evolution of splicing enhancers. Nature Communications. 11: 2845
Fredericks AM, Wang LJ, Fairbrother WG, et al. (2020) Alternative RNA splicing and alternative transcription start/end in acute respiratory distress syndrome. Intensive Care Medicine
Neil CR, Fairbrother WG. (2019) Intronic RNA: Ad'junk' mediator of post-transcriptional gene regulation. Biochimica Et Biophysica Acta. 1862: 194439
Mount SM, Avsec Ž, Carmel L, et al. (2019) Assessing predictions of the impact of variants on splicing in CAGI5. Human Mutation
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