Peter Bretscher - Publications

Affiliations: 
Microbiology and Immunology University of Saskatchewan, Saskatoon, SK, Canada 
Area:
Immunology

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Anderson CC, Bonney EA, Mueller TF, Corthay A, Havele C, Singh NJ, Øynebråten I, Bretscher PA. On antigen-specific signals, immune class regulation and energetics: Report III from the workshops on foundational concepts of immune regulation. Scandinavian Journal of Immunology. 98: e13311. PMID 38112131 DOI: 10.1111/sji.13311  0.308
2023 Bretscher P. What Determines the Class of Immunity an Antigen Induces? A Foundational Question Whose Rational Consideration Has Been Undermined by the Information Overload. Biology. 12. PMID 37759652 DOI: 10.3390/biology12091253  0.617
2022 Bretscher PA. Analyzing some concepts of immune regulation of the last three decades: Fostering greater research resilience despite the information overload. A personal view. Frontiers in Immunology. 13: 960742. PMID 36405696 DOI: 10.3389/fimmu.2022.960742  0.365
2020 Bretscher PA, Al-Yassin G, Anderson CC. On T cell development, T cell signals, T cell specificity and sensitivity, and the autoimmunity facilitated by lymphopenia. Scandinavian Journal of Immunology. e12888. PMID 32281665 DOI: 10.1111/sji.12888  0.473
2019 Bretscher P. On Analyzing How the Th1/Th2 Phenotype of an Immune Response Is Determined: Classical Observations Must Not Be Ignored. Frontiers in Immunology. 10: 1234. PMID 31231378 DOI: 10.3389/Fimmu.2019.01234  0.403
2019 Bretscher PA, Al-Yassin GA. On how the immune system preferentially interacts with antigen-specific molecules bound to antigen over unbound molecules, with emphasis on B cell receptor signalling. Scandinavian Journal of Immunology. e12795. PMID 31148206 DOI: 10.1111/sji.12795  0.324
2019 Bretscher PA. The history of the two-signal model of lymphocyte activation: A personal perspective. Scandinavian Journal of Immunology. e12762. PMID 30825214 DOI: 10.1111/sji.12762  0.491
2018 Al-Yassin GA, Bretscher PA. Does T Cell Activation Require a Quorum of Lymphocytes? Journal of Immunology (Baltimore, Md. : 1950). 201: 2855-2861. PMID 30397169 DOI: 10.4049/jimmunol.1800805  0.535
2017 Bretscher P, Corthay A, Anderson CC, Dembic Z, Havele C, Nagy ZA, Øynebråten I. Immune class regulation and its medical significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. PMID 28236642 DOI: 10.1111/sji.12525  0.574
2016 Anderson CC, Bretscher P, Corthay A, Dembic Z, Havele C, Nagy ZA, Øynebråten I. Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. PMID 27885703 DOI: 10.1111/Sji.12500  0.509
2016 Bretscher PA. Is the framework of Cohn's "Tritope Model" for how T cell receptors recognize peptide/self MHC complexes and allo- MHC plausible? The framework of Tritope Model of TcR recognition. Scandinavian Journal of Immunology. PMID 26991815 DOI: 10.1111/sji.12421  0.309
2015 Bretscher PA. A Conversation with Cohn on the Activation of CD4 T Cells Scandinavian Journal of Immunology. 82: 147-159. PMID 25998043 DOI: 10.1111/sji.12315  0.591
2014 Rudulier CD, McKinstry KK, Al-Yassin GA, Kroeger DR, Bretscher PA. The number of responding CD4 T cells and the dose of antigen conjointly determine the TH1/TH2 phenotype by modulating B7/CD28 interactions. Journal of Immunology (Baltimore, Md. : 1950). 192: 5140-50. PMID 24752446 DOI: 10.4049/Jimmunol.1301691  0.788
2014 Bretscher PA. On the Mechanism Determining the Th1/Th2 Phenotype of an Immune Response, and its Pertinence to Strategies for the Prevention, and Treatment, of Certain Infectious Diseases Scandinavian Journal of Immunology. 79: 361-376. PMID 24684592 DOI: 10.1111/sji.12175  0.313
2014 Bretscher PA. The Activation and Inactivation of Mature CD4 T cells: A Case for Peripheral Self-Nonself Discrimination Scandinavian Journal of Immunology. 79: 348-360. PMID 24684567 DOI: 10.1111/sji.12173  0.597
2013 Kroeger DR, Rudulier CD, Bretscher PA. Antigen presenting B cells facilitate CD4 T cell cooperation resulting in enhanced generation of effector and memory CD4 T cells. Plos One. 8: e77346. PMID 24155947 DOI: 10.1371/Journal.Pone.0077346  0.782
2012 Kroeger DR, Rudulier CD, Peters NC, Bretscher PA. Direct demonstration of CD4 T cell cooperation in the primary in vivo generation of CD4 effector T cells. International Immunology. 24: 519-27. PMID 22527289 DOI: 10.1093/Intimm/Dxs055  0.763
