Yuh Min Chook, Ph.D

Pharmacology and Biophysics University of Texas Southwestern Medical Center, Dallas, TX, United States 
Nuclear Transport
"Yuh Min Chook"
Cross-listing: Chemistry Tree


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William N. Lipscomb grad student 1994 Harvard (Chemistry Tree)
 (Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complexes with a transition state analog and prephenate)
Anthony  J. Pawson post-doc 1994-1996 Mt Sinai Hospital, Toronto (Neurotree)
Günter Blobel post-doc 1996-2001 Rockefeller
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Fung HYJ, Chook YM. (2022) Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1. Methods in Molecular Biology (Clifton, N.J.). 2502: 285-297
Gonzalez A, Mannen T, Çağatay T, et al. (2021) Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Scientific Reports. 11: 3754
Springhower CE, Rosen MK, Chook YM. (2020) Karyopherins and condensates. Current Opinion in Cell Biology. 64: 112-123
Lee Y, Pei J, Baumhardt JM, et al. (2019) Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site. Scientific Reports. 9: 6627
Zhang K, Shang G, Padavannil A, et al. (2018) Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proceedings of the National Academy of Sciences of the United States of America
Fu SC, Fung HYJ, Cağatay T, et al. (2018) Correlation of CRM1-NES affinity with nuclear export activity. Molecular Biology of the Cell. mbcE18020096
Pinarbasi ES, Cağatay T, Fung HYJ, et al. (2018) Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Scientific Reports. 8: 7083
Yoshizawa T, Ali R, Jiou J, et al. (2018) Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell. 173: 693-705.e22
Guo L, Kim HJ, Wang H, et al. (2018) Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20
Chook YM, Fontoura BMA, Rout MP. (2018) Günter Blobel 1936-2018. Nature Structural & Molecular Biology
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