Richard M. Longnecker - Publications

Affiliations: 
Northwestern University, Evanston, IL 
Area:
Microbiology Biology

199 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zhen J, Chen J, Huang H, Liao S, Liu S, Yuan Y, Sun R, Longnecker R, Wu T-T, Zhou ZH. Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features. Journal of Virology. e0119424. PMID 39470208 DOI: 10.1128/jvi.01194-24  0.317
2024 Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, Yamazaki Y, Fan Q, Matuozzo D, Harschnitz O, Kerrouche N, Nakajima K, Amin P, Yatim A, Rinchai D, Chen J, ... ... Longnecker R, et al. Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature. PMID 39048830 DOI: 10.1038/s41586-024-07745-x  0.377
2024 Zhen J, Chen J, Huang H, Liao S, Liu S, Yuan Y, Sun R, Longnecker R, Wu TT, Zhou ZH. Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features. Biorxiv : the Preprint Server For Biology. PMID 39026862 DOI: 10.1101/2024.07.09.602672  0.331
2024 Quan J, Fan Q, Simons LM, Smukowski SN, Pegg C, Longnecker R, Savas JN, Hultquist JF, Smith GA. Leveraging biotin-based proximity labeling to identify cellular factors governing early alphaherpesvirus infection. Mbio. e0144524. PMID 38953638 DOI: 10.1128/mbio.01445-24  0.353
2023 Fan Q, Hippler DP, Yang Y, Longnecker R, Connolly SA. Multiple Sites on Glycoprotein H (gH) Functionally Interact with the gB Fusion Protein to Promote Fusion during Herpes Simplex Virus (HSV) Entry. Mbio. e0336822. PMID 36629412 DOI: 10.1128/mbio.03368-22  0.405
2022 Ikeda M, Hayes CK, Schaller SJ, Longnecker R. Latent Membrane Proteins from EBV Differentially Target Cellular Pathways to Accelerate MYC-induced Lymphomagenesis. Blood Advances. PMID 35605249 DOI: 10.1182/bloodadvances.2022007695  0.396
2021 Fan Q, Longnecker R, Connolly SA. Herpes simplex virus glycoprotein B (gB) mutations define structural sites in domain I, the membrane proximal region, and the cytodomain that regulate entry. Journal of Virology. JVI0105021. PMID 34431697 DOI: 10.1128/JVI.01050-21  0.429
2020 Connolly SA, Jardetzky TS, Longnecker R. The structural basis of herpesvirus entry. Nature Reviews. Microbiology. PMID 33087881 DOI: 10.1038/s41579-020-00448-w  0.39
2020 Fish K, Comoglio F, Shaffer AL, Ji Y, Pan KT, Scheich S, Oellerich A, Doebele C, Ikeda M, Schaller SJ, Nguyen H, Muppidi J, Wright GW, Urlaub H, Serve H, ... ... Longnecker R, et al. Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A. Proceedings of the National Academy of Sciences of the United States of America. PMID 33020271 DOI: 10.1073/pnas.2007946117  0.698
2020 Chen J, Schaller S, Jardetzky TS, Longnecker R. EBV gH/gL and KSHV gH/gL bind to different sites on EphA2 to trigger fusion. Journal of Virology. PMID 32847853 DOI: 10.1128/Jvi.01454-20  0.485
2020 Giraldo D, Wilcox DR, Longnecker R. The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival. Mbio. 11. PMID 32457247 DOI: 10.1128/Mbio.00921-20  0.348
2020 Park SJ, Riccio RE, Kopp SJ, Ifergan I, Miller SD, Longnecker R. Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection. Mbio. 11. PMID 32398314 DOI: 10.1128/Mbio.00790-20  0.399
2020 Hippler DP, Fan Q, Longnecker R, Connolly SA. Selection of Mutations that Affect Herpesvirus Entry into Cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09212  0.307
2019 Chen J, Longnecker R. Epithelial cell infection by Epstein-Barr virus. Fems Microbiology Reviews. PMID 31584659 DOI: 10.1093/Femsre/Fuz023  0.554
2019 Möhl BS, Chen J, Longnecker R. Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells. Advances in Virus Research. 104: 313-343. PMID 31439152 DOI: 10.1016/Bs.Aivir.2019.05.006  0.556
2019 Sora RP, Ikeda M, Longnecker R. Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A. Mbio. 10. PMID 30992353 DOI: 10.1128/Mbio.00548-19  0.365
2019 Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R. Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor. Mbio. 10. PMID 30782663 DOI: 10.1128/Mbio.02892-18  0.543
2018 Fan Q, Kopp SJ, Byskosh NC, Connolly SA, Longnecker R. Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant. Mbio. 9. PMID 30327436 DOI: 10.1128/Mbio.01948-18  0.472
2018 Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, Ucur A, Ustek D, Cen Y, Gordon L, Longnecker R. Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma. Msphere. 3. PMID 30135222 DOI: 10.1128/mSphereDirect.00378-18  0.371
2018 Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R. Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus. Nature Microbiology. PMID 29292384 DOI: 10.1038/S41564-017-0081-7  0.586
2017 Fish K, Sora RP, Schaller SJ, Longnecker R, Ikeda M. EBV latent membrane protein 2A orchestrates p27(kip1) degradation via Cks1 to accelerate MYC-driven lymphoma in mice. Blood. PMID 29074502 DOI: 10.1182/Blood-2017-07-796821  0.727
2017 Möhl BS, Chen J, Park SJ, Jardetzky TS, Longnecker R. Epstein-Barr virus fusion with epithelial cells triggered by gB is restricted by a gL glycosylation site. Journal of Virology. PMID 28956769 DOI: 10.1128/Jvi.01255-17  0.579
2017 Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS. Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies. Proceedings of the National Academy of Sciences of the United States of America. PMID 28939750 DOI: 10.1073/Pnas.1704661114  0.514
2017 Rink JS, Yang S, Cen O, Taxter T, McMahon KM, Misener S, Behdad A, Longnecker R, Gordon LI, Thaxton CS. Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin. Molecular Pharmaceutics. PMID 28933554 DOI: 10.1021/Acs.Molpharmaceut.7B00710  0.334
