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Mark R. Fielden, Ph.D. - Publications

Affiliations: 
2002 Michigan State University, East Lansing, MI 
Area:
Molecular Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Minocherhomji S, Liu Y, He YD, Fielden MR. Biomarkers of Genome Instability in Normal Mammalian Genomes Following Drug-induced Replication Stress. Environmental and Molecular Mutagenesis. PMID 32078182 DOI: 10.1002/Em.22364  0.344
2019 Wong K, Chang P, Fielden M, Downey AM, Bunin D, Bakke J, Gahagen J, Iyer L, Doshi S, Wierzbicki W, Authier S. Pharmacodynamics of Romiplostim Alone and in Combination with Pegfilgrastim on Acute Radiation-Induced Thrombocytopenia and Neutropenia in Non-Human Primates. International Journal of Radiation Biology. 1-30. PMID 31216213 DOI: 10.1080/09553002.2019.1625488  0.31
2019 Valentine CC, Fielden M, Young R, Higgins J, Williams L, Li T, Kulkarni R, Minocherhomji S, Risques R, Danaher P, Salk J. Abstract 4649: Duplex Sequencing detects rare subclonal variants that mark early carcinogenesis and preneoplastic clonal evolution Cancer Research. 79: 4649-4649. DOI: 10.1158/1538-7445.Am2019-4649  0.325
2017 Young R, Salk J, Fielden M, Valentine C, Kulkarni R, Minocherhomii S. Application of duplex sequencing for in vivo mutation analysis in the cII transgene and endogenous genes in Big Blue ® mice Toxicology Letters. 280: S253. DOI: 10.1016/J.Toxlet.2017.07.702  0.325
2016 Fielden MR, Dean C, Black K, Sawant SG, Subramanian R, Tomlinson JE, Walter S, Zimmermann C, Griggs MW, McKeon ME, Lewis EM, Beevers C, Pyrah I. Nonclinical Safety Profile of Etelcalcetide, a Novel Peptide Calcimimetic for the Treatment of Secondary Hyperparathyroidism. International Journal of Toxicology. PMID 26941242 DOI: 10.1177/1091581816633407  0.341
2014 Guan P, Olaharski A, Fielden M, Roome N, Dragan Y, Sina J. Biomarkers of carcinogenicity and their roles in drug discovery and development. Expert Review of Clinical Pharmacology. 1: 759-71. PMID 24410606 DOI: 10.1586/17512433.1.6.759  0.332
2013 Garrido R, Zabka TS, Tao J, Fielden M, Fretland A, Albassam M. Quantitative histological assessment of xenobiotic-induced liver enzyme induction and pituitary-thyroid axis stimulation in rats using whole-slide automated image analysis. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 61: 362-71. PMID 23456825 DOI: 10.1369/0022155413482926  0.317
2011 Fielden MR, Adai A, Dunn RT, Olaharski A, Searfoss G, Sina J, Aubrecht J, Boitier E, Nioi P, Auerbach S, Jacobson-Kram D, Raghavan N, Yang Y, Kincaid A, Sherlock J, et al. Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 124: 54-74. PMID 21813463 DOI: 10.1093/Toxsci/Kfr202  0.374
2011 Wisler JA, Afshari C, Fielden M, Zimmermann C, Taylor S, Carnahan J, Vonderfecht S. Raf inhibition causes extensive multiple tissue hyperplasia and urinary bladder neoplasia in the rat. Toxicologic Pathology. 39: 809-22. PMID 21677315 DOI: 10.1177/0192623311410442  0.33
2011 Fielden M. Integration of Systems Toxicology into Drug Discovery General, Applied and Systems Toxicology. DOI: 10.1002/9780470744307.Gat210  0.317
2010 Shi L, Campbell G, Jones WD, Campagne F, Wen Z, Walker SJ, Su Z, Chu TM, Goodsaid FM, Pusztai L, Shaughnessy JD, Oberthuer A, Thomas RS, Paules RS, Fielden M, et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature Biotechnology. 28: 827-38. PMID 20676074 DOI: 10.1038/Nbt.1665  0.318
