Yousef Abu-Amer - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology, Cell Biology

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Chen M, Zhou H, Xu Y, Qiu L, Hu Z, Qin X, Chen S, Zhang Y, Cao Q, Abu-Amer Y, Ying Z. Lung-Specific Overexpression of Constitutively Active IKK2 Induces Pulmonary and Systemic Inflammations but Not Hypothalamic Inflammation and Glucose Intolerance. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29036520 DOI: 10.1093/toxsci/kfx154  0.56
2015 Swarnkar G, Abu-Amer Y. Regulation of NF-κB signaling in osteoclasts and myeloid progenitors. Methods in Molecular Biology (Clifton, N.J.). 1280: 527-42. PMID 25736770 DOI: 10.1007/978-1-4939-2422-6_31  0.56
2015 Swarnkar G, Karuppaiah K, Mbalaviele G, Chen TH, Abu-Amer Y. Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling. Proceedings of the National Academy of Sciences of the United States of America. 112: 154-9. PMID 25535389 DOI: 10.1073/pnas.1415213112  0.56
2014 Swarnkar G, Zhang K, Mbalaviele G, Long F, Abu-Amer Y. Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development. Plos One. 9: e91421. PMID 24618907 DOI: 10.1371/journal.pone.0091421  0.56
2014 Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ. Inflammasome-independent IL-1β mediates autoinflammatory disease in Pstpip2-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 1072-7. PMID 24395802 DOI: 10.1073/pnas.1318685111  0.56
2013 Zhang Y, Otero JE, Abu-Amer Y. Ubiquitin-like domain of IKKβ regulates osteoclastogenesis and osteolysis. Calcified Tissue International. 93: 78-85. PMID 23686246 DOI: 10.1007/s00223-013-9735-5  0.56
2013 Abu-Amer Y. NF-κB signaling and bone resorption Osteoporosis International. 24: 2377-2386. PMID 23468073 DOI: 10.1007/s00198-013-2313-x  0.56
2013 Yamanaka Y, Clohisy JC, Ito H, Matsuno T, Abu-Amer Y. Blockade of JNK and NFAT pathways attenuates orthopedic particle-stimulated osteoclastogenesis of human osteoclast precursors and murine calvarial osteolysis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 67-72. PMID 22847537 DOI: 10.1002/jor.22200  0.56
2012 Otero JE, Chen T, Zhang K, Abu-Amer Y. Constitutively active canonical NF-κB pathway induces severe bone loss in mice. Plos One. 7: e38694. PMID 22685599 DOI: 10.1371/journal.pone.0038694  0.56
2012 Alhawagri M, Yamanaka Y, Ballard D, Oltz E, Abu-Amer Y. Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 30: 554-60. PMID 21913221 DOI: 10.1002/jor.21555  0.56
2011 Yamanaka Y, Karuppaiah K, Abu-Amer Y. Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway. The Journal of Biological Chemistry. 286: 23735-41. PMID 21566132 DOI: 10.1074/jbc.M111.223669  0.56
2011 Dai S, Abu-Amer W, Karuppaiah K, Abu-Amer Y. Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO Journal of Cellular Biochemistry. 112: 2463-2470. PMID 21538482 DOI: 10.1002/jcb.23170  0.56
2010 Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y. Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis. The Journal of Biological Chemistry. 285: 25522-30. PMID 20534585 DOI: 10.1074/jbc.M110.121533  0.56
2010 Zhang Z, Xing X, Hensley G, Chang LW, Liao W, Abu-Amer Y, Sandell LJ. Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis and Rheumatism. 62: 1993-2003. PMID 20506172 DOI: 10.1002/art.27473  0.56
2010 Otero JE, Dai S, Alhawagri MA, Darwech I, Abu-Amer Y. IKKbeta activation is sufficient for RANK-independent osteoclast differentiation and osteolysis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 1282-94. PMID 20200955 DOI: 10.1002/jbmr.4  0.56
