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Sudha Seshadri - Publications

Affiliations: 
The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 
Area:
Alzheimer disease, epidemiology, genetics, MRI, stroke, endophenotype, biomarkers
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Year Citation  Score
2022 Mishra A, Duplaà C, Vojinovic D, Suzuki H, Sargurupremraj M, Zilhão NR, Li S, Bartz TM, Jian X, Zhao W, Hofer E, Wittfeld K, Harris SE, van der Auwera-Palitschka S, Luciano M, ... ... Seshadri S, et al. Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain : a Journal of Neurology. PMID 35511193 DOI: 10.1093/brain/awab432  0.301
2020 Sargurupremraj M, Suzuki H, Jian X, Sarnowski C, Evans TE, Bis JC, Eiriksdottir G, Sakaue S, Terzikhan N, Habes M, Zhao W, Armstrong NJ, Hofer E, Yanek LR, Hagenaars SP, ... ... Seshadri S, et al. Cerebral small vessel disease genomics and its implications across the lifespan. Nature Communications. 11: 6285. PMID 33293549 DOI: 10.1038/s41467-020-19111-2  0.308
2020 McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli C, Pase MP, Ninomiya T, Ohara T, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia. Journal of the American Heart Association. e014659. PMID 32921207 DOI: 10.1161/Jaha.119.014659  0.427
2020 Knol MJ, Lu D, Traylor M, Adams HH, Rafael J Romero J, Smith AV, Fornage M, Hofer E, Liu J, Hostettler IC, Luciano M, Trompet S, Giese AK, Hilal S, van den Akker EB, ... ... Seshadri S, et al. Association of common genetic variants with brain microbleeds: A Genome-wide Association Study. Neurology. PMID 32913026 DOI: 10.1212/Wnl.0000000000010852  0.33
2020 Jaworek T, Ryan KA, Gaynor BJ, McArdle PF, Stine OC, OConnor TD, Lopez H, Aparicio HJ, Gao Y, Lin X, Groves ML, Flaherty ML, Liu S, Yang Q, Wilson J, ... Seshadri S, et al. Exome Array Analysis of Early-Onset Ischemic Stroke. Stroke. STROKEAHA120031357. PMID 32912094 DOI: 10.1161/Strokeaha.120.031357  0.37
2020 Petrea RE, O'Donnell A, Beiser AS, Habes M, Aparicio H, DeCarli C, Seshadri S, Romero JR. Mid to Late Life Hypertension Trends and Cerebral Small Vessel Disease in the Framingham Heart Study. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 32755403 DOI: 10.1161/Hypertensionaha.120.15073  0.345
2020 Peloso GM, Beiser AS, Satizabal CL, Xanthakis V, Vasan RS, Pase MP, Destefano AL, Seshadri S. Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study. Neurology. PMID 32690788 DOI: 10.1212/Wnl.0000000000010306  0.341
2020 Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SK, Davis-Plourde KL, de Wolf F, Debette S, ... ... Seshadri S, et al. 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology. PMID 32611641 DOI: 10.1212/Wnl.0000000000010022  0.328
2020 Romero JR, Demissie S, Beiser A, Himali JJ, DeCarli C, Levy D, Seshadri S. Relation of plasma β-amyloid, clusterin, and tau with cerebral microbleeds: Framingham Heart Study. Annals of Clinical and Translational Neurology. PMID 32588552 DOI: 10.1002/Acn3.51066  0.374
2020 Lioutas VA, Beiser AS, Aparicio HJ, Himali JJ, Selim MH, Romero JR, Seshadri S. Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage Among Participants in the Framingham Heart Study Between 1948 and 2016. Jama Neurology. PMID 32511690 DOI: 10.1001/Jamaneurol.2020.1512  0.362
2020 Baradaran H, Demissie S, Himali JJ, Beiser A, Gupta A, Polak JF, DeCarli C, Seshadri S, Romero JR. The progression of carotid atherosclerosis and imaging markers of dementia. Alzheimer's & Dementia (New York, N. Y.). 6: e12015. PMID 32296732 DOI: 10.1002/Trc2.12015  0.326
2020 Gonzales MM, Wang CP, Quiben M, MacCarthy D, Seshadri S, Jacob M, Hazuda H. Joint trajectories of cognition and gait speed in Mexican American and European American older adults: The San Antonio longitudinal study of aging. International Journal of Geriatric Psychiatry. PMID 32281153 DOI: 10.1002/Gps.5310  0.304
2020 Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, Shatokhina N, Zsembik LCP, Thomopoulos SI, Zhu AH, Strike LT, ... ... Seshadri S, et al. The genetic architecture of the human cerebral cortex. Science (New York, N.Y.). 367. PMID 32193296 DOI: 10.1126/Science.Aay6690  0.31
2020 McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli C, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating ceramide ratios and risk of vascular brain aging and dementia. Annals of Clinical and Translational Neurology. PMID 31950603 DOI: 10.1002/Acn3.50973  0.393
2020 Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, Davis-Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, ... ... Seshadri S, et al. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Obesity Reviews : An Official Journal of the International Association For the Study of Obesity. PMID 31898862 DOI: 10.1111/Obr.12989  0.356
2020 Song R, Aparicio HJ, Seshadri S, Cho K, Wilson PW, Gaziano JM, Djousse L. Abstract P255: Moderate Alcohol Consumption and the Risk of Acute Ischemic Stroke and All-Cause Mortality: The Million Veteran Program Circulation. 141. DOI: 10.1161/Circ.141.Suppl_1.P255  0.304
2020 Djousse L, Ho Y, Treu T, Aparicio HJ, Seshadri S, Cho K, Wilson PW, Gaziano JM. Abstract MP28: Egg Consumption is Positively Associated With Ischemic Stroke: The Million Veteran Program Circulation. 141. DOI: 10.1161/Circ.141.Suppl_1.Mp28  0.325
2020 Baril A, Beiser AS, Redline S, McGrath ER, Aparicio HJ, Gottlieb DJ, Seshadri S, Himali JJ, Pase MP. 0419 IL-6 Moderates the Association Between Obstructive Sleep Apnea Severity and Incident Alzheimer’s Disease: The Framingham Heart Study Sleep. 43: A160-A161. DOI: 10.1093/Sleep/Zsaa056.416  0.317
2019 Whiteley WN, Anand S, Bangdiwala SI, Bosch J, Canavan M, Chertkow H, Gerstein HC, Gorelick P, O'Donnell M, Paré G, Pigeyre M, Seshadri S, Sharma M, Smith EE, Williamson J, et al. Are large simple trials for dementia prevention possible? Age and Ageing. PMID 31830268 DOI: 10.1093/Ageing/Afz152  0.325
2019 Pase MP, Himali JJ, Beiser AS, DeCarli C, McGrath ER, Satizabal CL, Aparicio HJ, Adams HHH, Reiner AP, Longstreth WT, Fornage M, Tracy RP, Lopez O, Psaty BM, Levy D, ... Seshadri S, et al. Association of CD14 with incident dementia and markers of brain aging and injury. Neurology. PMID 31818907 DOI: 10.1212/Wnl.0000000000008682  0.32
2019 Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Gwen Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, ... ... Seshadri S, et al. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet. Neurology. PMID 31706889 DOI: 10.1016/S1474-4422(19)30393-X  0.371
2019 Conner SC, Pase MP, Carneiro H, Raman MR, McKee AC, Alvarez VE, Walker JM, Satizabal CL, Himali JJ, Stein TD, Beiser A, Seshadri S. Mid-life and late-life vascular risk factor burden and neuropathology in old age. Annals of Clinical and Translational Neurology. PMID 31691546 DOI: 10.1002/Acn3.50936  0.324
2019 Seshadri S. Prevention of Dementia-Thinking Beyond the Age and Amyloid Boxes. Jama Neurology. 1-2. PMID 31682673 DOI: 10.1001/Jamaneurol.2019.3785  0.325
2019 Spartano NL, Demissie S, Himali JJ, Dukes KA, Murabito JM, Vasan RS, Beiser AS, Seshadri S. Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimer's & Dementia (New York, N. Y.). 5: 618-626. PMID 31660424 DOI: 10.1016/J.Trci.2019.08.007  0.336
2019 Satizabal CL, Adams HHH, Hibar DP, White CC, Knol MJ, Stein JL, Scholz M, Sargurupremraj M, Jahanshad N, Roshchupkin GV, Smith AV, Bis JC, Jian X, Luciano M, Hofer E, ... ... Seshadri S, et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. PMID 31636452 DOI: 10.1038/S41588-019-0511-Y  0.318
2019 Echouffo-Tcheugui J, Conner SC, Himali JJ, Beiser AS, Seshadri S. Author response: Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study. Neurology. 93: 685-686. PMID 31591178 DOI: 10.1212/Wnl.0000000000008256  0.302
2019 Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, ... ... Seshadri S, et al. Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: A Meta-Analysis of Population-Based Studies Involving 17,180 Individuals. Circulation Research. PMID 31476962 DOI: 10.1161/Circresaha.119.315380  0.343
2019 Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. Plos One. 14: e0219261. PMID 31393881 DOI: 10.1371/Journal.Pone.0219261  0.315
2019 McGrath ER, Himali JJ, Levy D, Conner SC, DeCarli CS, Pase MP, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating IGFBP-2: a novel biomarker for incident dementia. Annals of Clinical and Translational Neurology. PMID 31373442 DOI: 10.1002/Acn3.50854  0.3
2019 Wolters FJ, Yang Q, Biggs ML, Jakobsdottir J, Li S, Evans DS, Bis JC, Harris TB, Vasan RS, Zilhao NR, Ghanbari M, Ikram MA, Launer L, Psaty BM, Tranah GJ, ... ... Seshadri S, et al. The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE). Plos One. 14: e0219668. PMID 31356640 DOI: 10.1371/Journal.Pone.0219668  0.329
2019 Baker E, Sims R, Leonenko G, Frizzati A, Harwood JC, Grozeva D, Morgan K, Passmore P, Holmes C, Powell J, ... ... Seshadri S, et al. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. Plos One. 14: e0218111. PMID 31283791 DOI: 10.1371/Journal.Pone.0218111  0.352
2019 Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S. Plasma total-tau as a biomarker of stroke risk in the community. Annals of Neurology. PMID 31271449 DOI: 10.1002/Ana.25542  0.383
2019 Ma Y, Jun GR, Zhang X, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G, ... ... Seshadri S, et al. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. Jama Neurology. PMID 31180460 DOI: 10.1001/Jamaneurol.2019.1456  0.371
2019 Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, ... ... Seshadri S, et al. Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. PMID 31160810 DOI: 10.1038/S41588-019-0449-0  0.342
2019 Aparicio HJ, Himali JJ, Satizabal CL, Pase MP, Romero JR, Kase CS, Beiser AS, Seshadri S. Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study. Stroke. STROKEAHA119025171. PMID 31084341 DOI: 10.1161/Strokeaha.119.025171  0.368
2019 Kivimäki M, Singh-Manoux A, Pentti J, Sabia S, Nyberg ST, Alfredsson L, Goldberg M, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Nordin M, Oksanen T, Strandberg T, Suominen SB, ... ... Seshadri S, et al. Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis. Bmj (Clinical Research Ed.). 365: l1495. PMID 30995986 DOI: 10.1136/Bmj.L1495  0.364
2019 Mishra A, Chauhan G, Violleau MH, Vojinovic D, Jian X, Bis JC, Li S, Saba Y, Grenier-Boley B, Yang Q, Bartz TM, Hofer E, Soumaré A, Peng F, Duperron MG, ... ... Seshadri S, et al. Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects. Brain : a Journal of Neurology. PMID 30859180 DOI: 10.1093/Brain/Awz024  0.375
2019 McGrath ER, Himali JJ, Levy D, Conner SC, Pase MP, Abraham CR, Courchesne P, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study. Plos One. 14: e0213321. PMID 30830941 DOI: 10.1371/Journal.Pone.0213321  0.356
2019 Pase MP, Beiser AS, Himali JJ, Satizabal CL, Aparicio HJ, DeCarli C, Chêne G, Dufouil C, Seshadri S. Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes. Jama Neurology. PMID 30830207 DOI: 10.1001/Jamaneurol.2018.4666  0.327
