Robert J. DeLorenzo, M.D., Ph.D. - Publications

Affiliations: 
Pharmacology and Toxicology Virginia Commonwealth University School of Medicine, Richmond, VA 
Area:
Epilepsy, calcium signaling, neural plasticity

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Blair RE, Hawkins E, Pinchbeck LR, DeLorenzo RJ, Deshpande LS. . The Journal of Pharmacology and Experimental Therapeutics. PMID 37643794 DOI: 10.1124/jpet.123.001739  0.82
2021 Kirmani BF, Au K, Ayari L, John M, Shetty P, Delorenzo RJ. Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management. Aging and Disease. 12: 1097-1119. PMID 34221552 DOI: 10.14336/AD.2021.0302  0.307
2020 Deshpande LS, Blair RE, Halquist M, Kosmider L, DeLorenzo RJ. Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus. Annals of the New York Academy of Sciences. PMID 32961584 DOI: 10.1111/nyas.14500  0.769
2020 Deshpande LS, DeLorenzo RJ, Churn SB, Parsons JT. Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg/Ca ATPase Ca Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus. Brain Sciences. 10. PMID 32664397 DOI: 10.3390/Brainsci10070438  0.835
2019 Deshpande LS, DeLorenzo RJ. Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis. Neurobiology of Disease. PMID 30872159 DOI: 10.1016/J.Nbd.2019.03.006  0.84
2018 Phillips KF, Deshpande LS, DeLorenzo RJ. Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats. Frontiers in Neurology. 9: 438. PMID 29942282 DOI: 10.3389/Fneur.2018.00438  0.829
2016 Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ. Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication. Annals of the New York Academy of Sciences. PMID 27327161 DOI: 10.1111/Nyas.13122  0.803
2016 Deshpande LS, Blair RE, Huang BA, Phillips KF, DeLorenzo RJ. Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats. Neurotoxicology and Teratology. PMID 27224207 DOI: 10.1016/J.Ntt.2016.05.002  0.824
2015 Blair RE, Deshpande LS, DeLorenzo RJ. Cannabinoids: is there a potential treatment role in epilepsy? Expert Opinion On Pharmacotherapy. 16: 1911-4. PMID 26234319 DOI: 10.1517/14656566.2015.1074181  0.803
2015 Blair RE, Deshpande LS, DeLorenzo RJ. Endocannabinoids and epilepsy Cannabinoids in Neurologic and Mental Disease. 125-172. DOI: 10.1016/B978-0-12-417041-4.00006-0  0.789
2014 Deshpande LS, Phillips K, Huang B, DeLorenzo RJ. Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity. Neurotoxicology. 44: 352-7. PMID 25172410 DOI: 10.1016/J.Neuro.2014.08.008  0.767
2014 Deshpande LS, Carter DS, Phillips KF, Blair RE, DeLorenzo RJ. Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. Neurotoxicology. 44: 17-26. PMID 24785379 DOI: 10.1016/J.Neuro.2014.04.006  0.833
2014 Deshpande LS, Delorenzo RJ. Mechanisms of levetiracetam in the control of status epilepticus and epilepsy. Frontiers in Neurology. 5: 11. PMID 24550884 DOI: 10.3389/Fneur.2014.00011  0.799
2013 Phillips KF, Deshpande LS, DeLorenzo RJ. Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons. European Journal of Pharmacology. 698: 186-92. PMID 23085028 DOI: 10.1016/J.Ejphar.2012.10.010  0.811
2012 Sayers KW, Nguyen PT, Blair RE, Sim-Selley LJ, DeLorenzo RJ. Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. Epilepsia. 53: 897-907. PMID 22509801 DOI: 10.1111/J.1528-1167.2012.03460.X  0.394
2011 Deshpande LS, Blair RE, DeLorenzo RJ. Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons. Experimental Neurology. 229: 264-73. PMID 21324315 DOI: 10.1016/J.Expneurol.2011.02.007  0.809
2011 Carter DS, Deshpande LS, Rafiq A, Sombati S, DeLorenzo RJ. Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals. Seizure. 20: 218-24. PMID 21168348 DOI: 10.1016/J.Seizure.2010.11.022  0.842