2010 Mikaelian I, Buness A, de Vera-Mudry MC, Kanwal C, Coluccio D, Rasmussen E, Char HW, Carvajal V, Hilton H, Funk J, Hoflack JC, Fielden M, Herting F, Dunn M, Suter-Dick L. Primary endothelial damage is the mechanism of cardiotoxicity of tubulin-binding drugs. Toxicological Sciences : An Official Journal of the Society of Toxicology. 117: 144-51. PMID 20624997 DOI: 10.1093/Toxsci/Kfq189  0.309
2010 Fielden MR, Hassani M, Uppal H, Day-Lollini P, Button D, Martin RS, Garrido R, Liu X, Kolaja KL. Mechanism of subendocardial cell proliferation in the rat and relevance for understanding drug-induced valvular heart disease in humans. Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft FüR Toxikologische Pathologie. 62: 607-13. PMID 19781924 DOI: 10.1016/J.Etp.2009.08.009  0.362
2008 Natsoulis G, Pearson CI, Gollub J, P Eynon B, Ferng J, Nair R, Idury R, Lee MD, Fielden MR, Brennan RJ, Roter AH, Jarnagin K. The liver pharmacological and xenobiotic gene response repertoire. Molecular Systems Biology. 4: 175. PMID 18364709 DOI: 10.1038/Msb.2008.9  0.366
2008 Fielden MR, Kolaja KL. The role of early in vivo toxicity testing in drug discovery toxicology. Expert Opinion On Drug Safety. 7: 107-10. PMID 18324874 DOI: 10.1517/14740338.7.2.107  0.305
2008 Wang EJ, Snyder RD, Fielden MR, Smith RJ, Gu YZ. Validation of putative genomic biomarkers of nephrotoxicity in rats. Toxicology. 246: 91-100. PMID 18289764 DOI: 10.1016/J.Tox.2007.12.031  0.385
2008 Fielden MR, Nie A, McMillian M, Elangbam CS, Trela BA, Yang Y, Dunn RT, Dragan Y, Fransson-Stehen R, Bogdanffy M, Adams SP, Foster WR, Chen SJ, Rossi P, Kasper P, et al. Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 28-34. PMID 18281259 DOI: 10.1093/Toxsci/Kfn022  0.307
2007 Fielden MR, Brennan R, Gollub J. A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 90-100. PMID 17557906 DOI: 10.1093/Toxsci/Kfm156  0.386
2007 Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR. Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Molecular Pharmacology. 71: 1475-86. PMID 17327465 DOI: 10.1124/Mol.106.032748  0.389
2006 Day G, Brady L, Eynon B, Fielden M, Fujimoto S, Jarnagin K, Halbert D. Characterization of compound-induced hepatotoxicity using gene expression profiling in rat primary hepatocytes Toxicology Letters. 164: S213-S214. DOI: 10.1016/J.Toxlet.2006.07.102  0.354
2005 Fielden MR, Eynon BP, Natsoulis G, Jarnagin K, Banas D, Kolaja KL. A gene expression signature that predicts the future onset of drug-induced renal tubular toxicity. Toxicologic Pathology. 33: 675-83. PMID 16239200 DOI: 10.1080/01926230500321213  0.383
2005 Ganter B, Tugendreich S, Pearson CI, Ayanoglu E, Baumhueter S, Bostian KA, Brady L, Browne LJ, Calvin JT, Day GJ, Breckenridge N, Dunlea S, Eynon BP, Furness LM, Ferng J, ... Fielden MR, et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. Journal of Biotechnology. 119: 219-44. PMID 16005536 DOI: 10.1016/J.Jbiotec.2005.03.022  0.376
2005 Fielden MR, Pearson C, Brennan R, Kolaja KL. Preclinical drug safety analysis by chemogenomic profiling in the liver. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 5: 161-71. PMID 15952870 DOI: 10.2165/00129785-200505030-00003  0.329