2019 Conner SC, Benayoun L, Himali JJ, Adams SL, Yang Q, DeCarli C, Blusztajn JK, Beiser A, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts. Journal of Alzheimer's Disease : Jad. PMID 30775993 DOI: 10.3233/Jad-180977  0.416
2019 Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, ... ... Seshadri S, et al. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts. Plos One. 14: e0212293. PMID 30768625 DOI: 10.1371/Journal.Pone.0212293  0.393
2019 Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, ... ... Seshadri S, et al. Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology. PMID 30651383 DOI: 10.1212/Wnl.0000000000006851  0.335
2019 de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, ... ... Seshadri S, et al. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology. Blood. PMID 30642921 DOI: 10.1182/Blood-2018-05-849240  0.374
2019 Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, ... ... Seshadri S, et al. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 158-167. PMID 30642436 DOI: 10.1016/J.Jalz.2018.07.222  0.356
2019 Fornage M, Adams HH, Bis JC, Deary IJ, Launer L, Smith JA, Teumer A, Seshadri S, NeuroCHARGE. Abstract WP216: Epigenome-Wide Association Study of Cerebral White Matter Hyperintensities Stroke. 50. DOI: 10.1161/Str.50.Suppl_1.Wp216  0.384
2019 Jaworek T, Ryan K, Gaynor B, McArdle P, Stine OC, Aparicio HJ, Gao Y, Lin X, Groves ML, Kittner SJ, Wilson J, Yang Q, Seshadri S, Lui S, Mitchell BD, et al. Abstract WP211: Exome Association Analysis of Small Vessel Young Onset Ischemic Stroke Stroke. 50. DOI: 10.1161/Str.50.Suppl_1.Wp211  0.385
2019 Aparicio HJ, Demissie S, Himali JJ, Pase MP, Satizabal CL, Dukes KA, Lioutas V, Romero JR, Vasan RS, Beiser AS, Seshadri S. Abstract TMP55: Abdominal Obesity Predicts Stroke Risk in the Framingham Study Stroke. 50. DOI: 10.1161/Str.50.Suppl_1.Tmp55  0.304
2019 Seshadri S. SURVIVAL ADVANTAGE OF APOE2 Innovation in Aging. 3: S621-S621. DOI: 10.1093/Geroni/Igz038.2313  0.36
2019 Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. P4-543: AUTONOMIC BALANCE INDICES AND RISK OF DEMENTIA: THE FRAMINGHAM STUDY Alzheimer's & Dementia. 15: P1524-P1524. DOI: 10.1016/J.Jalz.2019.08.090  0.352
2019 Naj A, Sha J, Leonenko G, Chen Y, Chouraki V, Leber M, Sims R, Grenier-Boley B, Bis JC, Zhao Y, Kuzma AB, Kunkle BW, Karamujić-Čomić H, Lee SJVD, Bellenguez C, ... ... Seshadri S, et al. O2‐10‐06: Genome‐Wide Meta‐Analysis Of Late‐Onset Alzheimer'S Disease Using Rare Variant Imputation In 64,859 Subjects Identifies Risk Loci With Roles In Innate Immunity And Cardiovascular Traits: The International Genomics Of Alzheimer'S Project (Igap) Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4510  0.351
2019 Maillard P, Himali JJ, Beiser AS, Fletcher E, Peets B, Satizabal CL, Seshadri S, DeCarli C. P3-352: ASSOCIATION BETWEEN COGNITION AND CEREBRAL WHITE MATTER FREE WATER IN ADULTS FROM THE FRAMINGHAM HEART STUDY: A DIFFUSION TENSOR IMAGING VOXEL-BASED STUDY Alzheimer's & Dementia. 15: P1078-P1079. DOI: 10.1016/J.Jalz.2019.06.3385  0.309
2019 McGrath ER, Himali JJ, Xanthakis V, Duncan MS, Schaffer JE, Ory DS, Peterson LR, DeCarli CS, Pase MP, Satizabal CL, Vasan RS, Beiser AS, Seshadri S. P3-253: PLASMA CERAMIDES AND RISK OF DEMENTIA Alzheimer's & Dementia. 15: P1033-P1033. DOI: 10.1016/J.Jalz.2019.06.3284  0.32
2019 Himali JJ, Beiser AS, Melo van Lent D, O'Donnell A, Jacques PF, Vasan RS, Pase MP, Seshadri S. P2-568: ADHERENCE TO THE MIND DIET PREDICTS A LOWER RISK OF DEMENTIA IN THE FRAMINGHAM HEART STUDY Alzheimer's & Dementia. 15: P840-P841. DOI: 10.1016/J.Jalz.2019.06.2977  0.323
2018 Satizabal CL, Samieri C, Davis-Plourde KL, Voetsch B, Aparicio HJ, Pase MP, Romero JR, Helmer C, Vasan RS, Kase CS, Debette S, Beiser AS, Seshadri S. APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality. Stroke. 49: 2822-2829. PMID 30571417 DOI: 10.1161/Strokeaha.118.022132  0.367
2018 Beecham GW, Vardarajan B, Blue E, Bush W, Jaworski J, Barral S, DeStefano A, Hamilton-Nelson K, Kunkle B, Martin ER, Naj A, Rajabli F, Reitz C, Thornton T, van Duijn C, ... ... Seshadri S, et al. Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease. Neurology. Genetics. 4: e286. PMID 30569016 DOI: 10.1212/Nxg.0000000000000286  0.309
2018 Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, ... ... Seshadri S, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications. 9: 5141. PMID 30510157 DOI: 10.1038/S41467-018-07340-5  0.377
2018 Peloso GM, Beiser AS, Destefano AL, Seshadri S. Genetic Interaction with Plasma Lipids on Alzheimer's Disease in the Framingham Heart Study. Journal of Alzheimer's Disease : Jad. PMID 30412497 DOI: 10.3233/Jad-180751  0.359
2018 Cole JW, Xu H, Ryan K, Jaworek T, Dueker N, McArdle P, Gaynor B, Cheng YC, O'Connell J, Bevan S, Malik R, Ahmed NU, Amouyel P, Anjum S, Bis JC, ... ... Seshadri S, et al. Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. Plos One. 13: e0206554. PMID 30383853 DOI: 10.1371/Journal.Pone.0206554  0.347
2018 Echouffo-Tcheugui JB, Conner SC, Himali JJ, Maillard P, DeCarli CS, Beiser AS, Vasan RS, Seshadri S. Circulating cortisol and cognitive and structural brain measures: The Framingham Heart Study. Neurology. PMID 30355700 DOI: 10.1212/Wnl.0000000000006549  0.36
2018 Raman MR, Himali JJ, Conner SC, DeCarli C, Vasan RS, Beiser AS, Seshadri S, Maillard P, Satizabal CL. Circulating Vascular Growth Factors and Magnetic Resonance Imaging Markers of Small Vessel Disease and Atrophy in Middle-Aged Adults. Stroke. 49: 2227-2229. PMID 30354979 DOI: 10.1161/Strokeaha.118.022613  0.338
2018 Vojinovic D, Adams HH, Jian X, Yang Q, Smith AV, Bis JC, Teumer A, Scholz M, Armstrong NJ, Hofer E, Saba Y, Luciano M, Bernard M, Trompet S, Yang J, ... ... Seshadri S, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nature Communications. 9: 3945. PMID 30258056 DOI: 10.1038/S41467-018-06234-W  0.337
2018 Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S, Beiser AS, DeCarli C. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology. PMID 30232248 DOI: 10.1212/Wnl.0000000000006360  0.389
2018 Seiler S, Fletcher E, Hassan-Ali K, Weinstein M, Beiser A, Himali JJ, Satizabal CL, Seshadri S, DeCarli C, Maillard P. Cerebral tract integrity relates to white matter hyperintensities, cortex volume, and cognition. Neurobiology of Aging. 72: 14-22. PMID 30172922 DOI: 10.1016/J.Neurobiolaging.2018.08.005  0.306
2018 Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Seshadri S, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 30108311 DOI: 10.1038/S41380-018-0112-7  0.358
2018 Woo D, Anderson CD, Maguire J, Fornage M, Lee JM, Seshadri S, Markus HS, Majersik JJ, Jimenez-Conde J, Crawford K, Lindgren AG, Debette S. Top research priorities for stroke genetics. The Lancet. Neurology. 17: 663-665. PMID 30033056 DOI: 10.1016/S1474-4422(18)30243-6  0.303
2018 Jian X, Satizabal CL, Smith AV, Wittfeld K, Bis JC, Smith JA, Hsu FC, Nho K, Hofer E, Hagenaars SP, Nyquist PA, Mishra A, Adams HHH, Li S, Teumer A, ... ... Seshadri S, et al. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. Stroke. PMID 30002152 DOI: 10.1161/Strokeaha.118.020689  0.338
2018 Rajani RM, Quick S, Ruigrok SR, Graham D, Harris SE, Verhaaren BFJ, Fornage M, Seshadri S, Atanur SS, Dominiczak AF, Smith C, Wardlaw JM, Williams A. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine. 10. PMID 29973407 DOI: 10.1126/Scitranslmed.Aam9507  0.316
2018 Davies G, Lam M, Harris SE, Trampush JW, Luciano M, Hill WD, Hagenaars SP, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Liewald DCM, Okely JA, Ahola-Olli AV, Barnes CLK, Bertram L, ... ... Seshadri S, et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. 9: 2098. PMID 29844566 DOI: 10.1038/S41467-018-04362-X  0.341
2018 Dufouil C, Beiser A, Chêne G, Seshadri S. Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences. 73: S65-S72. PMID 29669105 DOI: 10.1093/Geronb/Gby001  0.348
2018 Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, Beiser A, Larson MG, Sääksjärvi K, Shipley MJ, Singh-Manoux A, Gerszten RE, Wang TJ, Havulinna AS, Würtz P, ... ... Seshadri S, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29519576 DOI: 10.1016/J.Jalz.2018.01.003  0.359
2018 Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, DeStefano A, Farrer LA, Goate A, Haines J, Jaworski J, ... ... Seshadri S, et al. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dementia and Geriatric Cognitive Disorders. 45: 1-17. PMID 29486463 DOI: 10.1159/000485503  0.367
2018 Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, ... ... Seshadri S, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics. PMID 29455858 DOI: 10.1016/J.Ajhg.2018.01.015  0.325
2018 Charidimou A, Shams S, Romero JR, Ding J, Veltkamp R, Horstmann S, Eiriksdottir G, van Buchem MA, Gudnason V, Himali JJ, Gurol ME, Viswanathan A, Imaizumi T, Vernooij MW, Seshadri S, et al. Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1). International Journal of Stroke : Official Journal of the International Stroke Society. 1747493017751931. PMID 29338604 DOI: 10.1177/1747493017751931  0.395
2018 van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, Melo van Lent D, Tynkkynen J, Fischer K, Hernesniemi J, Metspalu A, Singh-Manoux A, Verhoeven A, Willemsen G, de Leeuw FA, ... ... Seshadri S, et al. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29316447 DOI: 10.1016/J.Jalz.2017.11.012  0.344
2018 Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai PC, Vojinovic D, Simino J, Levy D, Liu C, Mendelson M, ... ... Seshadri S, et al. Meta-analysis of epigenome-wide association studies of cognitive abilities. Molecular Psychiatry. PMID 29311653 DOI: 10.1038/S41380-017-0008-Y  0.35
2018 Cole JW, Jaworek T, Ryan K, Gaynor B, McArdle P, Stine OC, Aparicio HJ, Gao Y, Lin X, Grove ML, Kittner SJ, Wilson JG, Yang Q, Seshadri S, Lui S, et al. Abstract WP160: Exome Array Analysis of Early-Onset Ischemic Stroke Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wp160  0.34
2018 Lioutas V, Ivan CS, Romero JR, Aparicio H, Beiser A, Himali J, Seshadri S. Abstract WMP49: Epidemiology of Transient Ischemic Attacks and Risk of Stroke in the Community-The Framingham Study Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wmp49  0.374
2018 Aparicio HJ, Himali JJ, Amabile N, Pase MP, Romero JR, Satizabal CL, Cheng S, Larson MG, DeCarli C, Wang TJ, Vasan RS, Beiser AS, Boulanger CM, Seshadri S. Abstract 171: Endothelial Microparticle Levels and Silent Stroke in the Framingham Heart Study Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.171  0.372
2018 Khan RR, Altmann A, Napolioni V, Kim Y, Guerreiro R, Bras JT, Carmona S, Pereira M, Santana I, Hardy J, Mead S, Cruchaga C, Fernandez MV, Holstege H, Flier WMVd, ... ... Seshadri S, et al. P4-240: Stop-Gain Variant In Microglia-Expressed Gene Gmip Is Associated With Early-Onset Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.07.061  0.339
