Alexander Y. Tsygankov - Publications

Affiliations: 
Cell Biology Temple University, Philadelphia, PA, United States 
Area:
Cell Biology, Biochemistry, Molecular Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)(346), a regulatory site of Syk. The Journal of Biological Chemistry. 292: 4360. PMID 28283589 DOI: 10.1074/jbc.A116.743732  0.48
2016 Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating pY346, a regulatory site of Syk. The Journal of Biological Chemistry. PMID 27609517 DOI: 10.1074/jbc.M116.743732  0.48
2016 Liverani E, Rico MC, Tsygankov AY, Kilpatrick LE, Kunapuli SP. P2Y12 Receptor Modulates Sepsis-Induced Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27055904 DOI: 10.1161/ATVBAHA.116.307401  1
2015 Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice. Blood. PMID 26516227 DOI: 10.1182/blood-2015-02-631135  1
2014 Newman TN, Liverani E, Ivanova E, Russo GL, Carpino N, Ganea D, Safadi F, Kunapuli SP, Tsygankov AY. Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo. Immunology and Cell Biology. 92: 837-50. PMID 25047644 DOI: 10.1038/icb.2014.60  1
2014 Adapala NS, Holland D, Scanlon V, Barbe MF, Langdon WY, Tsygankov AY, Lorenzo JA, Sanjay A. Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy. Bone. 67: 1-9. PMID 24994594 DOI: 10.1016/j.bone.2014.06.013  1
2014 Liverani E, Kilpatrick LE, Tsygankov AY, Kunapuli SP. The role of P2Y₁₂ receptor and activated platelets during inflammation. Current Drug Targets. 15: 720-8. PMID 24845219 DOI: 10.2174/1389450115666140519162133  1
2014 Adapala NS, Barbe MF, Tsygankov AY, Lorenzo JA, Sanjay A. Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b. Journal of Cellular Biochemistry. 115: 1277-89. PMID 24470255 DOI: 10.1002/jcb.24779  1
2014 Liverani E, Rico MC, Yaratha L, Tsygankov AY, Kilpatrick LE, Kunapuli SP. LPS-induced systemic inflammation is more severe in P2Y12 null mice. Journal of Leukocyte Biology. 95: 313-23. PMID 24142066 DOI: 10.1189/jlb.1012518  1
2013 Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. The Journal of Biological Chemistry. 288: 29160-9. PMID 23960082 DOI: 10.1074/jbc.M113.464107  1
2013 Lee H, Tsygankov AY. Cbl-family proteins as regulators of cytoskeleton-dependent phenomena. Journal of Cellular Physiology. 228: 2285-93. PMID 23744514 DOI: 10.1002/jcp.24412  1
2013 Back SH, Adapala NS, Barbe MF, Carpino NC, Tsygankov AY, Sanjay A. TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Cellular and Molecular Life Sciences : Cmls. 70: 1269-84. PMID 23149425 DOI: 10.1007/s00018-012-1203-2  1
2013 Tsygankov AY. TULA-family proteins: a new class of cellular regulators. Journal of Cellular Physiology. 228: 43-9. PMID 22689384 DOI: 10.1002/jcp.24128  1
2010 Adapala NS, Barbe MF, Langdon WY, Nakamura MC, Tsygankov AY, Sanjay A. The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. The Journal of Biological Chemistry. 285: 36745-58. PMID 20851882 DOI: 10.1074/jbc.M110.124628  1
2010 Lee H, Tsygankov AY. c-Cbl regulates glioma invasion through matrix metalloproteinase 2. Journal of Cellular Biochemistry. 111: 1169-78. PMID 20717917 DOI: 10.1002/jcb.22839  1
2010 Chen X, Ren L, Kim S, Carpino N, Daniel JL, Kunapuli SP, Tsygankov AY, Pei D. Determination of the substrate specificity of protein-tyrosine phosphatase TULA-2 and identification of Syk as a TULA-2 substrate. The Journal of Biological Chemistry. 285: 31268-76. PMID 20670933 DOI: 10.1074/jbc.M110.114181  1
2010 Thomas DH, Getz TM, Newman TN, Dangelmaier CA, Carpino N, Kunapuli SP, Tsygankov AY, Daniel JL. A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood. 116: 2570-8. PMID 20585042 DOI: 10.1182/blood-2010-02-268136  1