2017 Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky TS. The COMPLEXity in herpesvirus entry. Current Opinion in Virology. 24: 97-104. PMID 28538165 DOI: 10.1016/J.Coviro.2017.04.006  0.494
2017 Fan Q, Kopp SJ, Connolly SA, Longnecker R. Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype. Mbio. 8. PMID 28512095 DOI: 10.1128/Mbio.00614-17  0.483
2017 Fish K, Longnecker R. EBV germinates lymphoma from the germinal center in a battle with T and NK cells. Proceedings of the National Academy of Sciences of the United States of America. 114: 4571-4573. PMID 28442562 DOI: 10.1073/Pnas.1704102114  0.724
2017 Edwards RG, Longnecker R. Herpes virus entry mediator (HVEM) and ocular herpes infection: more than meets the eye. Journal of Virology. PMID 28404853 DOI: 10.1128/Jvi.00115-17  0.431
2017 Fan Q, Kopp S, Connolly SA, Muller WJ, Longnecker R. Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage. Scientific Reports. 7: 43712. PMID 28255168 DOI: 10.1038/Srep43712  0.427
2017 Edwards RG, Kopp SJ, Ifergan I, Shui JW, Kronenberg M, Miller SD, Longnecker R. Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy. Investigative Ophthalmology & Visual Science. 58: 282-291. PMID 28114589 DOI: 10.1167/Iovs.16-20668  0.414
2016 Chen J, Jardetzky TS, Longnecker R. The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment. Mbio. 7. PMID 27935841 DOI: 10.1128/Mbio.01871-16  0.539
2016 Sathiyamoorthy K, Hu YX, Möhl BS, Chen J, Longnecker R, Jardetzky TS. Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins. Nature Communications. 7: 13557. PMID 27929061 DOI: 10.1038/Ncomms13557  0.555
2016 Möhl BS, Chen J, Sathiyamoorthy K, Jardetzky TS, Longnecker R. Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus. Molecules and Cells. PMID 27094060 DOI: 10.14348/Molcells.2016.0066  0.576
2016 Wilcox DR, Folmsbee SS, Muller WJ, Longnecker R. The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis. Mbio. 7. PMID 27073094 DOI: 10.1128/Mbio.00437-16  0.383
2016 Yigit B, Halibozek PJ, Chen SS, O'Keeffe MS, Arnason J, Avigan D, Gattei V, Bhan A, Cen O, Longnecker R, Chiorazzi N, Wang N, Engel P, Terhorst C. A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells. Oncotarget. PMID 27029059 DOI: 10.18632/Oncotarget.8378  0.443
2016 Wilcox DR, Longnecker R. The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions. Plos Pathogens. 12: e1005449. PMID 26964062 DOI: 10.1371/Journal.Ppat.1005449  0.434
2016 Cen O, Kannan K, Huck JJ, Yu J, Zhang M, Gordon LI, Longnecker R. The Syk Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of EBV-Associated Lymphoma Blood. 128: 4179-4179. DOI: 10.1182/Blood.V128.22.4179.4179  0.412
2015 Möhl BS, Schröter C, Klupp BG, Fuchs W, Mettenleiter TC, Jardetzky TS, Longnecker R. Comparative mutagenesis of Pseudorabies and Epstein-Barr virus gH identifies a structural determinant within domain III of gH required for surface expression and entry function. Journal of Virology. PMID 26656711 DOI: 10.1128/Jvi.03032-15  0.51
2015 Wilcox DR, Muller WJ, Longnecker R. HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain. Proceedings of the National Academy of Sciences of the United States of America. 112: E6937-44. PMID 26621722 DOI: 10.1073/Pnas.1513045112  0.415
2015 Edwards RG, Kopp SJ, Karaba AH, Wilcox DR, Longnecker R. Herpesvirus Entry Mediator on Radiation-Resistant Cell Lineages Promotes Ocular Herpes Simplex Virus 1 Pathogenesis in an Entry-Independent Manner. Mbio. 6. PMID 26489863 DOI: 10.1128/Mbio.01532-15  0.743
2015 Cen O, Longnecker RM. Latent Membrane Protein 2 (LMP2). Current Topics in Microbiology and Immunology. 391: 151-180. PMID 26428374 DOI: 10.1007/978-3-319-22834-1_5  0.433
2015 Zhao M, Onakpa MM, Santarsiero BD, Huang XJ, Zhang XQ, Chen J, Cheng JJ, Longnecker R, Che CT. Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha. Organic Letters. PMID 26183449 DOI: 10.1021/Acs.Orglett.5B01806  0.306
2015 Fan Q, Longnecker R, Connolly SA. A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras. Journal of Virology. 89: 7159-69. PMID 25926636 DOI: 10.1128/Jvi.00740-15  0.487
2015 Wilcox DR, Wadhwani NR, Longnecker R, Muller WJ. Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults Plos Pathogens. 11: e1004580. PMID 25569138 DOI: 10.1371/Journal.Ppat.1004580  0.352
2015 Rowe CL, Chen J, Jardetzky TS, Longnecker R. Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers. Mbio. 6. PMID 25564465 DOI: 10.1128/Mbio.02285-14  0.51
2015 Rowe CL, Chen J, Jardetzky TS, Longnecker R. Membrane anchoring of epstein-barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers Mbio. 6. DOI: 10.1128/mBio.02285-14  0.43
2014 Möhl BS, Sathiyamoorthy K, Jardetzky TS, Longnecker R. The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells. Journal of Virology. 88: 13570-9. PMID 25231307 DOI: 10.1128/Jvi.02272-14  0.592
2014 Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS. Assembly and architecture of the EBV B cell entry triggering complex. Plos Pathogens. 10: e1004309. PMID 25144748 DOI: 10.1371/Journal.Ppat.1004309  0.587
2014 Chen J, Zhang X, Jardetzky TS, Longnecker R. The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion Journal of Virology. 88: 11686-11695. PMID 25100836 DOI: 10.1128/Jvi.01349-14  0.555
2014 Fan Q, Longnecker R, Connolly SA. Substitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gD-gH/gL functional interaction and a region within the gD profusion domain that is critical for fusion. Journal of Virology. 88: 6470-82. PMID 24672037 DOI: 10.1128/Jvi.00465-14  0.474