2011 Ziobro JM, Deshpande LS, Delorenzo RJ. An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. Brain Research. 1371: 110-20. PMID 21111720 DOI: 10.1016/J.Brainres.2010.11.065  0.831
2011 Deshpande LS, DeLorenzo RJ. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons. Neuroreport. 22: 15-8. PMID 21037491 DOI: 10.1097/Wnr.0B013E3283413231  0.838
2010 Nagarkatti N, Deshpande LS, Carter DS, DeLorenzo RJ. Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. The European Journal of Neuroscience. 32: 80-8. PMID 20597971 DOI: 10.1111/J.1460-9568.2010.07262.X  0.855
2010 Deshpande LS, Carter DS, Blair RE, DeLorenzo RJ. Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 623-31. PMID 20498005 DOI: 10.1093/Toxsci/Kfq157  0.835
2009 Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ. Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. Neuropharmacology. 57: 208-18. PMID 19540252 DOI: 10.1016/J.Neuropharm.2009.06.007  0.844
2009 Nagarkatti N, Deshpande LS, DeLorenzo RJ. Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis. Expert Review of Neurotherapeutics. 9: 813-24. PMID 19496685 DOI: 10.1586/Ern.09.21  0.848
2009 Blair RE, Deshpande LS, Holbert WH, Churn SB, DeLorenzo RJ. Age-dependent mortality in the pilocarpine model of status epilepticus. Neuroscience Letters. 453: 233-7. PMID 19429042 DOI: 10.1016/J.Neulet.2009.02.035  0.782
2009 Falenski KW, Carter DS, Harrison AJ, Martin BR, Blair RE, DeLorenzo RJ. Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Research. 1262: 64-72. PMID 19368833 DOI: 10.1016/J.Brainres.2009.01.036  0.821
2009 DeLorenzo RJ, Kirmani B, Deshpande LS, Jakkampudi V, Towne AR, Waterhouse E, Garnett L, Ramakrishnan V. Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia. Seizure. 18: 405-11. PMID 19324574 DOI: 10.1016/J.Seizure.2009.02.005  0.76
2008 Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, DeLorenzo RJ. Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neuroscience Letters. 441: 115-9. PMID 18583041 DOI: 10.1016/J.Neulet.2008.05.113  0.825
2008 Blair RE, Sombati S, Churn SB, Delorenzo RJ. Epileptogenesis causes an N-methyl-d-aspartate receptor/Ca2+-dependent decrease in Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent epileptiform discharges. European Journal of Pharmacology. 588: 64-71. PMID 18495112 DOI: 10.1016/J.Ejphar.2008.04.021  0.433
2008 Deshpande LS, Nagarkatti N, Ziobro JM, Sombati S, DeLorenzo RJ. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons. Epilepsia. 49: 1795-802. PMID 18494784 DOI: 10.1111/J.1528-1167.2008.01667.X  0.83
2008 Nagarkatti N, Deshpande LS, DeLorenzo RJ. Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neuroscience Letters. 436: 289-93. PMID 18406528 DOI: 10.1016/J.Neulet.2008.02.076  0.854
2008 Carter DS, Harrison AJ, Falenski KW, Blair RE, DeLorenzo RJ. Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus. Epilepsy Research. 79: 213-23. PMID 18394865 DOI: 10.1016/J.Eplepsyres.2008.02.006  0.846
2008 Sun DA, Deshpande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, DeLorenzo RJ. Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal neurons surviving brain injury. The European Journal of Neuroscience. 27: 1659-72. PMID 18371074 DOI: 10.1111/J.1460-9568.2008.06156.X  0.827
2008 Deshpande LS, Nagarkatti N, Sombati S, DeLorenzo RJ. The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Research. 79: 158-65. PMID 18353614 DOI: 10.1016/J.Eplepsyres.2008.01.002  0.833
2008 Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, DeLorenzo RJ. Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry. European Journal of Pharmacology. 583: 73-83. PMID 18289526 DOI: 10.1016/J.Ejphar.2008.01.025  0.854
2007 Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, DeLorenzo RJ. In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Research. 75: 171-9. PMID 17624736 DOI: 10.1016/J.Eplepsyres.2007.05.011  0.842
