Ian M. Slaymaker, Ph.D.

Affiliations: 
2013 Biochemistry and Molecular Biology University of Southern California, Los Angeles, CA, United States 
Area:
Biochemistry
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"Ian Slaymaker"

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Xiaojiang Chen grad student 2013 USC
 (Structural and biochemical studies of DNA helicase complexes: Conformational diversity of archaeal MCM.)
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Publications

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Chu SH, Packer M, Rees H, et al. (2021) Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation. The Crispr Journal. 4: 169-177
Porto EM, Komor AC, Slaymaker IM, et al. (2020) Base editing: advances and therapeutic opportunities. Nature Reviews. Drug Discovery
Gaudelli NM, Lam DK, Rees HA, et al. (2020) Directed evolution of adenine base editors with increased activity and therapeutic application. Nature Biotechnology
Slaymaker IM, Mesa P, Kellner MJ, et al. (2019) High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage. Cell Reports. 26: 3741-3751.e5
Tangprasertchai NS, Di Felice R, Zhang X, et al. (2017) CRISPR-Cas9 mediated DNA unwinding detected using site-directed spin labeling. Acs Chemical Biology
Smargon AA, Cox DB, Pyzocha NK, et al. (2017) Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Molecular Cell
Abudayyeh OO, Gootenberg JS, Konermann S, et al. (2016) C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science (New York, N.Y.)
Yamano T, Nishimasu H, Zetsche B, et al. (2016) Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. Cell
Slaymaker IM, Gao L, Zetsche B, et al. (2015) Rationally engineered Cas9 nucleases with improved specificity. Science (New York, N.Y.)
Zetsche B, Gootenberg JS, Abudayyeh OO, et al. (2015) Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System. Cell
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