Sarah R. Jacobs, Ph.D.

Affiliations: 
2009 Molecular Cancer Biology Duke University, Durham, NC 
Area:
General Biology, Oncology, Immunology
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"Sarah Jacobs"

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Jeffrey Rathmell grad student 2009 Duke
 (The role of glucose metabolism in T cell stimulation and homeostasis.)
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Publications

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Jacobs SR, Stopford CM, West JA, et al. (2015) Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway. Journal of Virology. 89: 11572-83
Ma Z, Jacobs SR, West JA, et al. (2015) Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses. Proceedings of the National Academy of Sciences of the United States of America
West JA, Wicks M, Gregory SM, et al. (2014) An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle. Journal of Virology. 88: 5778-87
Jacobs SR, Gregory SM, West JA, et al. (2013) The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. Journal of Virology. 87: 798-806
Bhatt AP, Jacobs SR, Freemerman AJ, et al. (2012) Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 109: 11818-23
Jacobs SR, Damania B. (2012) NLRs, inflammasomes, and viral infection. Journal of Leukocyte Biology. 92: 469-77
Jacobs SR, Damania B. (2011) The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes? Frontiers in Immunology. 2: 19
Michalek RD, Gerriets VA, Jacobs SR, et al. (2011) Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. Journal of Immunology (Baltimore, Md. : 1950). 186: 3299-303
Coloff JL, Mason EF, Altman BJ, et al. (2011) Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. The Journal of Biological Chemistry. 286: 5921-33
Altman BJ, Jacobs SR, Mason EF, et al. (2011) Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene. 30: 1855-67
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