2007 Deshpande LS, Limbrick DD, Sombati S, DeLorenzo RJ. Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. The Journal of Pharmacology and Experimental Therapeutics. 322: 443-52. PMID 17483292 DOI: 10.1124/Jpet.107.123182  0.824
2007 DeLorenzo RJ, Sun DA, Blair RE, Sombati S. An in vitro model of stroke-induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke-induced epileptogenesis. International Review of Neurobiology. 81: 59-84. PMID 17433918 DOI: 10.1016/S0074-7742(06)81005-6  0.763
2007 Falenski KW, Blair RE, Sim-Selley LJ, Martin BR, DeLorenzo RJ. Status epilepticus causes a long-lasting redistribution of hippocampal cannabinoid type 1 receptor expression and function in the rat pilocarpine model of acquired epilepsy. Neuroscience. 146: 1232-44. PMID 17433556 DOI: 10.1016/J.Neuroscience.2007.01.065  0.822
2007 Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, DeLorenzo RJ. Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neuroscience Letters. 418: 77-81. PMID 17374449 DOI: 10.1016/J.Neulet.2007.03.005  0.829
2007 Deshpande LS, Blair RE, Nagarkatti N, Sombati S, Martin BR, DeLorenzo RJ. Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus. Experimental Neurology. 204: 705-13. PMID 17289026 DOI: 10.1016/J.Expneurol.2007.01.001  0.834
2007 Deshpande LS, Blair RE, Ziobro JM, Sombati S, Martin BR, DeLorenzo RJ. Endocannabinoids block status epilepticus in cultured hippocampal neurons. European Journal of Pharmacology. 558: 52-9. PMID 17174949 DOI: 10.1016/J.Ejphar.2006.11.030  0.84
2007 Deshpande LS, Sombati S, Blair RE, Carter DS, Martin BR, DeLorenzo RJ. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neuroscience Letters. 411: 11-6. PMID 17110038 DOI: 10.1016/J.Neulet.2006.09.046  0.844
2006 Carter DS, Haider SN, Blair RE, Deshpande LS, Sombati S, DeLorenzo RJ. Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture. The Journal of Pharmacology and Experimental Therapeutics. 319: 1021-31. PMID 16971505 DOI: 10.1124/Jpet.106.110403  0.835
2006 DeLorenzo RJ, Sun DA, Deshpande LS. Erratum to "Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy." [Pharmacol. Ther. 105(3) (2005) 229-266]. Pharmacology & Therapeutics. 111: 288-325. PMID 16832874 DOI: 10.1016/J.Pharmthera.2004.10.015  0.842
2006 Blair RE, Deshpande LS, Sombati S, Falenski KW, Martin BR, DeLorenzo RJ. Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. The Journal of Pharmacology and Experimental Therapeutics. 317: 1072-8. PMID 16469864 DOI: 10.1124/Jpet.105.100354  0.826
2006 Leppik IE, Kelly KM, deToledo-Morrell L, Patrylo PR, DeLorenzo RJ, Mathern GW, White HS. Basic research in epilepsy and aging. Epilepsy Research. 68: S21-37. PMID 16384687 DOI: 10.1016/J.Eplepsyres.2005.07.014  0.441
2006 DeLorenzo RJ, Sun DA. Basic mechanisms in status epilepticus: role of calcium in neuronal injury and the induction of epileptogenesis. Advances in Neurology. 97: 187-97. PMID 16383128  0.715
2005 Delorenzo RJ, Sun DA, Deshpande LS. Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintainance of epilepsy. Pharmacology & Therapeutics. 105: 229-66. PMID 15737406 DOI: 10.1016/J.Pharmthera.2004.10.004  0.847
2004 Raza M, Blair RE, Sombati S, Carter DS, Deshpande LS, DeLorenzo RJ. Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 101: 17522-7. PMID 15583136 DOI: 10.1073/Pnas.0408155101  0.833
2004 Parsons JT, Sun DA, DeLorenzo RJ, Churn SB. Neuronal-specific endoplasmic reticulum Mg(2+)/Ca(2+) ATPase Ca(2+) sequestration in mixed primary hippocampal culture homogenates. Analytical Biochemistry. 330: 130-9. PMID 15183771 DOI: 10.1016/J.Ab.2004.03.025  0.711
