Ravikiran S. Yedidi, Ph.D.

Affiliations: 
2009 Biochemistry and Molecular Biology Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Medical Biophysics, Pharmacy
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"Ravikiran Yedidi"

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Ladislau C. Kovari grad student 2009 Wayne State
 (Structure based design of potent inhibitors against multidrug-resistant HIV-1 protease variants.)
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Publications

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Aoki M, Hayashi H, Yedidi RS, et al. (2015) The C5-substituted Tetrahydropyrano-tetrahydofuran-derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs Including Darunavir. Journal of Virology
Yedidi RS, Proteasa G, Martin PD, et al. (2014) A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF. Journal of Molecular Graphics & Modelling. 53: 105-11
Yedidi RS, Garimella H, Aoki M, et al. (2014) A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV. Antimicrobial Agents and Chemotherapy. 58: 3679-88
Yedidi RS, Liu Z, Kovari IA, et al. (2014) P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease Journal of Molecular Graphics and Modelling. 47: 18-24
Yedidi RS, Muhuhi JM, Liu Z, et al. (2013) Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. Biochemical and Biophysical Research Communications. 438: 703-8
Yedidi RS, Maeda K, Fyvie WS, et al. (2013) P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrobial Agents and Chemotherapy. 57: 4920-7
Liu Z, Yedidi RS, Wang Y, et al. (2013) Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance. Biochemical and Biophysical Research Communications. 437: 199-204
Liu Z, Yedidi RS, Wang Y, et al. (2013) Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex. Biochemical and Biophysical Research Communications. 431: 232-8
Liu Z, Wang Y, Yedidi RS, et al. (2013) Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes. Biochemical and Biophysical Research Communications. 430: 1022-7
Yedidi RS, Liu Z, Wang Y, et al. (2012) Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 421: 413-417
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