2018 Ding J, Davis-Plourde K, Sedaghat S, Tully P, Wang W, Windham BG, Phillips C, Griswold ME, White LR, Gudnason V, Debette S, Seshadri S, Ikram MA, Meirelles O, Tzourio C, et al. O3-11-01: Use Of Blood Pressure-Lowering Drugs And Risk Of Incident Dementia And Alzheimer'S Disease In Older People With And Without High Blood Pressure: A Meta-Analysis Of Individual Participant Data From Prospective Cohort Studies Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2831  0.327
2018 Jian X, Chiang T, Worley KC, Bis JC, Destefano AL, Seshadri S, Boerwinkle E, Fornage M, Salerno WJ. O3-06-01: Whole Exome Sequencing Study Identifies Rare Copy Number Variations For Late-Onset Alzheimer'S Disease: The Alzheimer'S Disease Sequencing Project Case-Control Analysis Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2800  0.309
2018 Wolters FJ, Chibnik LB, Waziry R, Anderson R, Bäckman K, Berr C, Beiser AS, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues J, Darweesh SK, Davis-Plourde K, Debette S, ... ... Seshadri S, et al. O1-05-01: Trends In Incidence Of Dementia And Alzheimer'S Disease: Results Of The Alzheimer Cohorts Consortium Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2354  0.343
2018 Raman MR, Katharina W, Conner SC, Teumer A, Nauck M, Hosten N, DeCarli CS, Vasan RS, Beiser AS, Himali JJ, Seshadri S, Grabe HJ, Satizabal CL. Igf-1 And Igfbp-3 Associations With Brain Mri: Meta-Analysis In Middle-Aged Adults From The Framingham Heart Study And Study Of Health In Pomerania Alzheimers & Dementia. 14: 92. DOI: 10.1016/J.Jalz.2018.06.2173  0.319
2017 Adams S, Conner S, Himali JJ, Beiser A, Vasan RS, Seshadri S, Pase MP. Vascular risk factor burden and new-onset depression in the community. Preventive Medicine. PMID 29197532 DOI: 10.1016/J.Ypmed.2017.11.022  0.341
2017 Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, ... ... Seshadri S, et al. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurology. Genetics. 3: e194. PMID 29184913 DOI: 10.1212/Nxg.0000000000000194  0.374
2017 Weinstein G, Zelber-Sagi S, Preis SR, Beiser AS, DeCarli C, Speliotes EK, Satizabal CL, Vasan RS, Seshadri S. Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-Aged Adults in the Framingham Study. Jama Neurology. PMID 29159396 DOI: 10.1001/Jamaneurol.2017.3229  0.345
2017 McGrath ER, Beiser AS, DeCarli C, Plourde KL, Vasan RS, Greenberg SM, Seshadri S. Blood pressure from mid- to late life and risk of incident dementia. Neurology. PMID 29117954 DOI: 10.1212/Wnl.0000000000004741  0.318
2017 Olson NC, Raffield LM, Lange LA, Lange EM, Longstreth WT, Chauhan G, Debette S, Seshadri S, Reiner AP, Tracy RP. Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk. Journal of Thrombosis and Haemostasis : Jth. PMID 29112333 DOI: 10.1111/Jth.13899  0.32
2017 Salinas J, Beiser A, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Mateen FJ, Berkman LF, Rosand J, Seshadri S. Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimer's & Dementia (New York, N. Y.). 3: 229-237. PMID 29067329 DOI: 10.1016/J.Trci.2017.03.001  0.374
2017 Chibnik LB, Wolters FJ, Bäckman K, Beiser A, Berr C, Bis JC, Boerwinkle E, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Debette S, Davis-Plourde KL, Dufouil C, Fornage M, ... ... Seshadri S, et al. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. European Journal of Epidemiology. PMID 29063414 DOI: 10.1007/S10654-017-0320-5  0.381
2017 Rannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, ... ... Seshadri S, et al. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. PMID 28954878 DOI: 10.1212/Wnl.0000000000004560  0.383
2017 Lin H, Satizabal C, Xie Z, Yang Q, Huan T, Joehanes R, Wen C, Munson PJ, Beiser A, Levy D, Seshadri S. Whole blood gene expression and white matter Hyperintensities. Molecular Neurodegeneration. 12: 67. PMID 28923099 DOI: 10.1186/S13024-017-0209-5  0.381
2017 Gorelick PB, Furie KL, Iadecola C, Smith EE, Waddy SP, Lloyd-Jones DM, Bae HJ, Bauman MA, Dichgans M, Duncan PW, Girgus M, Howard VJ, Lazar RM, Seshadri S, Testai FD, et al. Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association. Stroke. PMID 28883125 DOI: 10.1161/Str.0000000000000148  0.363
2017 Cooper LL, Himali JJ, Torjesen A, Tsao CW, Beiser A, Hamburg NM, DeCarli C, Vasan RS, Seshadri S, Pase MP, Mitchell GF. Inter-Relations of Orthostatic Blood Pressure Change, Aortic Stiffness, and Brain Structure and Function in Young Adults. Journal of the American Heart Association. 6. PMID 28862943 DOI: 10.1161/Jaha.117.006206  0.303
2017 Sánchez-Juan P, Seshadri S. Dynamic measurements of β-amyloid accumulation: The early effect of APOE. Neurology. PMID 28794255 DOI: 10.1212/Wnl.0000000000004344  0.366
2017 Pase MP, Himali JJ, Seshadri S, Jacques PF. Response by Pase et al to Letter Regarding Article, "Sweetened Beverages and the Risks of Incident Stroke and Dementia". Stroke. PMID 28784919 DOI: 10.1161/Strokeaha.117.018603  0.404
2017 Adams SL, Benayoun L, Tilton K, Chavez OR, Himali JJ, Blusztajn JK, Seshadri S, Delalle I. Methionine Sulfoxide Reductase-B3 (MsrB3) Protein Associates with Synaptic Vesicles and its Expression Changes in the Hippocampi of Alzheimer's Disease Patients. Journal of Alzheimer's Disease : Jad. PMID 28777754 DOI: 10.3233/Jad-170459  0.304
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Seshadri S, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.355
2017 Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. Plos One. 12: e0180046. PMID 28704393 DOI: 10.1371/Journal.Pone.0180046  0.304
2017 Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D'Agostino RB, Wolf PA, Vasan RS, DeCarli C, O'Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. PMID 28673480 DOI: 10.1016/J.Atherosclerosis.2017.06.919  0.394
2017 Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, ... ... Seshadri S, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience. PMID 28628103 DOI: 10.1038/Nn.4587  0.344
2017 Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, Weinstein G, Wang TJ, Gerszten RE, Vasan RS, Seshadri S. Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28602601 DOI: 10.1016/J.Jalz.2017.04.009  0.368
2017 Pase MP, Satizabal CL, Seshadri S. Role of Improved Vascular Health in the Declining Incidence of Dementia. Stroke. PMID 28596460 DOI: 10.1161/Strokeaha.117.013369  0.378
2017 Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke: The Framingham Study. Stroke. PMID 28596451 DOI: 10.1161/Strokeaha.116.016563  0.349
2017 Wu YT, Beiser AS, Breteler MMB, Fratiglioni L, Helmer C, Hendrie HC, Honda H, Ikram MA, Langa KM, Lobo A, Matthews FE, Ohara T, Pérès K, Qiu C, Seshadri S, et al. The changing prevalence and incidence of dementia over time - current evidence. Nature Reviews. Neurology. PMID 28497805 DOI: 10.1038/Nrneurol.2017.63  0.345
2017 Debette S, Saba Y, Vojinovic D, Jian X, Adams H, Chauhan G, Sargurupremraj M, Kaffashian S, Ding J, Bis JC, Nyquist P, Mather K, Van Duijn C, Launer LJ, Ikram MA, ... ... Seshadri S, et al. 19th Workshop of the International Stroke Genetics Consortium, April 28-29, 2016, Boston, Massachusetts, USA: 2016.001 MRI-defined cerebrovascular genomics-The CHARGE consortium. Neurology. Genetics. 3: S2-S11. PMID 28428977 DOI: 10.1212/NXG.0000000000000100  0.342
2017 Pase MP, Himali JJ, Beiser AS, Aparicio HJ, Satizabal CL, Vasan RS, Seshadri S, Jacques PF. Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study. Stroke. PMID 28428346 DOI: 10.1161/Strokeaha.116.016027  0.419
2017 Lubitz SA, Seshadri S, Benjamin EJ. Response by Lubitz et al to Letter Regarding Article, "Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study". Stroke. PMID 28416627 DOI: 10.1161/Strokeaha.117.017108  0.333
2017 Stefanidou M, Das RR, Beiser AS, Sundar B, Kelly-Hayes M, Kase CS, Devinsky O, Seshadri S, Friedman D. Incidence of seizures following initial ischemic stroke in a community-based cohort: The Framingham Heart Study. Seizure. 47: 105-110. PMID 28364691 DOI: 10.1016/J.Seizure.2017.03.009  0.305
2017 Romero JR, Beiser A, Himali JJ, Shoamanesh A, DeCarli C, Seshadri S. Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study. Neurobiology of Aging. 54: 94-99. PMID 28347929 DOI: 10.1016/J.Neurobiolaging.2017.02.018  0.426
2017 Qian J, Wolters FJ, Beiser A, Haan M, Ikram MA, Karlawish J, Langbaum JB, Neuhaus JM, Reiman EM, Roberts JS, Seshadri S, Tariot PN, Woods BM, Betensky RA, Blacker D. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. Plos Medicine. 14: e1002254. PMID 28323826 DOI: 10.1371/Journal.Pmed.1002254  0.375
2017 Pase MP, Himali JJ, Jacques PF, DeCarli C, Satizabal CL, Aparicio H, Vasan RS, Beiser AS, Seshadri S. Sugary beverage intake and preclinical Alzheimer's disease in the community. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28274718 DOI: 10.1016/J.Jalz.2017.01.024  0.317
2017 Westwood AJ, Beiser A, Jain N, Himali JJ, DeCarli C, Auerbach SH, Pase MP, Seshadri S. Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia. Neurology. PMID 28228567 DOI: 10.1212/Wnl.0000000000003732  0.313
2017 Georgakis MK, Synetos A, Mihas C, Karalexi MA, Tousoulis D, Seshadri S, Petridou ET. Left ventricular hypertrophy in association with cognitive impairment: a systematic review and meta-analysis. Hypertension Research : Official Journal of the Japanese Society of Hypertension. PMID 28202945 DOI: 10.1038/Hr.2017.11  0.351
2017 Weinstein G, Preis SR, Beiser AS, Kaess B, Chen TC, Satizabal C, Rahman F, Benjamin EJ, Ramachandran VS, Seshadri S. Clinical and Environmental Correlates of Serum BDNF: A descriptive study with plausible implications for AD research. Current Alzheimer Research. PMID 28164772 DOI: 10.2174/1567205014666170203094520  0.329
2017 Dufouil C, Beiser AS, McClure LA, Wolf PA, Tzourio C, Howard VJ, Westwood AJ, Himali JJ, Sullivan LM, Aparicio HJ, Kelly-Hayes M, Ritchie K, Kase CS, Pikula A, Romero JR, ... ... Seshadri S, et al. A Revised Framingham Stroke Risk Profile to Reflect Temporal Trends. Circulation. PMID 28159800 DOI: 10.1161/Circulationaha.115.021275  0.364
2017 Romero JR, Preis SR, Beiser A, Himali JJ, Shoamanesh A, Wolf PA, Kase CS, Ramachandran VS, DeCarli C, Seshadri S. Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study. Stroke. PMID 28143923 DOI: 10.1161/Strokeaha.116.015354  0.408
2017 Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, ... ... Seshadri S, et al. Novel genetic loci associated with hippocampal volume. Nature Communications. 8: 13624. PMID 28098162 DOI: 10.1038/Ncomms13624  0.352
2017 Rahman F, Himali JJ, Yin X, Beiser AS, Ellinor PT, Lubitz SA, Vasan RS, Magnani JW, McManus DD, Seshadri S, Benjamin EJ. Serum brain-derived neurotrophic factor and risk of atrial fibrillation. American Heart Journal. 183: 69-73. PMID 27979044 DOI: 10.1016/J.Ahj.2016.07.027  0.333
2017 Depas N, Wolters FJ, Xia F, Li S, Kern S, Lopez OL, Lambert J, Launer LJ, Zettergren A, Yang Q, Skoog I, Yaffe K, Seshadri S, Ikram MA, Chouraki V. PLASMA AMYLOID β PEPTIDE LEVELS AND RISK OF INCIDENT ALZHEIMER’S DISEASE AND DEMENTIA: UPDATE, REANALYSIS AND META-ANALYSIS OF INDIVIDUAL PARTICIPANTS’ DATA Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.637  0.321