2014 Fish K, Chen J, Longnecker R. Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma. Blood. 123: 530-40. PMID 24174629 DOI: 10.1182/Blood-2013-07-517649  0.72
2014 Möhl BS, Sathiyamoorthy K, Jardetzky TS, Longnecker R. The conserved disulfide bond within domain II of epstein-barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells Journal of Virology. 88: 13570-13579. DOI: 10.1128/JVI.02272-14  0.445
2013 Brägelmann J, Dagogo-Jack I, El Dinali M, Stricker T, Brown CD, Zuo Z, Khattri A, Keck M, McNerney ME, Longnecker R, Bieging K, Kocherginsky M, Alexander K, Salgia R, Lingen MW, et al. Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA. Oral Oncology. 49: 525-33. PMID 23490885 DOI: 10.1016/J.Oraloncology.2013.02.003  0.764
2013 Fan Q, Bohannon KP, Longnecker R. Drosophila Schneider 2 (S2) cells: a novel tool for studying HSV-induced membrane fusion. Virology. 437: 100-9. PMID 23399037 DOI: 10.1016/J.Virol.2013.01.004  0.444
2013 Garcia NJ, Chen J, Longnecker R. Modulation of Epstein-Barr Virus Glycoprotein B (gB) Fusion Activity by the gB Cytoplasmic Tail Domain Mbio. 4. PMID 23341550 DOI: 10.1128/Mbio.00571-12  0.576
2013 Rowe CL, Connolly SA, Chen J, Jardetzky TS, Longnecker R. A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion Virology. 436: 118-126. PMID 23200314 DOI: 10.1016/J.Virol.2012.10.039  0.493
2013 Zago A, Connolly SA, Spear PG, Longnecker R. The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination. Virus Research. 171: 227-30. PMID 23089849 DOI: 10.1016/J.Virusres.2012.10.015  0.506
2012 Karaba AH, Kopp SJ, Longnecker R. Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes. Proceedings of the National Academy of Sciences of the United States of America. 109: 20649-54. PMID 23184983 DOI: 10.1073/Pnas.1216967109  0.705
2012 Shim AH, Chang RA, Chen X, Longnecker R, He X. Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1. Proceedings of the National Academy of Sciences of the United States of America. 109: 12962-7. PMID 22826234 DOI: 10.1073/Pnas.1205309109  0.752
2012 Fan Q, Longnecker R. Is nectin-1 the "master" receptor for deadly herpes B virus infection? Virulence. 3: 405. PMID 22722246 DOI: 10.4161/Viru.20587  0.498
2012 Chang RA, Miller SD, Longnecker R. Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function. Scientific Reports. 2: 353. PMID 22616025 DOI: 10.1038/Srep00353  0.824
2012 Dargart JL, Fish K, Gordon LI, Longnecker R, Cen O. Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A. Antiviral Research. 95: 49-56. PMID 22609829 DOI: 10.1016/J.Antiviral.2012.05.003  0.716
2012 Gordon LI, Longnecker R. Off-targeting oft-targeted CD20 in cHL. Blood. 119: 4095-4096. PMID 22555658 DOI: 10.1182/Blood-2012-03-413146  0.427
2012 Vrazo AC, Chauchard M, Raab-Traub N, Longnecker R. Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice. Plos Pathogens. 8. PMID 22536156 DOI: 10.1371/Journal.Ppat.1002662  0.596
2012 Connolly SA, Longnecker R. Residues within the C-terminal arm of the herpes simplex virus 1 glycoprotein B ectodomain contribute to its refolding during the fusion step of virus entry. Journal of Virology. 86: 6386-93. PMID 22491468 DOI: 10.1128/Jvi.00104-12  0.514
2012 Fan Q, Amen M, Harden M, Severini A, Griffiths A, Longnecker RM. Herpes B Virus Utilizes Human Nectin-1 but Not HVEM or PILRα for Cell-Cell Fusion and Virus Entry Journal of Virology. 86: 4468-4476. PMID 22345445 DOI: 10.1128/Jvi.00041-12  0.556
2012 Chen J, Rowe CL, Jardetzky TS, Longnecker R. The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells. Mbio. 3. PMID 22215569 DOI: 10.1128/Mbio.00290-11  0.609
2011 Bieging KT, Fish K, Bondada S, Longnecker R. A shared gene expression signature in mouse models of EBV-associated and non-EBV-associated Burkitt lymphoma. Blood. 118: 6849-59. PMID 22039254 DOI: 10.1182/Blood-2011-02-338434  0.815
2011 Karaba AH, Kopp SJ, Longnecker R. Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea. Journal of Virology. 85: 10041-7. PMID 21795335 DOI: 10.1128/Jvi.05445-11  0.716
2011 Rowe CL, Matsuura H, Jardetzky TS, Longnecker R. Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42) Virology. 415: 122-131. PMID 21550622 DOI: 10.1016/J.Virol.2011.04.003  0.469
2011 Connolly SA, Jackson JO, Jardetzky TS, Longnecker R. Fusing structure and function: A structural view of the herpesvirus entry machinery Nature Reviews Microbiology. 9: 369-381. PMID 21478902 DOI: 10.1038/Nrmicro2548  0.497
2011 Plate AE, Reimer JJ, Jardetzky TS, Longnecker R. Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL. Virology. 413: 26-38. PMID 21376360 DOI: 10.1016/J.Virol.2010.12.006  0.827
2011 Cen O, Longnecker RM. Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt's Lymphoma Molecular Cancer Therapeutics. 10: 679-686. PMID 21282357 DOI: 10.1158/1535-7163.Mct-10-0833  0.433
2010 Matsuura H, Kirschner AN, Longnecker R, Jardetzky TS. Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex Proceedings of the National Academy of Sciences of the United States of America. 107: 22641-22646. PMID 21149717 DOI: 10.1073/Pnas.1011806108  0.534
2010 Jackson JO, Longnecker R. Reevaluating herpes simplex virus hemifusion. Journal of Virology. 84: 11814-11821. PMID 20844038 DOI: 10.1128/Jvi.01615-10  0.513