2012 Rudulier CD, Kroeger DR, Bretscher PA. Distinct roles of dendritic and B cells in the activation of naive CD4+ T cells. Immunotherapy. 4: 355-7. PMID 22512626 DOI: 10.2217/Imt.12.17  0.786
2012 Rudulier CD, Kroeger DR, Bretscher PA. The activation, by antigen, of naïve TCR transgenic CD4 T cells cultured at physiological, rather than artificially high, frequencies more accurately reflects the in vivo activation of normal numbers of naïve CD4(+) T cells. Cellular Immunology. 274: 115-20. PMID 22370222 DOI: 10.1016/J.Cellimm.2012.01.004  0.776
2010 Power C, Marfleet TW, Qualtiere L, Xiao W, Bretscher P. Development of Th1 imprints to rBCG expressing a foreign protein: implications for vaccination against HIV-1 and diverse influenza strains. Journal of Biomedicine & Biotechnology. 2010: 591348. PMID 20625498 DOI: 10.1155/2010/591348  0.33
2009 Hamilton D, Ismail N, Kroeger D, Rudulier C, Bretscher P. Macroimmunology and immunotherapy of cancer. Immunotherapy. 1: 367-83. PMID 20635957 DOI: 10.2217/Imt.09.6  0.708
2009 Peters NC, Kroeger DR, Mickelwright S, Bretscher PA. CD4 T cell cooperation is required for the in vivo activation of CD4 T cells. International Immunology. 21: 1213-24. PMID 19736293 DOI: 10.1093/Intimm/Dxp085  0.773
2006 Strutt TM, Uzonna J, McKinstry KK, Bretscher PA. Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC. International Immunology. 18: 719-28. PMID 16569677 DOI: 10.1093/intimm/dxl009  0.579
2005 Ismail N, Basten A, Briscoe H, Bretscher PA. Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen. Immunology. 115: 34-41. PMID 15819695 DOI: 10.1111/J.1365-2567.2005.02128.X  0.522
2005 Strutt T, Bretscher P. Cooperation between CD4 T helper cells is required for the generation of alloantigen-specific, IFN-gamma-producing human CD4 T cells. Immunology and Cell Biology. 83: 175-81. PMID 15748214 DOI: 10.1111/J.1440-1711.2005.01306.X  0.637
2005 Peters NC, Hamilton DH, Bretscher PA. Analysis of cytokine-producing Th cells from hen egg lysozyme-immunized mice reveals large numbers specific for "cryptic" peptides and different repertoires among different Th populations. European Journal of Immunology. 35: 56-65. PMID 15597327 DOI: 10.1002/Eji.200425581  0.698
2002 Bretscher P, Peters N. Two signal models of lymphocyte activation incorporate a mechanism of peripheral tolerance, and have implications for achieving immunological unresponsiveness and effective transplantation. Vox Sanguinis. 83: 155-8. PMID 12617128 DOI: 10.1111/J.1423-0410.2002.Tb05292.X  0.621
2001 Uzonna JE, Wei G, Yurkowski D, Bretscher P. Immune elimination of Leishmania major in mice: Implications for immune memory, vaccination, and reactivation disease Journal of Immunology. 167: 6967-6974. PMID 11739516 DOI: 10.4049/Jimmunol.167.12.6967  0.354
2001 Ismail N, Bretscher PA. More antigen-dependent CD4+ T cell/CD4+ T cell interactions are required for the primary generation of Th2 than of Th1 cells European Journal of Immunology. 31: 1765-1771. PMID 11385621 DOI: 10.1002/1521-4141(200106)31:6<1765::AID-IMMU1765>3.0.CO;2-T  0.577
2001 Bretscher PA, Ismail N, Peters N, Uzonna J. Cell-to-cell interactions and signaling within the immune system:Towards integrating mechanism and physiology Neuroimmune Biology. 1: 71-85. DOI: 10.1016/S1567-7443(01)80009-0  0.67
2000 Bretscher P. Contemporary models for peripheral tolerance and the classical 'historical postulate' Seminars in Immunology. 12: 221-229. PMID 10910743 DOI: 10.1006/Smim.2000.0235  0.453
1999 Power CA, Grand CL, Ismail N, Peters NC, Yurkowski DP, Bretscher PA. A valid ELISPOT assay for enumeration of ex vivo, antigen-specific, IFNgamma-producing T cells. Journal of Immunological Methods. 227: 99-107. PMID 10485258 DOI: 10.1016/S0022-1759(99)00074-5  0.71
1999 Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells Proceedings of the National Academy of Sciences of the United States of America. 96: 185-190. PMID 9874793 DOI: 10.1073/pnas.96.1.185  0.423
1997 Bretscher PA, Ogunremi O, Menon JN. Distinct immunological states in murine cutaneous leishmaniasis by immunising with different amounts of antigen: the generation of beneficial, potentially harmful, harmful and potentially extremely harmful states. Behring Institute Mitteilungen. 153-9. PMID 9382736  0.302
