Heather L. Wieman, Ph.D.

2008 Duke University, Durham, NC 
Molecular Biology
"Heather Wieman"


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Jeffrey Rathmell grad student 2008 Duke
 (Growth factor-mediated regulation of Glut1 trafficking and degradation.)
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Altman BJ, Wofford JA, Zhao Y, et al. (2009) Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. Molecular Biology of the Cell. 20: 1180-91
Wardell SE, Ilkayeva OR, Wieman HL, et al. (2009) Glucose metabolism as a target of histone deacetylase inhibitors. Molecular Endocrinology (Baltimore, Md.). 23: 388-401
Wieman HL, Horn SR, Jacobs SR, et al. (2009) An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. The Biochemical Journal. 418: 345-67
Zhao Y, Wieman HL, Jacobs SR, et al. (2008) Chapter Twenty-Two Mechanisms and Methods in Glucose Metabolism and Cell Death Methods in Enzymology. 442: 439-457
MacIver NJ, Jacobs SR, Wieman HL, et al. (2008) Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival Journal of Leukocyte Biology. 84: 949-957
Jacobs SR, Herman CE, MacIver NJ, et al. (2008) Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways Journal of Immunology. 180: 4476-4486
Wofford JA, Wieman HL, Jacobs SR, et al. (2008) IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival Blood. 111: 2101-2111
Zhao Y, Altman BJ, Coloff JL, et al. (2007) Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Molecular and Cellular Biology. 27: 4328-39
Wieman HL, Wofford JA, Rathmell JC. (2007) Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Molecular Biology of the Cell. 18: 1437-46
Palti Y, Silverstein JT, Wieman H, et al. (2006) Evaluation of family growth response to fishmeal and gluten-based diets in rainbow trout (Oncorhynchus mykiss) Aquaculture. 255: 548-556
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