2010 Liu F, Marquardt G, Kirschner AN, Longnecker R, Jardetzky TS. Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays Journal of Virology. 84: 10375-10385. PMID 20668073 DOI: 10.1128/Jvi.00381-10  0.533
2010 Fan Q, Longnecker R. The Ig-like V-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion Journal of Virology. 84: 8664-8672. PMID 20573830 DOI: 10.1128/Jvi.01039-10  0.419
2010 Swanson-Mungerson M, Bultema R, Longnecker R. Epstein–Barr virus LMP2A imposes sensitivity to apoptosis Journal of General Virology. 91: 2197-2202. PMID 20484564 DOI: 10.1099/Vir.0.021444-0  0.525
2010 Shaw PL, Kirschner AN, Jardetzky TS, Longnecker R. Characteristics of Epstein-Barr virus envelope protein gp42 Virus Genes. 40: 307-319. PMID 20162447 DOI: 10.1007/S11262-010-0455-X  0.513
2010 Bieging KT, Swanson-Mungerson M, Amick AC, Longnecker R. Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A. Cell Cycle (Georgetown, Tex.). 9: 901-8. PMID 20160479 DOI: 10.4161/Cc.9.5.10840  0.825
2010 Jackson JO, Lin E, Spear PG, Longnecker R. Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry. Journal of Virology. 84: 2038-46. PMID 20007280 DOI: 10.1128/Jvi.02215-09  0.507
2009 Bieging KT, Amick AC, Longnecker R. Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 17945-50. PMID 19815507 DOI: 10.1073/Pnas.0907994106  0.805
2009 Plate AE, Smajlovi? J, Jardetzky TS, Longnecker R. Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion Journal of Virology. 83: 7678-7689. PMID 19457993 DOI: 10.1128/Jvi.00457-09  0.838
2009 Sorem J, Jardetzky TS, Longnecker R. Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes Journal of Virology. 83: 6664-6672. PMID 19369343 DOI: 10.1128/Jvi.00195-09  0.833
2009 Sorem J, Longnecker R. Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells. The Journal of General Virology. 90: 591-5. PMID 19218203 DOI: 10.1099/Vir.0.007237-0  0.824
2009 Kirschner AN, Sorem J, Longnecker R, Jardetzky TS. Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry Structure. 17: 223-233. PMID 19217393 DOI: 10.1016/J.Str.2008.12.010  0.802
2009 Backovic M, Longnecker R, Jardetzky TS. Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B Proceedings of the National Academy of Sciences of the United States of America. 106: 2880-2885. PMID 19196955 DOI: 10.1073/Pnas.0810530106  0.523
2009 Bultema R, Longnecker R, Swanson-Mungerson M. Epstein-Barr virus LMP2A accelerates MYC-induced lymphomagenesis. Oncogene. 28: 1471-1476. PMID 19182823 DOI: 10.1038/Onc.2008.492  0.524
2009 Ikeda M, Longnecker R. The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling. Virology. 385: 183-191. PMID 19081591 DOI: 10.1016/J.Virol.2008.11.018  0.483
2009 Hsiao FC, Tai AK, Deglon A, Sutkowski N, Longnecker R, Huber BT. EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM. Virology. 385: 261-6. PMID 19070345 DOI: 10.1016/J.Virol.2008.11.025  0.327
2009 Reimer JJ, Backovic M, Deshpande CG, Jardetzky T, Longnecker R. Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis. Journal of Virology. 83: 734-47. PMID 18987135 DOI: 10.1128/Jvi.01817-08  0.563
2009 Anderson LJ, Longnecker R. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood. 113: 108-16. PMID 18815281 DOI: 10.1182/Blood-2008-06-160937  0.536
2009 Bieging KT, Amick AC, Longnecker R. Abstract B30: EBV LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B30  0.785
2008 Rovedo M, Longnecker R. Epstein-Barr Virus Latent Membrane Protein 2A Preferentially Signals through the Src Family Kinase Lyn Journal of Virology. 82: 8520-8528. PMID 18579586 DOI: 10.1128/Jvi.00843-08  0.832
2008 Anderson LJ, Longnecker R. EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway. The Journal of General Virology. 89: 1563-8. PMID 18559925 DOI: 10.1099/Vir.0.2008/001461-0  0.506
2008 Rechsteiner MP, Berger C, Zauner L, Sigrist JA, Weber M, Longnecker R, Bernasconi M, Nadal D. Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection. Journal of Virology. 82: 1739-47. PMID 18057232 DOI: 10.1128/Jvi.01723-07  0.616
2008 Anderson LJ, Longnecker R. An auto-regulatory loop for EBV LMP2A involves activation of Notch Virology. 371: 257-266. PMID 17980397 DOI: 10.1016/J.Virol.2007.10.009  0.391
2007 Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR. Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor. Journal of Immunology (Baltimore, Md. : 1950). 179: 4435-43. PMID 17878339 DOI: 10.4049/Jimmunol.179.7.4435  0.377
2007 Backovic M, Leser GP, Lamb RA, Longnecker R, Jardetzky TS. Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins. Virology. 368: 102-13. PMID 17655906 DOI: 10.1016/J.Virol.2007.06.031  0.492
2007 Fukuda M, Longnecker R. Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt pathway Journal of Virology. 81: 9299-9306. PMID 17582000 DOI: 10.1128/Jvi.00537-07  0.444
2007 Kirschner AN, Lowrey AS, Longnecker R, Jardetzky TS. Binding-site interactions between epstein-barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion Journal of Virology. 81: 9216-9229. PMID 17581996 DOI: 10.1128/Jvi.00575-07  0.516
2007 Backovic M, Jardetzky TS, Longnecker R. Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity Journal of Virology. 81: 9596-9600. PMID 17553877 DOI: 10.1128/Jvi.00758-07  0.564
2007 Omerović J, Longnecker R. Functional Homology of gHs and gLs from EBV-related γ-herpesviruses for EBV-induced Membrane Fusion Virology. 365: 157-165. PMID 17477951 DOI: 10.1016/J.Virol.2007.03.054  0.589
2007 Swanson-Mungerson M, Longnecker RM. Epstein–Barr virus latent membrane protein 2A and autoimmunity Trends in Immunology. 28: 213-218. PMID 17398159 DOI: 10.1016/J.It.2007.03.002  0.465
