| Year |
Citation |
Score |
| 2019 |
Casaletto JB, Geddie ML, Abu-Yousif AO, Masson K, Fulgham A, Boudot A, Maiwald T, Kearns JD, Kohli N, Su S, Razlog M, Raue A, Kalra A, Håkansson M, Logan DT, ... ... MacBeath G, et al. MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. Proceedings of the National Academy of Sciences of the United States of America. PMID 30898885 DOI: 10.1073/Pnas.1819085116 |
0.354 |
|
| 2018 |
Hass H, Masson K, Wohlgemuth S, Paragas V, Allen JE, Sevecka M, Pace E, Timmer J, Stelling J, MacBeath G, Schoeberl B, Raue A. Abstract 1312: Predicting ligand-dependent tumors from multi-dimensional signaling features Cancer Research. 78: 1312-1312. DOI: 10.1158/1538-7445.Am2018-1312 |
0.366 |
|
| 2017 |
Mathews S, Finn G, Kudla AJ, Rimkunas V, Laivins P, MacBeath G, Czibere A, Baum J. Abstract A19: Identification of Heregulin (HRG) expression as a driver of a difficult-to-treat cancer phenotype and development of a companion diagnostic for the HRG-ErbB3 targeting drug seribantumab Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A19 |
0.301 |
|
| 2017 |
Finn G, Zhang H, Blois A, Mathews s, Kudla A, Baum J, Cieslewicz M, macbeath g, Adiwijaya B, Czibere A. Abstract A14: A randomized trial of exemestane +/- seribantumab (MM-121) in postmenopausal women with locally advanced or metastatic ER/PR+ HER2- breast cancer: Final analysis and extended subgroup analysis Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A14 |
0.308 |
|
| 2015 |
Curley MD, Sabnis GJ, Wille L, Adiwijaya BS, Garcia G, Moyo V, Kazi AA, Brodie A, MacBeath G. Seribantumab, an anti-ERBB3 antibody, delays the onset of resistance and restores sensitivity to letrozole in an estrogen receptor-positive breast cancer model. Molecular Cancer Therapeutics. PMID 26310543 DOI: 10.1158/1535-7163.Mct-15-0169 |
0.312 |
|
| 2015 |
Yarar D, Lahdenranta J, Kubasek W, Nielsen UB, MacBeath G. Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells. Molecular Cancer Therapeutics. PMID 26116360 DOI: 10.1158/1535-7163.Mct-15-0075 |
0.363 |
|
| 2015 |
Masson K, Grantcharova V, Burenkova O, Wainszelbaum M, Iadevaia S, Adams S, Raue A, Czibere A, Schoeberl B, MacBeath G. Abstract LB-243: The ErbB3-targeting antibody MM-121 (seribantumab) reverses heregulin-driven resistance to multiple chemotherapies on tumor cell growth Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-243 |
0.328 |
|
| 2015 |
Abu-Yousif AO, Casaletto JB, Masson K, Fulgham A, Geddie M, Schoeberl B, Nielsen U, MacBeath G. Abstract 1690: Mechanistic characterization of MM-131, a bispecific antibody that blocks c-Met signaling through concurrent targeting of EpCAM Cancer Research. 75: 1690-1690. DOI: 10.1158/1538-7445.Am2015-1690 |
0.328 |
|
| 2015 |
Wainszelbaum MJ, Fessler J, Lahdenranta J, Burenkova O, Gerami-Moayed N, Hashambhoy-Ramsay Y, Rimkunas V, MacBeath G. Abstract LB-C25: Inhibition of ERBB3 with MM-121, IGF1-R with MM-141 or Met with MM-131 increases the activity of EGFR inhibitor MM-151 in colorectal cancer models expressing multiple resistance ligands Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Lb-C25 |
0.335 |
|
| 2014 |
Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159: 844-56. PMID 25417160 DOI: 10.1016/J.Cell.2014.10.032 |
0.726 |
|
| 2014 |
AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK. A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nature Genetics. 46: 1363-71. PMID 25362484 DOI: 10.1038/Ng.3138 |
0.771 |
|
| 2014 |
Yi CR, Allen JE, Russo B, Lee SY, Heindl JE, Baxt LA, Herrera BB, Kahoud E, MacBeath G, Goldberg MB. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. The Journal of Biological Chemistry. 289: 30101-13. PMID 25124035 DOI: 10.1074/Jbc.M114.595868 |
0.516 |
|
| 2014 |
Jiang N, Wang D, Hu Z, Shin HJ, Qian G, Rahman MA, Zhang H, Amin AR, Nannapaneni S, Wang X, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, et al. Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma. Molecular Cancer Therapeutics. 13: 1826-36. PMID 24748655 DOI: 10.1158/1535-7163.Mct-13-1093 |
