| Year |
Citation |
Score |
| 2023 |
Umemoto S, Nakahashi-Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, Mori H, Yamanoue T, Shibata T, Sawada SI, Ishige K, Hirano T, Fujihashi K, Akiyoshi K, Kurashima Y, et al. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. Npj Vaccines. 8: 106. PMID 37488116 DOI: 10.1038/s41541-023-00700-3 |
0.341 |
|
| 2022 |
Yoshimatsu H, Kataoka K, Fujihashi K, Miyake T, Ono Y. A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions. Vaccine. 40: 1116-1127. PMID 35086743 DOI: 10.1016/j.vaccine.2022.01.027 |
0.413 |
|
| 2021 |
Kiyono H, Yuki Y, Nakahashi-Ouchida R, Fujihashi K. Mucosal vaccines: wisdom from now and then. International Immunology. PMID 34436595 DOI: 10.1093/intimm/dxab056 |
0.35 |
|
| 2021 |
Kataoka K, Kawabata S, Koyanagi K, Hashimoto Y, Miyake T, Fujihashi K. Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of . Frontiers in Immunology. 12: 634923. PMID 33717178 DOI: 10.3389/fimmu.2021.634923 |
0.533 |
|
| 2019 |
Joo S, Suwanto A, Sato A, Nakahashi-Ouchida R, Mori H, Uchida Y, Sato S, Kurashima Y, Yuki Y, Fujihashi K, Kawaguchi Y, Kiyono H. A role for the CCR5-CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization. Mucosal Immunology. PMID 31551493 DOI: 10.1038/S41385-019-0203-Z |
0.542 |
|
| 2019 |
Tateishi K, Fujihashi K, Yamamoto N, Hasegawa H, Ainai A, Sato K, Iho S, Yamamoto S, Maeyama JI, Odagiri T, Asanuma H. CpG ODN G9.1 as a novel nasal ODN adjuvant elicits complete protection from influenza virus infection without causing inflammatory immune responses. Vaccine. PMID 31345642 DOI: 10.1016/J.Vaccine.2019.07.032 |
0.447 |
|
| 2019 |
Pais R, Omosun Y, Igietseme JU, Fujihashi K, Eko FO. Route of Vaccine Administration Influences the Impact of Fms-Like Tyrosine Kinase 3 Ligand (Flt3L) on Chlamydial-Specific Protective Immune Responses. Frontiers in Immunology. 10: 1577. PMID 31333682 DOI: 10.3389/Fimmu.2019.01577 |
0.564 |
|
| 2019 |
Hashizume-Takizawa T, Shibata N, Kurashima Y, Kiyono H, Kurita-Ochiai T, Fujihashi K. Distinct Roles for Peyer's Patch B Cells for Induction of Antigen-specific IgA Antibody Responses in Mice Administered Oral Recombinant Salmonella. International Immunology. PMID 30868152 DOI: 10.1093/Intimm/Dxz029 |
0.536 |
|
| 2017 |
Nagano H, Kawabata M, Sugita G, Tsuruhara A, Ohori J, Jimura T, Miyashita K, Kurono Y, Tomonaga K, Briles DE, Fujihashi K. Transcutaneous immunization with pneumococcal surface protein A in mice. The Laryngoscope. PMID 29226330 DOI: 10.1002/Lary.26971 |
0.427 |
|
| 2017 |
Pais R, Omosun Y, He Q, Blas-Machado U, Black C, Igietseme JU, Fujihashi K, Eko FO. Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice. Plos One. 12: e0178537. PMID 28570663 DOI: 10.1371/Journal.Pone.0178537 |
0.556 |
|
| 2017 |
Kataoka K, Fukuyama Y, Briles DE, Miyake T, Fujihashi K. Dendritic cell-targeting DNA-based nasal adjuvants for protective mucosal immunity to Streptococcus pneumoniae. Microbiology and Immunology. PMID 28463465 DOI: 10.1111/1348-0421.12487 |
0.498 |
|
| 2017 |
Tsuruhara A, Aso K, Tokuhara D, Ohori J, Kawabata M, Kurono Y, McGhee JR, Fujihashi K. Rejuvenation of mucosal immunosenescence by adipose tissue-derived mesenchymal stem cells. International Immunology. 29: 5-10. PMID 28391291 DOI: 10.1093/Intimm/Dxx001 |
0.54 |
|
| 2016 |
Aso K, Tsuruhara A, Takagaki K, Oki K, Ota M, Nose Y, Tanemura H, Urushihata N, Sasanuma J, Sano M, Hirano A, Aso R, McGhee JR, Fujihashi K. Adipose-Derived Mesenchymal Stem Cells Restore Impaired Mucosal Immune Responses in Aged Mice. Plos One. 11: e0148185. PMID 26840058 DOI: 10.1371/Journal.Pone.0148185 |
0.561 |
|
| 2015 |
Fukuyama Y, Ikeda Y, Ohori J, Sugita G, Aso K, Fujihashi K, Briles DE, McGhee JR, Fujihashi K. A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly. Immune Network. 15: 9-15. PMID 25713504 DOI: 10.4110/In.2015.15.1.9 |
0.484 |
|
| 2015 |
Fukuyama Y, Yuki Y, Katakai Y, Harada N, Takahashi H, Takeda S, Mejima M, Joo S, Kurokawa S, Sawada S, Shibata H, Park EJ, Fujihashi K, Briles DE, Yasutomi Y, et al. Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunology. PMID 25669148 DOI: 10.1038/Mi.2015.5 |
0.447 |
|
| 2015 |
Sato S, Kiyono H, Fujihashi K. Mucosal Immunosenescence in the Gastrointestinal Tract: A Mini-Review. Gerontology. 61: 336-42. PMID 25531743 DOI: 10.1159/000368897 |
0.494 |
|
| 2014 |
Gu L, Krendelchtchikova V, Krendelchtchikov A, Oster RA, Fujihashi K, Matthews QL. A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "Antigen Capsid-Incorporation" strategy. Virology Journal. 11: 112. PMID 24935650 DOI: 10.1186/1743-422X-11-112 |
0.402 |
|
| 2014 |
Fujihashi K, Sato S, Kiyono H. Mucosal adjuvants for vaccines to control upper respiratory infections in the elderly. Experimental Gerontology. 54: 21-6. PMID 24440991 DOI: 10.1016/J.Exger.2014.01.006 |
0.494 |
|
| 2014 |
Short KR, von Köckritz-Blickwede M, Langereis JD, Chew KY, Job ER, Armitage CW, Hatcher B, Fujihashi K, Reading PC, Hermans PW, Wijburg OL, Diavatopoulos DA. Antibodies mediate formation of neutrophil extracellular traps in the middle ear and facilitate secondary pneumococcal otitis media. Infection and Immunity. 82: 364-70. PMID 24191297 DOI: 10.1128/Iai.01104-13 |
0.368 |
|
| 2013 |
Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J, Yamamoto M, Gilbert RS, Tokuhara Y, Fujihashi K, Kunisawa J, Yuki Y, Kiyono H, McGhee JR, Fujihashi K. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. Plos One. 8: e60453. PMID 23565250 DOI: 10.1371/Journal.Pone.0060453 |
