Howard J. Jacob - Related publications

Affiliations: 
HudsonAlpha Institute for Biotechnology, Huntsville, AL, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 McCarter C, Howrylak J, Kim S. Learning gene networks underlying clinical phenotypes using SNP perturbation. Plos Computational Biology. 16: e1007940. PMID 33095769 DOI: 10.1371/journal.pcbi.1007940   
2020 Ghoussaini M, Mountjoy E, Carmona M, Peat G, Schmidt EM, Hercules A, Fumis L, Miranda A, Carvalho-Silva D, Buniello A, Burdett T, Hayhurst J, Baker J, Ferrer J, Gonzalez-Uriarte A, et al. Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics. Nucleic Acids Research. PMID 33045747 DOI: 10.1093/nar/gkaa840   
2020 Nguyen ND, Jin T, Wang D. Varmole: A biologically drop-connect deep neural network model for prioritizing disease risk variants and genes. Bioinformatics (Oxford, England). PMID 33031552 DOI: 10.1093/bioinformatics/btaa866   
2020 Bean DM, Al-Chalabi A, Dobson RJB, Iacoangeli A. A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis. Genes. 11. PMID 32575372 DOI: 10.3390/genes11060668   
2020 Teng J, Huang S, Chen Z, Gao N, Ye S, Diao S, Ding X, Yuan X, Zhang H, Li J, Zhang Z. Optimizing genomic prediction model given causal genes in a dairy cattle population. Journal of Dairy Science. PMID 32952023 DOI: 10.3168/jds.2020-18233   
2020 Teng J, Huang S, Chen Z, Gao N, Ye S, Diao S, Ding X, Yuan X, Zhang H, Li J, Zhang Z. Optimizing genomic prediction model given causal genes in a dairy cattle population. Journal of Dairy Science. PMID 32952023 DOI: 10.3168/jds.2020-18233   
2020 Teng J, Huang S, Chen Z, Gao N, Ye S, Diao S, Ding X, Yuan X, Zhang H, Li J, Zhang Z. Optimizing genomic prediction model given causal genes in a dairy cattle population. Journal of Dairy Science. PMID 32952023 DOI: 10.3168/jds.2020-18233   
2020 Link N, Bellen HJ. Using to drive the diagnosis and understand the mechanisms of rare human diseases. Development (Cambridge, England). 147. PMID 32988995 DOI: 10.1242/dev.191411   
2020 Au PYB, Eaton A, Dyment DA. Genetic mechanisms of neurodevelopmental disorders. Handbook of Clinical Neurology. 173: 307-326. PMID 32958182 DOI: 10.1016/B978-0-444-64150-2.00024-1   
2020 Manshaei R, Merico D, Reuter MS, Engchuan W, Mojarad BA, Chaturvedi R, Heung T, Pellecchia G, Zarrei M, Nalpathamkalam T, Khan R, Okello JBA, Liston E, Curtis M, Yuen RKC, et al. Genes and Pathways Implicated in Tetralogy of Fallot Revealed by Ultra-Rare Variant Burden Analysis in 231 Genome Sequences. Frontiers in Genetics. 11: 957. PMID 33110418 DOI: 10.3389/fgene.2020.00957   
2020 Owen KA, Price A, Ainsworth H, Aidukaitis BN, Bachali P, Catalina MD, Dittman JM, Howard TD, Kingsmore KM, Labonte AC, Marion MC, Robl RD, Zimmerman KD, Langefeld CD, Grammer AC, et al. Analysis of Trans-Ancestral SLE Risk Loci Identifies Unique Biologic Networks and Drug Targets in African and European Ancestries. American Journal of Human Genetics. PMID 33031749 DOI: 10.1016/j.ajhg.2020.09.007   
2020 Díaz-Santiago E, Jabato FM, Rojano E, Seoane P, Pazos F, Perkins JR, Ranea JAG. Phenotype-genotype comorbidity analysis of patients with rare disorders provides insight into their pathological and molecular bases. Plos Genetics. 16: e1009054. PMID 33001999 DOI: 10.1371/journal.pgen.1009054   