2007 Ikeda M, Longnecker R. Cholesterol is Critical for Epstein-Barr Virus Latent Membrane Protein 2A Trafficking and Protein Stability Virology. 360: 461-468. PMID 17150237 DOI: 10.1016/J.Virol.2006.10.046  0.459
2007 Rovedo M, Longnecker R. Epstein-Barr Virus Latent Membrane Protein 2B (LMP2B) Modulates LMP2A Activity Journal of Virology. 81: 84-94. PMID 17035319 DOI: 10.1128/Jvi.01302-06  0.845
2006 Kirschner AN, Omerovi? J, Popov B, Longnecker R, Jardetzky TS. Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion Journal of Virology. 80: 9444-9454. PMID 16973550 DOI: 10.1128/Jvi.00572-06  0.535
2006 Swanson-Mungerson M, Bultema R, Longnecker R. Epstein-Barr Virus LMP2A Enhances B-Cell Responses In Vivo and In Vitro Journal of Virology. 80: 6764-6770. PMID 16809282 DOI: 10.1128/Jvi.00433-06  0.516
2006 Lu J, Lin WH, Chen SY, Longnecker R, Tsai SC, Chen CL, Tsai CH. Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells. The Journal of Biological Chemistry. 281: 8806-14. PMID 16431925 DOI: 10.1074/Jbc.M507305200  0.504
2005 Omerović J, Lev L, Longnecker R. The Amino Terminus of Epstein-Barr Virus Glycoprotein gH Is Important for Fusion with Epithelial and B Cells Journal of Virology. 79: 12408-12415. PMID 16160168 DOI: 10.1128/Jvi.79.19.12408-12415.2005  0.581
2005 Fukuda M, Longnecker RM. Epstein-Barr Virus (EBV) Latent Membrane Protein 2A Regulates B-Cell Receptor-Induced Apoptosis and EBV Reactivation through Tyrosine Phosphorylation Journal of Virology. 79: 8655-8660. PMID 15956608 DOI: 10.1128/Jvi.79.13.8655-8660.2005  0.53
2005 Swanson-Mungerson MA, Caldwell RG, Bultema R, Longnecker RM. Epstein-Barr Virus LMP2A Alters In Vivo and In Vitro Models of B-Cell Anergy, but Not Deletion, in Response to Autoantigen Journal of Virology. 79: 7355-7362. PMID 15919890 DOI: 10.1128/Jvi.79.12.7355-7362.2005  0.554
2005 Stefan M, Portis T, Longnecker R, Nicholls RD. A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted PWS loci do not alter genome-wide mRNA levels Genomics. 85: 630-640. PMID 15820315 DOI: 10.1016/J.Ygeno.2005.02.004  0.305
2005 Park SJ, Seo MD, Lee SK, Ikeda M, Longnecker R, Lee BJ. Expression and characterization of N-terminal domain of Epstein-Barr virus latent membrane protein 2A in Escherichia coli. Protein Expression and Purification. 41: 9-17. PMID 15802216 DOI: 10.1016/J.Pep.2004.07.006  0.478
2005 Ikeda M, Longnecker RM. Pre-B-cell colony formation assay. Methods of Molecular Biology. 292: 279-283. PMID 15507715 DOI: 10.1385/1-59259-848-X:279  0.507
2005 McShane MP, Longnecker R. Analysis of fusion using a virus-free cell fusion assay. Methods in Molecular Biology (Clifton, N.J.). 292: 187-96. PMID 15507709 DOI: 10.1385/1-59259-848-X:187  0.849
2004 McShane MP, Longnecker R. Cell-surface expression of a mutated Epstein-Barr virus glycoprotein B allows fusion independent of other viral proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 17474-9. PMID 15583133 DOI: 10.1073/Pnas.0404535101  0.855
2004 Katzman RB, Longnecker R. LMP2A does not require palmitoylation to localize to buoyant complexes or for function. Journal of Virology. 78: 10878-87. PMID 15452208 DOI: 10.1128/Jvi.78.20.10878-10887.2004  0.772
2004 Portis T, Longnecker RM. Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway. Oncogene. 23: 8619-8628. PMID 15361852 DOI: 10.1038/Sj.Onc.1207905  0.488
2004 Portis T, Ikeda M, Longnecker RM. Epstein-Barr virus LMP2A: regulating cellular ubiquitination processes for maintenance of viral latency? Trends in Immunology. 25: 422-426. PMID 15275641 DOI: 10.1016/J.It.2004.05.009  0.553
2004 Silva AL, Omerovi? J, Jardetzky TS, Longnecker R. Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion Journal of Virology. 78: 5946-5956. PMID 15140992 DOI: 10.1128/Jvi.78.11.5946-5956.2004  0.511
2004 Ikeda A, Merchant M, Lev L, Longnecker R, Ikeda M. Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development. Journal of Immunology. 172: 5329-5337. PMID 15100272 DOI: 10.4049/Jimmunol.172.9.5329  0.73
2004 Shaikh S, Skoczylas C, Longnecker R, Rundell K. Inability of simian virus 40 to establish productive infection of lymphoblastic cell lines. Journal of Virology. 78: 4917-20. PMID 15078974 DOI: 10.1128/Jvi.78.9.4917-4920.2004  0.455
2004 Portis T, Longnecker R. Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation. Virology. 318: 524-533. PMID 14972521 DOI: 10.1016/J.Virol.2003.09.017  0.548
2004 Fukuda M, Longnecker R. Latent Membrane Protein 2A Inhibits Transforming Growth Factor-β1-Induced Apoptosis through the Phosphatidylinositol 3-Kinase/Akt Pathway Journal of Virology. 78: 1697-1705. PMID 14747535 DOI: 10.1128/Jvi.78.4.1697-1705.2004  0.374
2003 Katzman RB, Longnecker R. Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein-Barr virus. The Journal of General Virology. 84: 2987-92. PMID 14573803 DOI: 10.1099/Vir.0.19252-0  0.811
2003 Ressing ME, Van Leeuwen D, Verreck FAW, Gomez R, Heemskerk B, Toebes M, Mullen MM, Jardetzky TS, Longnecker R, Schilham MW, Ottenhoff THM, Neefjes J, Schumacher TN, Hutt-Fletcher LM, Wiertz EJHJ. Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition Proceedings of the National Academy of Sciences of the United States of America. 100: 11583-11588. PMID 14504389 DOI: 10.1073/Pnas.2034960100  0.476
2003 Spear PG, Longnecker R. Herpesvirus entry: an update. Journal of Virology. 77: 10179-85. PMID 12970403 DOI: 10.1128/Jvi.77.19.10179-10185.2003  0.498