2017 Raman MR, Himali JJ, Conner SC, DeCarli CS, Vasan RS, Beiser AS, Seshadri S, Satizabal CL. [P3-241]: MRI FINDINGS ASSOCIATED WITH CIRCULATING VEGF AND STIE2 CONCENTRATIONS IN YOUNG AND MIDDLE-AGED ADULTS IN THE FRAMINGHAM HEART STUDY Alzheimer's & Dementia. 13: P1032-P1032. DOI: 10.1016/J.Jalz.2017.06.1454  0.302
2016 Lioutas VA, Beiser A, Himali J, Aparicio H, Romero JR, DeCarli C, Seshadri S. Lacunar Infarcts and Intracerebral Hemorrhage Differences: A Nested Case-Control Analysis in the FHS (Framingham Heart Study). Stroke. PMID 28008091 DOI: 10.1161/Strokeaha.116.014839  0.338
2016 Snyder HM, Ahles T, Calderwood S, Carrillo MC, Chen H, Chang CC, Craft S, De Jager P, Driver JA, Fillet H, Knopman D, Lotze M, Tierney MC, Petanceska S, Saykin A, ... Seshadri S, et al. Exploring the nexus of Alzheimer's disease and related dementias with cancer and cancer therapies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27998721 DOI: 10.1016/J.Jalz.2016.11.002  0.317
2016 Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, Yet I, Spector TD, Bell JT, Hannon E, Mill J, ... ... Seshadri S, et al. Genetic Variation at 16q24.2 is associated with small vessel stroke. Annals of Neurology. PMID 27997041 DOI: 10.1002/Ana.24840  0.395
2016 Smith EE, Saposnik G, Biessels GJ, Doubal FN, Fornage M, Gorelick PB, Greenberg SM, Higashida RT, Kasner SE, Seshadri S. Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. PMID 27980126 DOI: 10.1161/Str.0000000000000116  0.411
2016 Iadecola C, Yaffe K, Biller J, Bratzke LC, Faraci FM, Gorelick PB, Gulati M, Kamel H, Knopman DS, Launer LJ, Saczynski JS, Seshadri S, Zeki Al Hazzouri A. Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association. Hypertension (Dallas, Tex. : 1979). 68: e67-e94. PMID 27977393 DOI: 10.1161/Hyp.0000000000000053  0.379
2016 Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, ... ... Seshadri S, et al. Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. Plos Genetics. 12: e1006327. PMID 27764101 DOI: 10.1371/Journal.Pgen.1006327  0.341
2016 Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Rentería ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivières S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, et al. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nature Neuroscience. PMID 27694991 DOI: 10.1038/Nn.4398  0.352
2016 Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, ... ... Seshadri S, et al. Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke. Thrombosis and Haemostasis. 116. PMID 27604134 DOI: 10.1160/Th16-02-0113  0.37
2016 Shoamanesh A, Preis SR, Beiser AS, Kase CS, Wolf PA, Vasan RS, Benjamin EJ, Seshadri S, Romero JR. Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study. Neurology. PMID 27558379 DOI: 10.1212/Wnl.0000000000003115  0.343
2016 Nation DA, Preis SR, Beiser A, Bangen KJ, Delano-Wood L, Lamar M, Libon DJ, Seshadri S, Wolf PA, Au R. Pulse Pressure Is Associated With Early Brain Atrophy and Cognitive Decline: Modifying Effects of APOE-ε4. Alzheimer Disease and Associated Disorders. 30: 210-215. PMID 27556935 DOI: 10.1097/Wad.0000000000000127  0.367
2016 Camargo EC, Weinstein G, Beiser AS, Tan ZS, DeCarli C, Kelly-Hayes M, Kase C, Murabito JM, Seshadri S. Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study. Journal of Alzheimer's Disease : Jad. 53: 1597-608. PMID 27540965 DOI: 10.3233/Jad-160229  0.328
2016 Pase MP, Beiser A, Himali JJ, Tsao C, Satizabal CL, Vasan RS, Seshadri S, Mitchell GF. Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia. Stroke; a Journal of Cerebral Circulation. PMID 27491735 DOI: 10.1161/Strokeaha.116.013508  0.373
2016 Dichgans M, Wardlaw J, Smith E, Zietemann V, Seshadri S, Sachdev P, Biessels GJ, Fazekas F, Benavente O, Pantoni L, De Leeuw FE, Norrving B, Matthews P, Chen C, et al. METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27490018 DOI: 10.1016/J.Jalz.2016.06.004  0.384
2016 Weinstein G, Beiser AS, Preis SR, Courchesne P, Chouraki V, Levy D, Seshadri S. Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke. Alzheimer's & Dementia (Amsterdam, Netherlands). 3: 103-9. PMID 27453932 DOI: 10.1016/J.Dadm.2016.06.005  0.415
2016 Tan ZS, Spartano NL, Beiser AS, DeCarli C, Auerbach SH, Vasan RS, Seshadri S. Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 27422439 DOI: 10.1093/Gerona/Glw130  0.409
2016 Bangen KJ, Himali JJ, Beiser AS, Nation DA, Libon DJ, Fox CS, Seshadri S, Wolf PA, McKee AC, Au R, Delano-Wood L. Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 27392855 DOI: 10.3233/Jad-160163  0.376
2016 Adams SL, Tilton K, Kozubek JA, Seshadri S, Delalle I. Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. Journal of Neuropathology and Experimental Neurology. PMID 27346750 DOI: 10.1093/Jnen/Nlw056  0.303
2016 Chouraki V, Reitz C, Maury F, Bis JC, Bellenguez C, Yu L, Jakobsdottir J, Mukherjee S, Adams HH, Choi SH, Larson EB, Fitzpatrick A, Uitterlinden AG, de Jager PL, Hofman A, ... ... Seshadri S, et al. Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27340842 DOI: 10.3233/Jad-150749  0.381
2016 Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, ... ... Seshadri S, et al. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. PMID 27329260 DOI: 10.1111/Acel.12490  0.3
2016 De Guio F, Jouvent E, Biessels GJ, Black SE, Brayne C, Chen C, Cordonnier C, De Leeuw FE, Dichgans M, Doubal F, Duering M, Dufouil C, Duzel E, Fazekas F, Hachinski V, ... ... Seshadri S, et al. Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27170700 DOI: 10.1177/0271678X16647396  0.302
2016 Pase MP, Beiser A, Enserro D, Xanthakis V, Aparicio H, Satizabal CL, Himali JJ, Kase CS, Vasan RS, DeCarli C, Seshadri S. Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia. Stroke; a Journal of Cerebral Circulation. PMID 27073239 DOI: 10.1161/Strokeaha.115.012608  0.357
2016 Therkelsen KE, Preis SR, Beiser A, DeCarli C, Seshadri S, Wolf P, Au R, Fox CS. Neck Circumference, Brain Imaging Measures, and Neuropsychological Testing Measures. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. PMID 27056441 DOI: 10.1016/J.Jstrokecerebrovasdis.2016.02.016  0.304
2016 Salinas J, Beiser A, Himali JJ, Rosand J, Seshadri S, Dunn EC. Factors Associated With New-Onset Depression After Stroke. The Journal of Neuropsychiatry and Clinical Neurosciences. appineuropsych151103. PMID 27056020 DOI: 10.1176/Appi.Neuropsych.15110388  0.32
2016 Jak AJ, Preis SR, Beiser AS, Seshadri S, Wolf PA, Bondi MW, Au R. Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study. Journal of the International Neuropsychological Society : Jins. 1-7. PMID 27029348 DOI: 10.1017/S1355617716000199  0.353
2016 Romero JR, Preis SR, Beiser A, DeCarli C, D'Agostino RB, Wolf PA, Vasan RS, Polak JF, Seshadri S. Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study. Journal of the American Heart Association. 5. PMID 26994127 DOI: 10.1161/Jaha.115.002377  0.392
2016 Maillard P, Mitchell GF, Himali JJ, Beiser A, Tsao CW, Pase MP, Satizabal CL, Vasan RS, Seshadri S, DeCarli C. Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. PMID 26965846 DOI: 10.1161/Strokeaha.116.012949  0.311
2016 Malik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, Zhao W, Abrantes P, Amouyel P, Attia JR, Battey TW, Berger K, Boncoraglio GB, Chauhan G, Cheng YC, ... ... Seshadri S, et al. Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology. PMID 26935894 DOI: 10.1212/Wnl.0000000000002528  0.334
2016 Choi SH, Ruggiero D, Sorice R, Song C, Nutile T, Vernon Smith A, Concas MP, Traglia M, Barbieri C, Ndiaye NC, Stathopoulou MG, Lagou V, Maestrale GB, Sala C, Debette S, ... ... Seshadri S, et al. Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. Plos Genetics. 12: e1005874. PMID 26910538 DOI: 10.1371/Journal.Pgen.1005874  0.309
2016 Karakis I, Pase MP, Beiser A, Booth SL, Jacques PF, Rogers G, DeCarli C, Vasan RS, Wang TJ, Himali JJ, Annweiler C, Seshadri S. Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study. Journal of Alzheimer's Disease : Jad. PMID 26890771 DOI: 10.3233/Jad-150991  0.405
2016 Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H. Silent Brain Infarction and Risk of Future Stroke: A Systematic Review and Meta-Analysis. Stroke; a Journal of Cerebral Circulation. PMID 26888534 DOI: 10.1161/Strokeaha.115.011889  0.36
2016 Satizabal CL, Beiser AS, Chouraki V, Chêne G, Dufouil C, Seshadri S. Incidence of Dementia over Three Decades in the Framingham Heart Study. The New England Journal of Medicine. 374: 523-32. PMID 26863354 DOI: 10.1056/Nejmoa1504327  0.329
2016 Tsao CW, Himali JJ, Beiser AS, Larson MG, DeCarli C, Vasan RS, Mitchell GF, Seshadri S. Association of arterial stiffness with progression of subclinical brain and cognitive disease. Neurology. PMID 26791155 DOI: 10.1212/Wnl.0000000000002368  0.339
2016 Pase MP, Himali JJ, Mitchell GF, Beiser A, Maillard P, Tsao C, Larson MG, DeCarli C, Vasan RS, Seshadri S. Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study. Hypertension. PMID 26754644 DOI: 10.1161/Hypertensionaha.115.06610  0.363
2016 Freudenberger P, Petrovic K, Sen A, Töglhofer AM, Fixa A, Hofer E, Perl S, Zweiker R, Seshadri S, Schmidt R, Schmidt H. Fitness and cognition in the elderly: The Austrian Stroke Prevention Study. Neurology. PMID 26740674 DOI: 10.1212/Wnl.0000000000002329  0.348
2016 Cheng YC, Stanne TM, Giese AK, Ho WK, Traylor M, Amouyel P, Holliday EG, Malik R, Xu H, Kittner SJ, Cole JW, O'Connell JR, Danesh J, Rasheed A, Zhao W, ... ... Seshadri S, et al. Genome-Wide Association Analysis of Young Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke; a Journal of Cerebral Circulation. PMID 26732560 DOI: 10.1161/Strokeaha.115.011328  0.358
2016 Williams SR, Hsu FC, Keene KL, Chen WM, Nelson S, Southerland AM, Madden EB, Coull B, Gogarten SM, Furie KL, Dzhivhuho G, Rowles JL, Mehndiratta P, Malik R, Dupuis J, ... ... Seshadri S, et al. Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke. Neurology. 86: 351-9. PMID 26718567 DOI: 10.1212/Wnl.0000000000002319  0.347
2016 Jian X, Bis JC, Kunkle BW, Hamilton KL, Beecham GW, Bush WS, Salerno W, Lancour D, Ma Y, Chen Y, DeStefano AL, Dupuis J, Boerwinkle E, Schellenberg GD, Seshadri S, et al. Rare Deleterious And Loss-Of-Function Variants In Oprl1 And Gas2L2 Contribute To The Risk Of Late-Onset Alzheimer’S Disease: Alzheimer’S Disease Sequencing Project Case-Control Study Alzheimers & Dementia. 12: 163. DOI: 10.1016/J.Jalz.2016.06.765  0.319
2016 Huang K, Jin SC, Harari O, Kapoor M, Bertelsen S, Czajkowski J, Lambert j, Chouraki V, Bellenguez C, Grenier-Boley B, Deming Y, McKenzie A, Renton AE, Budde J, Del-Aguila JL, ... ... Seshadri S, et al. A Common Allele In Spi1 Lowers Risk And Delays Age At Onset For Alzheimer'S Disease Alzheimers & Dementia. 12: 253. DOI: 10.1016/J.Jalz.2016.06.453  0.372
2016 Pase MP, Beiser AS, Himali JJ, Tsao C, Satizabal CL, Vasan RS, Seshadri S, Mitchell GF. Aortic Stiffness And The Risk Of Incident Mild Cognitive Impairment And Dementia Alzheimers & Dementia. 12: 247. DOI: 10.1016/J.Jalz.2016.06.442  0.351