2004 Blair RE, Sombati S, Lawrence DC, McCay BD, DeLorenzo RJ. Epileptogenesis causes acute and chronic increases in GABAA receptor endocytosis that contributes to the induction and maintenance of seizures in the hippocampal culture model of acquired epilepsy. The Journal of Pharmacology and Experimental Therapeutics. 310: 871-80. PMID 15084648 DOI: 10.1124/jpet.104.068478  0.358
2004 Sun DA, Sombati S, Blair RE, DeLorenzo RJ. Long-lasting alterations in neuronal calcium homeostasis in an in vitro model of stroke-induced epilepsy. Cell Calcium. 35: 155-63. PMID 14706289 DOI: 10.1016/J.Ceca.2003.09.003  0.759
2003 Wallace MJ, Blair RE, Falenski KW, Martin BR, DeLorenzo RJ. The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. The Journal of Pharmacology and Experimental Therapeutics. 307: 129-37. PMID 12954810 DOI: 10.1124/Jpet.103.051920  0.815
2003 Rafiq A, Gong QZ, Lyeth BG, DeLorenzo RJ, Coulter DA. Induction of prolonged electrographic seizures in vitro has a defined threshold and is all or none: implications for diagnosis of status epilepticus. Epilepsia. 44: 1034-41. PMID 12887434 DOI: 10.1046/J.1528-1157.2003.51902.X  0.347
2003 Limbrick DD, Sombati S, DeLorenzo RJ. Calcium influx constitutes the ionic basis for the maintenance of glutamate-induced extended neuronal depolarization associated with hippocampal neuronal death. Cell Calcium. 33: 69-81. PMID 12531183 DOI: 10.1016/S0143-4160(02)00054-4  0.637
2002 Sun DA, Sombati S, Blair RE, DeLorenzo RJ. Calcium-dependent epileptogenesis in an in vitro model of stroke-induced "epilepsy". Epilepsia. 43: 1296-305. PMID 12423378 DOI: 10.1046/J.1528-1157.2002.09702.X  0.738
2002 Raza M, Shaheen F, Choudhary MI, Rahman AU, Sombati S, DeLorenzo RJ. In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum. Neuroscience Letters. 333: 103-6. PMID 12419491 DOI: 10.1016/S0304-3940(02)01027-3  0.353
2002 Wallace MJ, Martin BR, DeLorenzo RJ. Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity. European Journal of Pharmacology. 452: 295-301. PMID 12359270 DOI: 10.1016/S0014-2999(02)02331-2  0.791
2001 Wallace MJ, Wiley JL, Martin BR, DeLorenzo RJ. Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects. European Journal of Pharmacology. 428: 51-7. PMID 11779037 DOI: 10.1016/S0014-2999(01)01243-2  0.795
2001 Parsons JT, Churn SB, DeLorenzo RJ. Chronic inhibition of cortex microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake in the rat pilocarpine model following epileptogenesis. Journal of Neurochemistry. 79: 319-27. PMID 11677260 DOI: 10.1046/j.1471-4159.2001.00576.x  0.364
2001 Sun DA, Sombati S, DeLorenzo RJ. Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy". Stroke; a Journal of Cerebral Circulation. 32: 2344-50. PMID 11588324  0.402
2001 Pal S, Sun D, Limbrick D, Rafiq A, DeLorenzo RJ. Epileptogenesis induces long-term alterations in intracellular calcium release and sequestration mechanisms in the hippocampal neuronal culture model of epilepsy. Cell Calcium. 30: 285-96. PMID 11587552 DOI: 10.1054/Ceca.2001.0236  0.715
2001 Raza M, Shaheen F, Choudhary MI, Suria A, Rahman AU, Sombati S, DeLorenzo RJ. Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum. Phytotherapy Research : Ptr. 15: 426-30. PMID 11507736 DOI: 10.1002/ptr.792  0.313
2001 Kurz JE, Sheets D, Parsons JT, Rana A, Delorenzo RJ, Churn SB. A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. Journal of Neurochemistry. 78: 304-15. PMID 11461966 DOI: 10.1046/J.1471-4159.2001.00426.X  0.355
2001 Raza M, Pal S, Rafiq A, DeLorenzo RJ. Long-term alteration of calcium homeostatic mechanisms in the pilocarpine model of temporal lobe epilepsy. Brain Research. 903: 1-12. PMID 11382382 DOI: 10.1016/S0006-8993(01)02127-8  0.469