0.771 |
|
| 2013 |
Kobayashi R, Ochiai T, Hashizume-Takizawa T, Fujihashi K, Yamamoto M. Characterization of Inflammation-derived CD11c+ Dendritic Cells in Mouse Model of Periodontal Disease International Journal of Oral-Medical Sciences. 11: 300-306. DOI: 10.5466/Ijoms.11.300 |
0.331 |
|
| 2012 |
McGhee JR, Fujihashi K. Inside the mucosal immune system. Plos Biology. 10: e1001397. PMID 23049482 DOI: 10.1371/Journal.Pbio.1001397 |
0.404 |
|
| 2012 |
Takahashi E, Kataoka K, Indalao IL, Konoha K, Fujii K, Chida J, Mizuno D, Fujihashi K, Kido H. Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus. Journal of Virology. 86: 10924-34. PMID 22896605 DOI: 10.1128/Jvi.01207-12 |
0.5 |
|
| 2012 |
Fujkuyama Y, Tokuhara D, Kataoka K, Gilbert RS, McGhee JR, Yuki Y, Kiyono H, Fujihashi K. Novel vaccine development strategies for inducing mucosal immunity. Expert Review of Vaccines. 11: 367-79. PMID 22380827 DOI: 10.1586/erv.11.196 |
0.739 |
|
| 2012 |
Fukuyama Y, Tokuhara D, Sekine S, Kataoka K, Markham JD, Irwin AR, Moon GH, Tokuhara Y, Fujihashi K, Davydova J, Yamamoto M, Gilbert RS, Fujihashi K. Notch-ligand expression by NALT dendritic cells regulates mucosal Th1- and Th2-type responses. Biochemical and Biophysical Research Communications. 418: 6-11. PMID 22200492 DOI: 10.1016/J.Bbrc.2011.12.046 |
0.767 |
|
| 2012 |
Asanuma H, Zamri NB, Sekine S, Fukuyama Y, Tokuhara D, Gilbert RS, Fukuiwa T, Fujihashi K, Sata T, Tashiro M, Fujihashi K. A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging. Vaccine. 30: 803-12. PMID 22100889 DOI: 10.1016/J.Vaccine.2011.10.093 |
0.782 |
|
| 2012 |
Hong SH, Byun YH, Nguyen CT, Kim SY, Seong BL, Park S, Woo GJ, Yoon Y, Koh JT, Fujihashi K, Rhee JH, Lee SE. Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection. Vaccine. 30: 466-74. PMID 22051136 DOI: 10.1016/J.Vaccine.2011.10.058 |
0.436 |
|
| 2011 |
Gilbert RS, Kobayashi R, Sekine S, Fujihashi K. Functional transforming growth factor-β receptor type II expression by CD4+ T cells in Peyer's patches is essential for oral tolerance induction. Plos One. 6: e27501. PMID 22087328 DOI: 10.1371/Journal.Pone.0027501 |
0.748 |
|
| 2011 |
Kataoka K, Fujihashi K, Terao Y, Gilbert RS, Sekine S, Kobayashi R, Fukuyama Y, Kawabata S, Fujihashi K. Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells. Plos One. 6: e25396. PMID 21980444 DOI: 10.1371/Journal.Pone.0025396 |
0.75 |
|
| 2011 |
Briles DE, Miyaji E, Fukuyama Y, Ferreira DM, Fujihashi K. Elicitation of mucosal immunity by proteins of Streptococcus pneumoniae. Advances in Oto-Rhino-Laryngology. 72: 25-7. PMID 21865682 DOI: 10.1159/000324589 |
0.517 |
|
| 2011 |
Baatarjav T, Kataoka K, Gilbert RS, Terao Y, Fukui M, Goto M, Kawabata S, Yamamoto M, Fujihashi K, Ito HO. Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination. Vaccine. 29: 5747-57. PMID 21683111 DOI: 10.1016/J.Vaccine.2011.05.097 |
0.775 |
|
| 2011 |
Kataoka K, Fujihashi K, Oma K, Fukuyama Y, Hollingshead SK, Sekine S, Kawabata S, Ito HO, Briles DE, Oishi K. The nasal dendritic cell-targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia. Infection and Immunity. 79: 2819-28. PMID 21536790 DOI: 10.1128/Iai.01360-10 |
0.6 |
|
| 2011 |
Kobayashi R, Kono T, Bolerjack BA, Fukuyama Y, Gilbert RS, Fujihashi K, Ruby J, Kataoka K, Wada M, Yamamoto M, Fujihashi K. Induction of IL-10-producing CD4+ T-cells in chronic periodontitis. Journal of Dental Research. 90: 653-8. PMID 21335536 DOI: 10.1177/0022034510397838 |
0.745 |
|
| 2011 |
Fukuyama Y, King JD, Kataoka K, Kobayashi R, Gilbert RS, Hollingshead SK, Briles DE, Fujihashi K. A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 2454-61. PMID 21242514 DOI: 10.4049/Jimmunol.1002837 |
0.793 |
|
| 2011 |
Kono T, Kobayashi R, Fujihashi K. Characterization of Gingival Th1, Th2 and Th17 Cells in Murine Periodontitis Model International Journal of Oral-Medical Sciences. 9: 213-219. DOI: 10.5466/Ijoms.9.213 |
0.49 |
|
| 2010 |
Takahashi I, Fujihashi K, Kiyono H. Mucosal regulatory cells in the gastrointestinal tract and periodontium. Periodontology 2000. 54: 247-56. PMID 20712644 DOI: 10.1111/J.1600-0757.2009.00335.X |
0.366 |
|
| 2010 |
Fukuyama Y, King JD, Kataoka K, Kobayashi R, Gilbert RS, Oishi K, Hollingshead SK, Briles DE, Fujihashi K. Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae. Journal of Immunology (Baltimore, Md. : 1950). 185: 1755-62. PMID 20585031 DOI: 10.4049/Jimmunol.1000831 |
0.768 |
|
| 2010 |
Liu C, Hashizume T, Kurita-Ochiai T, Fujihashi K, Yamamoto M. Oral immunization with Porphyromonas gingivalis outer membrane protein and CpGoligodeoxynucleotides elicits T helper 1 and 2 cytokines for enhanced protective immunity. Molecular Oral Microbiology. 25: 178-89. PMID 20502628 DOI: 10.1111/J.2041-1014.2009.00560.X |
0.512 |
|
| 2010 |
Takahashi E, Kataoka K, Fujii K, Chida J, Mizuno D, Fukui M, Hiro-O Ito, Fujihashi K, Kido H. Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus. Microbes and Infection / Institut Pasteur. 12: 778-83. PMID 20452454 DOI: 10.1016/J.Micinf.2010.04.013 |
0.476 |
|
| 2010 |
Obata T, Goto Y, Kunisawa J, Sato S, Sakamoto M, Setoyama H, Matsuki T, Nonaka K, Shibata N, Gohda M, Kagiyama Y, Nochi T, Yuki Y, Fukuyama Y, Mukai A, ... ... Fujihashi K, et al. Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 7419-24. PMID 20360558 DOI: 10.1073/Pnas.1001061107 |