2020 Wang H, Yang J, Zhang Y, Wang J. Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions. Methods (San Diego, Calif.). PMID 33096239 DOI: 10.1016/j.ymeth.2020.10.010   
2020 Liu W, Li M, Zhang W, Zhou G, Wu X, Wang J, Lu Q, Zhao H. Leveraging functional annotation to identify genes associated with complex diseases. Plos Computational Biology. 16: e1008315. PMID 33137096 DOI: 10.1371/journal.pcbi.1008315   
2020 Zhang C, Genchev GZ, Bergau D, Lu H. Correlations Between Phenotypes and Biological Process Ontologies in Monogenic Human Diseases. Interdisciplinary Sciences, Computational Life Sciences. PMID 33113078 DOI: 10.1007/s12539-020-00400-9   
2020 Powell SK, O'Shea C, Brennand KJ, Akbarian S. Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry. PMID 33131715 DOI: 10.1016/j.biopsych.2020.06.033   
2020 Akhatar J, Singh MP, Sharma A, Kaur H, Kaur N, Sharma S, Bharti B, Sardana VK, Banga SS. Association Mapping of Seed Quality Traits Under Varying Conditions of Nitrogen Application in L. Czern & Coss. Frontiers in Genetics. 11: 744. PMID 33088279 DOI: 10.3389/fgene.2020.00744   
2020 Pan Q, Liu YJ, Bai XF, Han XL, Jiang Y, Ai B, Shi SS, Wang F, Xu MC, Wang YZ, Zhao J, Chen JX, Zhang J, Li XC, Zhu J, et al. VARAdb: a comprehensive variation annotation database for human. Nucleic Acids Research. PMID 33095866 DOI: 10.1093/nar/gkaa922   
2020 Cohen C, Figueiredo EA, Belangero PS, Andreoli CV, Leal MF, Ejnisman B. Genetic Aspects in Shoulder Disorders. Revista Brasileira De Ortopedia. 55: 537-542. PMID 33093716 DOI: 10.1055/s-0040-1702955   
2020 Alqudah AM, Haile JK, Alomari DZ, Pozniak CJ, Kobiljski B, Börner A. Genome-wide and SNP network analyses reveal genetic control of spikelet sterility and yield-related traits in wheat. Scientific Reports. 10: 2098. PMID 32034248 DOI: 10.1038/s41598-020-59004-4   
2020 Chen SY, Oliveira HR, Schenkel FS, Pedrosa VB, Melka MG, Brito LF. Using imputed whole-genome sequence variants to uncover candidate mutations and genes affecting milking speed and temperament in Holstein cattle. Journal of Dairy Science. PMID 32952011 DOI: 10.3168/jds.2020-18897   
2020 Méjécase C, Malka S, Guan Z, Slater A, Arno G, Moosajee M. Practical guide to genetic screening for inherited eye diseases. Therapeutic Advances in Ophthalmology. 12: 2515841420954592. PMID 33015543 DOI: 10.1177/2515841420954592   
2020 Ivanov DK, Bostelmann G, Lan-Leung B, Williams J, Partridge L, Escott-Price V, Thornton JM. A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. Plos One. 15: e0240824. PMID 33104720 DOI: 10.1371/journal.pone.0240824   
2020 Mhaske A, Dileep KV, Kumar M, Poojary M, Pandhare K, Zhang KYJ, Scaria V, Binukumar BK. ATP7A Clinical Genetics Resource - A comprehensive clinically annotated database and resource for genetic variants in ATP7A gene. Computational and Structural Biotechnology Journal. 18: 2347-2356. PMID 32994893 DOI: 10.1016/j.csbj.2020.08.021   
2020 Loo SL, Ong A, Kyaw W, Thibaut LM, Lan R, Tanaka MM. A comparative examination of non-synonymous polymorphism counts in bacterial genomes. Applied and Environmental Microbiology. PMID 33097502 DOI: 10.1128/AEM.02002-20   
