☰ Cell Biology Tree

Timothy R. Zacharewski

Affiliations:

Biochemistry and Molecular Biology

Michigan State University, East Lansing, MI

Area:

Molecular Biology, Toxicology

Website:

http://dbzach.fst.msu.edu/index.php/people/tim-zacharewski/

Google:

"Timothy Richard Zacharewski" OR "Timothy R Zacharewski"

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Parents

Stephen Safe	grad student	1990	Texas A & M (Chemistry Tree)
(In vitro studies of PCDD and PCDF action)
Pierre Chambon	post-doc	1990-1992	Université Louis Pasteur (Neurotree)

Children

Kelly A. Fader	grad student	2013-	Michigan State
Russell R. Fling	grad student	2016-	Michigan State
Warren J Sink	grad student	2021-	Michigan State
Jason B. Matthew	grad student	2001	Michigan State
Mark R. Fielden	grad student	2002	Michigan State
Darrell R. Boverhof	grad student	2005	Michigan State
Lyle D. Burgoon	grad student	2005	Michigan State
Cora J. Fong	grad student	2007	Michigan State
Edward Dere	grad student	2010	Michigan State
Anna K. Kopec	grad student	2010	Michigan State
Suntae Kim	grad student	2011	Michigan State
Michelle M. Angrish	grad student	2012	Michigan State
Agnes Forgacs	grad student	2013	Michigan State
Rance Nault	grad student	2011-2016	Michigan State
Giovan N. Cholico	post-doc	2021-	Michigan State
Karina Orłowska	post-doc	2021-	Michigan State

Collaborators

BETA: Related publications

Publications

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Jurgelewicz A, Nault R, Harkema J, et al. (2023) Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity. Scientific Reports. 13: 16598
Orlowska K, Fling RR, Nault R, et al. (2023) Cystine/Glutamate Xc Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. Chemical Research in Toxicology
Fling RR, Zacharewski TR. (2021) Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo--Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences. 22
Cholico GN, Fling RR, Zacharewski NA, et al. (2021) Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation. Scientific Reports. 11: 15689
Fling RR, Doskey CM, Fader KA, et al. (2020) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. Scientific Reports. 10: 14831
Nault R, Fader KA, Bhattacharya S, et al. (2020) Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cellular and Molecular Gastroenterology and Hepatology
Doskey CM, Fader KA, Nault R, et al. (2020) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology. 115034
Nault R, Bals B, Teymouri F, et al. (2019) A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology. 114872
Josyula N, Andersen ME, Kaminski NE, et al. (2019) Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver. Archives of Toxicology
Dornbos P, Jurgelewicz A, Fader KA, et al. (2019) Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice. Scientific Reports. 9: 15828

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