2001 Limbrick DD, Pal S, DeLorenzo RJ. Hippocampal neurons exhibit both persistent Ca2+ influx and impairment of Ca2+ sequestration/extrusion mechanisms following excitotoxic glutamate exposure. Brain Research. 894: 56-67. PMID 11245815 DOI: 10.1016/S0006-8993(00)03303-5  0.588
2000 Pal S, Limbrick DD, Rafiq A, DeLorenzo RJ. Induction of spontaneous recurrent epileptiform discharges causes long-term changes in intracellular calcium homeostatic mechanisms. Cell Calcium. 28: 181-93. PMID 11020380 DOI: 10.1054/Ceca.2000.0146  0.647
2000 Parsons JT, Churn SB, Kochan LD, DeLorenzo RJ. Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake. Journal of Neurochemistry. 75: 1209-18. PMID 10936204 DOI: 10.1046/j.1471-4159.2000.0751209.x  0.306
2000 Morris TA, Jafari N, DeLorenzo RJ. Chronic DeltaFosB expression and increased AP-1 transcription factor binding are associated with the long term plasticity changes in epilepsy. Brain Research. Molecular Brain Research. 79: 138-49. PMID 10925151 DOI: 10.1016/S0169-328X(00)00112-1  0.378
2000 Churn SB, Sombati S, Jakoi ER, Severt L, DeLorenzo RJ, Sievert L. Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 97: 5604-9. PMID 10779547 DOI: 10.1073/Pnas.080071697  0.766
2000 DeLorenzo RJ, Sombati S, Coulter DA. Effects of topiramate on sustained repetitive firing and spontaneous recurrent seizure discharges in cultured hippocampal neurons. Epilepsia. 41: S40-4. PMID 10768299 DOI: 10.1111/J.1528-1157.2000.Tb02170.X  0.425
2000 Kochan LD, Churn SB, Omojokun O, Rice A, DeLorenzo RJ. Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat. Neuroscience. 95: 735-43. PMID 10670440 DOI: 10.1016/S0306-4522(99)00462-5  0.358
1999 Blair RE, Churn SB, Sombati S, Lou JK, DeLorenzo RJ. Long-lasting decrease in neuronal Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent seizures. Brain Research. 851: 54-65. PMID 10642828 DOI: 10.1016/S0006-8993(99)02100-9  0.342
1999 Pal S, Sombati S, Limbrick DD, DeLorenzo RJ. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Research. 851: 20-31. PMID 10642824 DOI: 10.1016/S0006-8993(99)02035-1  0.635
1999 Coulter DA, DeLorenzo RJ. Basic mechanisms of status epilepticus. Advances in Neurology. 79: 725-33. PMID 10514858  0.359
1999 Morris TA, Jafari N, Rice AC, Vasconcelos O, DeLorenzo RJ. Persistent increased DNA-binding and expression of serum response factor occur with epilepsy-associated long-term plasticity changes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8234-43. PMID 10493724  0.383
1999 Rice AC, DeLorenzo RJ. N-methyl-D-aspartate receptor activation regulates refractoriness of status epilepticus to diazepam. Neuroscience. 93: 117-23. PMID 10430476 DOI: 10.1016/S0306-4522(99)00132-3  0.355
1999 Delorenzo RJ, Morris TA. ■ REVIEW : Long-Term Modulation of Gene Expression in Epilepsy The Neuroscientist. 5: 86-99. DOI: 10.1177/107385849900500213  0.368
1998 DeLorenzo RJ, Pal S, Sombati S. Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture. Proceedings of the National Academy of Sciences of the United States of America. 95: 14482-7. PMID 9826726 DOI: 10.1073/pnas.95.24.14482  0.442
1998 Rice AC, Floyd CL, Lyeth BG, Hamm RJ, DeLorenzo RJ. Status epilepticus causes long-term NMDA receptor-dependent behavioral changes and cognitive deficits. Epilepsia. 39: 1148-57. PMID 9821978 DOI: 10.1111/J.1528-1157.1998.Tb01305.X  0.365
1998 Rice AC, DeLorenzo RJ. NMDA receptor activation during status epilepticus is required for the development of epilepsy. Brain Research. 782: 240-7. PMID 9519269 DOI: 10.1016/S0006-8993(97)01285-7  0.378
1998 Shapiro SM, Churn SB, Pal S, Limbrick D, DeLorenzo RJ. Bilirubin Alters Intracellular Calcium Homeostasis • 1135 Pediatric Research. 43: 195-195. DOI: 10.1203/00006450-199804001-01156  0.665