2020 Corces MR, Shcherbina A, Kundu S, Gloudemans MJ, Frésard L, Granja JM, Louie BH, Eulalio T, Shams S, Bagdatli ST, Mumbach MR, Liu B, Montine KS, Greenleaf WJ, Kundaje A, et al. Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases. Nature Genetics. PMID 33106633 DOI: 10.1038/s41588-020-00721-x   
2020 Sun S, Dong B, Zou Q. Revisiting genome-wide association studies from statistical modelling to machine learning. Briefings in Bioinformatics. PMID 33126243 DOI: 10.1093/bib/bbaa263   
2020 Satturu V, Vattikuti JL, J DS, Kumar A, Singh RK, M SP, Zaw H, Jubay ML, Satish L, Rathore A, Mulinti S, Lakshmi Vg I, Chakraborty A, Thirunavukkarasu N. Multiple Genome Wide Association Mapping Models Identify Quantitative Trait Nucleotides for Brown Planthopper () Resistance in MAGIC Population of Rice. Vaccines. 8. PMID 33066559 DOI: 10.3390/vaccines8040608   
2020 Zhang Q, Cai Z, Lhomme M, Sahana G, Lesnik P, Guerin M, Fredholm M, Karlskov-Mortensen P. Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels. Scientific Reports. 10: 18434. PMID 33116219 DOI: 10.1038/s41598-020-75612-6   
2020 Liu L, Zhou J, Chen CJ, Zhang J, Wen W, Tian J, Zhang Z, Gu Y. GWAS-Based Identification of New Loci for Milk Yield, Fat, and Protein in Holstein Cattle. Animals : An Open Access Journal From Mdpi. 10. PMID 33167458 DOI: 10.3390/ani10112048   
2020 Sahu PK, Sao R, Mondal S, Vishwakarma G, Gupta SK, Kumar V, Singh S, Sharma D, Das BK. Next Generation Sequencing Based Forward Genetic Approaches for Identification and Mapping of Causal Mutations in Crop Plants: A Comprehensive Review. Plants (Basel, Switzerland). 9. PMID 33066352 DOI: 10.3390/plants9101355   
2020 Cooper SE, Schwartzentruber J, Bello E, Coomber EL, Bassett AR. Screening for functional transcriptional and splicing regulatory variants with GenIE. Nucleic Acids Research. PMID 33152068 DOI: 10.1093/nar/gkaa960   
2020 Pierce SE, Booms A, Prahl J, van der Schans EJC, Tyson T, Coetzee GA. Post-GWAS knowledge gap: the how, where, and when. Npj Parkinson's Disease. 6: 23. PMID 32964108 DOI: 10.1038/s41531-020-00125-y   
2020 Panjwani N, Wang F, Mastromatteo S, Bao A, Wang C, He G, Gong J, Rommens JM, Sun L, Strug LJ. LocusFocus: Web-based colocalization for the annotation and functional follow-up of GWAS. Plos Computational Biology. 16: e1008336. PMID 33090994 DOI: 10.1371/journal.pcbi.1008336   
2020 Tamargo-Gómez I, Fernández ÁF, Mariño G. Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes. International Journal of Molecular Sciences. 21. PMID 33147747 DOI: 10.3390/ijms21218196   
2020 Jiang K, Du F, Lv L, Zhuo H, Xu T, Peng L, Chen Y, Li L, Zhang J. Genetic Fine Mapping and Genomic Annotation Defines Causal Mechanisms at A Novel Colorectal Cancer Susceptibility Locus in Han Chinese. Journal of Cancer. 11: 6841-6849. PMID 33123275 DOI: 10.7150/jca.47189   
2020 McKnight I, Hart C, Park IH, Shim JW. Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. Experimental Neurology. 113523. PMID 33157092 DOI: 10.1016/j.expneurol.2020.113523   
2020 Shi X, Chai X, Yang Y, Cheng Q, Jiao Y, Chen H, Huang J, Yang C, Liu J. A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies. Nucleic Acids Research. PMID 32978944 DOI: 10.1093/nar/gkaa767   
2020 Yang T, Wei P, Pan W. Integrative Analysis Of Multi-Omics Data For Discovering Low-Frequency Variants Associated With Low-Density Lipoprotein Cholesterol Levels. Bioinformatics (Oxford, England). PMID 33070182 DOI: 10.1093/bioinformatics/btaa898   