2003 Speck P, Callen DF, Longnecker R. Absence of the Epstein-Barr virus genome in breast cancer-derived cell lines. Journal of the National Cancer Institute. 95: 1253-4; author reply. PMID 12928356 DOI: 10.1093/Jnci/Djg041  0.354
2003 Portis T, Dyck P, Longnecker R. Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma. Blood. 102: 4166-4178. PMID 12907455 DOI: 10.1182/Blood-2003-04-1018  0.558
2003 Swanson-Mungerson M, Ikeda M, Lev L, Longnecker R, Portis T. Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein–Barr virus (EBV)-associated diseases Journal of Antimicrobial Chemotherapy. 52: 152-154. PMID 12837743 DOI: 10.1093/Jac/Dkg306  0.407
2003 McShane MP, Mullen MM, Haan KM, Jardetzky TS, Longnecker R. Mutational analysis of the HLA class II interaction with Epstein-Barr virus glycoprotein 42 Journal of Virology. 77: 7655-7662. PMID 12805465 DOI: 10.1128/Jvi.77.13.7655-7662.2003  0.778
2003 Ikeda A, Caldwell RG, Longnecker R, Ikeda M. Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling. Journal of Virology. 77: 5529-5534. PMID 12692257 DOI: 10.1128/Jvi.77.9.5529-5534.2003  0.464
2003 Portis T, Longnecker R. Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte Development Journal of Virology. 77: 105-114. PMID 12477815 DOI: 10.1128/Jvi.77.1.105-114.2003  0.527
2002 Cooper L, Longnecker RM. Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease. Antiviral Research. 56: 219-231. PMID 12406506 DOI: 10.1016/S0166-3542(02)00110-9  0.486
2002 Ikeda M, Ikeda A, Longnecker R. Lysine-independent ubiquitination of Epstein-Barr virus LMP2A. Virology. 300: 153-159. PMID 12202215 DOI: 10.1006/Viro.2002.1562  0.456
2002 Inabe K, Miyawaki T, Longnecker R, Matsukura H, Tsukada S, Kurosaki T. Bruton's tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-γ2 activation Febs Letters. 514: 260-262. PMID 11943162 DOI: 10.1016/S0014-5793(02)02375-X  0.398
2002 Mullen MM, Haan KM, Longnecker R, Jardetzky TS. Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1 Molecular Cell. 9: 375-385. PMID 11864610 DOI: 10.1016/S1097-2765(02)00465-3  0.818
2002 Portis T, Cooper L, Dennis P, Longnecker R. The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease. Frontiers in Bioscience : a Journal and Virtual Library. 7: d414-26. PMID 11815296 DOI: 10.2741/Portis  0.52
2002 Speck P, Ikeda M, Ikeda A, Lederman HM, Longnecker R. Signal transduction through the B cell antigen receptor is normal in ataxia-telangiectasia B lymphocytes. Journal of Biological Chemistry. 277: 4123-4127. PMID 11733529 DOI: 10.1074/Jbc.M110109200  0.476
2001 Merchant M, Swart R, Katzman RB, Ikeda M, Ikeda A, Longnecker R, Dykstra ML, Pierce SK. The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function. International Reviews of Immunology. 20: 805-35. PMID 11913951 DOI: 10.3109/08830180109045591  0.838
2001 Haan KM, Kyeong Lee S, Longnecker R. Different functional domains in the cytoplasmic tail of glycoprotein B are involved in Epstein-Barr virus-induced membrane fusion Virology. 290: 106-114. PMID 11882994 DOI: 10.1006/Viro.2001.1141  0.845
2001 Scholle F, Longnecker R, Raab-Traub N. Analysis of the Phosphorylation Status of Epstein–Barr Virus LMP2A in Epithelial Cells Virology. 291: 208-214. PMID 11878890 DOI: 10.1006/Viro.2001.1197  0.383
2001 Merchant M, Longnecker R. LMP2A survival and developmental signals are transmitted through Btk-dependent and Btk-independent pathways Virology. 291: 46-54. PMID 11878875 DOI: 10.1006/Viro.2001.1187  0.736
2001 Dawson CW, George JH, Blake SMS, Longnecker RM, Young LS. The Epstein–Barr Virus Encoded Latent Membrane Protein 2A Augments Signaling from Latent Membrane Protein 1 Virology. 289: 192-207. PMID 11689042 DOI: 10.1006/Viro.2001.1142  0.479
2001 Engels N, Merchant M, Pappu R, Chan AC, Longnecker R, Wienands J. Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module Journal of Experimental Medicine. 194: 255-264. PMID 11489945 DOI: 10.1084/Jem.194.3.255  0.728
2001 Gahn B, Siller-Lopez F, Pirooz AD, Yvon E, Gottschalk S, Longnecker R, Brenner MK, Heslop HE, Aguilar-Cordova E, Rooney CM. Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen : A potential treatment strategy for Epstein-Barr virus-positive Hodgkin's lymphoma International Journal of Cancer. 93: 706-713. PMID 11477583 DOI: 10.1002/Ijc.1396  0.377
2001 Ikeda M, Ikeda A, Longnecker R. PY Motifs of Epstein-Barr Virus LMP2A Regulate Protein Stability and Phosphorylation of LMP2A-Associated Proteins Journal of Virology. 75: 5711-5718. PMID 11356981 DOI: 10.1128/Jvi.75.12.5711-5718.2001  0.54
2001 Haan KM, Aiyar A, Longnecker R. Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines Journal of Virology. 75: 3016-3020. PMID 11222728 DOI: 10.1128/Jvi.75.6.3016-3020.2001  0.85
2001 Dykstra ML, Longnecker R, Pierce SK. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR. Immunity. 14: 57-67. PMID 11163230 DOI: 10.1016/S1074-7613(01)00089-9  0.463
2000 Speck P, Longnecker R. Infection of breast epithelial cells with epstein-barr virus via cell-to-cell contact Journal of the National Cancer Institute. 92: 1849-1851. PMID 11078764 DOI: 10.1093/Jnci/92.22.1849  0.446
2000 Speck P, Haan KM, Longnecker R. Epstein-Barr virus entry into cells Virology. 277: 1-5. PMID 11062029 DOI: 10.1006/Viro.2000.0624  0.812
2000 Swart R, Ruf IK, Sample J, Longnecker R. Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-kinase/Akt pathway Journal of Virology. 74: 10838-10845. PMID 11044134 DOI: 10.1128/Jvi.74.22.10838-10845.2000  0.833
