Douglas S. Micalizzi, Ph.D.

Affiliations: 
2009 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Molecular Biology, Oncology
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"Douglas Micalizzi"

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Heide L. Ford grad student 2009 University of Colorado, Denver
 (The role of Transforming Growth Factor-beta and epithelial -to -mesenchymal transition in Six1-induced metastasis.)
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Publications

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Towers CG, Guarnieri AL, Micalizzi DS, et al. (2015) The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications. 6: 10077
Iwanaga R, Wang CA, Micalizzi DS, et al. (2012) Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways. Breast Cancer Research : Bcr. 14: R100
Wang CA, Jedlicka P, Patrick AN, et al. (2012) SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer. The Journal of Clinical Investigation. 122: 1895-906
Smith AL, Iwanaga R, Drasin DJ, et al. (2012) The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene. 31: 5162-71
Farabaugh SM, Micalizzi DS, Jedlicka P, et al. (2012) Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene. 31: 552-62
Micalizzi DS, Wang CA, Farabaugh SM, et al. (2010) Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Research. 70: 10371-80
Micalizzi DS, Farabaugh SM, Ford HL. (2010) Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. Journal of Mammary Gland Biology and Neoplasia. 15: 117-34
Micalizzi DS, Ford HL. (2009) Epithelial-mesenchymal transition in development and cancer. Future Oncology (London, England). 5: 1129-43
Micalizzi DS, Christensen KL, Jedlicka P, et al. (2009) The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. The Journal of Clinical Investigation. 119: 2678-90
Coletta RD, Christensen KL, Micalizzi DS, et al. (2008) Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. Cancer Research. 68: 2204-13
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