2009 Darwech I, Otero J, Alhawagri M, Dai S, Abu-Amer Y. Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis. Journal of Cellular Biochemistry. 108: 1337-45. PMID 19830703 DOI: 10.1002/jcb.22364  0.56
2009 Abu-Amer Y. Inflammation, cancer, and bone loss. Current Opinion in Pharmacology. 9: 427-33. PMID 19577517 DOI: 10.1016/j.coph.2009.06.007  0.56
2008 Yamanaka Y, Abu-Amer W, Foglia D, Otero J, Clohisy JC, Abu-Amer Y. NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 1577-84. PMID 18655139 DOI: 10.1002/jor.20714  0.56
2008 Otero JE, Dai S, Foglia D, Alhawagri M, Vacher J, Pasparakis M, Abu-Amer Y. Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation. The Journal of Biological Chemistry. 283: 24546-53. PMID 18567579 DOI: 10.1074/jbc.M800434200  0.56
2008 Abu-Amer Y, Darwech I, Otero J. Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss. Autoimmunity. 41: 204-11. PMID 18365833 DOI: 10.1080/08916930701694543  0.56
2007 Dufort FJ, Bleiman BF, Gumina MR, Blair D, Wagner DJ, Roberts MF, Abu-Amer Y, Chiles TC. Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. Journal of Immunology (Baltimore, Md. : 1950). 179: 4953-7. PMID 17911579  0.56
2007 Abu-Amer Y, Darwech I, Clohisy JC. Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies. Arthritis Research & Therapy. 9: S6. PMID 17634145 DOI: 10.1186/ar2170  0.56
2007 Kiesel J, Miller C, Abu-Amer Y, Aurora R. Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 2181-97. PMID 17584858 DOI: 10.1002/dvdy.21206  0.56
2006 Yamanaka Y, Abu-Amer Y, Faccio R, Clohisy JC. Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 1349-57. PMID 16732613 DOI: 10.1002/jor.20199  0.56
2006 Clohisy JC, Yamanaka Y, Faccio R, Abu-Amer Y. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 1358-65. PMID 16705717 DOI: 10.1002/jor.20184  0.56
2006 Mbalaviele G, Anderson G, Jones A, De Ciechi P, Settle S, Mnich S, Thiede M, Abu-Amer Y, Portanova J, Monahan J. Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction. The Journal of Pharmacology and Experimental Therapeutics. 317: 1044-53. PMID 16501068 DOI: 10.1124/jpet.105.100362  0.56
2005 Abu-Amer Y. Advances in osteoclast differentiation and function. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 347-55. PMID 16178795 DOI: 10.2174/1568008054863808  0.56
2005 Hirayama T, Dai S, Abbas S, Yamanaka Y, Abu-Amer Y. Inhibition of inflammatory bone erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation. Arthritis and Rheumatism. 52: 2719-29. PMID 16142755 DOI: 10.1002/art.21286  0.56
2005 Silva MJ, Brodt MD, Ko M, Abu-Amer Y. Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 mice. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 419-27. PMID 15746986 DOI: 10.1359/JBMR.041128  0.56
2004 Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Ross FP, Teitelbaum SL. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. Journal of Immunology (Baltimore, Md. : 1950). 173: 4838-46. PMID 15470024  0.56
2004 Abu-Amer Y, Abbas S, Hirayama T. TNF receptor type 1 regulates RANK ligand expression by stromal cells and modulates osteoclastogenesis. Journal of Cellular Biochemistry. 93: 980-9. PMID 15389885 DOI: 10.1002/jcb.20197  0.56
2004 Dai S, Hirayama T, Abbas S, Abu-Amer Y. The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. The Journal of Biological Chemistry. 279: 37219-22. PMID 15252035 DOI: 10.1074/jbc.C400258200  0.56