2016 Chen Y, DeStefano AL, Bis JC, Jian X, Lee SJvd, Choi SH, Ahmad S, Cupples LA, Mosley TH, Fitzpatrick AL, Lopez OL, Ikram MA, Psaty BM, Boerwinkle E, Duijn CMv, ... Seshadri S, et al. Identification Of Whole Exome Sequencing Variants Associated With Late-Onset Alzheimer'S Disease In The Cohorts For Heart And Aging Research In Genomic Epidemiology (Charge) Consortium Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.344  0.346
2016 Marcora E, Renton AE, Beecham GW, Boerwinkle E, Cantwell L, Cruchaga C, Cweibel R, Felsenfeld A, Fornage M, Kapoor M, Kauwe K, Khaladkar M, Kobolt D, Ma Y, Mayeux R, ... ... Seshadri S, et al. F1-01-02: Alzheimer's Disease Sequencing Project: Search for Alzheimer's Disease Resilience Genes That May Modify Disease Susceptibility in Specific Apoe Genotype Backgrounds Alzheimer's & Dementia. 12: P162-P163. DOI: 10.1016/J.Jalz.2016.06.272  0.317
2016 Knopman DS, Wang W, Whitmer RA, Launer LJ, Seshadri S, Kalaria RN, Prince MJ, Snyder HM, Carrillo MC, Amouyel P. Epidemiology Of Vascular Related Risk Factors For Dementia Alzheimers & Dementia. 12: 276. DOI: 10.1016/J.Jalz.2016.06.2384  0.349
2016 Yuan J, Himali JJ, Beiser AS, McKee AC, Stein TD, Seshadri S, Auerbach SH, Wolf PA, Au R, Delano-Wood L. P3-297: CVD is Pathologically Associated with Greater Alzheimer's Disease in Non-Demented Older Adults Alzheimer's & Dementia. 12: P954-P955. DOI: 10.1016/J.Jalz.2016.06.1961  0.331
2015 Nayor M, Enserro DM, Beiser AS, Cheng S, DeCarli C, Vasan RS, Seshadri S. Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. PMID 26696648 DOI: 10.1161/Strokeaha.115.010405  0.375
2015 Harris SE, Malik R, Marioni R, Campbell A, Seshadri S, Worrall BB, Sudlow CL, Hayward C, Bastin ME, Starr JM, Porteous DJ, Wardlaw JM, Deary IJ. Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology. PMID 26695942 DOI: 10.1212/Wnl.0000000000002306  0.398
2015 Pase MP, Beiser A, Aparicio H, DeCarli C, Ramachandran V, Murabito J, Seshadri S. Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26542262 DOI: 10.1016/J.Jalz.2015.09.006  0.329
2015 Seshadri S, Moonis M. Dipping to clear amyloid: Cerebrovascular reactivity and neurodegeneration--cause or effect? Neurology. 85: 1918-9. PMID 26537050 DOI: 10.1212/Wnl.0000000000002177  0.359
2015 Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N, Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, ... ... Seshadri S, et al. Common polygenic variation enhances risk prediction for Alzheimer's disease. Brain : a Journal of Neurology. PMID 26490334 DOI: 10.1093/Brain/Awv268  0.366
2015 Knopman DS, Beiser A, Machulda MM, Fields J, Roberts RO, Pankratz VS, Aakre J, Cha RH, Rocca WA, Mielke MM, Boeve BF, Devine S, Ivnik RJ, Au R, Auerbach S, ... ... Seshadri S, et al. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 85: 1712-21. PMID 26453643 DOI: 10.1212/Wnl.0000000000002100  0.35
2015 Hofer E, Cavalieri M, Bis JC, DeCarli C, Fornage M, Sigurdsson S, Srikanth V, Trompet S, Verhaaren BF, Wolf C, Yang Q, Adams HH, Amouyel P, Beiser A, Buckley BM, ... ... Seshadri S, et al. White Matter Lesion Progression: Genome-Wide Search for Genetic Influences. Stroke; a Journal of Cerebral Circulation. PMID 26451028 DOI: 10.1161/Strokeaha.115.009252  0.365
2015 Luciano M, Marioni RE, Valdés Hernández M, Muñoz Maniega S, Hamilton IF, Royle NA, Chauhan G, Bis JC, Debette S, DeCarli C, Fornage M, Schmidt R, Ikram MA, Launer LJ, ... Seshadri S, et al. Structural Brain MRI Trait Polygenic Score Prediction of Cognitive Abilities. Twin Research and Human Genetics : the Official Journal of the International Society For Twin Studies. 1-8. PMID 26427786 DOI: 10.1017/Thg.2015.71  0.35
2015 Nishtala A, Himali JJ, Beiser A, Murabito JM, Seshadri S, Wolf PA, Au R. Midlife Hypertension Risk and Cognition in the Non-Demented Oldest Old: Framingham Heart Study. Journal of Alzheimer's Disease : Jad. 47: 197-204. PMID 26402768 DOI: 10.3233/Jad-141881  0.369
2015 Saber H, Himali JJ, Shoamanesh A, Beiser A, Pikula A, Harris TB, Roubenoff R, Romero JR, Kase CS, Vasan RS, Seshadri S. Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke; a Journal of Cerebral Circulation. 46: 2881-5. PMID 26337973 DOI: 10.1161/Strokeaha.115.009463  0.357
2015 Olson NC, Butenas S, Lange LA, Lange EM, Cushman M, Jenny NS, Walston J, Souto JC, Soria JM, Chauhan G, Debette S, Longstreth WT, Seshadri S, Reiner AP, Tracy RP. Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study. Journal of Thrombosis and Haemostasis : Jth. 13: 1867-77. PMID 26286125 DOI: 10.1111/Jth.13111  0.372
2015 Andersson C, Preis SR, Beiser A, DeCarli C, Wollert KC, Wang TJ, Januzzi JL, Vasan RS, Seshadri S. Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident Stroke. Stroke; a Journal of Cerebral Circulation. PMID 26219649 DOI: 10.1161/Strokeaha.115.009026  0.349
2015 Miller IN, Himali JJ, Beiser AS, Murabito JM, Seshadri S, Wolf PA, Au R. Normative Data for the Cognitively Intact Oldest-Old: The Framingham Heart Study. Experimental Aging Research. 41: 386-409. PMID 26214098 DOI: 10.1080/0361073X.2015.1053755  0.317
2015 Hanscombe KB, Traylor M, Hysi PG, Bevan S, Dichgans M, Rothwell PM, Worrall BB, Seshadri S, Sudlow C, Williams FM, Markus HS, Lewis CM. Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. Stroke; a Journal of Cerebral Circulation. 46: 2069-74. PMID 26159793 DOI: 10.1161/Strokeaha.115.009387  0.368
2015 Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, ... ... Seshadri S, et al. Directional dominance on stature and cognition in diverse human populations. Nature. 523: 459-62. PMID 26131930 DOI: 10.1038/Nature14618  0.33
2015 Aparicio HJ, Seshadri S. Heart of the Matter. Stroke; a Journal of Cerebral Circulation. 46: 1755-6. PMID 26022635 DOI: 10.1161/Strokeaha.115.009348  0.381
2015 Auer PL, Nalls M, Meschia JF, Worrall BB, Longstreth WT, Seshadri S, Kooperberg C, Burger KM, Carlson CS, Carty CL, Chen WM, Cupples LA, DeStefano AL, Fornage M, Hardy J, et al. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. Jama Neurology. 72: 781-8. PMID 25961151 DOI: 10.1001/Jamaneurol.2015.0582  0.381
2015 Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, de Vries B, Holliday EG, Terwindt GM, Sturm J, Bis JC, Hopewell JC, Ferrari MD, Rannikmae K, Wessman M, ... ... Seshadri S, et al. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology. 84: 2132-45. PMID 25934857 DOI: 10.1212/Wnl.0000000000001606  0.326
2015 Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, Davies G, Trompet S, Smith JA, Wolf C, Chibnik LB, Liu Y, Vitart V, Kirin M, Petrovic K, ... ... Seshadri S, et al. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Molecular Psychiatry. PMID 25869804 DOI: 10.1038/Mp.2015.37  0.343
2015 Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, ... ... Seshadri S, et al. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 131: 2061-9. PMID 25862742 DOI: 10.1161/Circulationaha.115.015489  0.344
2015 van der Lee SJ, Holstege H, Wong TH, Jakobsdottir J, Bis JC, Chouraki V, van Rooij JG, Grove ML, Smith AV, Amin N, Choi SH, Beiser AS, Garcia ME, van IJcken WF, Pijnenburg YA, ... ... Seshadri S, et al. PLD3 variants in population studies. Nature. 520: E2-3. PMID 25832410 DOI: 10.1038/Nature14038  0.328
2015 Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Seshadri S, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/Mp.2015.23  0.351
2015 Kaess BM, Preis SR, Lieb W, Beiser AS, Yang Q, Chen TC, Hengstenberg C, Erdmann J, Schunkert H, Seshadri S, Vasan RS, Assimes TL, Deloukas P, Holm H, et al. Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. Journal of the American Heart Association. 4: e001544. PMID 25762803 DOI: 10.1161/Jaha.114.001544  0.344
2015 Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O'Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ. Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study. Circulation. 131: 1333-9. PMID 25700178 DOI: 10.1161/Circulationaha.114.012438  0.389
2015 Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, ... ... Seshadri S, et al. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry. PMID 25687773 DOI: 10.1038/Mp.2015.6  0.344
2015 Chauhan G, Adams HH, Bis JC, Weinstein G, Yu L, Töglhofer AM, Smith AV, van der Lee SJ, Gottesman RF, Thomson R, Wang J, Yang Q, Niessen WJ, Lopez OL, Becker JT, ... ... Seshadri S, et al. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging. Neurobiology of Aging. 36: 1765.e7-16. PMID 25670335 DOI: 10.1016/J.Neurobiolaging.2014.12.028  0.419
2015 Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, ... ... Seshadri S, et al. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology. 84: 918-26. PMID 25653287 DOI: 10.1212/Wnl.0000000000001309  0.34
2015 Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, ... ... Seshadri S, et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Molecular Psychiatry. 20: 183-92. PMID 25644384 DOI: 10.1038/Mp.2014.188  0.36
2015 Shoamanesh A, Preis SR, Beiser AS, Vasan RS, Benjamin EJ, Kase CS, Wolf PA, DeCarli C, Romero JR, Seshadri S. Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology. 84: 825-32. PMID 25632086 DOI: 10.1212/Wnl.0000000000001279  0.32
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, Cheng YC, Cotlarciuc I, Bis JC, Boerwinkle E, Boncoraglio GB, Clarke R, Cole JW, Fornage M, Furie KL, ... ... Seshadri S, et al. Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke; a Journal of Cerebral Circulation. 46: 615-9. PMID 25613305 DOI: 10.1161/Strokeaha.114.007930  0.345
2015 Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, ... ... Seshadri S, et al. Common genetic variants influence human subcortical brain structures. Nature. 520: 224-9. PMID 25607358 DOI: 10.1038/Nature14101  0.323
2015 Lopez LM, Hill WD, Harris SE, Valdes Hernandez M, Munoz Maniega S, Bastin ME, Bailey E, Smith C, McBride M, McClure J, Graham D, Dominiczak A, Yang Q, Fornage M, Ikram MA, ... ... Seshadri S, et al. Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke; a Journal of Cerebral Circulation. 46: 341-7. PMID 25586835 DOI: 10.1161/Strokeaha.114.007649  0.397
2015 Pikula A, Beiser AS, Wang J, Himali JJ, Kelly-Hayes M, Kase CS, Yang Q, Seshadri S, Wolf PA. Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study. Neurology. 84: 472-9. PMID 25568296 DOI: 10.1212/Wnl.0000000000001202  0.33
2015 Jefferson AL, Beiser AS, Seshadri S, Wolf PA, Au R. APOE and mild cognitive impairment: the Framingham Heart Study. Age and Ageing. 44: 307-11. PMID 25497326 DOI: 10.1093/Ageing/Afu183  0.33
2015 Chouraki V, Beiser A, Younkin L, Preis SR, Weinstein G, Hansson O, Skoog I, Lambert JC, Au R, Launer L, Wolf PA, Younkin S, Seshadri S. Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 249-57.e1. PMID 25217292 DOI: 10.1016/J.Jalz.2014.07.001  0.355
2015 Chêne G, Beiser A, Au R, Preis SR, Wolf PA, Dufouil C, Seshadri S. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 310-20. PMID 24418058 DOI: 10.1016/J.Jalz.2013.10.005  0.382
2015 Lee SJvd, Adams HHH, Chouraki V, Satizabal CL, Yang Q, Li S, Debette SA, Yanek LR, DeCarli C, Hofer E, Yu L, Smith AV, Amin N, Seshadri S, Launer LJ, et al. Genome-wide association study of lobar brain volumes Alzheimers & Dementia. 11: 278. DOI: 10.1016/J.Jalz.2015.07.370  0.306