2004 Sun YV, Boverhof DR, Burgoon LD, Fielden MR, Zacharewski TR. Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences. Nucleic Acids Research. 32: 4512-23. PMID 15328365 DOI: 10.1093/Nar/Gkh782  0.716
2003 Fielden MR, Samy SM, Chou KC, Zacharewski TR. Effect of human dietary exposure levels of genistein during gestation and lactation on long-term reproductive development and sperm quality in mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 41: 447-54. PMID 12615117 DOI: 10.1016/S0278-6915(02)00284-3  0.617
2002 Fielden MR, Halgren RG, Fong CJ, Staub C, Johnson L, Chou K, Zacharewski TR. Gestational and lactational exposure of male mice to diethylstilbestrol causes long-term effects on the testis, sperm fertilizing ability in vitro, and testicular gene expression. Endocrinology. 143: 3044-59. PMID 12130571 DOI: 10.1210/Endo.143.8.8968  0.709
2002 Fielden MR, Fong CJ, Haslam SZ, Zacharewski TR. Normal mammary gland morphology in pubertal female mice following in utero and lactational exposure to genistein at levels comparable to human dietary exposure. Toxicology Letters. 133: 181-91. PMID 12119126 DOI: 10.1016/S0378-4274(02)00154-6  0.69
2002 Fielden MR, Halgren RG, Dere E, Zacharewski TR. GP3: GenePix post-processing program for automated analysis of raw microarray data. Bioinformatics (Oxford, England). 18: 771-3. PMID 12050078 DOI: 10.1093/Bioinformatics/18.5.771  0.645
2002 Fielden MR, Matthews JB, Fertuck KC, Halgren RG, Zacharewski TR. In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Critical Reviews in Toxicology. 32: 67-112. PMID 11951993 DOI: 10.1080/20024091064183  0.606
2001 Fielden MR, Halgren RG, Tashiro CH, Yeo BR, Chittim B, Chou K, Zacharewski TR. Effects of gestational and lactational exposure to Aroclor 1242 on sperm quality and in vitro fertility in early adult and middle-aged mice. Reproductive Toxicology (Elmsford, N.Y.). 15: 281-92. PMID 11390173 DOI: 10.1016/S0890-6238(01)00129-0  0.574
2001 Fielden MR, Zacharewski TR. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 60: 6-10. PMID 11222867 DOI: 10.1093/Toxsci/60.1.6  0.596
2001 Halgren RG, Fielden MR, Fong CJ, Zacharewski TR. Assessment of clone identity and sequence fidelity for 1189 IMAGE cDNA clones. Nucleic Acids Research. 29: 582-8. PMID 11139630 DOI: 10.1093/Nar/29.2.582  0.672
2000 Fielden MR, Wu ZF, Sinal CJ, Jury HH, Bend JR, Hammond GL, Zacharewski TR. Estrogen receptor- and aryl hydrocarbon receptor-mediated activities of a coal-tar creosote Environmental Toxicology and Chemistry. 19: 1262-1271. DOI: 10.1002/Etc.5620190507  0.592
1998 Zacharewski TR, Meek MD, Clemons JH, Wu ZF, Fielden MR, Matthews JB. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 282-93. PMID 10048131 DOI: 10.1006/toxs.1998.2505  0.569
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives. 105: 1238-48. PMID 9370515  0.623
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the Estrogenicity of 2,4,6,2 prime ,6 prime -Pentachlorobiphenyl (PCB 104), Its Hydroxylated Metabolite 2,4,6,2 prime ,6 prime -Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2 prime ,4 prime ,6 prime -Hexachlorobiphenyl (PCB 155) Environmental Health Perspectives. 105: 1238. DOI: 10.2307/3433904  0.573
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