2004 Clohisy JC, Hirayama T, Frazier E, Han SK, Abu-Amer Y. NF-kB signaling blockade abolishes implant particle-induced osteoclastogenesis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 13-20. PMID 14656654 DOI: 10.1016/S0736-0266(03)00156-6  0.56
2003 Clohisy JC, Roy BC, Biondo C, Frazier E, Willis D, Teitelbaum SL, Abu-Amer Y. Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis. Journal of Immunology (Baltimore, Md. : 1950). 171: 5547-53. PMID 14607962  0.56
2003 Abbas S, Clohisy JC, Abu-Amer Y. Mitogen-activated protein (MAP) kinases mediate PMMA-induction of osteoclasts Journal of Orthopaedic Research. 21: 1041-1048. PMID 14554217 DOI: 10.1016/S0736-0266(03)00081-0  0.56
2003 Abbas S, Zhang YH, Clohisy JC, Abu-Amer Y. Tumor necrosis factor-alpha inhibits pre-osteoblast differentiation through its type-1 receptor. Cytokine. 22: 33-41. PMID 12946103 DOI: 10.1016/S1043-4666(03)00106-6  0.56
2003 Khan E, Abu-Amer Y. Activation of peroxisome proliferator-activated receptor-gamma inhibits differentiation of preosteoblasts. The Journal of Laboratory and Clinical Medicine. 142: 29-34. PMID 12878983 DOI: 10.1016/S0022-2143(03)00058-1  0.56
2003 Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y, Goldknopf J, Hruska KA. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 18: 669-85. PMID 12674328 DOI: 10.1359/jbmr.2003.18.4.669  0.56
2003 Abbas S, Abu-Amer Y. Dominant-negative IkappaB facilitates apoptosis of osteoclasts by tumor necrosis factor-alpha. The Journal of Biological Chemistry. 278: 20077-82. PMID 12637573 DOI: 10.1074/jbc.M208619200  0.56
2003 Clohisy JC, Frazier E, Hirayama T, Abu-Amer Y. RANKL is an essential cytokine mediator of polymethylmethacrylate particle-induced osteoclastogenesis. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 21: 202-12. PMID 12568950 DOI: 10.1016/S0736-0266(02)00133-X  0.56
2002 Lam J, Abu-Amer Y, Nelson CA, Fremont DH, Ross FP, Teitelbaum SL. Tumour necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis. Annals of the Rheumatic Diseases. 61: ii82-3. PMID 12379631  0.56
2002 Clohisy JC, Teitelbaum S, Chen S, Erdmann JM, Abu-Amer Y. Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 20: 174-81. PMID 11918294 DOI: 10.1016/S0736-0266(01)00088-2  0.56
2001 Abu-Amer Y, Dowdy SF, Ross FP, Clohisy JC, Teitelbaum SL. TAT Fusion Proteins Containing Tyrosine 42-deleted IκBα Arrest Osteoclastogenesis Journal of Biological Chemistry. 276: 30499-30503. PMID 11408488 DOI: 10.1074/jbc.M104725200  0.56
2001 Abu-Amer Y. IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB Journal of Clinical Investigation. 107: 1375-1385. PMID 11390419  0.56
2001 Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, Abu-Amer Y. Tumor necrosis factor-α (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways Journal of Biological Chemistry. 276: 563-568. PMID 11032840 DOI: 10.1074/jbc.M008198200  0.56
2000 Abu-Amer Y, Erdmann J, Alexopoulou L, Kollias G, Patrick Ross F, Teitelbaum SL. Tumor necrosis factor receptors types 1 and 2 differentially regulate osteoclastogenesis Journal of Biological Chemistry. 275: 27307-27310. PMID 10874036 DOI: 10.1074/jbc.M003886200  0.56
2000 Mbalaviele G, Abu-Amer Y, Meng A, Jaiswal R, Beck S, Pittenger MF, Thiede MA, Marshak DR. Activation of peroxisome proliferator-activated receptor-gamma pathway inhibits osteoclast differentiation. The Journal of Biological Chemistry. 275: 14388-93. PMID 10799521 DOI: 10.1074/jbc.275.19.14388  0.56