0.496 |
|
| 2010 |
Nakagaki H, Sekine S, Terao Y, Toe M, Tanaka M, Ito HO, Kawabata S, Shizukuishi S, Fujihashi K, Kataoka K. Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to the salivary statherin-derived peptide. Infection and Immunity. 78: 1185-92. PMID 20008529 DOI: 10.1128/Iai.01224-09 |
0.329 |
|
| 2010 |
Fujihashi K, Boyaka PN, McGhee JR. The Mucosal Immune Response Topley and Wilson's Microbiology and Microbial Infections. DOI: 10.1002/9780470688618.Taw0109 |
0.503 |
|
| 2009 |
Cong Y, Feng T, Fujihashi K, Schoeb TR, Elson CO. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proceedings of the National Academy of Sciences of the United States of America. 106: 19256-61. PMID 19889972 DOI: 10.1073/Pnas.0812681106 |
0.492 |
|
| 2009 |
Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, ... Fujihashi K, et al. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of Experimental Medicine. 206: 2351-64. PMID 19822644 DOI: 10.1084/Jem.20091436 |
0.455 |
|
| 2009 |
Kataoka K, Fujihashi K. Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccines. Expert Review of Vaccines. 8: 1183-93. PMID 19722892 DOI: 10.1586/Erv.09.80 |
0.432 |
|
| 2009 |
Yuki Y, Tokuhara D, Nochi T, Yasuda H, Mejima M, Kurokawa S, Takahashi Y, Kataoka N, Nakanishi U, Hagiwara Y, Fujihashi K, Takaiwa F, Kiyono H. Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine. 27: 5982-8. PMID 19665603 DOI: 10.1016/J.Vaccine.2009.07.071 |
0.453 |
|
| 2009 |
Fujihashi K, Kiyono H. Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends in Immunology. 30: 334-43. PMID 19540811 DOI: 10.1016/J.It.2009.04.004 |
0.458 |
|
| 2009 |
Yoshino N, Fujihashi K, Hagiwara Y, Kanno H, Takahashi K, Kobayashi R, Inaba N, Noda M, Sato S. Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategy. Vaccine. 27: 4808-17. PMID 19539583 DOI: 10.1016/J.Vaccine.2009.05.081 |
0.41 |
|
| 2008 |
Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, Szalai A, Fujihashi K, Rajewsky K, Schroeder HW. Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production Journal of Immunology. 181: 8409-8415. PMID 19050258 DOI: 10.4049/Jimmunol.181.12.8409 |
0.417 |
|
| 2008 |
Fukuiwa T, Sekine S, Kobayashi R, Suzuki H, Kataoka K, Gilbert RS, Kurono Y, Boyaka PN, Krieg AM, McGhee JR, Fujihashi K. A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity. Vaccine. 26: 4849-59. PMID 18625280 DOI: 10.1016/J.Vaccine.2008.06.091 |
0.791 |
|
| 2008 |
Suzuki H, Sekine S, Kataoka K, Pascual DW, Maddaloni M, Kobayashi R, Fujihashi K, Kozono H, McGhee JR, Fujihashi K. Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology. 135: 917-25. PMID 18565333 DOI: 10.1053/J.Gastro.2008.05.037 |
0.506 |
|
| 2008 |
Sekine S, Kataoka K, Fukuyama Y, Adachi Y, Davydova J, Yamamoto M, Kobayashi R, Fujihashi K, Suzuki H, Curiel DT, Shizukuishi S, McGhee JR, Fujihashi K. A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. Journal of Immunology (Baltimore, Md. : 1950). 180: 8126-34. PMID 18523277 DOI: 10.4049/Jimmunol.180.12.8126 |
0.562 |
|
| 2008 |
Rynda A, Maddaloni M, Mierzejewska D, Ochoa-Repáraz J, Maslanka T, Crist K, Riccardi C, Barszczewska B, Fujihashi K, McGhee JR, Pascual DW. Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1. Journal of Immunology (Baltimore, Md. : 1950). 180: 5187-200. PMID 18390700 DOI: 10.4049/Jimmunol.180.8.5187 |
0.5 |
|
| 2007 |
Asanuma H, Fujihashi K, Miyakoshi T, Yoshikawa T, Fujita-Yamaguchi Y, Kojima N, Nakata M, Suzuki Y, Tamura S, Kurata T, Sata T. Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine. Vaccine. 25: 6975-80. PMID 17716790 DOI: 10.1016/J.Vaccine.2007.06.060 |
0.451 |
|
| 2007 |
Youn HJ, Ko SY, Lee KA, Ko HJ, Lee YS, Fujihashi K, Boyaka PN, Kim SH, Horimoto T, Kweon MN, Kang CY. A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system. Vaccine. 25: 5189-98. PMID 17548137 DOI: 10.1016/J.Vaccine.2007.04.081 |
0.486 |
|
| 2007 |
Kataoka K, Fujihashi K, Sekine S, Fukuiwa T, Kobayashi R, Suzuki H, Nagata H, Takatsu K, Shizukuishi S, McGhee JR, Fujihashi K. Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responses. Journal of Immunology (Baltimore, Md. : 1950). 178: 6058-65. PMID 17475830 DOI: 10.4049/Jimmunol.178.10.6058 |
0.516 |
|
| 2007 |
Fujihashi K, Staats HF, Kozaki S, Pascual DW. Mucosal vaccine development for botulinum intoxication. Expert Review of Vaccines. 6: 35-45. PMID 17280477 DOI: 10.1586/14760584.6.1.35 |
0.431 |
|
| 2007 |
Kim HD, Tahara K, Maxwell JA, Lalonde R, Fukuiwa T, Fujihashi K, Van Kampen KR, Kong FK, Tang DC, Fukuchi K. Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease. The Journal of Gene Medicine. 9: 88-98. PMID 17219449 DOI: 10.1002/Jgm.993 |
0.361 |
|
| 2006 |
Dohi T, Fujihashi K. Type 1 and 2 T helper cell-mediated colitis. Current Opinion in Gastroenterology. 22: 651-7. PMID 17053444 DOI: 10.1097/01.Mog.0000245545.80160.0F |
0.367 |
|
| 2006 |
Maddaloni M, Staats HF, Mierzejewska D, Hoyt T, Robinson A, Callis G, Kozaki S, Kiyono H, McGhee JR, Fujihashi K, Pascual DW. Mucosal vaccine targeting improves onset of mucosal and systemic immunity to botulinum neurotoxin A. Journal of Immunology (Baltimore, Md. : 1950). 177: 5524-32. PMID 17015739 DOI: 10.4049/Jimmunol.177.8.5524 |
0.55 |
|
| 2006 |
Hagiwara Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, Fujihashi K. A second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. Journal of Immunology (Baltimore, Md. : 1950). 177: 3045-54. PMID 16920941 DOI: 10.4049/Jimmunol.177.5.3045 |
0.523 |
|
| 2006 |
Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin C, Gartland GL, Nitschke L, Pelkonen J, Fujihashi K, Rajewsky K, Schroeder HW. Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production Journal of Experimental Medicine. 203: 1567-1578. PMID 16754718 DOI: 10.1084/Jem.20052217 |
0.351 |
|
| 2006 |
Duverger A, Jackson RJ, van Ginkel FW, Fischer R, Tafaro A, Leppla SH, Fujihashi K, Kiyono H, McGhee JR, Boyaka PN. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. Journal of Immunology (Baltimore, Md. : 1950). 176: 1776-83. PMID 16424208 DOI: 10.4049/Jimmunol.176.3.1776 |
0.57 |
|
| 2006 |
Sasaki M, Fujihashi K. Flt3 Ligand and CpG ODN Abrogate Impaired Antigen Presenting Cell Function by Aged Dendritic Cells International Journal of Oral-Medical Sciences. 5: 22-30. DOI: 10.5466/Ijoms.5.22 |
0.508 |
|
| 2006 |
Mizuno T, Fujihashi K. Combination of Nasal Lymphotactin and Macrophage Chemoattractant Protein-1 Expressing Plasmids Elicits Antigen-Specific Salivary S-IgA Antibody Immunity International Journal of Oral-Medical Sciences. 4: 124-135. DOI: 10.5466/Ijoms.4.124 |
0.59 |
|
| 2005 |
van Ginkel FW, Jackson RJ, Yoshino N, Hagiwara Y, Metzger DJ, Connell TD, Vu HL, Martin M, Fujihashi K, McGhee JR. Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract. Infection and Immunity. 73: 6892-902. PMID 16177369 DOI: 10.1128/Iai.73.10.6892-6902.2005 |
0.438 |
|
| 2005 |
Hino A, Fukuyama S, Kataoka K, Kweon MN, Fujihashi K, Kiyono H. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. Journal of Immunology (Baltimore, Md. : 1950). 174: 7423-32. PMID 15905591 DOI: 10.4049/Jimmunol.174.11.7423 |
0.397 |
|
| 2005 |
Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K. A novel neurotoxoid vaccine prevents mucosal botulism. Journal of Immunology (Baltimore, Md. : 1950). 174: 2190-5. PMID 15699151 DOI: 10.4049/Jimmunol.174.4.2190 |
0.49 |
|
| 2005 |
Kataoka K, Suzuki H, Sims RL, Sekine S, Kobayashi R, Fujihashi K, Fukuiwa T, Mizuno T, Jackson RJ, Boyaka PN, McGhee JR, Fujihashi K. Dendritic Cells Targeting Flt3 Ligand As Molecular Mucosal Adjuvant International Journal of Oral-Medical Sciences. 3: 111-120. DOI: 10.5466/Ijoms.3.111 |
0.541 |
|
| 2005 |
Chen J, Zajac AJ, Xu X, Yang P, Wu Q, Fujihashi K, Hsu H, Mountz JD. 1090. Adenovirus Fiber Incorporates an Immunodominant MHC Class I Restricted Epitope Peptide Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.637 |
0.356 |
|
| 2005 |
Chen J, Yang P, Wu Q, Zajac AJ, Wang X, Fujihashi K, Hsu H, Mountz JD. 991. Adenovirus-Mediated IL-12 Gene Transfer Increase Virus Specific CD8 T Cell Response in Aged Mice Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.538 |
0.506 |
|
| 2005 |
Fujihashi K, McGhee JR. Th1/Th2/Th3 cells for regulation of mucosal immunity, tolerance, and inflammation Mucosal Immunology, Two-Volume Set. 539-558. DOI: 10.1016/B978-012491543-5/50032-2 |
0.453 |
|
| 2004 |
Fujihashi K, McGhee JR. Mucosal immunity and tolerance in the elderly. Mechanisms of Ageing and Development. 125: 889-98. PMID 15563935 DOI: 10.1016/J.Mad.2004.05.009 |
0.528 |
|
| 2004 |
Yoshino N, Lü FX, Fujihashi K, Hagiwara Y, Kataoka K, Lu D, Hirst L, Honda M, van Ginkel FW, Takeda Y, Miller CJ, Kiyono H, McGhee JR. A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates. Journal of Immunology (Baltimore, Md. : 1950). 173: 6850-7. PMID 15557179 DOI: 10.4049/Jimmunol.173.11.6850 |
0.425 |
|
| 2004 |
Dohi T, Fujihashi K, Koga T, Etani Y, Yoshino N, Kawamura YI, McGhee JR. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. The American Journal of Pathology. 165: 1257-68. PMID 15466391 DOI: 10.1016/S0002-9440(10)63385-8 |
0.435 |
|
| 2004 |
Yamamoto M, Kweon MN, Rennert PD, Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunity. Journal of Immunology (Baltimore, Md. : 1950). 173: 762-9. PMID 15240662 DOI: 10.4049/Jimmunol.173.2.762 |
0.534 |
|
| 2004 |
Hino A, Kweon MN, Fujihashi K, McGhee JR, Kiyono H. Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrhea. The American Journal of Pathology. 164: 1327-35. PMID 15039220 DOI: 10.1016/S0002-9440(10)63219-1 |
0.396 |
|
| 2004 |
Kataoka K, McGhee JR, Kobayashi R, Fujihashi K, Shizukuishi S, Fujihashi K. Nasal Flt3 ligand cDNA elicits CD11c+CD8+ dendritic cells for enhanced mucosal immunity. Journal of Immunology (Baltimore, Md. : 1950). 172: 3612-9. PMID 15004163 DOI: 10.4049/Jimmunol.172.6.3612 |
0.554 |
|
| 2003 |
Kawamura YI, Kawashima R, Shirai Y, Kato R, Hamabata T, Yamamoto M, Furukawa K, Fujihashi K, McGhee JR, Hayashi H, Dohi T. Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation. European Journal of Immunology. 33: 3205-12. PMID 14579289 DOI: 10.1002/Eji.200324135 |
0.454 |
|
| 2003 |
Boyaka PN, Tafaro A, Fischer R, Fujihashi K, Jirillo E, McGhee JR. Therapeutic manipulation of the immune system: enhancement of innate and adaptive mucosal immunity. Current Pharmaceutical Design. 9: 1965-72. PMID 12871182 DOI: 10.2174/1381612033454225 |
0.549 |
|
| 2003 |
Boyaka PN, Tafaro A, Fischer R, Leppla SH, Fujihashi K, McGhee JR. Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. Journal of Immunology (Baltimore, Md. : 1950). 170: 5636-43. PMID 12759444 DOI: 10.4049/Jimmunol.170.11.5636 |
0.582 |
|
| 2003 |
Dohi T, Fujihashi K, Koga T, Shirai Y, Kawamura YI, Ejima C, Kato R, Saitoh K, McGhee JR. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Gastroenterology. 124: 672-82. PMID 12612906 DOI: 10.1053/Gast.2003.50092 |
0.465 |
|
| 2003 |
Kato H, Fujihashi K, Kato R, Dohi T, Fujihashi K, Hagiwara Y, Kataoka K, Kobayashi R, McGhee JR. Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions. International Immunology. 15: 145-58. PMID 12578844 DOI: 10.1093/Intimm/Dxg011 |
0.553 |
|
| 2003 |
Hagiwara Y, McGhee JR, Fujihashi K, Kobayashi R, Yoshino N, Kataoka K, Etani Y, Kweon MN, Tamura S, Kurata T, Takeda Y, Kiyono H, Fujihashi K. Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissue. Journal of Immunology (Baltimore, Md. : 1950). 170: 1754-62. PMID 12574339 DOI: 10.4049/Jimmunol.170.4.1754 |
0.581 |
|
| 2003 |
Boyaka PN, Ohmura M, Fujihashi K, Koga T, Yamamoto M, Kweon MN, Takeda Y, Jackson RJ, Kiyono H, Yuki Y, McGhee JR. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. Journal of Immunology (Baltimore, Md. : 1950). 170: 454-62. PMID 12496431 DOI: 10.4049/Jimmunol.170.1.454 |
0.489 |
|
| 2003 |
Kawamura YI, Shirai Y, Hamabata T, Yamamoto M, Furukawa K, Fujihashi K, Jerry MR, Dohi T. Cholera toxin adjuvanticity is dependent upon Gm1-mediated NF-κB translocation and activation of dendritic cells Gastroenterology. 124: A73. DOI: 10.1016/S0016-5085(03)80358-X |
0.411 |
|
| 2002 |
Kweon MN, Yamamoto M, Watanabe F, Tamura S, Van Ginkel FW, Miyauchi A, Takagi H, Takeda Y, Hamabata T, Fujihashi K, McGhee JR, Kiyono H. A nontoxic chimeric enterotoxin adjuvant induces protective immunity in both mucosal and systemic compartments with reduced IgE antibodies. The Journal of Infectious Diseases. 186: 1261-9. PMID 12402195 DOI: 10.1086/344526 |
0.538 |
|
| 2002 |
Fujihashi K, Koga T, van Ginkel FW, Hagiwara Y, McGhee JR. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine. 20: 2431-8. PMID 12057597 DOI: 10.1016/S0264-410X(02)00155-X |
0.465 |
|
| 2002 |
Hiroi T, Kiyono H, Fujihashi K, McGhee JR. Quantitation of T-cell cytokine responses by ELISA, ELISPOT, flow cytometry and reverse transcriptase-PCR methods Methods in Microbiology. 32: 301-329. DOI: 10.1016/S0580-9517(02)32097-X |
0.464 |
|
| 2001 |
Ohmura M, Yamamoto M, Kiyono H, Fujihashi K, Takeda Y, McGhee JR. Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin. Vaccine. 20: 756-62. PMID 11738739 DOI: 10.1016/S0264-410X(01)00412-1 |
0.518 |
|
| 2001 |
Fujihashi K, Kato H, van Ginkel FW, Koga T, Boyaka PN, Jackson RJ, Kato R, Hagiwara Y, Etani Y, Goma I, Fujihashi K, Kiyono H, McGhee JR. A revisit of mucosal IgA immunity and oral tolerance. Acta Odontologica Scandinavica. 59: 301-8. PMID 11680650 DOI: 10.1080/000163501750541174 |
0.498 |
|
| 2001 |
Wormley FL, Steele C, Wozniak K, Fujihashi K, McGhee JR, Fidel PL. Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis. Infection and Immunity. 69: 7162-4. PMID 11598094 DOI: 10.1128/Iai.69.11.7162-7164.2001 |
0.433 |
|
| 2001 |
Jones HP, Hodge LM, Fujihashi K, Kiyono H, McGhee JR, Simecka JW. The pulmonary environment promotes Th2 cell responses after nasal-pulmonary immunization with antigen alone, but Th1 responses are induced during instances of intense immune stimulation. Journal of Immunology (Baltimore, Md. : 1950). 167: 4518-26. PMID 11591779 DOI: 10.4049/Jimmunol.167.8.4518 |
0.52 |
|
| 2001 |
Dohi T, Rennert PD, Fujihashi K, Kiyono H, Shirai Y, Kawamura YI, Browning JL, McGhee JR. Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. Journal of Immunology (Baltimore, Md. : 1950). 167: 2781-90. PMID 11509623 DOI: 10.4049/Jimmunol.167.5.2781 |
0.482 |
|
| 2001 |
Yuki Y, Byun Y, Fujita M, Izutani W, Suzuki T, Udaka S, Fujihashi K, McGhee JR, Kiyono H. Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis. Biotechnology and Bioengineering. 74: 62-9. PMID 11353411 DOI: 10.1002/Bit.1095 |
0.384 |
|
| 2001 |
Fujihashi K, Dohi T, Rennert PD, Yamamoto M, Koga T, Kiyono H, McGhee JR. Peyer's patches are required for oral tolerance to proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 3310-5. PMID 11248075 DOI: 10.1073/Pnas.061412598 |
0.526 |
|
| 2001 |
Byun Y, Ohmura M, Fujihashi K, Yamamoto S, McGhee JR, Udaka S, Kiyono H, Takeda Y, Kohsaka T, Yuki Y. Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies. Vaccine. 19: 2061-70. PMID 11228378 DOI: 10.1016/S0264-410X(00)00411-4 |
0.443 |
|
| 2001 |
Kato H, Fujihashi K, Kato R, Yuki Y, McGhee JR. Oral tolerance revisited: prior oral tolerization abrogates cholera toxin-induced mucosal IgA responses. Journal of Immunology (Baltimore, Md. : 1950). 166: 3114-21. PMID 11207263 DOI: 10.4049/Jimmunol.166.5.3114 |
0.546 |
|
| 2001 |
Etani Y, McGhee JR, Fujihashi K. A revisit of the hapten-induced colitis model: Adoptive T cell transfer studies Gastroenterology. 120: A193. DOI: 10.1016/S0016-5085(08)80957-2 |
0.334 |
|
| 2000 |
Boyaka PN, Wright PF, Marinaro M, Kiyono H, Johnson JE, Gonzales RA, Ikizler MR, Werkhaven JA, Jackson RJ, Fujihashi K, Di Fabio S, Staats HF, McGhee JR. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. The American Journal of Pathology. 157: 2023-35. PMID 11106575 DOI: 10.1016/S0002-9440(10)64841-9 |
0.493 |
|
| 2000 |
Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. Journal of Immunology (Baltimore, Md. : 1950). 165: 5352-9. PMID 11046071 DOI: 10.4049/Jimmunol.165.9.5352 |
0.545 |
|
| 2000 |
Dohi T, Fujihashi K, Kiyono H, Elson CO, McGhee JR. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Gastroenterology. 119: 724-33. PMID 10982767 DOI: 10.1053/Gast.2000.16500 |
0.46 |
|
| 2000 |
Yamamoto M, Kiyono H, Kweon MN, Yamamoto S, Fujihashi K, Kurazono H, Imaoka K, Bluethmann H, Takahashi I, Takeda Y, Azuma M, McGhee JR. Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or -independent immune responses. The Journal of Infectious Diseases. 182: 180-90. PMID 10882596 DOI: 10.1086/315694 |
0.521 |
|
| 2000 |
Yamamoto M, Rennert P, McGhee JR, Kweon MN, Yamamoto S, Dohi T, Otake S, Bluethmann H, Fujihashi K, Kiyono H. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. Journal of Immunology (Baltimore, Md. : 1950). 164: 5184-91. PMID 10799877 DOI: 10.4049/Jimmunol.164.10.5184 |
0.574 |
|
| 2000 |
Fujihashi K, Koga T, McGhee JR. Mucosal vaccination and immune responses in the elderly. Vaccine. 18: 1675-80. PMID 10689147 DOI: 10.1016/S0264-410X(99)00505-8 |
0.544 |
|
| 1999 |
Fujihashi K, Dohi T, Kweon MN, McGhee JR, Koga T, Cooper MD, Tonegawa S, Kiyono H. gammadelta T cells regulate mucosally induced tolerance in a dose-dependent fashion. International Immunology. 11: 1907-16. PMID 10590256 DOI: 10.1093/Intimm/11.12.1907 |
0.52 |
|
| 1999 |
Kurono Y, Suzuki M, Mogi G, Yamamoto M, Fujihashi K, McGhee JR, Kiyono H. Effects of intranasal immunization on protective immunity against otitis media. International Journal of Pediatric Otorhinolaryngology. 49: S227-9. PMID 10577810 DOI: 10.1016/S0165-5876(99)00165-2 |
0.578 |
|
| 1999 |
Pascual DW, Hone DM, Hall S, van Ginkel FW, Yamamoto M, Walters N, Fujihashi K, Powell RJ, Wu S, Vancott JL, Kiyono H, McGhee JR. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infection and Immunity. 67: 6249-56. PMID 10569734 DOI: 10.1128/Iai.67.12.6249-6256.1999 |
0.485 |
|
| 1999 |
Mbawuike IN, Fujihashi K, DiFabio S, Kawabata S, McGhee JR, Couch RB, Kiyono H. Human interleukin-12 enhances interferon-gamma-producing influenza-specific memory CD8+ cytotoxic T lymphocytes. The Journal of Infectious Diseases. 180: 1477-86. PMID 10515806 DOI: 10.1086/315090 |
0.452 |
|
| 1999 |
Kurono Y, Yamamoto M, Fujihashi K, Kodama S, Suzuki M, Mogi G, McGhee JR, Kiyono H. Nasal immunization induces Haemophilus influenzae-specific Th1 and Th2 responses with mucosal IgA and systemic IgG antibodies for protective immunity. The Journal of Infectious Diseases. 180: 122-32. PMID 10353870 DOI: 10.1086/314827 |
0.57 |
|
| 1999 |
Boyaka PN, Marinaro M, Vancott JL, Takahashi I, Fujihashi K, Yamamoto M, van Ginkel FW, Jackson RJ, Kiyono H, McGhee JR. Strategies for mucosal vaccine development. The American Journal of Tropical Medicine and Hygiene. 60: 35-45. PMID 10344675 DOI: 10.4269/Ajtmh.1999.60.35 |
0.473 |
|
| 1999 |
Dohi T, Fujihashi K, Rennert PD, Iwatani K, Kiyono H, McGhee JR. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. The Journal of Experimental Medicine. 189: 1169-80. PMID 10209035 DOI: 10.1084/Jem.189.8.1169 |
0.507 |
|
| 1999 |
McGhee JR, Kiyono H, Kubota M, Kawabata S, Miller CJ, Lehner T, Imaoka K, Fujihashi K. Mucosal Th1- versus Th2-type responses for antibody- or cell-mediated immunity to simian immunodeficiency virus in rhesus macaques. The Journal of Infectious Diseases. 179: S480-4. PMID 10099124 DOI: 10.1086/314807 |
0.552 |
|
| 1998 |
Kawabata S, Boyaka PN, Coste M, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. 115: 866-73. PMID 9753489 DOI: 10.1016/S0016-5085(98)70258-6 |
0.402 |
|
| 1998 |
Salvi GE, Brown CE, Fujihashi K, Kiyono H, Smith FW, Beck JD, Offenbacher S. Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. Journal of Periodontal Research. 33: 212-25. PMID 9689617 DOI: 10.1111/J.1600-0765.1998.Tb02193.X |
0.35 |
|
| 1998 |
Yuki Y, Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Human milk proteins including secretory IgA fail to elicit tolerance after feeding. International Immunology. 10: 537-45. PMID 9620610 DOI: 10.1093/Intimm/10.4.537 |
0.536 |
|
| 1998 |
Kawabata S, Miller CJ, Lehner T, Fujihashi K, Kubota M, McGhee JR, Imaoka K, Hiroi T, Kiyono H. Induction of Th2 cytokine expression for p27-specific IgA B cell responses after targeted lymph node immunization with simian immunodeficiency virus antigens in rhesus macaques. The Journal of Infectious Diseases. 177: 26-33. PMID 9419166 DOI: 10.1086/513811 |
0.531 |
|
| 1998 |
Kurono Y, Fujihashi K, Suzuki M, Mogi G, Kiyono H. The role of interferon (IFN)-^|^gamma; in inducing IgA responses in nasal mucosa against outer membrane protein P6 of nontypeable Haemophilus influenzae Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology). 37: 98-102. DOI: 10.7248/Jjrhi1982.37.2_98 |
0.319 |
|
| 1998 |
Fujihashi K, VanCott JL, McGhee JF, Hiroi T, Kiyono H. 2.4 Measuring Cytokine Responses by ELISA, ELISPOT and RT-PCR Methods Methods in Microbiology. 25: 257-286. DOI: 10.1016/S0580-9517(08)70683-4 |
0.475 |
|
| 1997 |
Kawabata S, Boyaka PN, Coste M, Fujihashi K, Hamada S, McGhee JR, Kiyono H. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochemical and Biophysical Research Communications. 241: 797-802. PMID 9434789 DOI: 10.1006/Bbrc.1997.7839 |
0.371 |
|
| 1997 |
Fujihashi K, McGhee JR, Yamamoto M, Peschon JJ, Kiyono H. An interleukin-7 internet for intestinal intraepithelial T cell development: knockout of ligand or receptor reveal differences in the immunodeficient state. European Journal of Immunology. 27: 2133-8. PMID 9341750 DOI: 10.1002/Eji.1830270903 |
0.384 |
|
| 1997 |
Fujihashi K, Kweon MN, Kiyono H, VanCott JL, van Ginkel FW, Yamamoto M, McGhee JR. A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity. Springer Seminars in Immunopathology. 18: 477-94. PMID 9144866 DOI: 10.1007/Bf00824054 |
0.57 |
|
| 1997 |
Yamamoto S, Kiyono H, Yamamoto M, Imaoka K, Fujihashi K, Van Ginkel FW, Noda M, Takeda Y, McGhee JR. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proceedings of the National Academy of Sciences of the United States of America. 94: 5267-72. PMID 9144226 DOI: 10.1073/Pnas.94.10.5267 |
0.507 |
|
| 1997 |
Yamamoto S, Takeda Y, Yamamoto M, Kurazono H, Imaoka K, Yamamoto M, Fujihashi K, Noda M, Kiyono H, McGhee JR. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrheagenicity but retain adjuvanticity. The Journal of Experimental Medicine. 185: 1203-10. PMID 9104807 DOI: 10.1084/Jem.185.7.1203 |
0.457 |
|
| 1997 |
Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. Journal of Periodontal Research. 32: 115-9. PMID 9085220 DOI: 10.1111/J.1600-0765.1997.Tb01391.X |
0.36 |
|
| 1996 |
Jackson RJ, Marinaro M, VanCott JL, Yamamoto M, Okahashi N, Fujihashi K, Kiyono H, Chatfield SN, McGhee JR. Mucosal immunity: regulation by helper T cells and a novel method for detection. Journal of Biotechnology. 44: 209-16. PMID 8717406 DOI: 10.1016/0168-1656(95)00095-X |
0.505 |
|
| 1996 |
Fujihashi K, McGhee JR, Kweon MN, Cooper MD, Tonegawa S, Takahashi I, Hiroi T, Mestecky J, Kiyono H. gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses. The Journal of Experimental Medicine. 183: 1929-35. PMID 8666951 DOI: 10.1084/Jem.183.4.1929 |
0.58 |
|
| 1996 |
Takahashi I, Marinaro M, Kiyono H, Jackson RJ, Nakagawa I, Fujihashi K, Hamada S, Clements JD, Bost KL, McGhee JR. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. The Journal of Infectious Diseases. 173: 627-35. PMID 8627026 DOI: 10.1093/Infdis/173.3.627 |
0.541 |
|
| 1996 |
Fujihashi K, Kawabata S, Hiroi T, Yamamoto M, McGhee JR, Nishikawa S, Kiyono H. Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 93: 3613-8. PMID 8622984 DOI: 10.1073/Pnas.93.8.3613 |
0.383 |
|
| 1996 |
Jackson RJ, Fujihashi K, Kiyono H, McGhee JR. Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses. Journal of Immunological Methods. 190: 189-97. PMID 8621954 DOI: 10.1016/0022-1759(95)00276-6 |
0.356 |
|
| 1996 |
Yamamoto M, Vancott JL, Okahashi N, Marinaro M, Kiyono H, Fujihashi K, Jackson RJ, Chatfield SN, Bluethmann H, McGhee JR. The role of Th1 and Th2 cells for mucosal IgA responses. Annals of the New York Academy of Sciences. 778: 64-71. PMID 8611017 DOI: 10.1111/J.1749-6632.1996.Tb21115.X |
0.545 |
|
| 1996 |
Fujihashi K, McGhee JR, Yamamoto M, Hiroi T, Kiyono H. Role of gamma delta T cells in the regulation of mucosal IgA response and oral tolerance. Annals of the New York Academy of Sciences. 778: 55-63. PMID 8611016 DOI: 10.1111/J.1749-6632.1996.Tb21114.X |
0.555 |
|
| 1996 |
Takahashi I, Kiyono H, Jackson RJ, Fujihashi K, Staats HF, Hamada S, Clements JD, Bost KL, McGhee JR. Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. Infection and Immunity. 64: 1290-8. PMID 8606092 DOI: 10.1128/Iai.64.4.1290-1298.1996 |
0.464 |
|
| 1995 |
Aicher WK, Eibel H, Fujihashi K, Boehm T, Beagley KW, McGhee JR, Kiyono H. Analysis of intestinal intraepithelial lymphocyte (IEL) T cells in mice expressing anti-CD8 immunoglobulin transgenes. Advances in Experimental Medicine and Biology. 371: 125-8. PMID 8525887 DOI: 10.1007/978-1-4615-1941-6_23 |
0.377 |
|
| 1995 |
Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Polarized Th2 cytokine expression by both mucosal gamma delta and alpha beta T cells. European Journal of Immunology. 25: 2743-51. PMID 7589066 DOI: 10.1002/Eji.1830251005 |
0.437 |
|
| 1994 |
Yamamoto M, Fujihashi K, Amano M, McGhee JR, Beagley KW, Kiyono H. Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: signaling of high density alpha beta T cell receptor+ and gamma delta T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-gamma and interleukin-5 production, while low density T cells undergo DNA fragmentation. European Journal of Immunology. 24: 1301-6. PMID 8206090 DOI: 10.1002/Eji.1830240609 |
0.386 |
|
| 1994 |
Di Fabio S, Mbawuike IN, Kiyono H, Fujihashi K, Couch RB, McGhee JR. Quantitation of human influenza virus-specific cytotoxic T lymphocytes: correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8+ T cells. International Immunology. 6: 11-9. PMID 8148319 DOI: 10.1093/Intimm/6.1.11 |
0.392 |
|
| 1994 |
Fujihashi K, Yamamoto M, McGhee JR, Kiyono H. Function of alpha beta TCR+ and gamma delta TCR+ IELs for the gastrointestinal immune response. International Reviews of Immunology. 11: 1-14. PMID 8057042 DOI: 10.3109/08830189409061713 |
0.338 |
|
| 1994 |
Xu-Amano J, Jackson RJ, Fujihashi K, Kiyono H, Staats HF, McGhee JR. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. Vaccine. 12: 903-11. PMID 7975832 DOI: 10.1016/0264-410X(94)90033-7 |
0.504 |
|
| 1994 |
Hiroi T, Fujihashi K, McGhee JR, Kiyono H. Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues. European Journal of Immunology. 24: 2653-8. PMID 7957557 DOI: 10.1002/Eji.1830241113 |
0.423 |
|
| 1994 |
McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, Kiyono H. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reproduction, Fertility, and Development. 6: 369-79. PMID 7831485 DOI: 10.1071/Rd9940369 |
0.562 |
|
| 1993 |
