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Alan W. Lau, Ph.D.

Affiliations: 
2007 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Cell Biology, Molecular Biology
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"Alan Lau"
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Margaret M. Chou grad student 2007 Penn
 (Non-clathrin endocytosis: Mechanisms of regulating Arf6 and its endocytic pathway.)

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Publications

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Gasser JA, Inuzuka H, Lau AW, et al. (2014) SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell. 56: 595-607
Dai X, Liu P, Lau AW, et al. (2014) Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Medicine. 3: 1211-24
Fukushima H, Ogura K, Wan L, et al. (2013) SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16
Lau AW, Inuzuka H, Fukushima H, et al. (2013) Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Research. 23: 947-61
Inuzuka H, Gao D, Finley LW, et al. (2012) Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93
Fukushima H, Matsumoto A, Inuzuka H, et al. (2012) SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Reports. 1: 434-43
Lau AW, Fukushima H, Wei W. (2012) The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Frontiers in Bioscience (Landmark Edition). 17: 2197-212
Min SH, Lau AW, Lee TH, et al. (2012) Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Molecular Cell. 46: 771-83
Erickson-Johnson MR, Chou MM, Evers BR, et al. (2011) Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Laboratory Investigation; a Journal of Technical Methods and Pathology. 91: 1427-33
Inuzuka H, Fukushima H, Shaik S, et al. (2011) Mcl-1 ubiquitination and destruction. Oncotarget. 2: 239-44
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