Lu Chen, Ph.D.
Affiliations: | 2021- | Fox Chase Cancer Center, Philadelphia |
Area:
telomere and telomerase, RNA biology, agingWebsite:
www.luchenlab.orgGoogle:
"https://scholar.google.com/citations?user=q7rrWCAAAAAJ&hl=en"Cross-listing: Telomere and Telomerase Tree
Parents
Sign in to add mentor| Joan W. Conaway | grad student | 2008-2013 | University of Kansas Medical Center |
| Steven E. Artandi | post-doc | 2013-2021 | Stanford (Telomere and Telomerase Tree) |
Children
Sign in to add trainee| Musinu Zakari | post-doc | 2022- | Fox Chase Cancer Center, Philadelphia |
| Soon-keat Ooi | post-doc | 2021-2022 | Fox Chase Cancer Center, Philadelphia |
Collaborators
Sign in to add collaborator| Ylli Doksani | collaborator | 2022- | IFOM -FIRC Institute of Molecular Oncology |
BETA: Related publications
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Publications
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| Huda A, Arakawa H, Mazzucco G, et al. (2023) The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Science Advances. 9: eadf2011 |
| Chen L, Roake CM, Maccallini P, et al. (2022) TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research |
| Galati A, Scatolini L, Micheli E, et al. (2021) The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. Febs Letters |
| Chen L, Chang HY, Artandi SE. (2021) Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. Star Protocols. 2: 100477 |
| Vaidyanathan S, Baik R, Chen L, et al. (2021) Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Chen L, Bellone RR, Wang Y, et al. (2020) A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma. Dna Repair. 97: 103022 |
| Chen L, Roake CM, Galati A, et al. (2020) Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Cell Reports. 30: 1358-1372.e5 |
| Roake CM, Chen L, Chakravarthy AL, et al. (2019) Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Molecular Cell |
| Chen L, Roake CM, Freund A, et al. (2018) An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Cell |
| Lin S, Nascimento EM, Gajera CR, et al. (2018) Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature |