Melanie Mediavilla-Varela, Ph.D. - Publications

Affiliations: 
2009 Loma Linda University, Loma Linda, United States 
Area:
Microbiology Biology, Genetics, Cell Biology

25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Maharaj K, Powers JJ, Mediavilla-Varela M, Achille A, Gamal W, Quayle S, Jones SS, Sahakian E, Pinilla-Ibarz J. HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model. Frontiers in Immunology. 11: 590072. PMID 33329575 DOI: 10.3389/fimmu.2020.590072  0.627
2020 Maharaj K, Powers JJ, Achille A, Mediavilla-Varela M, Gamal W, Burger KL, Fonseca R, Jiang K, Miskin HP, Maryanski D, Monastyrskyi A, Duckett DR, Roush WR, Cleveland JL, Sahakian E, et al. The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells. Blood Advances. 4: 3072-3084. PMID 32634240 DOI: 10.1182/Bloodadvances.2020001800  0.614
2019 Mediavilla-Varela M, Agrawal V, Page MM, Kreahling J, Altiok S. Abstract 34: A high-content imaging platform for quantitative assessment of immunogenic tumor cell killing and T-cell proliferation in 3D tumoroids of fresh patient tumor samples Cancer Research. 79: 34-34. DOI: 10.1158/1538-7445.Sabcs18-34  0.383
2019 Agrawal V, Mediavilla-Varela M, Page MM, Kreahling J, Altiok S. Abstract 42: The importance of intact tumor immune microenvironment in unpropagated 3D fresh patient tumoroids in immuno-oncology drug testing for immunogenic tumor cell death and T-cell activation Cancer Research. 79: 42-42. DOI: 10.1158/1538-7445.Am2019-42  0.374
2018 Gray JE, Chiappori A, Williams CC, Tanvetyanon T, Haura EB, Creelan BC, Kim J, Boyle TA, Pinder-Schenck M, Khalil F, Altiok S, Devane R, Noyes D, Mediavilla-Varela M, Smilee R, et al. A phase I/randomized phase II study of GM.CD40L vaccine in combination with CCL21 in patients with advanced lung adenocarcinoma. Cancer Immunology, Immunotherapy : Cii. PMID 30209589 DOI: 10.1007/S00262-018-2236-7  0.332
2018 Mediavilla-Varela M, Page MM, Kreahling J, Altiok S. Abstract 1020: Characterization of the immune landscape and analysis of tumor response after anti-PD-1 blockade in a 3Dex vivosystem of non-small lung cancer Tumor Biology. DOI: 10.1158/1538-7445.Am2018-1020  0.301
2017 Mediavilla-Varela M, Castro J, Chiappori A, Noyes D, Hernandez DC, Stagg J, Antonia SJ. A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment. Neoplasia (New York, N.Y.). 19: 530-536. PMID 28582704 DOI: 10.1016/J.Neo.2017.02.004  0.321
2017 Mediavilla-Varela M, Page MM, Kreahling J, Freimark BD, Shan J, Kallinteris NL, Antonia SJ, Altiok S. Effect of bavituximab in combination with nivolumab on tumor immune response in a 3D ex vivo system of lung cancer patients. Journal of Clinical Oncology. 35: e23091-e23091. DOI: 10.1200/Jco.2017.35.15_Suppl.E23091  0.378
2017 Mediavilla-Varela M, Page MM, Kreahling J, Antonia SJ, Altiok S. Anti-PD1 treatment to induce M1 polarization of tumor infiltrating macrophages in a 3D ex vivo system of lung cancer patients. Journal of Clinical Oncology. 35: e23090-e23090. DOI: 10.1200/Jco.2017.35.15_Suppl.E23090  0.335
2016 Mediavilla-Varela M, Boateng K, Noyes D, Antonia SJ. The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. Bmc Cancer. 16: 176. PMID 26935219 DOI: 10.1186/S12885-016-2162-Z  0.352
2016 Basu A, Cajigas-Du Ross CK, Rios-Colon L, Mediavilla-Varela M, Daniels-Wells TR, Leoh LS, Rojas H, Banerjee H, Martinez SR, Acevedo-Martinez S, Casiano CA. LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer. Plos One. 11: e0146549. PMID 26771192 DOI: 10.1371/Journal.Pone.0146549  0.773
2014 Gordian E, Li J, Pevzner Y, Mediavilla-Varela M, Luddy K, Ohaegbulam K, Daniel KG, Haura EB, Muñoz-Antonia T. Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer. Plos One. 9: e114131. PMID 25501935 DOI: 10.1371/Journal.Pone.0114131  0.396
2014 Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, Diao L, Wang J, Roybal JD, Patel M, Ungewiss C, ... ... Mediavilla-Varela M, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nature Communications. 5: 5241. PMID 25348003 DOI: 10.1038/Ncomms6241  0.329
2014 Pacheco FJ, Almaguel FG, Evans W, Rios-Colon L, Filippov V, Leoh LS, Rook-Arena E, Mediavilla-Varela M, De Leon M, Casiano CA. Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating oxidative stress, ceramide production, lysosomal dysfunction, and autophagic features. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 63: 859-71. PMID 25095742 DOI: 10.1007/S00011-014-0760-2  0.711
2014 Mediavilla-Varela M, Noyes D, Boateng K, Antonia S. Abstract 1704: Combination of Pirfenidone and Cisplatin as a potential therapeutic strategy in NSCLC Cancer Research. 74: 1704-1704. DOI: 10.1158/1538-7445.Am2014-1704  0.397
2013 Mediavilla-Varela M, Luddy K, Noyes D, Khalil FK, Neuger AM, Soliman H, Antonia SJ. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biology & Therapy. 14: 860-8. PMID 23917542 DOI: 10.4161/Cbt.25643  0.395
2013 Mediavilla-Varela M, Luddy K, Noyes D, Boateng K, Antonia S. Abstract 4948: Pirfenidone as a potential therapeutic treatment for CAFs and cancer cells in NSCLC. Cancer Research. 73: 4948-4948. DOI: 10.1158/1538-7445.Am2013-4948  0.438
2013 Basu A, Cajigas C, Medina B, Rojas H, Banerjee H, Mediavilla-Varela M, Leoh L, Casiano C. Abstract 3117: Overexpression of the stress transcription co-activator LEDGF/p75 contributes to the upregulation of the stress protective genes HSP27, ERp57 and CYGB in prostate cancer. Cancer Research. 73: 3117-3117. DOI: 10.1158/1538-7445.Am2013-3117  0.818
2011 Leoh LS, Mediavilla-Varela M, Basu A, Daniels TR, Martinez S, Pacheco FJ, Padilla A, Asuelime G, Rios-Colon L, Leon MD, Casiano CA. Abstract 2083: The stress oncoprotein LEDGF/p75 attenuates oxidative stress-induced necrosis but not apoptosis in prostate cancer cells Cancer Research. 71: 2083-2083. DOI: 10.1158/1538-7445.Am2011-2083  0.743
2010 Soliman H, Mediavilla-Varela M, Antonia S. Indoleamine 2,3-dioxygenase: is it an immune suppressor? Cancer Journal (Sudbury, Mass.). 16: 354-9. PMID 20693847 DOI: 10.1097/Ppo.0B013E3181Eb3343  0.344
2010 Basu A, Mediavilla-Varela M, Martinez S, Rojas H, Banergee H, Roy S, Lilly MB, Leon MD, Casiano CA. Abstract 2715: Peroxiredoxin 3: A potential biological determinant of prostate cancer health disparities Cancer Research. 70: 2715-2715. DOI: 10.1158/1538-7445.Am10-2715  0.799
2010 Basu A, Banerjee H, Rojas H, Martinez S, Mediavilla-Varela M, Sourav R, Jia Z, Mercola D, Lilly MB, Leon MD, Casiano CA. Abstract A108: Differential expression of peroxiredoxins in prostate cancer: Ethnic differences in the association of PRDX3 expression with clinical outcomes Cancer Epidemiology, Biomarkers & Prevention. 19. DOI: 10.1158/1055-9965.Disp-10-A108  0.801
2009 Mediavilla-Varela M, Pacheco FJ, Almaguel F, Perez J, Sahakian E, Daniels TR, Leoh LS, Padilla A, Wall NR, Lilly MB, De Leon M, Casiano CA. Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75. Molecular Cancer. 8: 68. PMID 19715609 DOI: 10.1186/1476-4598-8-68  0.758
2008 Brown-Bryan TA, Leoh LS, Ganapathy V, Pacheco FJ, Mediavilla-Varela M, Filippova M, Linkhart TA, Gijsbers R, Debyser Z, Casiano CA. Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Molecular Cancer Research : McR. 6: 1293-307. PMID 18708362 DOI: 10.1158/1541-7786.Mcr-08-0125  0.739
2006 Casiano CA, Mediavilla-Varela M, Tan EM. Tumor-associated antigen arrays for the serological diagnosis of cancer. Molecular & Cellular Proteomics : McP. 5: 1745-59. PMID 16733262 DOI: 10.1074/Mcp.R600010-Mcp200  0.727
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