2015 Blacker D, Qian J, Beiser AS, Haan M, Karlawish J, Langbaum JB, Reiman EM, Neuhaus J, Seshadri S, Tariot PN, Betensky RA. O1-10-03: APOE risk in the Alzheimer's prevention initiative Alzheimer's & Dementia. 11: P154-P155. DOI: 10.1016/J.Jalz.2015.07.083  0.314
2015 Chouraki V, Preis SR, Yang Q, Beiser AS, Li S, Larson MG, Vasan RS, Seshadri S. O1-04-06: Association of plasma biomarkers with risk of incident dementia in the framingham heart study: A metabolomics approach Alzheimer's & Dementia. 11: P134-P135. DOI: 10.1016/J.Jalz.2015.07.050  0.335
2015 Seshadri S. S1-01-04: Vascular contributions to cognitive impairment Alzheimer's & Dementia. 11: P114-P114. DOI: 10.1016/J.Jalz.2015.07.005  0.3
2015 Weinstein G, Preis SR, Beiser AS, Satizabal CL, Spartano NL, Chen TC, Ramachandran VS, Seshadri S. P3-081: Associations between BDNF serum levels and Alzheimer's disease-related measures: The framingham study Alzheimer's & Dementia. 11: P649-P649. DOI: 10.1016/J.Jalz.2015.06.948  0.325
2015 Satizabal CL, Himali JJ, Beiser AS, Maillard P, DeCarli C, Ramachandran VS, Seshadri S. P1-244: Adipokines are associated with MRI markers of brain aging in young adults Alzheimer's & Dementia. 11: P446-P447. DOI: 10.1016/J.Jalz.2015.06.444  0.314
2014 Seshadri S. Indexes of subclinical atherosclerosis: signposts on the highway to disease. Jacc. Cardiovascular Imaging. 7: 1116-8. PMID 25459593 DOI: 10.1016/J.Jcmg.2014.09.004  0.321
2014 Weinstein G, Preis SR, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S. Cognitive performance after stroke--the Framingham Heart Study. International Journal of Stroke : Official Journal of the International Stroke Society. 9: 48-54. PMID 25352473 DOI: 10.1111/Ijs.12275  0.403
2014 Dufouil C, Seshadri S, Chêne G. Cardiovascular risk profile in women and dementia. Journal of Alzheimer's Disease : Jad. 42: S353-63. PMID 25351109 DOI: 10.3233/Jad-141629  0.344
2014 Chouraki V, Seshadri S. Genetics of Alzheimer's disease. Advances in Genetics. 87: 245-94. PMID 25311924 DOI: 10.1016/B978-0-12-800149-3.00005-6  0.359
2014 French CR, Seshadri S, Destefano AL, Fornage M, Arnold CR, Gage PJ, Skarie JM, Dobyns WB, Millen KJ, Liu T, Dietz W, Kume T, Hofker M, Emery DJ, Childs SJ, et al. Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. The Journal of Clinical Investigation. 124: 4877-81. PMID 25250569 DOI: 10.1172/Jci75109  0.381
2014 Lüneburg N, Lieb W, Zeller T, Chen MH, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT, Fornage M, König IR, Loley C, et al. Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. Circulation. Cardiovascular Genetics. 7: 864-72. PMID 25245031 DOI: 10.1161/Circgenetics.113.000264  0.318
2014 Weinstein G, Seshadri S. Circulating biomarkers that predict incident dementia. Alzheimer's Research & Therapy. 6: 6. PMID 25031629 DOI: 10.1186/Alzrt235  0.372
2014 Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, ... ... Seshadri S, et al. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology. 83: 678-85. PMID 25031287 DOI: 10.1212/Wnl.0000000000000707  0.348
2014 Bis JC, DeStefano A, Liu X, Brody JA, Choi SH, Verhaaren BF, Debette S, Ikram MA, Shahar E, Butler KR, Gottesman RF, Muzny D, Kovar CL, Psaty BM, Hofman A, ... ... Seshadri S, et al. Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium. Plos One. 9: e99798. PMID 24959832 DOI: 10.1371/Journal.Pone.0099798  0.399
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Seshadri S, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661  0.345
2014 Weinstein G, Seshadri S. Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply. Jama Neurology. 71: 653-4. PMID 24818683 DOI: 10.1001/Jamaneurol.2014.215  0.327
2014 Seshadri S, de Leeuw FE. Understanding brain function through small vessel disease: what zebras can teach us about horses. Neurology. 82: 1940-1. PMID 24793189 DOI: 10.1212/Wnl.0000000000000484  0.33
2014 Romero JR, Preis SR, Beiser A, DeCarli C, Viswanathan A, Martinez-Ramirez S, Kase CS, Wolf PA, Seshadri S. Risk factors, stroke prevention treatments, and prevalence of cerebral microbleeds in the Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. 45: 1492-4. PMID 24713533 DOI: 10.1161/Strokeaha.114.004130  0.404
2014 Westwood AJ, Beiser A, Decarli C, Harris TB, Chen TC, He XM, Roubenoff R, Pikula A, Au R, Braverman LE, Wolf PA, Vasan RS, Seshadri S. Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy. Neurology. 82: 1613-9. PMID 24706014 DOI: 10.1212/Wnl.0000000000000382  0.371
2014 Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, ... ... Seshadri S, et al. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke. Plos Genetics. 10: e1004214. PMID 24651765 DOI: 10.1371/Journal.Pgen.1004214  0.398
2014 Kaur B, Himali JJ, Seshadri S, Beiser AS, Au R, McKee AC, Auerbach S, Wolf PA, DeCarli CS. Association between neuropathology and brain volume in the Framingham Heart Study. Alzheimer Disease and Associated Disorders. 28: 219-25. PMID 24614264 DOI: 10.1097/Wad.0000000000000032  0.344
2014 Ruiz A, Heilmann S, Becker T, Hernández I, Wagner H, Thelen M, Mauleón A, Rosende-Roca M, Bellenguez C, Bis JC, Harold D, Gerrish A, Sims R, Sotolongo-Grau O, Espinosa A, ... ... Seshadri S, et al. Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene. Translational Psychiatry. 4: e358. PMID 24495969 DOI: 10.1038/Tp.2014.2  0.341
2014 Ibrahim-Verbaas CA, Fornage M, Bis JC, Choi SH, Psaty BM, Meigs JB, Rao M, Nalls M, Fontes JD, O'Donnell CJ, Kathiresan S, Ehret GB, Fox CS, Malik R, Dichgans M, ... ... Seshadri S, et al. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke; a Journal of Cerebral Circulation. 45: 403-12. PMID 24436238 DOI: 10.1161/Strokeaha.113.003044  0.381
2014 Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, de Stefano AL, Fornage M, Psaty BM, Ikram MA, Launer LJ, ... ... Seshadri S, et al. Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke; a Journal of Cerebral Circulation. 45: 394-402. PMID 24436234 DOI: 10.1161/Strokeaha.113.002938  0.39
2014 Weinstein G, Beiser AS, Choi SH, Preis SR, Chen TC, Vorgas D, Au R, Pikula A, Wolf PA, DeStefano AL, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. Jama Neurology. 71: 55-61. PMID 24276217 DOI: 10.1001/Jamaneurol.2013.4781  0.364
2014 Dichgans M, Malik R, König IR, Rosand J, Clarke R, Gretarsdottir S, Thorleifsson G, Mitchell BD, Assimes TL, Levi C, O'Donnell CJ, Fornage M, Thorsteinsdottir U, Psaty BM, Hengstenberg C, ... Seshadri S, et al. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke; a Journal of Cerebral Circulation. 45: 24-36. PMID 24262325 DOI: 10.1161/Strokeaha.113.002707  0.345
2014 Murabito JM, Beiser AS, Decarli C, Seshadri S, Wolf PA, Au R. Parental longevity is associated with cognition and brain ageing in middle-aged offspring. Age and Ageing. 43: 358-63. PMID 24212919 DOI: 10.1093/Ageing/Aft175  0.35
2014 Nishtala A, Preis SR, Beiser A, Devine S, Hankee L, Seshadri S, Wolf PA, Au R. Midlife cardiovascular risk impacts executive function: Framingham offspring study. Alzheimer Disease and Associated Disorders. 28: 16-22. PMID 23995818 DOI: 10.1097/Wad.0B013E3182A715Bc  0.303
2014 Boada M, Antúnez C, Ramírez-Lorca R, DeStefano AL, González-Pérez A, Gayán J, López-Arrieta J, Ikram MA, Hernández I, Marín J, Galán JJ, Bis JC, Mauleón A, Rosende-Roca M, Moreno-Rey C, ... ... Seshadri S, et al. ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. Molecular Psychiatry. 19: 682-7. PMID 23857120 DOI: 10.1038/Mp.2013.86  0.351
2014 Li M, Luo XJ, Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, Nöthen MM, Schulze TG, Sullivan PF, Bergen SE, ... ... Seshadri S, et al. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Molecular Psychiatry. 19: 452-61. PMID 23568192 DOI: 10.1038/Mp.2013.37  0.338
2014 Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Connelly JJ, Lillard TS, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, ... ... Seshadri S, et al. Correction to Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke (PLoS Genet, (2014), 10, 7 (e1004571), 10.1371/journal.pgen.1004571) Plos Genetics. 10. DOI: 10.1371/Journal.Pgen.1004571  0.316
2014 Bangen K, Himali J, Beiser A, Delano-Wood L, Nation DA, Lamar M, Libon D, Bondi M, Seshadri S, Wolf P, McKee A, Au R. P1-315: INFLUENCE OF MIDLIFE ELEVATED BLOOD GLUCOSE AND APOE GENOTYPE ON VASCULAR AND ALZHEIMER'S DISEASE NEUROPATHOLOGY Alzheimer's & Dementia. 10: P427-P427. DOI: 10.1016/J.Jalz.2014.05.556  0.316
2014 Chauhan G, Adams HHH, Bis J, Weinstein G, Yu L, Smith A, Lee Svd, Lopez O, Becker JT, Vernooij M, Schmidt H, Srikanth V, Knopman DS, Amouyel P, DeCarli C, ... ... Seshadri S, et al. Association Of Alzheimer Disease Gwas Loci With Mri-Markers Of Brain Aging Alzheimers & Dementia. 10: 258. DOI: 10.1016/J.Jalz.2014.04.406  0.386
2014 Chouraki VA, DeStefano A, Bellenguez C, Reitz C, Duijn Cv, Bennett D, Maury F, Lambert J, Jakobsdottir J, Bis JC, Launer L, Crane P, Mayeux R, Choi SH, Seshadri S. Do The Variants Identified In Igap Improve Risk Prediction Of Alzheimer'S Disease? Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.04.377  0.355
2014 Dourlen P, Dermaut B, Grenier-Boley B, Bellenguez C, Dupont C, Abdelfettah F, Schellenberg GD, Lambert J, Williams J, Amouyel P, Seshadri S. Functional Validation Of Novel Alzheimer Genetic Risk Loci Using Drosophila Alzheimers & Dementia. 10: 246. DOI: 10.1016/J.Jalz.2014.04.376  0.335
2014 Lee SJvd, Naj A, Duijn Cv, Schellenberg GD, Jakobsdottir J, Williams J, Wang L, Vronskaya M, Amouyel P, Sims R, Seshadri S. Exome Chip Meta-Analysis Of Alzheimer'S Disease In The Igap Consortium Alzheimers & Dementia. 10: 245. DOI: 10.1016/J.Jalz.2014.04.374  0.32
2014 WF, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, RP, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, ... ... Seshadri S, et al. Erratum: Ischemic stroke is associated with the ABO locus: The EuroCLOT study (Annals of Neurology (2013) 73 (16-31)) Annals of Neurology. 75: 166-167. DOI: 10.1002/Ana.24105  0.338
2013 Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, ... ... Seshadri S, et al. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. Bmc Neurology. 13: 165. PMID 24195705 DOI: 10.1186/1471-2377-13-165  0.357
2013 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Seshadri S, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802  0.361
2013 Hankee LD, Preis SR, Beiser AS, Devine SA, Liu Y, Seshadri S, Wolf PA, Au R. Qualitative neuropsychological measures: normative data on executive functioning tests from the Framingham offspring study. Experimental Aging Research. 39: 515-35. PMID 24151914 DOI: 10.1080/0361073X.2013.839029  0.323
2013 Pekkala S, Wiener D, Himali JJ, Beiser AS, Obler LK, Liu Y, McKee A, Auerbach S, Seshadri S, Wolf PA, Au R. Lexical retrieval in discourse: an early indicator of Alzheimer's dementia. Clinical Linguistics & Phonetics. 27: 905-21. PMID 23985011 DOI: 10.3109/02699206.2013.815278  0.315
2013 Rosenquist KJ, Massaro JM, Pencina KM, D'Agostino RB, Beiser A, O'Connor GT, O'Donnell CJ, Wolf PA, Polak JF, Seshadri S, Fox CS. Neck circumference, carotid wall intima-media thickness, and incident stroke. Diabetes Care. 36: e153-4. PMID 23970728 DOI: 10.2337/Dc13-0379  0.341