2010 Daniel JL, Dangelmaier CA, Mada S, Buitrago L, Jin J, Langdon WY, Tsygankov AY, Kunapuli SP, Sanjay A. Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation. The Journal of Biological Chemistry. 285: 17282-91. PMID 20400514 DOI: 10.1074/jbc.M109.080200  1
2010 Adapala NS, Barbe MF, Langdon WY, Tsygankov AY, Sanjay A. Cbl-phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony-stimulating factor-mediated osteoclast survival and cytoskeletal reorganization. Annals of the New York Academy of Sciences. 1192: 376-84. PMID 20392263 DOI: 10.1111/j.1749-6632.2009.05346.x  1
2009 Pappas J, Wolfson AD, Jung WJ, Oleszak EL, Helm CW, Freedman RS, Tsygankov AY, Platsoucas CD. Differential expression of CD3zeta message and protein in tumor infiltrating lymphocytes from solid tumor specimens and malignant ascites from patients with ovarian carcinoma. Anticancer Research. 29: 4673-82. PMID 20032419  1
2009 Tsygankov AY. TULA-family proteins: an odd couple. Cellular and Molecular Life Sciences : Cmls. 66: 2949-52. PMID 19585081 DOI: 10.1007/s00018-009-0071-x  1
2009 Tsygankov AY. Current developments in anti-HIV/AIDS gene therapy. Current Opinion in Investigational Drugs (London, England : 2000). 10: 137-49. PMID 19197791  1
2008 Lee H, Gaughan JP, Tsygankov AY. c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1- and Rap1-mediated signaling. The International Journal of Biochemistry & Cell Biology. 40: 1930-43. PMID 18403249 DOI: 10.1016/j.biocel.2008.02.013  1
2008 Tsygankov AY. Multidomain STS/TULA proteins are novel cellular regulators. Iubmb Life. 60: 224-31. PMID 18344182 DOI: 10.1002/iub.36  1
2008 Smirnova EV, Collingwood TS, Bisbal C, Tsygankova OM, Bogush M, Meinkoth JL, Henderson EE, Annan RS, Tsygankov AY. TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology. 372: 10-23. PMID 18006034 DOI: 10.1016/j.virol.2007.10.012  1
2007 Salerno D, Hasham MG, Marshall R, Garriga J, Tsygankov AY, Graña X. Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene. 405: 65-78. PMID 17949927 DOI: 10.1016/j.gene.2007.09.010  1
2007 Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY. T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis. The Journal of Biological Chemistry. 282: 30920-8. PMID 17709377 DOI: 10.1074/jbc.M706870200  1
2007 Avraamides C, Bromberg ME, Gaughan JP, Thomas SM, Tsygankov AY, Panetti TS. Hic-5 promotes endothelial cell migration to lysophosphatidic acid. American Journal of Physiology. Heart and Circulatory Physiology. 293: H193-203. PMID 17337598 DOI: 10.1152/ajpheart.00728.2006  1
2007 Raymond AD, Hasham M, Tsygankov AY, Henderson EE. Herpesvirus saimiri terminal membrane proteins modulate HIV-1 replication by altering Nef and Tat functions. Current Hiv Research. 5: 79-86. PMID 17266559 DOI: 10.2174/157016207779316314  1
2007 Swaminathan G, Feshchenko EA, Tsygankov AY. c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl. Oncogene. 26: 4095-105. PMID 17237826 DOI: 10.1038/sj.onc.1210184  1
2006 Turner LS, Tsygankov AY, Henderson EE. StpC-based gene therapy targeting latent reservoirs of HIV-1. Antiviral Research. 72: 233-41. PMID 16891001 DOI: 10.1016/j.antiviral.2006.06.010  1
2006 Raymond AD, Hasham M, Tsygankov AY, Henderson EE. H. saimiri tyrosine-kinase interacting protein inhibits Tat function: a prototypic strategy for restricting HIV-1-induced cytopathic effects in immune cells. Virology. 352: 253-67. PMID 16780912 DOI: 10.1016/j.virol.2006.04.016  1
2006 Swaminathan G, Tsygankov AY. The Cbl family proteins: ring leaders in regulation of cell signaling. Journal of Cellular Physiology. 209: 21-43. PMID 16741904 DOI: 10.1002/jcp.20694  1
2005 Teckchandani AM, Panetti TS, Tsygankov AY. c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1. Experimental Cell Research. 307: 247-58. PMID 15922744 DOI: 10.1016/j.yexcr.2005.03.010  1