0.316 |
|
| 2013 |
Onsum MD, Geretti E, Paragas V, Kudla AJ, Moulis SP, Luus L, Wickham TJ, McDonagh CF, Macbeath G, Hendriks BS. Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients. The American Journal of Pathology. 183: 1446-60. PMID 24035511 DOI: 10.1016/J.Ajpath.2013.07.015 |
0.348 |
|
| 2013 |
Wagner JP, Wolf-Yadlin A, Sevecka M, Grenier JK, Root DE, Lauffenburger DA, MacBeath G. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling. 6: ra58. PMID 23861540 DOI: 10.4172/2153-0602.C1.003 |
0.368 |
|
| 2013 |
Gujral TS, Karp ES, Chan M, Chang BH, MacBeath G. Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions. Chemistry & Biology. 20: 816-27. PMID 23790492 DOI: 10.1016/J.Chembiol.2013.04.021 |
0.808 |
|
| 2013 |
Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Reports. 3: 630-7. PMID 23478020 DOI: 10.1016/J.Celrep.2013.02.010 |
0.736 |
|
| 2013 |
Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Molecular & Cellular Proteomics : McP. 12: 1204-13. PMID 23358503 DOI: 10.1074/Mcp.M112.025858 |
0.804 |
|
| 2013 |
Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 32: 3470-6. PMID 22945653 DOI: 10.1038/Onc.2012.378 |
0.72 |
|
| 2013 |
Jiang N, Wang D, Hu Z, Rahman AM, Zhang H, Amin RA, Wang X, Chen Z, Dong SM, Garcia G, MacBeath G, Ma J, Khuri FR, Saba NF, Chen GZ. Abstract LB-79: Combined treatment with HER3 antibody MM-121/SAR 256212 and EGFR antibody cetuximab in pre-clinical models of head and neck cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-79 |
0.301 |
|
| 2013 |
Wainszelbaum MJ, Sevecka MS, Burenkova O, Garcia G, Kubasek W, MacBeath G. Abstract 5464: In-vitro studies of MM-121/SAR 256212, an anti-ErbB-3 antibody, in combination with erlotinib in EGFR-wild-type NSCLC. Cancer Research. 73: 5464-5464. DOI: 10.1158/1538-7445.Am2013-5464 |
0.306 |
|
| 2012 |
Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 149: 780-94. PMID 22579283 DOI: 10.1016/J.Cell.2012.03.031 |
0.769 |
|
| 2012 |
Beyer EM, MacBeath G. Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation. Molecular & Cellular Proteomics : McP. 11: M111.013292. PMID 22323825 DOI: 10.1074/Mcp.M111.013292 |
0.722 |
|
| 2012 |
Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Science Signaling. 5: pl1. PMID 22234610 DOI: 10.1126/Scisignal.2002372 |
0.721 |
|
| 2012 |
Onsum M, Yarar D, Paragas V, Zhang B, Nguyen S, Schoeberl B, McDonagh C, MacBeath G, Nielsen U. Abstract 4945: Targeting ErbB3-addicted cancers across the HER2 spectrum Cancer Research. 72: 4945-4945. DOI: 10.1158/1538-7445.Am2012-4945 |
0.37 |
|
| 2012 |
Geretti E, Paragas V, Onsum M, Kudla A, Moulis S, Luus L, Wickham T, McDonagh C, MacBeath G, Hendriks B. Abstract P1-07-03: Quantification of HER2 expression at the single cell level and HER2 intratumoral heterogeneity of breast cancer tissue samples using automated image analysis Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-P1-07-03 |
0.33 |
|
| 2011 |
Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G. A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. Chemistry & Biology. 18: 1143-52. PMID 21944753 DOI: 10.1016/J.Chembiol.2011.06.013 |
0.8 |
|
| 2011 |
Jung AS, Kaushansky A, Macbeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (Georgetown, Tex.). 10: 1838-44. PMID 21527831 DOI: 10.4161/Cc.10.11.15776 |
0.746 |
|
| 2011 |
Knickerbocker T, MacBeath G. Detecting and quantifying multiple proteins in clinical samples in high-throughput using antibody microarrays. Methods in Molecular Biology (Clifton, N.J.). 723: 3-13. PMID 21370055 DOI: 10.1007/978-1-61779-043-0_1 |
0.765 |
|
| 2011 |
Sevecka M, Wolf-Yadlin A, MacBeath G. Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling. Molecular & Cellular Proteomics : McP. 10: M110.005363. PMID 21296872 DOI: 10.1074/Mcp.M110.005363 |
