Brandy L. Akin, Ph.D.
Affiliations: | 2010 | Biochemistry and Molecular Biology | Indiana University, Bloomington, Bloomington, IN, United States |
Area:
Molecular Biology, BiochemistryGoogle:
"Brandy Akin"Parents
Sign in to add mentor| Larry R. Jones | grad student | 2010 | Indiana University | |
| (Investigating the molecular mechanism of phospholamban regulation of the Ca2+-pump of cardiac sarcoplasmic reticulum.) | ||||
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Publications
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| Akin BL, Hurley TD, Chen Z, et al. (2013) The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. The Journal of Biological Chemistry. 288: 30181-91 |
| Akin BL, Jones LR. (2012) Characterizing phospholamban to sarco(endo)plasmic reticulum Ca2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking. The Journal of Biological Chemistry. 287: 7582-93 |
| Akin BL, Jones LR. (2012) Characterizing phospholamban to sarco(endo)plasmic reticulum Ca 2+-ATPase 2a (SERCA2a) protein binding interactions in human cardiac sarcoplasmic reticulum vesicles using chemical cross-linking (Journal of Biological Chemistry (2012) 287, (7582-7593)) Journal of Biological Chemistry. 287: 18586 |
| Akin BL, Jones LR. (2011) Highly Specific, Conformationally-Dependent Cross-Linking of Lys27 of PLB to SERCA2a in Cardiac SR Vesicles from Humans Biophysical Journal. 100: 466a |
| Akin BL, Chen Z, Jones LR. (2010) Superinhibitory phospholamban mutants compete with Ca2+ for binding to SERCA2a by stabilizing a unique nucleotide-dependent conformational state. The Journal of Biological Chemistry. 285: 28540-52 |
| Chen Z, Akin BL, Jones LR. (2010) Ca2+ binding to site I of the cardiac Ca2+ pump is sufficient to dissociate phospholamban. The Journal of Biological Chemistry. 285: 3253-60 |
| Chopra N, Yang T, Asghari P, et al. (2009) Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proceedings of the National Academy of Sciences of the United States of America. 106: 7636-41 |
| Chen Z, Akin BL, Jones LR. (2009) Ca2+ Binding to Site I of the Cardiac Ca2+ Pump (SERCA2a) is Sufficient to Dissociate Phospholamban (PLB) Biophysical Journal. 96: 142a-143a |
| Akin BL, Chen Z, Jones LR. (2009) Cross-Linkable, Gain-of-Function Phospholamban (PLB) Mutant Reveals the Molecular Mechanism of SERCA2a Inhibition Biophysical Journal. 96: 210a-211a |
| Chopra N, Kannankeril PJ, Yang T, et al. (2007) Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circulation Research. 101: 617-26 |