2000 Merchant M, Caldwell RG, Longnecker R. The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo Journal of Virology. 74: 9115-9124. PMID 10982358 DOI: 10.1128/Jvi.74.19.9115-9124.2000  0.729
2000 Longan L, Longnecker R. Epstein-Barr virus latent membrane protein 2A has no growth-altering effects when expressed in differentiating epithelia. Journal of General Virology. 81: 2245-2252. PMID 10950982 DOI: 10.1099/0022-1317-81-9-2245  0.47
2000 Haan KM, Longnecker R. Coreceptor restriction within the HLA-DQ locus for Epstein-Barr virus infection Proceedings of the National Academy of Sciences of the United States of America. 97: 9252-9257. PMID 10908662 DOI: 10.1073/Pnas.160171697  0.825
2000 Longnecker R, Merchant M, Brown ME, Fruehling S, Bickford JO, Ikeda M, Harty RN. WW- and SH3-domain interactions with epstein-barr virus LMP2A Experimental Cell Research. 257: 332-340. PMID 10837147 DOI: 10.1006/Excr.2000.4900  0.669
2000 Longnecker R. Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence? Advances in Cancer Research. 79: 175-200. PMID 10818681 DOI: 10.1016/S0065-230X(00)79006-3  0.522
2000 Ikeda M, Ikeda A, Longan LC, Longnecker R. The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases. Virology. 268: 178-191. PMID 10683340 DOI: 10.1006/Viro.1999.0166  0.528
2000 Haan KM, Kwok WW, Longnecker R, Speck P. Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor Journal of Virology. 74: 2451-2454. PMID 10666279 DOI: 10.1128/Jvi.74.5.2451-2454.2000  0.826
2000 Caldwell RG, Brown RC, Longnecker R. Epstein-Barr Virus LMP2A-Induced B-Cell Survival in Two Unique Classes of EμLMP2A Transgenic Mice Journal of Virology. 74: 1101-1113. PMID 10627520 DOI: 10.1128/Jvi.74.3.1101-1113.2000  0.598
1999 Swart R, Fruehling S, Longnecker RM. Tyrosines 60, 64, and 101 of Epstein–Barr Virus LMP2A Are Not Essential for Blocking B Cell Signal Transduction Virology. 263: 485-495. PMID 10544120 DOI: 10.1006/Viro.1999.9964  0.84
1999 Speck P, Kline KA, Cheresh P, Longnecker R. Epstein-Barr virus lacking latent membrane protein 2 immortalizes B cells with efficiency indistinguishable from that of wild-type virus. The Journal of General Virology. 80: 2193-203. PMID 10466819 DOI: 10.1099/0022-1317-80-8-2193  0.553
1999 Speck P, Longnecker RM. Epstein-Barr virus (EBV) infection visualized by EGFP expression demonstrates dependence on known mediators of EBV entry Archives of Virology. 144: 1123-1137. PMID 10446648 DOI: 10.1007/S007050050574  0.514
1999 Gabriel JM, Merchant M, Ohta T, Ji Y, Caldwell RG, Ramsey MJ, Tucker JD, Longnecker R, Nicholls RD. A transgene insertion creating a heritable chromosome deletion mouse model of Prader-Willi and angelman syndromes. Proceedings of the National Academy of Sciences of the United States of America. 96: 9258-63. PMID 10430930 DOI: 10.1073/Pnas.96.16.9258  0.606
1999 Scholle F, Longnecker R, Raab-Traub N. Epithelial cell adhesion to extracellular matrix proteins induces tyrosine phosphorylation of the Epstein-Barr virus latent membrane protein 2: a role for C-terminal Src kinase. Journal of Virology. 73: 4767-4775. PMID 10233937 DOI: 10.1128/Jvi.73.6.4767-4775.1999  0.472
1999 Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E. An Epstein-Barr Virus That Expresses Only the First 231 LMP1 Amino Acids Efficiently Initiates Primary B-Lymphocyte Growth Transformation Journal of Virology. 73: 10525-10530. DOI: 10.1128/Jvi.73.12.10525-10530.1999  0.489
1998 Pertel PE, Spear PG, Longnecker R. Human herpesvirus-8 glycoprotein B interacts with Epstein-Barr virus (EBV) glycoprotein 110 but fails to complement the infectivity of EBV mutants. Virology. 251: 402-13. PMID 9837804 DOI: 10.1006/Viro.1998.9412  0.529
1998 Caldwell RG, Wilson JB, Anderson SJ, Longnecker R. Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity. 9: 405-11. PMID 9768760 DOI: 10.1016/S1074-7613(00)80623-8  0.61
1998 Fruehling S, Swart R, Dolwick KM, Kremmer E, Longnecker RM. Tyrosine 112 of Latent Membrane Protein 2A Is Essential for Protein Tyrosine Kinase Loading and Regulation of Epstein-Barr Virus Latency Journal of Virology. 72: 7796-7806. PMID 9733815 DOI: 10.1128/Jvi.72.10.7796-7806.1998  0.841
1998 Fluckiger AC, Li Z, Kato RM, Wahl MI, Ochs HD, Longnecker R, Kinet JP, Witte ON, Scharenberg AM, Rawlings DJ. Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation. The Embo Journal. 17: 1973-85. PMID 9524120 DOI: 10.1093/Emboj/17.7.1973  0.361
1997 Lee SK, Compton T, Longnecker R. Failure to complement infectivity of EBV and HSV-1 glycoprotein B (gB) deletion mutants with gBs from different human herpesvirus subfamilies. Virology. 237: 170-81. PMID 9344919 DOI: 10.1006/Viro.1997.8765  0.457
1997 Fruehling S, Longnecker R. The Immunoreceptor Tyrosine-Based Activation Motif of Epstein–Barr Virus LMP2A Is Essential for Blocking BCR-Mediated Signal Transduction☆ Virology. 235: 241-251. PMID 9281504 DOI: 10.1006/Viro.1997.8690  0.531
1997 Rochford R, Miller CL, Cannon MJ, Izumi KM, Kieff E, Longnecker R. In vivo growth of Epstein-Barr virus transformed B cells with mutations in latent membrane protein 2 (LMP2). Archives of Virology. 142: 707-20. PMID 9170499 DOI: 10.1007/S007050050113  0.52
1997 Lee SK, Longnecker R. The Epstein-Barr virus glycoprotein 110 carboxy-terminal tail domain is essential for lytic virus replication. Journal of Virology. 71: 4092-4097. DOI: 10.1128/Jvi.71.5.4092-4097.1997  0.477