2005 Teckchandani AM, Birukova AA, Tar K, Verin AD, Tsygankov AY. The multidomain protooncogenic protein c-Cbl binds to tubulin and stabilizes microtubules. Experimental Cell Research. 306: 114-27. PMID 15878338 DOI: 10.1016/j.yexcr.2005.02.014  1
2005 Dangelmaier CA, Quinter PG, Jin J, Tsygankov AY, Kunapuli SP, Daniel JL. Rapid ubiquitination of Syk following GPVI activation in platelets. Blood. 105: 3918-24. PMID 15701717 DOI: 10.1182/blood-2004-09-3689  1
2005 Tsygankov AY. Cell transformation by Herpesvirus saimiri. Journal of Cellular Physiology. 203: 305-18. PMID 15389624 DOI: 10.1002/jcp.20225  1
2004 Raymond AD, Hasham MG, Tsygankov AY, Henderson EE. Herpesvirus saimiri-encoded proteins Tip and StpC modulate human immunodeficiency virus type 1 replication in T-cell lines and lymphocytes independently of viral tropism. Virology. 324: 60-6. PMID 15183053 DOI: 10.1016/j.virol.2004.03.021  1
2004 Tsygankov AY, Shore SK. Src: regulation, role in human carcinogenesis and pharmacological inhibitors. Current Pharmaceutical Design. 10: 1745-56. PMID 15180537 DOI: 10.2174/1381612043384457  1
2004 Feshchenko EA, Smirnova EV, Swaminathan G, Teckchandani AM, Agrawal R, Band H, Zhang X, Annan RS, Carr SA, Tsygankov AY. TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. Oncogene. 23: 4690-706. PMID 15107835 DOI: 10.1038/sj.onc.1207627  1
2004 Hasham MG, Tsygankov AY. Tip, an Lck-interacting protein of Herpesvirus saimiri, causes Fas- and Lck-dependent apoptosis of T lymphocytes. Virology. 320: 313-29. PMID 15016553 DOI: 10.1016/j.virol.2003.11.032  1
2004 Sorokina EM, Merlo JJ, Tsygankov AY. Molecular mechanisms of the effect of herpesvirus saimiri protein StpC on the signaling pathway leading to NF-kappaB activation. The Journal of Biological Chemistry. 279: 13469-77. PMID 14724292 DOI: 10.1074/jbc.M305250200  1
2003 Wang S, Hasham MG, Isordia-Salas I, Tsygankov AY, Colman RW, Guo YL. Upregulation of Cdc2 and cyclin A during apoptosis of endothelial cells induced by cleaved high-molecular-weight kininogen. American Journal of Physiology. Heart and Circulatory Physiology. 284: H1917-23. PMID 12742823 DOI: 10.1152/ajpheart.00861.2002  1
2003 Tsygankov AY. Non-receptor protein tyrosine kinases. Frontiers in Bioscience : a Journal and Virtual Library. 8: s595-635. PMID 12700079  1
2001 Tsygankov AY, Teckchandani AM, Feshchenko EA, Swaminathan G. Beyond the RING: CBL proteins as multivalent adapters. Oncogene. 20: 6382-402. PMID 11607840 DOI: 10.1038/sj.onc.1204781  1
2001 Guse AH, Tsygankov AY, Weber K, Mayr GW. Transient Tyrosine Phosphorylation of Human Ryanodine Receptor upon T Cell Stimulation Journal of Biological Chemistry. 276: 34722-34727. PMID 11466305 DOI: 10.1074/jbc.M100715200  1
2001 Teckchandani AM, Feshchenko EA, Tsygankov AY. c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases. Oncogene. 20: 1739-55. PMID 11313921 DOI: 10.1038/sj.onc.1204246  1
2001 Merlo JJ, Tsygankov AY. Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-kappaB activity and interleukin-2 gene expression. Virology. 279: 325-38. PMID 11145913 DOI: 10.1006/viro.2000.0714  1
1999 Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A, Lipkowitz S, Yarden Y. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Molecular Cell. 4: 1029-1040. PMID 10635327 DOI: 10.1016/S1097-2765(00)80231-2  1
1999 Henderson EE, Tsygankov AY, Merlo JJ, Romano G, Guan M. Altered replication of human immunodeficiency virus type 1 (HIV-1) in T cell lines retrovirally transduced to express Herpesvirus saimiri proteins StpC and/or Tip. Virology. 264: 125-33. PMID 10544137 DOI: 10.1006/viro.1999.9988  1
1999 Feshchenko EA, Shore SK, Tsygankov AY. Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts. Oncogene. 18: 3703-15. PMID 10391678 DOI: 10.1038/sj.onc.1202672  1