2013 Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, ... ... Seshadri S, et al. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 128: 1310-24. PMID 23969696 DOI: 10.1161/Circulationaha.113.002251  0.368
2013 Tsao CW, Seshadri S, Beiser AS, Westwood AJ, Decarli C, Au R, Himali JJ, Hamburg NM, Vita JA, Levy D, Larson MG, Benjamin EJ, Wolf PA, Vasan RS, Mitchell GF. Relations of arterial stiffness and endothelial function to brain aging in the community. Neurology. 81: 984-91. PMID 23935179 DOI: 10.1212/Wnl.0B013E3182A43E1C  0.315
2013 Pikula A, Beiser AS, Chen TC, Preis SR, Vorgias D, DeCarli C, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Serum brain-derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham Study. Stroke; a Journal of Cerebral Circulation. 44: 2768-75. PMID 23929745 DOI: 10.1161/Strokeaha.113.001447  0.341
2013 Weinstein G, Beiser AS, Decarli C, Au R, Wolf PA, Seshadri S. Brain imaging and cognitive predictors of stroke and Alzheimer disease in the Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. 44: 2787-94. PMID 23920020 DOI: 10.1161/Strokeaha.113.000947  0.444
2013 Seshadri S. Delaying dementia: can antihypertensives prevent Alzheimer dementia? Neurology. 81: 860-2. PMID 23911755 DOI: 10.1212/Wnl.0B013E3182A35296  0.375
2013 Schilling S, DeStefano AL, Sachdev PS, Choi SH, Mather KA, DeCarli CD, Wen W, Høgh P, Raz N, Au R, Beiser A, Wolf PA, Romero JR, Zhu YC, Lunetta KL, ... ... Seshadri S, et al. APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis. Neurology. 81: 292-300. PMID 23858411 DOI: 10.1212/Wnl.0B013E31829Bfda4  0.405
2013 Romero JR, Mercado M, Beiser AS, Pikula A, Seshadri S, Kelly-Hayes M, Wolf PA, Kase CS. Transient global amnesia and neurological events: the framingham heart study. Frontiers in Neurology. 4: 47. PMID 23675365 DOI: 10.3389/Fneur.2013.00047  0.355
2013 Bangen KJ, Beiser A, Delano-Wood L, Nation DA, Lamar M, Libon DJ, Bondi MW, Seshadri S, Wolf PA, Au R. APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 22: 1361-9. PMID 23601373 DOI: 10.1016/J.Jstrokecerebrovasdis.2013.03.013  0.363
2013 Williams FM, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, Traylor M, Bevan S, Dichgans M, Rothwell PM, Sudlow C, Farrall M, Silander K, Kaunisto M, Wagner P, ... ... Seshadri S, et al. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Annals of Neurology. 73: 16-31. PMID 23381943 DOI: 10.1002/Ana.23838  0.366
2013 Weinstein G, Beiser AS, Au R, Decarli C, Wolf PA, Seshadri S. Association of parental stroke with brain injury and cognitive measures in offspring: the Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. 44: 812-5. PMID 23362080 DOI: 10.1161/Strokeaha.112.680520  0.368
2013 Nyborn JA, Himali JJ, Beiser AS, Devine SA, Du Y, Kaplan E, O'Connor MK, Rinn WE, Denison HS, Seshadri S, Wolf PA, Au R. The Framingham Heart Study clock drawing performance: normative data from the offspring cohort. Experimental Aging Research. 39: 80-108. PMID 23316738 DOI: 10.1080/0361073X.2013.741996  0.315
2013 Weinstein G, Wolf PA, Beiser AS, Au R, Seshadri S. Risk estimations, risk factors, and genetic variants associated with Alzheimer's disease in selected publications from the Framingham Heart Study. Journal of Alzheimer's Disease : Jad. 33: S439-45. PMID 22796871 DOI: 10.3233/Jad-2012-129040  0.418
2013 Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, DeCarli C, Milberg W. Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 22: 119-25. PMID 21835633 DOI: 10.1016/J.Jstrokecerebrovasdis.2011.06.020  0.354
2013 Chouraki V, Beiser A, Younkin L, Au R, DeCarli C, Wolf P, Younkin S, Seshadri S. P1-235: Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study Alzheimer's & Dementia. 9: P238-P239. DOI: 10.1016/J.Jalz.2013.05.459  0.399
2013 Weinstein G, Beiser A, Preis S, Chen TC, Vorgas D, Au R, Pikula A, Wolf P, Ramachandran VS, Seshadri S. Serum brain-derived neurotrophic factor and risk of dementia: The Framingham Heart Study Alzheimers & Dementia. 9: 232. DOI: 10.1016/J.Jalz.2013.05.443  0.359
2013 Choi SH, Reitz C, Chouraki V, Mukherjee S, Yu L, Ikram M, Bis J, Ibrahim-Verbaas C, Bruijn Rd, Vardarajan B, Fitzpatrick A, Lopez O, Launer L, Grenier-Bolay B, Larson E, ... ... Seshadri S, et al. Genetic variants associated with incidence of late-onset Alzheimer's disease in Caucasians Alzheimers & Dementia. 9: 176. DOI: 10.1016/J.Jalz.2013.05.286  0.358
2013 Weinstein G, Beiser A, Courchesne P, Chouraki V, Au R, Wolf P, Levy D, Seshadri S. O4-02-01: Plasma clusterin levels and risk of dementia and Alzheimer's disease: The Framingham Heart Study Alzheimer's & Dementia. 9: P681-P681. DOI: 10.1016/J.Jalz.2013.04.340  0.356
2012 Chen MH, Huang J, Chen WM, Larson MG, Fox CS, Vasan RS, Seshadri S, O'Donnell CJ, Yang Q. Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study. Plos One. 7: e51589. PMID 23284720 DOI: 10.1371/Journal.Pone.0051589  0.303
2012 Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O, Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity in young adults in the Framingham Heart Study: a cross-sectional study. The Lancet. Neurology. 11: 1039-47. PMID 23122892 DOI: 10.1016/S1474-4422(12)70241-7  0.343
2012 Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth W, Wiggins KL, Yadav S, ... ... Seshadri S, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. The Lancet. Neurology. 11: 951-62. PMID 23041239 DOI: 10.1016/S1474-4422(12)70234-X  0.387
2012 Jun G, Moncaster JA, Koutras C, Seshadri S, Buros J, McKee AC, Levesque G, Wolf PA, St George-Hyslop P, Goldstein LE, Farrer LA. δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. Plos One. 7: e43728. PMID 22984439 DOI: 10.1371/journal.pone.0043728  0.36
2012 Romero JR, Preis SR, Beiser AS, DeCarli C, Lee DY, Viswanathan A, Benjamin EJ, Fontes J, Au R, Pikula A, Wang J, Kase CS, Wolf PA, Irrizary MC, Seshadri S. Lipoprotein phospholipase A2 and cerebral microbleeds in the Framingham Heart Study. Stroke; a Journal of Cerebral Circulation. 43: 3091-4. PMID 22961963 DOI: 10.1161/Strokeaha.112.656744  0.353
2012 Kao PF, Banigan MG, Vanderburg CR, McKee AC, Polgar PR, Seshadri S, Delalle I. Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology. 71: 654-64. PMID 22710966 DOI: 10.1097/Nen.0B013E31825D06B7  0.347
2012 Seshadri S. Homocysteine and the risk of dementia. Clinical Chemistry. 58: 1059-60. PMID 22510400 DOI: 10.1373/Clinchem.2011.181099  0.307
2012 Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S, Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S, Verhaaren BF, ... ... Seshadri S, et al. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nature Genetics. 44: 545-51. PMID 22504421 DOI: 10.1038/Ng.2237  0.346
2012 Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, Kaakinen M, Kreiner-Møller E, Bradfield JP, Freathy RM, Geller F, Guxens M, Cousminer DL, Kerkhof M, Timpson NJ, ... ... Seshadri S, et al. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics. 44: 532-8. PMID 22504419 DOI: 10.1038/Ng.2238  0.302
2012 Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, Vrooman HA, Sigurdsson S, Ropele S, Taal HR, Mook-Kanamori DO, Coker LH, Longstreth WT, Niessen WJ, DeStefano AL, et al. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics. 44: 539-44. PMID 22504418 DOI: 10.1038/Ng.2245  0.312
2012 Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty MM, Christoforou A, ... ... Seshadri S, et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. 44: 552-61. PMID 22504417 DOI: 10.1038/Ng.2250  0.355
2012 Au R, Seshadri S, Knox K, Beiser A, Himali JJ, Cabral HJ, Auerbach S, Green RC, Wolf PA, McKee AC. The Framingham Brain Donation Program: neuropathology along the cognitive continuum. Current Alzheimer Research. 9: 673-86. PMID 22471865 DOI: 10.2174/156720512801322609  0.391
2012 Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation. 125: 2100-7. PMID 22456473 DOI: 10.1161/Circulationaha.110.989145  0.349
2012 Driver JA, Beiser A, Au R, Kreger BE, Splansky GL, Kurth T, Kiel DP, Lu KP, Seshadri S, Wolf PA. Inverse association between cancer and Alzheimer's disease: results from the Framingham Heart Study. Bmj (Clinical Research Ed.). 344: e1442. PMID 22411920 DOI: 10.1136/Bmj.E1442  0.347
2012 Tan ZS, Harris WS, Beiser AS, Au R, Himali JJ, Debette S, Pikula A, Decarli C, Wolf PA, Vasan RS, Robins SJ, Seshadri S. Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging. Neurology. 78: 658-64. PMID 22371413 DOI: 10.1212/Wnl.0B013E318249F6A9  0.34
2012 van Himbergen TM, Beiser AS, Ai M, Seshadri S, Otokozawa S, Au R, Thongtang N, Wolf PA, Schaefer EJ. Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study. Archives of Neurology. 69: 594-600. PMID 22213409 DOI: 10.1001/Archneurol.2011.670  0.338
2012 Hsieh YC, Seshadri S, Chung WT, Hsieh FI, Hsu YH, Lin HJ, Tseng HP, Lien LM, Bai CH, Hu CJ, Jeng JS, Tang SC, Chen CI, Yu CC, Chiou HY, et al. Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan. Journal of Biomedical Science. 19: 1. PMID 22212150 DOI: 10.1186/1423-0127-19-1  0.362
2012 Barral S, Fernández-Cadenas I, Bis JC, Montaner J, Ikram AM, Launer LJ, Fornage M, Schmidt H, Brickman AM, Seshadri S, Mayeux R. No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts. Neurobiology of Aging. 33: 629.e1-3. PMID 22074807 DOI: 10.1016/J.Neurobiolaging.2011.10.010  0.381
2012 Camargo E, Beiser A, Tan Z, Au R, DeCarli C, Pikula A, Kelly-Hayes M, Kase C, Wolf P, Seshadri S. Walking Speed, Handgrip Strength and Risk of Dementia and Stroke: The Framingham Offspring Study (S24.003) Neurology. 78: S24.003-S24.003. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S24.003  0.455
2012 Maillard P, Seshadri S, Beiser A, Fletcher E, Himali J, Preis S, Au R, Carmichael O, Wolf P, DeCarli C. Effects of Vascular Risk Factors on White Matter Integrity in Middle-Aged Adults: A Voxel-Based Diffusion Tensor Imaging Study (P03.089) Neurology. 78: P03.089-P03.089. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P03.089  0.306
2012 Rovira MB, Antunez C, Ramirez-Lorca R, Destefano A, González-Pérez A, Gayán J, López-Arrieta J, Ikram M, Hernandez I, Marín J, Galán JJ, Bis J, Mauleon A, Rosende-Roca M, Moreno-Rey C, ... ... Seshadri S, et al. ATP5H/KCTD2 locus and Alzheimer's disease: An etiological link between key brain functions and dementia Alzheimers & Dementia. 8: 721. DOI: 10.1016/J.Jalz.2012.05.2107  0.367
2011 Poly C, Massaro JM, Seshadri S, Wolf PA, Cho E, Krall E, Jacques PF, Au R. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. The American Journal of Clinical Nutrition. 94: 1584-91. PMID 22071706 DOI: 10.3945/Ajcn.110.008938  0.359
2011 Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang SJ, Pihur V, Vollenweider P, O'Reilly PF, Amin N, ... ... Seshadri S, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478: 103-9. PMID 21909115 DOI: 10.1038/Nature10405  0.3
2011 Jefferson AL, Himali JJ, Au R, Seshadri S, Decarli C, O'Donnell CJ, Wolf PA, Manning WJ, Beiser AS, Benjamin EJ. Relation of left ventricular ejection fraction to cognitive aging (from the Framingham Heart Study). The American Journal of Cardiology. 108: 1346-51. PMID 21880293 DOI: 10.1016/J.Amjcard.2011.06.056  0.407