Fujihashi K, McGhee JR, Beagley KW, McPherson DT, McPherson SA, Huang CM, Kiyono H. Cytokine-specific ELISPOT assay. Single cell analysis of IL-2, IL-4 and IL-6 producing cells. Journal of Immunological Methods. 160: 181-9. PMID 8459105 DOI: 10.1016/0022-1759(93)90176-8 |
0.334 |
|
| 1993 |
Jackson RJ, Fujihashi K, Xu-Amano J, Kiyono H, Elson CO, McGhee JR. Optimizing oral vaccines: induction of systemic and mucosal B-cell and antibody responses to tetanus toxoid by use of cholera toxin as an adjuvant. Infection and Immunity. 61: 4272-9. PMID 8406816 DOI: 10.1128/Iai.61.10.4272-4279.1993 |
0.481 |
|
| 1993 |
Kang DW, Ohkawa S, Difabio S, Merrill KW, Fujihashi K, Yamamoto M, Miller CJ, Marthas M, McGhee JR, Eldridge JH. Characterization of T and B cells isolated from mucosa-associated tissues of the rhesus macaque. Cellular Immunology. 151: 379-91. PMID 8402944 DOI: 10.1006/Cimm.1993.1247 |
0.421 |
|
| 1993 |
Beagley KW, Fujihashi K, Black CA, Lagoo AS, Yamamoto M, McGhee JR, Kiyono H. The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes. European Journal of Immunology. 23: 2049-52. PMID 8344373 DOI: 10.1002/Eji.1830230852 |
0.393 |
|
| 1993 |
Fujihashi K, Yamamoto M, McGhee JR, Beagley KW, Kiyono H. Function of alpha beta TCR+ intestinal intraepithelial lymphocytes: Th1- and Th2-type cytokine production by CD4+CD8- and CD4+CD8+ T cells for helper activity. International Immunology. 5: 1473-81. PMID 8260458 DOI: 10.1093/Intimm/5.11.1473 |
0.441 |
|
| 1992 |
McGhee JR, Fujihashi K, Beagley KW, Kiyono H. Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunologic Research. 10: 418-22. PMID 1955769 DOI: 10.1007/Bf02919734 |
0.43 |
|
| 1992 |
Kiyono H, Fujihashi K, Taguchi T, Aicher WK, McGhee JR. Regulatory functions for murine intraepithelial lymphocytes in mucosal responses. Immunologic Research. 10: 324-30. PMID 1955757 DOI: 10.1007/Bf02919716 |
0.47 |
|
| 1992 |
McGhee JR, Fujihashi K, Lue C, Beagley KW, Mestecky J, Kiyono H. Role of IL-6 in human antigen-specific and polyclonal IgA responses. Advances in Experimental Medicine and Biology. 310: 113-21. PMID 1808988 DOI: 10.1007/978-1-4615-3838-7_13 |
0.396 |
|
| 1992 |
Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H. Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help. The Journal of Experimental Medicine. 175: 695-707. PMID 1531495 DOI: 10.1084/jem.175.3.695 |
0.395 |
|
| 1992 |
Fujihashi K, Kono Y, Kiyono H. Effects of IL6 on B cells in mucosal immune response and inflammation Research in Immunology. 143: 744-749. PMID 1439148 DOI: 10.1016/0923-2494(92)80015-D |
0.428 |
|
| 1992 |
Aicher WK, Fujihashi K, Yamamoto M, Kiyono H, Pitts AM, McGhee JR. Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site. International Immunology. 4: 959-68. PMID 1390438 DOI: 10.1093/Intimm/4.9.959 |
0.504 |
|
| 1992 |
Aicher WK, Fujihashi K, Taguchi T, McGhee JR, Yamamoto M, Eldridge JH, Gay S, Kiyono H. Intestinal intraepithelial lymphocyte T cells are resistant to lpr gene-induced T cell abnormalities. European Journal of Immunology. 22: 137-45. PMID 1346108 DOI: 10.1002/Eji.1830220121 |
0.475 |
|
| 1992 |
Mega J, Fujihashi K, Yamamoto M, McGhee JR, Hirasawa M, Kiyono H. Cytokine production and T cell receptor expression by salivary gland T cells and intraepithelial T lymphocytes for the regulation of the IgA response. Advances in Experimental Medicine and Biology. 327: 119-31. PMID 1295332 DOI: 10.1007/978-1-4615-3410-5_14 |
0.391 |
|
| 1992 |
Xu-Amano J, Beagley KW, Mega J, Fujihashi K, Kiyono H, McGhee JR. Induction of T helper cells and cytokines for mucosal IgA responses. Advances in Experimental Medicine and Biology. 327: 107-17. PMID 1295331 DOI: 10.1007/978-1-4615-3410-5_13 |
0.44 |
|
| 1991 |
Kiyono H, Taguchi T, Aicher WK, Beagley KW, Fujihashi K, Eldridge JH, McGhee JR. Immunoregulatory confluence: T cells, Fc receptors and cytokines for IgA immune responses. International Reviews of Immunology. 6: 263-73. PMID 2102907 DOI: 10.3109/08830189009056636 |
0.475 |
|
| 1991 |
Fujihashi K, McGhee JR, Lue C, Beagley KW, Taga T, Hirano T, Kishimoto T, Mestecky J, Kiyono H. Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis. The Journal of Clinical Investigation. 88: 248-52. PMID 2056119 DOI: 10.1172/Jci115284 |
0.386 |
|
| 1991 |
Lue C, Kiyono H, McGhee JR, Fujihashi K, Kishimoto T, Hirano T, Mestecky J. Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells. Cellular Immunology. 132: 423-32. PMID 1988161 DOI: 10.1016/0008-8749(91)90039-E |
0.459 |
|
| 1989 |
Fujihashi K, Kiyono H, Beagley KW, Eldridge JH, McGhee JR. Role of the galt contrasuppressor T cell circuit in isotype-specific immunoregulation. Advances in Experimental Medicine and Biology. 237: 649-53. PMID 2978205 DOI: 10.1007/978-1-4684-5535-9_98 |
0.549 |
|
| 1989 |
Beagley KW, Fujihashi K, Aicher W, Xu J, Kiyono H, Eldridge JH, Bruce MG, Taguchi T, Green DR, Singh B. Mucosal homeostasis: role of interleukins, isotype-specific factors and contrasuppression in the IgA response. Immunological Investigations. 18: 77-89. PMID 2659524 DOI: 10.3109/08820138909112229 |
0.546 |
|
| 1988 |
Fujihashi K, Taguchi T, Kiyono H, Aicher W, McGhee JR, Kurihara Y, Otake S, Hirasawa M. The role of CD3+, CD4−, and CD8− T cells in mucosal immunoregulation Clinical Immunology Newsletter. 9: 200-203. DOI: 10.1016/0197-1859(88)90068-4 |
0.413 |
|
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