1997 Jaitly R, Sgro JA, Towne AR, Ko D, DeLorenzo RJ. Prognostic value of EEG monitoring after status epilepticus: a prospective adult study. Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society. 14: 326-34. PMID 9337142 DOI: 10.1097/00004691-199707000-00005  0.363
1997 Parsons JT, Churn SB, DeLorenzo RJ. Ischemia-induced inhibition of calcium uptake into rat brain microsomes mediated by Mg2+/Ca2+ ATPase. Journal of Neurochemistry. 68: 1124-34. PMID 9048758  0.3
1996 Coulter DA, Rafiq A, Shumate M, Gong QZ, DeLorenzo RJ, Lyeth BG. Brain injury-induced enhanced limbic epileptogenesis: anatomical and physiological parallels to an animal model of temporal lobe epilepsy. Epilepsy Research. 26: 81-91. PMID 8985690 DOI: 10.1016/S0920-1211(96)00044-7  0.468
1996 Vick RS, Rafiq A, Coulter DA, Jakoi ER, DeLorenzo RJ. GABAA alpha 2 mRNA levels are decreased following induction of spontaneous epileptiform discharges in hippocampal-entorhinal cortical slices. Brain Research. 721: 111-9. PMID 8793090 DOI: 10.1016/0006-8993(96)00060-1  0.755
1996 DeLorenzo RJ, Limbrick DD. Effects of glutamate on calcium influx and sequestration/extrusion mechanisms in hippocampal neurons. Advances in Neurology. 71: 37-46. PMID 8790787  0.365
1996 Rice A, Rafiq A, Shapiro SM, Jakoi ER, Coulter DA, DeLorenzo RJ. Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 93: 9665-9. PMID 8790388 DOI: 10.1073/Pnas.93.18.9665  0.771
1995 Jakoi ER, Panchision DM, Gerwin CM, DeLorenzo RJ. Post-transcriptional regulation of gene expression in hippocampal neurons by glutamate receptor activation. Brain Research. 693: 124-32. PMID 8653400 DOI: 10.1016/0006-8993(95)00599-L  0.812
1995 Rafiq A, Zhang YF, DeLorenzo RJ, Coulter DA. Long-duration self-sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus. Journal of Neurophysiology. 74: 2028-42. PMID 8592194 DOI: 10.1152/Jn.1995.74.5.2028  0.352
1995 Limbrick DD, Churn SB, Sombati S, DeLorenzo RJ. Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death. Brain Research. 690: 145-56. PMID 8535831 DOI: 10.1016/0006-8993(95)00552-2  0.622
1995 Churn SB, Limbrick D, Sombati S, DeLorenzo RJ. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 3200-14. PMID 7722657  0.322
1995 Sombati S, Delorenzo RJ. Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture. Journal of Neurophysiology. 73: 1706-11. PMID 7643176  0.396
1995 Panchision DM, Gerwin CM, DeLorenzo RJ, Jakoi ER. Glutamate receptor activation regulates mRNA at both transcriptional and posttranscriptional levels. Journal of Neurochemistry. 65: 969-77. PMID 7643127 DOI: 10.1046/J.1471-4159.1995.65030969.X  0.792
1995 Churn S, Limbrick D, Sombati S, DeLorenzo R. Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons The Journal of Neuroscience. 15: 3200-3214. DOI: 10.1523/Jneurosci.15-04-03200.1995  0.576
1993 Perlin JB, Gerwin CM, Panchision DM, Vick RS, Jakoi ER, DeLorenzo RJ. Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 90: 1741-5. PMID 8446587 DOI: 10.1073/Pnas.90.5.1741  0.817
1993 Rafiq A, DeLorenzo RJ, Coulter DA. Generation and propagation of epileptiform discharges in a combined entorhinal cortex/hippocampal slice. Journal of Neurophysiology. 70: 1962-74. PMID 8294965 DOI: 10.1152/Jn.1993.70.5.1962  0.305
1993 Churn SB, Sombati S, Taft WC, DeLorenzo RJ. Excitotoxicity affects membrane potential and calmodulin kinase II activity in cultured rat cortical neurons. Stroke; a Journal of Cerebral Circulation. 24: 271-7; discussion 27. PMID 8093648  0.338
1992 Coulter DA, Sombati S, DeLorenzo RJ. Electrophysiology of glutamate neurotoxicity in vitro: induction of a calcium-dependent extended neuronal depolarization. Journal of Neurophysiology. 68: 362-73. PMID 1388200 DOI: 10.1152/Jn.1992.68.2.362  0.366