0.393 |
|
| 2011 |
Krall JA, Beyer EM, MacBeath G. High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. Plos One. 6: e15945. PMID 21264347 DOI: 10.1371/Journal.Pone.0015945 |
0.791 |
|
| 2011 |
Oyama SK, Paragas V, Adams S, Luus L, Huhalov A, Kudla AJ, Overland R, Nielsen UB, Niyikiza C, McDonagh CF, MacBeath G. Abstract 654: MM-111, an ErbB2/ErbB3 bispecific antibody, effectively combines with lapatinib to inhibit growth of ErbB2-overexpressing tumor cells Cancer Research. 71: 654-654. DOI: 10.1158/1538-7445.Am2011-654 |
0.317 |
|
| 2010 |
Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF. Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements. Plos Biology. 8. PMID 20808760 DOI: 10.1371/Journal.Pbio.1000457 |
0.672 |
|
| 2010 |
Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF. Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. The Journal of Cell Biology. 190: 143-57. PMID 20624904 DOI: 10.1083/Jcb.200909095 |
0.816 |
|
| 2010 |
Gujral TS, MacBeath G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. Plos One. 5: e10024. PMID 20383323 DOI: 10.1371/Journal.Pone.0010024 |
0.683 |
|
| 2010 |
Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang BH, MacBeath G. Quantifying protein-protein interactions in high throughput using protein domain microarrays. Nature Protocols. 5: 773-90. PMID 20360771 DOI: 10.1038/Nprot.2010.36 |
0.784 |
|
| 2010 |
Shalek AK, Robinson JT, Karp ES, Lee JS, Ahn DR, Yoon MH, Sutton A, Jorgolli M, Gertner RS, Gujral TS, MacBeath G, Yang EG, Park H. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 1870-5. PMID 20080678 DOI: 10.1073/Pnas.0909350107 |
0.773 |
|
| 2009 |
Gujral TS, MacBeath G. Emerging miniaturized proteomic technologies to study cell signaling in clinical samples. Science Signaling. 2: pe65. PMID 19843955 DOI: 10.1126/Scisignal.293Pe64 |
0.685 |
|
| 2009 |
Wolf-Yadlin A, Sevecka M, MacBeath G. Dissecting protein function and signaling using protein microarrays. Current Opinion in Chemical Biology. 13: 398-405. PMID 19660979 DOI: 10.1016/J.Cbpa.2009.06.027 |
0.439 |
|
| 2009 |
Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G. Linear combinations of docking affinities explain quantitative differences in RTK signaling. Molecular Systems Biology. 5: 235. PMID 19156127 DOI: 10.1038/Msb.2008.72 |
0.778 |
|
| 2008 |
Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chemistry & Biology. 15: 808-17. PMID 18721752 DOI: 10.1016/J.Chembiol.2008.07.006 |
0.815 |
|
| 2008 |
Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G. Predicting PDZ domain-peptide interactions from primary sequences. Nature Biotechnology. 26: 1041-5. PMID 18711339 DOI: 10.1038/Nbt.1489 |
0.797 |
|
| 2008 |
Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G. A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Molecular Biosystems. 4: 643-53. PMID 18493663 DOI: 10.1039/B801018H |
0.818 |
|
| 2008 |
Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G. Predicting PDZ domain-peptide interactions from primary sequences (Nature Biotechnology (2008) 26, (1041-1045)) Nature Biotechnology. 26: 1193. DOI: 10.1038/Nbt1008-1193C |
0.77 |
|
| 2007 |
Macbeath G. Protein arrays: sandwich approach for analyzing complex solutions. Csh Protocols. 2007: pdb.prot4633. PMID 21357035 DOI: 10.1101/Pdb.Prot4633 |
0.395 |
|
| 2007 |
Macbeath G. Protein arrays: probing the array and detecting radioactive spots for kinase-substrate interactions. Csh Protocols. 2007: pdb.prot4632. PMID 21357034 DOI: 10.1101/Pdb.Prot4632 |
0.37 |
|
| 2007 |
Macbeath G. Protein arrays: labeling the compounds and probing the array for protein-small molecule interactions. Csh Protocols. 2007: pdb.prot4631. PMID 21357033 DOI: 10.1101/Pdb.Prot4631 |
0.339 |
|
| 2007 |
Macbeath G. Protein arrays: labeling the protein and probing the array for protein-protein interactions. Csh Protocols. 2007: pdb.prot4630. PMID 21357032 DOI: 10.1101/Pdb.Prot4630 |