1996 Longnecker R, Miller CL. Regulation of Epstein-Barr virus latency by latent membrane protein 2. Trends in Microbiology. 4: 38-42. PMID 8824794 DOI: 10.1016/0966-842X(96)81504-6  0.543
1996 Fruehling S, Lee SK, Herrold R, Frech B, Laux G, Kremmer E, Grässer FA, Longnecker R. Identification of latent membrane protein 2A (LMP2A) domains essential for the LMP2A dominant-negative effect on B-lymphocyte surface immunoglobulin signal transduction. Journal of Virology. 70: 6216-6226. PMID 8709248 DOI: 10.1128/Jvi.70.9.6216-6226.1996  0.479
1996 Herrold RE, Marchini A, Fruehling S, Longnecker R. Glycoprotein 110, the Epstein-Barr virus homolog of herpes simplex virus glycoprotein B, is essential for Epstein-Barr virus replication in vivo. Journal of Virology. 70: 2049-2054. PMID 8627735 DOI: 10.1128/Jvi.70.3.2049-2054.1996  0.554
1995 Miller CL, Burkhardt AL, Lee JH, Stealey B, Longnecker R, Bolen JB, Kieff E. Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity. 2: 155-66. PMID 7895172 DOI: 10.1016/S1074-7613(95)80040-9  0.442
1994 Miller CL, Lee JH, Kieff E, Longnecker R. An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking. Proceedings of the National Academy of Sciences of the United States of America. 91: 772-6. PMID 8290598 DOI: 10.1073/Pnas.91.2.772  0.543
1993 Longnecker R, Miller CL, Tomkinson B, Miao XQ, Kieff E. Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B. Journal of Virology. 67: 5068-74. PMID 8392630 DOI: 10.1128/Jvi.67.8.5068-5074.1993  0.535
1993 Longnecker R, Miller CL, Miao XQ, Tomkinson B, Kieff E. The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro. Journal of Virology. 67: 2006-13. PMID 8383224 DOI: 10.1128/Jvi.67.4.2006-2013.1993  0.526
1993 Tomkinson B, Robertson E, Yalamanchili R, Longnecker R, Kieff E. Epstein-Barr virus recombinants from overlapping cosmid fragments. Journal of Virology. 67: 7298-7306. PMID 8230453 DOI: 10.1128/Jvi.67.12.7298-7306.1993  0.414
1993 Miller CL, Longnecker R, Kieff E. Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes. Journal of Virology. 67: 3087-94. PMID 7684459 DOI: 10.1128/Jvi.67.6.3087-3094.1993  0.523
1993 Marchini A, Kieff E, Longnecker R. Marker rescue of a transformation-negative Epstein-Barr virus recombinant from an infected Burkitt lymphoma cell line: a method useful for analysis of genes essential for transformation. Journal of Virology. 67: 606-609. DOI: 10.1128/Jvi.67.1.606-609.1993  0.473
1992 Longnecker R, Miller CL, Miao XQ, Marchini A, Kieff E. The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential. Journal of Virology. 66: 6461-9. PMID 1328675 DOI: 10.1128/Jvi.66.11.6461-6469.1992  0.515
1992 Burkhardt AL, Bolen JB, Kieff E, Longnecker R. An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. Journal of Virology. 66: 5161-5167. PMID 1321296 DOI: 10.1128/Jvi.66.8.5161-5167.1992  0.468
1992 Marchini A, Longnecker R, Kieff E. Epstein-Barr virus (EBV)-negative B-lymphoma cell lines for clonal isolation and replication of EBV recombinants. Journal of Virology. 66: 4972-4981. PMID 1321281 DOI: 10.1128/Jvi.66.8.4972-4981.1992  0.544
1991 Longnecker R, Druker B, Roberts TM, Kieff E. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. Journal of Virology. 65: 3681-92. PMID 1710288 DOI: 10.1128/Jvi.65.7.3681-3692.1991  0.535
1991 Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, Kieff E, Rickinson A. Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell. 65: 1107-1115. PMID 1648447 DOI: 10.1016/0092-8674(91)90007-L  0.582
1990 Adams AE, Johnson DI, Longnecker RM, Sloat BF, Pringle JR. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. The Journal of Cell Biology. 111: 131-42. PMID 2195038 DOI: 10.1083/Jcb.111.1.131  0.359
1990 Longnecker R, Kieff E. A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1. Journal of Virology. 64: 2319-2326. PMID 2157888 DOI: 10.1128/Jvi.64.5.2319-2326.1990  0.466
1988 Meignier B, Longnecker R, Roizman B. In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020: construction and evaluation in rodents. The Journal of Infectious Diseases. 158: 602-14. PMID 2842408 DOI: 10.1093/Infdis/158.3.602  0.347
1988 Meignier B, Longnecker R, Mavromara-Nazos P, Sears AE, Roizman B. Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology. 162: 251-4. PMID 2827384 DOI: 10.1016/0042-6822(88)90417-5  0.407
1987 Purves FC, Longnecker RM, Leader DP, Roizman B. Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture. Journal of Virology. 61: 2896-901. PMID 3039176 DOI: 10.1128/Jvi.61.9.2896-2901.1987  0.488
1987 Longnecker R, Chatterjee S, Whitley RJ, Roizman B. Identification of a herpes simplex virus 1 glycoprotein gene within a gene cluster dispensable for growth in cell culture. Proceedings of the National Academy of Sciences of the United States of America. 84: 4303-7. PMID 3035578 DOI: 10.1073/Pnas.84.12.4303  0.408
1987 Longnecker R, Roizman B. Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome Science. 236: 573-576. PMID 3033823 DOI: 10.1126/Science.3033823  0.308
1986 Longnecker R, Roizman B. Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the alpha 47 gene. Journal of Virology. 58: 583-591. PMID 3009870 DOI: 10.1128/Jvi.58.2.583-591.1986  0.318
1986 Ackermann M, Longnecker R, Roizman B, Pereira L. Identification, properties, and gene location of a novel glycoprotein specified by herpes simplex virus 1. Virology. 150: 207-220. PMID 3006335 DOI: 10.1016/0042-6822(86)90280-1  0.386
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