Keefe T. Chan, Ph.D.

Affiliations: 
2010 University of Wisconsin, Madison, Madison, WI 
Area:
Cell Biology
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"Keefe Chan"

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Anna Huttenlocher grad student 2010 UW Madison
 (The roles of FAK and calpain 2 in regulating adhesion dynamics during cell migration and invasion.)
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Publications

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Carson CC, Moschos SJ, Edmiston SN, et al. (2015) IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2167-76
Chan KT, Asokan SB, King SJ, et al. (2014) LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. The Journal of Cell Biology. 207: 299-315
Liu W, Monahan KB, Pfefferle AD, et al. (2012) LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21: 751-64
Chan KT, Roadcap DW, Holoweckyj N, et al. (2012) Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. The Biochemical Journal. 444: 89-96
Chan KT, Creed SJ, Bear JE. (2011) Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends in Cell Biology. 21: 481-8
Chan KT, Bennin DA, Huttenlocher A. (2010) Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). The Journal of Biological Chemistry. 285: 11418-26
Chan KT, Cortesio CL, Huttenlocher A. (2009) FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. The Journal of Cell Biology. 185: 357-70
Cortesio CL, Chan KT, Perrin BJ, et al. (2008) Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. The Journal of Cell Biology. 180: 957-71
Cortesio CL, Chan KT, Huttenlocher A. (2008) Adhesion Dynamics in Motile Cells Cell Junctions: Adhesion, Development, and Disease. 71-88
Lokuta MA, Senetar MA, Bennin DA, et al. (2007) Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Molecular Biology of the Cell. 18: 5069-80
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