Jack D. Stopa, Ph.D.
Affiliations: | 2012 | Boston University, Boston, MA, United States |
Area:
Biochemistry, Molecular BiologyGoogle:
"Jack Stopa"Parents
Sign in to add mentor| Dean Tolan | grad student | 2012 | Boston University | |
| (Small molecule stabilization of A149P-aldolase, the most prevalent form of aldolase B associated with hereditary fructose intolerance.) | ||||
| Bruce Furie | post-doc | 2013-2019 | Harvard - BIDMC (Chemistry Tree) | |
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Publications
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| Eriksson O, Stopa J, Furie B. (2019) Identification of PDI Substrates by Mechanism-Based Kinetic Trapping. Methods in Molecular Biology (Clifton, N.J.). 1967: 165-182 |
| Zwicker JI, Schlechter BL, Stopa JD, et al. (2019) Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. Jci Insight |
| Bekendam RH, Iyu D, Passam F, et al. (2018) Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. Journal of Thrombosis and Haemostasis : Jth |
| Stopa JD, Zwicker JI. (2018) The intersection of protein disulfide isomerase and cancer associated thrombosis. Thrombosis Research. 164: S130-S135 |
| Zwicker JI, Schlechter BL, Stopa JD, et al. (2018) Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study) Blood. 132: 985-985 |
| Stopa JD, Baker KM, Grover SP, et al. (2017) Kinetic-based Trapping by Intervening Sequence Variants of the Active Sites of Protein Disulfide Isomerase Identifies Platelet Protein Substrates. The Journal of Biological Chemistry |
| Stopa JD, Neuberg D, Puligandla M, et al. (2017) Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. Jci Insight. 2: e89373 |
| Stopa JD, Neuberg DS, Puligandla M, et al. (2016) PDI Inhibition Blocks Thrombin Generation in Humans By Interfering with Platelet Factor V Activation Blood. 128: 2628-2628 |
| Lin L, Gopal S, Sharda A, et al. (2015) Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain. The Journal of Biological Chemistry. 290: 23543-52 |
| Passam FH, Lin L, Gopal S, et al. (2015) Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis. Blood. 125: 2276-85 |