2000 Inoue M, Ross FP, Erdmann JM, Abu-Amer Y, Wei S, Teitelbaum SL. Tumor necrosis factor α regulates αvβ5 integrin expression by osteoclast precursors in vitro and in vivo Endocrinology. 141: 284-290. PMID 10614649 DOI: 10.1210/en.141.1.284  0.56
1999 Abu-Amer Y, Teitelbaum SL, Chappel JC, Schlesinger P, Ross FP. Expression and regulation of RAB3 proteins in osteoclasts and their precursors. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 14: 1855-60. PMID 10571685 DOI: 10.1359/jbmr.1999.14.11.1855  0.56
1999 Adams AE, Abu-Amer Y, Chappel J, Stueckle S, Ross FP, Teitelbaum SL, Suva LJ. 1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast-supporting stromal cells. Journal of Cellular Biochemistry. 74: 587-95. PMID 10440928 DOI: 10.1002/(SICI)1097-4644(19990915)74:4<587::AID-JCB8>3.0.CO;2-G  0.56
1999 Huang Z, Ritter C, Brown A, Finch J, Abu-Amer Y, Ross P, Slatopolsky E. Cloning and localization of Rab3 isoforms in bovine, rat, and human parathyroid glands Biochemical and Biophysical Research Communications. 255: 645-651. PMID 10049764 DOI: 10.1006/bbrc.1999.0226  0.56
1999 Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL. Tumor necrosis factor-α mediates orthopedic implant osteolysis American Journal of Pathology. 154: 203-210. PMID 9916934  0.56
1998 Abu-Amer Y, Rossl FP, McHugh KP, Livolsi A, Peyron JF, Teitelbaum SL. Tumor necrosis factor-α activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of IκBα Journal of Biological Chemistry. 273: 29417-29423. PMID 9792645 DOI: 10.1074/jbc.273.45.29417  0.56
1997 Chappel J, Ross FP, Abu-Amer Y, Shaw A, Teitelbaum SL. 1,25-dihydroxyvitamin D3 regulates pp60(c-src) activity and expression of a pp60(c-src) activating phosphatase Journal of Cellular Biochemistry. 67: 432-438. PMID 9383703 DOI: 10.1002/(SICI)1097-4644(19971215)67:4<432::AID-JCB2>3.0.CO;2-T  0.56
1997 Abu-Amer Y, Tondravi MM. NF-κB and bone: The breaking point Nature Medicine. 3: 1189-1190. PMID 9359684  0.56
1997 Abu-Amer Y, Ross FP, Edwards J, Teitelbaum SL. Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor Journal of Clinical Investigation. 100: 1557-1565. PMID 9294124  0.56
1997 Abu-Amer Y, Ross FP, Schlesinger P, Tondravi MM, Teitelbaum SL. Substrate recognition by osteoclast precursors induces C- src/microtubule association Journal of Cell Biology. 137: 247-254. PMID 9105052 DOI: 10.1083/jcb.137.1.247  0.56
1996 Matayoshi A, Brown C, Dipersio JF, Haug J, Abu-Amer Y, Liapis H, Kuestner R, Pacifici R. Human blood-mobilized hematopoietic precursors differentiate into osteoclasts in the absence of stromal cells Proceedings of the National Academy of Sciences of the United States of America. 93: 10785-10790. PMID 8855258 DOI: 10.1073/pnas.93.20.10785  0.56
1995 Teitelbaum SL, Abu-Amer Y, Ross FP. Molecular mechanisms of bone resorption Journal of Cellular Biochemistry. 59: 1-10. PMID 8530528 DOI: 10.1002/jcb.240590102  0.56
1994 Abu-Amer Y, Bar-Shavit Z. Modulation of vitamin D increased H2O2 production and MAC-2 expression in the bone marrow-derived macrophages by estrogen Calcified Tissue International. 55: 29-32. PMID 7922786 DOI: 10.1007/BF00310165  0.56
1993 Abu-Amer Y, Bar-Shavit Z. Impaired Bone Marrow-Derived Macrophage Differentiation in Vitamin D Deficiency Cellular Immunology. 151: 356-368. PMID 8402942 DOI: 10.1006/cimm.1993.1245  0.56
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