2020 Jacobs BM, Taylor T, Awad A, Baker D, Giovanonni G, Noyce AJ, Dobson R. Summary-data-based Mendelian randomization prioritizes potential druggable targets for multiple sclerosis. Brain Communications. 2: fcaa119. PMID 33005893 DOI: 10.1093/braincomms/fcaa119   
2020 Mata-Nicolás E, Montero-Pau J, Gimeno-Paez E, Garcia-Carpintero V, Ziarsolo P, Menda N, Mueller LA, Blanca J, Cañizares J, van der Knaap E, Díez MJ. Exploiting the diversity of tomato: the development of a phenotypically and genetically detailed germplasm collection. Horticulture Research. 7: 66. PMID 32377357 DOI: 10.1038/s41438-020-0291-7   
2020 Thapa KS, Chen AB, Lai D, Xuei X, Wetherill L, Tischfield JA, Liu Y, Edenberg HJ. Identification of Functional Genetic Variants Associated with Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. Alcoholism, Clinical and Experimental Research. PMID 33119910 DOI: 10.1111/acer.14492   
2020 Sheng X, Qiu C, Liu H, Gluck C, Hsu JY, He J, Hsu CY, Sha D, Weir MR, Isakova T, Raj D, Rincon-Choles H, Feldman HI, Townsend R, Li H, et al. Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 33144501 DOI: 10.1073/pnas.2005905117   
2020 Luyapan J, Ji X, Li S, Xiao X, Zhu D, Duell EJ, Christiani DC, Schabath MB, Arnold SM, Zienolddiny S, Brunnström H, Melander O, Thornquist MD, MacKenzie TA, Amos CI, et al. A new efficient method to detect genetic interactions for lung cancer GWAS. Bmc Medical Genomics. 13: 162. PMID 33126877 DOI: 10.1186/s12920-020-00807-9   
2020 Leal-Gutiérrez JD, Rezende FM, Reecy JM, Kramer LM, Peñagaricano F, Mateescu RG. Whole Genome Sequence Data Provides Novel Insights Into the Genetic Architecture of Meat Quality Traits in Beef. Frontiers in Genetics. 11: 538640. PMID 33101375 DOI: 10.3389/fgene.2020.538640   
2020 Kulkarni R, Chopra R, Chagoya J, Simpson CE, Baring MR, Hillhouse A, Puppala N, Chamberlin K, Burow MD. Use of Targeted Amplicon Sequencing in Peanut to Generate Allele Information on Allotetraploid Sub-Genomes. Genes. 11. PMID 33080972 DOI: 10.3390/genes11101220   
2020 Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, et al. Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics. PMID 33067325 DOI: 10.1534/genetics.120.303596   
2020 Aref-Eshghi E, Kerkhof J, Carere DA, Volodarsky M, Bhai P, Colaiacovo S, Saleh M, Caudle M, Karp N, Prasad C, Balci T, Lin H, Campbell C, Siu VM, Sadikovic B. Clinical and technical assessment of MedExome vs. NGS panels in patients with suspected genetic disorders in Southwestern Ontario. Journal of Human Genetics. PMID 33093641 DOI: 10.1038/s10038-020-00860-3   
2020 Rashid NU, Li Q, Yeh JJ, Ibrahim JG. Modeling Between-Study Heterogeneity for Improved Replicability in Gene Signature Selection and Clinical Prediction. Journal of the American Statistical Association. 115: 1125-1138. PMID 33012902 DOI: 10.1080/01621459.2019.1671197   
2020 Sui M, Wang Y, Bao Y, Wang X, Li R, Lv Y, Yan M, Quan C, Li C, Teng W, Li W, Zhao X, Han Y. Genome-wide association analysis of sucrose concentration in soybean (Glycine max L.) seed based on high-throughput sequencing. The Plant Genome. e20059. PMID 33058418 DOI: 10.1002/tpg2.20059