Irene Litosch

1985- Molecular & Cellular Pharmacology University of Miami, Coral Gables, FL 
Pharmacology, Molecular Biology
"Irene Litosch"
DOI: 10.1002/ajh.2830080406
DOI: 10.1016/0304-4165(81)90112-4


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Kwang Soo Lee grad student 1979 SUNY Downstate Medical Center (Chemistry Tree)
 (Studies on calcium transport in sickle red cell membranes)
John N. Fain post-doc 1979-1982 Brown (Chemistry Tree)
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Litosch I. (2016) Decoding Gαq signaling. Life Sciences. 152: 99-106
Litosch I. (2015) Regulating G protein activity by lipase-independent functions of phospholipase C. Life Sciences. 137: 116-24
Litosch I. (2013) Regulation of phospholipase C-β(1) GTPase-activating protein (GAP) function and relationship to G(q) efficacy. Iubmb Life. 65: 936-40
Litosch I. (2013) G protein co-signaling and challenges for translational research Translational Neuroscience. 4: 66-73
Litosch I. (2012) Negative feedback regulation of Gq signaling by protein kinase C is disrupted by diacylglycerol kinase ζ in COS-7 cells. Biochemical and Biophysical Research Communications. 417: 956-60
Litosch I. (2011) RhoA co-ordinates with heterotrimeric G proteins to regulate efficacy. Biochemical and Biophysical Research Communications. 415: 215-9
Litosch I. (2009) Phosphatidic acid potentiates G(alpha)q stimulation of phospholipase C-beta1 signaling. Biochemical and Biophysical Research Communications. 390: 603-7
Litosch I, Pujari R, Lee SJ. (2009) Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1). Cellular Signalling. 21: 1379-84
Ross EM, Mateu D, Gomes AV, et al. (2006) Structural determinants for phosphatidic acid regulation of phospholipase C-beta1. The Journal of Biological Chemistry. 281: 33087-94
Litosch I. (2003) Regulation of phospholipase C-beta activity by phosphatidic acid: isoform dependence, role of protein kinase C, and G protein subunits. Biochemistry. 42: 1618-23
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