1992 Jakoi ER, Sombati S, Gerwin C, DeLorenzo RJ. Excitatory amino acid receptor activation produces a selective and long-lasting modulation of gene expression in hippocampal neurons. Brain Research. 582: 282-90. PMID 1382803 DOI: 10.1016/0006-8993(92)90145-Y  0.769
1992 Perlin JB, Churn SB, Lothman EW, DeLorenzo RJ. Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat. Epilepsy Research. 11: 111-8. PMID 1319899 DOI: 10.1016/0920-1211(92)90045-U  0.307
1991 Sombati S, Coulter DA, DeLorenzo RJ. Neurotoxic activation of glutamate receptors induces an extended neuronal depolarization in cultured hippocampal neurons. Brain Research. 566: 316-9. PMID 1687663 DOI: 10.1016/0006-8993(91)91716-E  0.306
1990 Churn SB, Taft WC, Billingsley MS, Blair RE, DeLorenzo RJ. Temperature modulation of ischemic neuronal death and inhibition of calcium/calmodulin-dependent protein kinase II in gerbils. Stroke; a Journal of Cerebral Circulation. 21: 1715-21. PMID 2264078  0.359
1990 Churn SB, Taft WC, DeLorenzo RJ. Effects of ischemia on multifunctional calcium/calmodulin-dependent protein kinase type II in the gerbil. Stroke; a Journal of Cerebral Circulation. 21: III112-6. PMID 2173173  0.334
1989 Taft WC, Clifton GL, Blair RE, DeLorenzo RJ. Phenytoin protects against ischemia-produced neuronal cell death. Brain Research. 483: 143-8. PMID 2706503 DOI: 10.1016/0006-8993(89)90045-0  0.367
1988 Taft WC, Tennes-Rees KA, Blair RE, Clifton GL, DeLorenzo RJ. Cerebral ischemia decreases endogenous calcium-dependent protein phosphorylation in gerbil brain. Brain Research. 447: 159-63. PMID 2838127 DOI: 10.1016/0006-8993(88)90978-X  0.319
1987 Taft WC, Goldenring JR, DeLorenzo RJ. Molecular mechanisms of neuronal excitability: possible involvement of CaM kinase II in seizure activity. Advances in Experimental Medicine and Biology. 221: 409-25. PMID 2829586 DOI: 10.1007/978-1-4684-7618-7_30  0.347
1987 Taft WC, DeLorenzo RJ. Regulation of calcium channels in brain: implications for the clinical neurosciences. The Yale Journal of Biology and Medicine. 60: 99-106. PMID 2437710  0.351
1986 DeLorenzo RJ. A molecular approach to the calcium signal in brain: relationship to synaptic modulation and seizure discharge. Advances in Neurology. 44: 435-64. PMID 3010680  0.369
1986 DeLorenzo RJ, Bowling AC, Taft WC. A molecular approach to the development of anticonvulsants. Annals of the New York Academy of Sciences. 477: 238-46. PMID 2433983  0.32
1985 Johansen J, Taft WC, Yang J, Kleinhaus AL, DeLorenzo RJ. Inhibition of Ca2+ conductance in identified leech neurons by benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 82: 3935-9. PMID 3858853  0.323
1984 DeLorenzo RJ. Calmodulin systems in neuronal excitability: a molecular approach to epilepsy. Annals of Neurology. 16: S104-14. PMID 6150680  0.35
1975 Walton KG, DeLorenzo RJ, Curran PF, Greengard P. Regulation of protein phosphorylation and sodium transport in toad bladder. The Journal of General Physiology. 65: 153-77. PMID 163889 DOI: 10.1085/jgp.65.2.153  0.324
1973 Delorenzo RJ, Greengard P. Activation by adenosine 3':5'-monophosphate of a membrane-bound phosphoprotein phosphatase from toad bladder. Proceedings of the National Academy of Sciences of the United States of America. 70: 1831-5. PMID 4352657 DOI: 10.1073/pnas.70.6.1831  0.31
1973 DeLorenzo RJ, Walton KG, Curran PF, Greengard P. Regulation of phosphorylation of a specific protein in toad-bladder membrane by antidiuretic hormone and cyclic AMP, and its possible relationship to membrane permeability changes. Proceedings of the National Academy of Sciences of the United States of America. 70: 880-4. PMID 4351809 DOI: 10.1073/pnas.70.3.880  0.322
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