1999 Tsygankov AY, Romano G. Mechanisms of cell transformation by Herpesvirus saimiri Anticancer Research. 19: 973-983. PMID 10368641  1
1998 Merlo JJ, Romano G, Gordon SS, Feshchenko EA, Peng G, Henderson EE, Tsygankov AY. Human T cells transduced by a retroviral vector to express Herpesvirus saimiri proteins TIP and STPC. Anticancer Research. 18: 2389-96. PMID 9703884  1
1998 Feshchenko EA, Langdon WY, Tsygankov AY. Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells Journal of Biological Chemistry. 273: 8323-8331. PMID 9525940 DOI: 10.1074/jbc.273.14.8323  1
1998 Merlo JJ, Tsygankov AY. Herpesvirus saimiri proteins Tip and StpC upregulate IL-2 gene expression in T cells Faseb Journal. 12.  1
1997 Rojavin MA, Tsygankov AY, Ziskin MC. Interaction of cyclophosphamide and ketamine in vivo Neuroimmunomodulation. 3: 333-335. PMID 9266543  1
1997 Rojavin MA, Tsygankov AY, Ziskin MC. In vivo effects of millimeter waves on cellular immunity of cyclophosphamide-treated mice Electromagnetic Biology and Medicine. 16: 281-292.  1
1997 Rojavin MA, Tsygankov AY, Ziskin MC. Millimeter waves in vivo increase immune activity of mice treated with cyclophosphamide Faseb Journal. 11.  1
1996 Tsygankov AY, Mahajan S, Fincke JE, Bolen JB. Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells Journal of Biological Chemistry. 271: 27130-27137. PMID 8900205 DOI: 10.1074/jbc.271.43.27130  1
1996 Wiese N, Tsygankov AY, Klauenberg U, Bolen JB, Fleischer B, Bröker BM. Selective activation of T cell kinase p56lck by Herpesvirus saimiri protein tip Journal of Biological Chemistry. 271: 847-852. PMID 8557695  1
1996 Tsygankov AY. Herpesvirus saimiri protein Tip interacts with and activates tyrosine protein kinase P56LCK in T cells Faseb Journal. 10.  1
1995 Biesinger B, Tsygankov AY, Fickenscher H, Emmrich F, Fleckenstein B, Bolen JB, Bröker BM. The product of the Herpesvirus saimiri open reading frame 1 (Tip) interacts with T cell-specific kinase p56lck in transformed cells Journal of Biological Chemistry. 270: 4729-4734. PMID 7876245  1
1994 Bröker BM, Tsygankov AY, Fickenscher H, Chitaev NA, Müller-Fleckenstein I, Fleckenstein B, Bolen JB, Emmrich F. Engagement of the CD4 receptor inhibits the interleukin-2-dependent proliferation of human T cells transformed by Herpesvirus saimiri European Journal of Immunology. 24: 843-850. PMID 8149955  1
1994 Tsygankov AY, Spana C, Rowley RB, Penhallow RC, Burkhardt AL, Bolen JB. Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes Journal of Biological Chemistry. 269: 7792-7800. PMID 8126006  1
1994 Tsygankov AY, Kim HW, Pratt JC, Spana C, Class K, Gaulton GN, Kamoun M, Bolen JB. Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation Journal of Leukocyte Biology. 55: 289-298. PMID 8120446 DOI: 10.1002/jlb.55.3.289  1
1993 Tsygankov AY, Broker BM, Guse AH, Meinke U, Roth E, Rossmann C, Emmrich F. Preincubation with anti-CD4 influences activation of human T cells by subsequent co-cross-linking of CD4 with CD3 Journal of Leukocyte Biology. 54: 430-438. PMID 8228621  1
1993 Bröker BM, Tsygankov AY, Müller-Fleckenstein I, Guse AH, Chitaev NA, Biesinger B, Fleckenstein B, Emmrich F. Immortalization of human T cell clones by Herpesvirus saimiri: Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors Journal of Immunology. 151: 1184-1192. PMID 7687626  1
1992 Tsygankov AY, Bröker BM, Fargnoli J, Ledbetter JA, Bolen JB. Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking Journal of Biological Chemistry. 267: 18259-18262. PMID 1526965  1
1992 Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction Faseb Journal. 6: 3403-3409. PMID 1281458  1
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