| Year |
Citation |
Score |
| 2014 |
Himmel DM, Myshakina NS, Ilina T, Van Ry A, Ho WC, Parniak MA, Arnold E. Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs. Journal of Molecular Biology. 426: 2617-31. PMID 24840303 DOI: 10.1016/J.Jmb.2014.05.006 |
0.397 |
|
| 2011 |
Felts AK, Labarge K, Bauman JD, Patel DV, Himmel DM, Arnold E, Parniak MA, Levy RM. Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Journal of Chemical Information and Modeling. 51: 1986-98. PMID 21714567 DOI: 10.1021/Ci200194W |
0.33 |
|
| 2011 |
Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF. Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Journal of Medicinal Chemistry. 54: 4462-73. PMID 21568335 DOI: 10.1021/Jm2000757 |
0.325 |
|
| 2009 |
Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure (London, England : 1993). 17: 1625-35. PMID 20004166 DOI: 10.1016/J.Str.2009.09.016 |
0.354 |
|
| 2009 |
Himmel DM, Mui S, O'Neall-Hennessey E, Szent-Györgyi AG, Cohen C. The on-off switch in regulated myosins: different triggers but related mechanisms. Journal of Molecular Biology. 394: 496-505. PMID 19769984 DOI: 10.1016/J.Jmb.2009.09.035 |
0.567 |
|
| 2008 |
Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Research. 36: 5083-92. PMID 18676450 DOI: 10.1093/Nar/Gkn464 |
0.388 |
|
| 2008 |
Knight JL, Zhou Z, Gallicchio E, Himmel DM, Friesner RA, Arnold E, Levy RM. Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling. Acta Crystallographica. Section D, Biological Crystallography. 64: 383-96. PMID 18391405 DOI: 10.1107/S090744490800070X |
0.377 |
|
| 2008 |
Himmel D, Pauly T, Bauman J, Dharia C, Clark A, Ryan K, Maegley K, Arnold E. Structure for an HIV-1 reverse transcriptase RNase H inhibitor bound at the active site Acta Crystallographica Section a Foundations of Crystallography. 64: C348-C348. DOI: 10.1107/S0108767308088880 |
0.369 |
|
| 2007 |
Yang Y, Gourinath S, Kovács M, Nyitray L, Reutzel R, Himmel DM, O'Neall-Hennessey E, Reshetnikova L, Szent-Györgyi AG, Brown JH, Cohen C. Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure (London, England : 1993). 15: 553-64. PMID 17502101 DOI: 10.1016/J.Str.2007.03.010 |
0.624 |
|
| 2006 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chemical Biology. 1: 702-12. PMID 17184135 DOI: 10.1021/Cb600303Y |
0.398 |
|
| 2005 |
Himmel DM, Das K, Clark AD, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. Journal of Medicinal Chemistry. 48: 7582-91. PMID 16302798 DOI: 10.1021/Jm0500323 |
0.336 |
|
| 2005 |
Benjahad A, Croisy M, Monneret C, Bisagni E, Mabire D, Coupa S, Poncelet A, Csoka I, Guillemont J, Meyer C, Andries K, Pauwels R, de Béthune MP, Himmel DM, Das K, et al. 4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains. Journal of Medicinal Chemistry. 48: 1948-64. PMID 15771439 DOI: 10.1021/Jm0408621 |
0.312 |
|
| 2005 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain M, McCoy-Simandle K, Clark PK, Clark Jr AD, Knight JL, Levy RM, Hughes SH, Parniak MA, Arnold E. X-ray structure for an RNase H inhibitor bound to HIV-1 reverse transcriptase Acta Crystallographica Section a Foundations of Crystallography. 61: c249-c249. DOI: 10.1107/S0108767305089397 |
0.363 |
|
| 2004 |
Risal D, Gourinath S, Himmel DM, Szent-Györgyi AG, Cohen C. Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding. Proceedings of the National Academy of Sciences of the United States of America. 101: 8930-5. PMID 15184651 DOI: 10.1073/Pnas.0403002101 |
0.617 |
|
| 2003 |
Gourinath S, Himmel DM, Brown JH, Reshetnikova L, Szent-Györgyi AG, Cohen C. Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head. Structure (London, England : 1993). 11: 1621-7. PMID 14656445 DOI: 10.1016/J.Str.2003.10.013 |
0.622 |
|
| 2002 |
Himmel DM, Gourinath S, Reshetnikova L, Shen Y, Szent-Györgyi AG, Cohen C. Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor. Proceedings of the National Academy of Sciences of the United States of America. 99: 12645-50. PMID 12297624 DOI: 10.1073/Pnas.202476799 |
0.615 |
|
| 1999 |
Houdusse A, Kalabokis VN, Himmel D, Szent-Györgyi AG, Cohen C. Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head. Cell. 97: 459-70. PMID 10338210 DOI: 10.1016/S0092-8674(00)80756-4 |
0.638 |
|
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