Lu Chen, Ph.D.

2021- Fox Chase Cancer Center, Philadelphia 
telomere and telomerase, RNA biology, aging
Cross-listing: Telomere and Telomerase Tree

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Murayama T, Nakayama J, Jiang X, et al. (2024) Targeting DHX9 triggers tumor-intrinsic interferon response and replication stress in Small Cell Lung Cancer. Cancer Discovery
Huda A, Arakawa H, Mazzucco G, et al. (2023) The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Science Advances. 9: eadf2011
Chen L, Roake CM, Maccallini P, et al. (2022) TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research
Galati A, Scatolini L, Micheli E, et al. (2021) The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. Febs Letters
Chen L, Chang HY, Artandi SE. (2021) Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. Star Protocols. 2: 100477
Vaidyanathan S, Baik R, Chen L, et al. (2021) Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. Molecular Therapy : the Journal of the American Society of Gene Therapy
Chen L, Bellone RR, Wang Y, et al. (2020) A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma. Dna Repair. 97: 103022
Chen L, Roake CM, Galati A, et al. (2020) Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Cell Reports. 30: 1358-1372.e5
Roake CM, Chen L, Chakravarthy AL, et al. (2019) Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Molecular Cell
Chen L, Roake CM, Freund A, et al. (2018) An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Cell
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