0.412 |
|
| 2007 |
Macbeath G. Protein arrays: preparation of microscope slides. Csh Protocols. 2007: pdb.prot4629. PMID 21357031 DOI: 10.1101/Pdb.Prot4629 |
0.352 |
|
| 2007 |
Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G. PDZ domain binding selectivity is optimized across the mouse proteome. Science (New York, N.Y.). 317: 364-9. PMID 17641200 DOI: 10.1126/Science.1144592 |
0.816 |
|
| 2007 |
Knickerbocker T, Chen JR, Thadhani R, MacBeath G. An integrated approach to prognosis using protein microarrays and nonparametric methods. Molecular Systems Biology. 3: 123. PMID 17593911 DOI: 10.1038/Msb4100167 |
0.76 |
|
| 2006 |
Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nature Reviews. Molecular Cell Biology. 7: 803-12. PMID 17057751 DOI: 10.1038/Nrm2042 |
0.312 |
|
| 2006 |
Gordus A, MacBeath G. Circumventing the problems caused by protein diversity in microarrays: implications for protein interaction networks. Journal of the American Chemical Society. 128: 13668-9. PMID 17044677 DOI: 10.1021/Ja065381G |
0.777 |
|
| 2006 |
Sevecka M, MacBeath G. State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling. Nature Methods. 3: 825-31. PMID 16990815 DOI: 10.1038/Nmeth931 |
0.368 |
|
| 2006 |
Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G. Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. Journal of the American Chemical Society. 128: 5913-22. PMID 16637659 DOI: 10.1021/Ja060943H |
0.819 |
|
| 2006 |
Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 439: 168-74. PMID 16273093 DOI: 10.1038/Nature04177 |
0.821 |
|
| 2003 |
Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proceedings of the National Academy of Sciences of the United States of America. 100: 9330-5. PMID 12876202 DOI: 10.1073/Pnas.1633513100 |
0.46 |
|
| 2002 |
MacBeath G. Protein microarrays and proteomics. Nature Genetics. 32: 526-32. PMID 12454649 DOI: 10.1038/Ng1037 |
0.391 |
|
| 2001 |
MacBeath G. Proteomics comes to the surface. Nature Biotechnology. 19: 828-9. PMID 11533639 DOI: 10.1038/Nbt0901-828 |
0.341 |
|
| 2000 |
MacBeath G, Schreiber SL. Printing proteins as microarrays for high-throughput function determination. Science (New York, N.Y.). 289: 1760-3. PMID 10976071 DOI: 10.1126/Science.289.5485.1760 |
0.563 |
|
| 1999 |
MacBeath G, Koehler AN, Schreiber SL. Printing small molecules as microarrays and detecting protein-ligand interactions en masse [19] Journal of the American Chemical Society. 121: 7967-7968. DOI: 10.1021/Ja991083Q |
0.487 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Probing enzyme quaternary structure by combinatorial mutagenesis and selection. Protein Science : a Publication of the Protein Society. 7: 1757-67. PMID 10082372 DOI: 10.1002/Pro.5560070810 |
0.55 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii. Biochemistry. 37: 10062-73. PMID 9665711 DOI: 10.1021/Bi980449T |
0.5 |
|
| 1998 |
MacBeath G, Kast P. UGA read-through artifacts--when popular gene expression systems need a pATCH. Biotechniques. 24: 789-94. PMID 9591128 DOI: 10.2144/98245St02 |
0.335 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity. Protein Science : a Publication of the Protein Society. 7: 325-35. PMID 9521108 DOI: 10.1002/Pro.5560070212 |
0.56 |
|
| 1998 |
MacBeath G, Kast P, Hilvert D. Redesigning enzyme topology by directed evolution. Science (New York, N.Y.). 279: 1958-61. PMID 9506949 DOI: 10.1126/Science.279.5358.1958 |
0.569 |
|
| 1996 |
MacBeath G, Hilvert D. Hydrolytic antibodies: variations on a theme. Chemistry & Biology. 3: 433-45. PMID 8807874 DOI: 10.1016/S1074-5521(96)90091-5 |
0.485 |
|
| 1994 |
MacBeath G, Hilvert D. Monitoring Catalytic Activity by Immunoassay: Implications for Screening Journal of the American Chemical Society. 116: 6101-6106. DOI: 10.1021/Ja00093A006 |
0.47 |
|
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