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Melvin I. Simon, Ph.D.

Biology California Institute of Technology, Pasadena, CA 
Signal Transduction
"Melvin Simon"

Cross-listing: Chemistry Tree


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Helen Van Vunakis grad student 1963 Brandeis (Chemistry Tree)
 (The photodynamic reaction of methylene blue with nucleic acids and their components)
Arthur B. Pardee post-doc 1964 Princeton (Chemistry Tree)


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Michael R. Silverman grad student 1972 UCSD
Cindy M. Quezada grad student 2003 Caltech (Chemistry Tree)
Xiaoyan R. Bao grad student 2007 Caltech (Chemistry Tree)
Ching-Kang J. Chen post-doc Caltech (Neurotree)
Narasimhan Gautam post-doc Caltech (Neurotree)
Gail Mandel post-doc UCSD (Neurotree)
Philip Matsumura post-doc Caltech (Marine Ecology Tree)
Robert R. Bourret research scientist 1987-1992 Caltech (Physics Tree)
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Wiley SE, Andreyev AY, Divakaruni AS, et al. (2013) Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. Embo Molecular Medicine. 5: 904-18
Divakaruni AS, Wiley SE, Rogers GW, et al. (2013) Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proceedings of the National Academy of Sciences of the United States of America. 110: 5422-7
Gan X, Wang J, Wang C, et al. (2012) PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Nature Cell Biology. 14: 686-96
Xue T, Do MT, Riccio A, et al. (2011) Melanopsin signalling in mammalian iris and retina. Nature. 479: 67-73
Kim SJ, Park GH, Kim D, et al. (2011) Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proceedings of the National Academy of Sciences of the United States of America. 108: 3371-6
Rebres RA, Roach TI, Fraser ID, et al. (2011) Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. The Journal of Biological Chemistry. 286: 942-51
Bao XR, Fraser ID, Wall EA, et al. (2010) Variability in G-protein-coupled signaling studied with microfluidic devices. Biophysical Journal. 99: 2414-22
Imamachi N, Park GH, Lee H, et al. (2009) TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 106: 11330-5
Wall EA, Zavzavadjian JR, Chang MS, et al. (2009) Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Science Signaling. 2: ra28
Hsueh RC, Natarajan M, Fraser I, et al. (2009) Deciphering signaling outcomes from a system of complex networks. Science Signaling. 2: ra22
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