1992 Tuttosi S, Bretscher PA. Antigen-specific CD8+ T cells switch the immune response induced by antigen from AN IgG to a cell-mediated mode Journal of Immunology. 148: 397-403. PMID 1729360  0.523
1992 Bretscher PA, Wei G, Menon JN, Bielefeldt-Ohmann H. Establishment of stable, cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major Science. 257: 539-542. PMID 1636090  0.305
1991 Bretscher PA. The regulatory functions of CD4+ and CD8+ T-cell subsets in immune class regulation Research in Immunology. 142: 45-50. PMID 1905414 DOI: 10.1016/0923-2494(91)90011-7  0.534
1991 Swain SL, Gajewski TF, Fitch FW, Locksley RM, Daynes RA, Araneo BA, Powrie F, Fowell D, McKnight AJ, Mason D, Romagnani S, Bretscher PA, Mosmann T. CD4+ T-cell subsets: Regulation of differentiation and function: Discussion Research in Immunology. 142: 68-79.  0.51
1987 LeClercq SA, Bretscher PA. T cells expressing delayed-type hypersensitivity can be derived from a humorally immune lymphocyte population European Journal of Immunology. 17: 949-954. PMID 3497043  0.455
1986 Bretscher PA. A cascade of T-T interactions, mediated by the linked recognition of antigen, in the induction of T cells able to help delayed-type hypersensitivity responses Journal of Immunology. 137: 3726-3733. PMID 2431041  0.456
1986 Bretscher PA. How significant are 'autoreactive' T cells? Immunology Today. 7: 301-302. DOI: 10.1016/0167-5699(86)90066-6  0.43
1984 Bretscher PA, Wilkins J, Diner UE. Hapten-Ficoll conjugates induce T-cell-dependent IgM anti-hapten responses and T cells mediating hapten-specific delayed-type hypersensitivity Cellular Immunology. 85: 396-405. PMID 6201291 DOI: 10.1016/0008-8749(84)90253-3  0.471
1984 Bretscher PA. In vitro induction of specific T cells able to help in the generation of delayed-type hypersensitivity by thymus-dependent and type-II 'thymus-independent' antigens Scandinavian Journal of Immunology. 20: 519-525. PMID 6083601  0.432
1983 Bretscher PA. Regulation of the class of immune response induced by antigen. I. Specific T cells switch the in vivo response from a cell-mediated to humoral mode Cellular Immunology. 81: 345-356. PMID 6227392 DOI: 10.1016/0008-8749(83)90242-3  0.468
1983 Bretscher PA. In vitro analysis of the cellular interactions between unprimed lymphocytes responsible for determining the class of response an antigen induces: Specific T cells switch a cell-mediated response to a humoral response Journal of Immunology. 131: 1103-1107. PMID 6193175  0.384
1982 Tucker MJ, Bretscher PA. T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants Journal of Experimental Medicine. 155: 1037-1049. PMID 6174668  0.384
1981 Bretscher PA. Significance and mechanisms of cellular regulation of the immune response Federation Proceedings. 40: 1473-1478. PMID 6452291  0.409
1979 Bretscher PA. In vitro induction of delayed-type hypersensitivity European Journal of Immunology. 9: 311-316. PMID 89035  0.306
1977 Ramshaw IA, Bretscher PA, Parish CR. Regulation of the immune response. II. Repressor T cells in cyclophosphamide induced tolerant mice European Journal of Immunology. 7: 180-185. PMID 324776  0.383
1977 Ramshaw IA, McKenzie IFC, Bretscher PA, Parish CR. Discrimination of suppressor T cells of humoral and cell-mediated immunity by anti-Ly and anti-Ia sera Cellular Immunology. 31: 364-369. PMID 301441 DOI: 10.1016/0008-8749(77)90038-7  0.477
1977 Pilarski LM, Bretscher PA, Baum LL. Helper T cells are required for the polyclonal stimulation of cytotoxic T cells by concanavalin A Journal of Experimental Medicine. 145: 1237-1249. PMID 300781  0.473
1976 Ramshaw IA, Bretscher PA, Parish CR. Regulation of the immune response. I. Suppression of delayed type hypersensitivity by T cells from mice expressing humoral immunity European Journal of Immunology. 6: 674-679. PMID 1087845  0.445
1974 Bretscher PA. On the control between cell-mediated, IgM and IgG immunity Cellular Immunology. 13: 171-195. PMID 4451975 DOI: 10.1016/0008-8749(74)90237-8  0.303
1973 Bretscher P. Hypothesis: A model for generalised autoimmunity Cellular Immunology. 6: 1-11. PMID 4119340 DOI: 10.1016/0008-8749(73)90001-4  0.313
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