2011 Schnabel RB, Kerr KF, Lubitz SA, Alkylbekova EL, Marcus GM, Sinner MF, Magnani JW, Wolf PA, Deo R, Lloyd-Jones DM, Lunetta KL, Mehra R, Levy D, Fox ER, Arking DE, ... ... Seshadri S, et al. Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circulation. Cardiovascular Genetics. 4: 557-64. PMID 21846873 DOI: 10.1161/Circgenetics.110.959197  0.363
2011 Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, DeCarli C. Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology. 77: 461-8. PMID 21810696 DOI: 10.1212/WNL.0b013e318227b227  0.386
2011 Walter S, Atzmon G, Demerath EW, Garcia ME, Kaplan RC, Kumari M, Lunetta KL, Milaneschi Y, Tanaka T, Tranah GJ, Völker U, Yu L, Arnold A, Benjamin EJ, Biffar R, ... ... Seshadri S, et al. A genome-wide association study of aging. Neurobiology of Aging. 32: 2109.e15-28. PMID 21782286 DOI: 10.1016/J.Neurobiolaging.2011.05.026  0.367
2011 Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, ... ... Seshadri S, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke; a Journal of Cerebral Circulation. 42: 2672-713. PMID 21778438 DOI: 10.1161/Str.0B013E3182299496  0.46
2011 Jefferson AL, Massaro JM, Beiser AS, Seshadri S, Larson MG, Wolf PA, Au R, Benjamin EJ. Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology. 37: 21-30. PMID 21757961 DOI: 10.1159/000328864  0.314
2011 Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, ... ... Seshadri S, et al. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Annals of Neurology. 69: 928-39. PMID 21681796 DOI: 10.1002/Ana.22403  0.37
2011 Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S. Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study. Diabetes Care. 34: 1766-70. PMID 21680719 DOI: 10.2337/Dc11-0308  0.359
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Seshadri S, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803  0.315
2011 Broer L, Ikram MA, Schuur M, DeStefano AL, Bis JC, Liu F, Rivadeneira F, Uitterlinden AG, Beiser AS, Longstreth WT, Hofman A, Aulchenko Y, Seshadri S, Fitzpatrick AL, Oostra BA, et al. Association of HSP70 and its co-chaperones with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 25: 93-102. PMID 21403392 DOI: 10.3233/Jad-2011-101560  0.351
2011 Seshadri S, Beiser A, Au R, Wolf PA, Evans DA, Wilson RS, Petersen RC, Knopman DS, Rocca WA, Kawas CH, Corrada MM, Plassman BL, Langa KM, Chui HC. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 35-52. PMID 21255742 DOI: 10.1016/J.Jalz.2010.12.002  0.372
2011 Jefferson A, Beiser A, Seshadri S, Wolf P, Au R. P4-467: The association between APOE-e4 and mild cognitive impairment prevalence varies by method for defining cognitive impairment Alzheimer's & Dementia. 7: e73-e73. DOI: 10.1016/J.Jalz.2011.09.160  0.309
2011 Seshadri S. PL-01-01: Genetic studies of Alzheimer's disease Alzheimer's & Dementia. 7: S83-S83. DOI: 10.1016/J.Jalz.2011.05.195  0.319
2010 Seshadri S. Beauty and the beast: B12, homocysteine, and the brain: a bemusing saga! Neurology. 75: 1402-3. PMID 20956785 DOI: 10.1212/Wnl.0B013E3181F8836F  0.333
2010 Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Annals of Neurology. 68: 136-44. PMID 20695006 DOI: 10.1002/Ana.22062  0.328
2010 Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation. 122: 690-7. PMID 20679552 DOI: 10.1161/Circulationaha.109.905091  0.344
2010 Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology. 75: 35-41. PMID 20603483 DOI: 10.1212/Wnl.0B013E3181E62138  0.306
2010 Stavitsky K, Du Y, Seichepine D, Laudate TM, Beiser A, Seshadri S, Decarli C, Wolf PA, Au R. White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study. Neuroepidemiology. 35: 117-22. PMID 20551699 DOI: 10.1159/000313443  0.394
2010 Albert M, Massaro J, DeCarli C, Beiser A, Seshadri S, Wolf PA, Au R. Profiles by sex of brain MRI and cognitive function in the framingham offspring study. Alzheimer Disease and Associated Disorders. 24: 190-3. PMID 20505436 DOI: 10.1097/Wad.0B013E3181C1Ed44  0.307
2010 Zade D, Beiser A, McGlinchey R, Au R, Seshadri S, Palumbo C, Wolf PA, Decarli C, Milberg W. Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 19: 261-8. PMID 20471857 DOI: 10.1016/J.Jstrokecerebrovasdis.2009.05.001  0.411
2010 Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. Jama. 303: 1832-40. PMID 20460622 DOI: 10.1001/Jama.2010.574  0.368
2010 Tan ZS, Seshadri S. Inflammation in the Alzheimer's disease cascade: culprit or innocent bystander? Alzheimer's Research & Therapy. 2: 6. PMID 20388190 DOI: 10.1186/Alzrt29  0.383
2010 Newman AB, Walter S, Lunetta KL, Garcia ME, Slagboom PE, Christensen K, Arnold AM, Aspelund T, Aulchenko YS, Benjamin EJ, Christiansen L, D'Agostino RB, Fitzpatrick AL, Franceschini N, Glazer NL, ... ... Seshadri S, et al. A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 478-87. PMID 20304771 DOI: 10.1093/Gerona/Glq028  0.327
2010 Seshadri S, Beiser A, Pikula A, Himali JJ, Kelly-Hayes M, Debette S, DeStefano AL, Romero JR, Kase CS, Wolf PA. Parental occurrence of stroke and risk of stroke in their children: the Framingham study. Circulation. 121: 1304-12. PMID 20212282 DOI: 10.1161/Circulationaha.109.854240  0.319
2010 Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke; a Journal of Cerebral Circulation. 41: 600-6. PMID 20167919 DOI: 10.1161/Strokeaha.109.570044  0.418
2010 Debette S, Bis JC, Fornage M, Schmidt H, Ikram MA, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, DeCarli C, Lumley T, Knopman DS, Enzinger C, Eiriksdottir G, ... ... Seshadri S, et al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke; a Journal of Cerebral Circulation. 41: 210-7. PMID 20044523 DOI: 10.1161/Strokeaha.109.569194  0.375
2010 Romero JR, Vasan RS, Beiser AS, Au R, Benjamin EJ, DeCarli C, Wolf PA, Seshadri S. Association of matrix metalloproteinases with MRI indices of brain ischemia and aging. Neurobiology of Aging. 31: 2128-35. PMID 19128858 DOI: 10.1016/J.Neurobiolaging.2008.11.004  0.32
2009 Debette S, Seshadri S. Genetics of atherothrombotic and lacunar stroke. Circulation. Cardiovascular Genetics. 2: 191-8. PMID 20031584 DOI: 10.1161/Circgenetics.108.828319  0.354
2009 Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. Jama. 302: 2565-72. PMID 20009056 DOI: 10.1001/Jama.2009.1836  0.34
2009 Debette S, Wolf PA, Beiser A, Au R, Himali JJ, Pikula A, Auerbach S, Decarli C, Seshadri S. Association of parental dementia with cognitive and brain MRI measures in middle-aged adults. Neurology. 73: 2071-8. PMID 20007524 DOI: 10.1212/Wnl.0B013E3181C67833  0.385
2009 Debette S, Seshadri S. Vascular risk factors and dementia revisited. Journal of Neurology, Neurosurgery, and Psychiatry. 80: 1183-4. PMID 19864653 DOI: 10.1136/Jnnp.2009.181289  0.388
2009 DeStefano AL, Seshadri S, Beiser A, Atwood LD, Massaro JM, Au R, Wolf PA, DeCarli C. Bivariate heritability of total and regional brain volumes: the Framingham Study. Alzheimer Disease and Associated Disorders. 23: 218-23. PMID 19812462 DOI: 10.1097/Wad.0B013E31819Cadd8  0.34
2009 Pikula A, Böger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS, Wolf PA, Seshadri S. Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. Stroke; a Journal of Cerebral Circulation. 40: 2959-64. PMID 19644064 DOI: 10.1161/Strokeaha.109.557116  0.346
2009 Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, et al. Genomewide association studies of stroke. The New England Journal of Medicine. 360: 1718-28. PMID 19369658 DOI: 10.1056/Nejmoa0900094  0.376
2009 Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C, Wolf PA. Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: the Framingham study. Stroke; a Journal of Cerebral Circulation. 40: 1590-6. PMID 19265054 DOI: 10.1161/Strokeaha.108.535245  0.39
2009 Petrea RE, Beiser AS, Seshadri S, Kelly-Hayes M, Kase CS, Wolf PA. Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke; a Journal of Cerebral Circulation. 40: 1032-7. PMID 19211484 DOI: 10.1161/Strokeaha.108.542894  0.315
2009 Ikram MA, Seshadri S, Bis JC. Genomewide Association Studies of Stroke Journal of Vascular Surgery. 50: 467. DOI: 10.1016/J.Jvs.2009.06.027  0.336
2009 Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. O3-02-03: Association of MRI markers of vascular brain injury with mild cognitive impairment, incident stroke and mortality: The Framingham Offspring Study Alzheimer's & Dementia. 5: P128-P128. DOI: 10.1016/J.Jalz.2009.05.432  0.375
2009 Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Vasan RS, DeCarli CD, Wolf PA, Seshadri S. O2-02-07: Association of metabolic dysregulation with volumetric brain mri and cognitive markers of subclinical brain aging in middle-aged adults: The Framingham Offspring study Alzheimer's & Dementia. 5: P106-P106. DOI: 10.1016/J.Jalz.2009.05.331  0.337
2009 Das RR, Seshadri S. Diabetes and stroke Current Cardiovascular Risk Reports. 3: 35-41. DOI: 10.1007/S12170-009-0007-X  0.346
2008 Tan ZS, Beiser A, Vasan RS, Au R, Auerbach S, Kiel DP, Wolf PA, Seshadri S. Thyroid function and the risk of Alzheimer disease: the Framingham Study. Archives of Internal Medicine. 168: 1514-20. PMID 18663163 DOI: 10.1001/Archinte.168.14.1514  0.364
2008 Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke; a Journal of Cerebral Circulation. 39: 2929-35. PMID 18583555 DOI: 10.1161/Strokeaha.108.516575  0.386
2008 Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C. Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Archives of Neurology. 65: 642-9. PMID 18474741 DOI: 10.1001/Archneur.65.5.642  0.377
2008 Jefferson AL, Beiser AS, Himali JJ, Au R, Massaro JM, Seshadri S, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. P4-031: Systolic function is associated with brain aging: The Framingham Heart Study Alzheimer's & Dementia. 4: T676-T676. DOI: 10.1016/J.Jalz.2008.05.2095  0.329
2007 Seshadri S, Wolf PA. Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study. The Lancet. Neurology. 6: 1106-14. PMID 18031707 DOI: 10.1016/S1474-4422(07)70291-0  0.405
2007 Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D'Agostino RB, Fox CS, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh C, O'Donnell CJ, Seshadri S, Vasan RS, et al. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. Bmc Medical Genetics. 8: S5. PMID 17903304 DOI: 10.1186/1471-2350-8-S1-S5  0.371
2007 Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB, Decarli C, Atwood LD, Wolf PA. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. Bmc Medical Genetics. 8: S15. PMID 17903297 DOI: 10.1186/1471-2350-8-S1-S15  0.452
2007 Lunetta KL, D'Agostino RB, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. Bmc Medical Genetics. 8: S13. PMID 17903295 DOI: 10.1186/1471-2350-8-S1-S13  0.31
2007 Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, ... ... Seshadri S, et al. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. Bmc Medical Genetics. 8: S1. PMID 17903291 DOI: 10.1186/1471-2350-8-S1-S1  0.341
2007 Tan ZS, Beiser AS, Vasan RS, Roubenoff R, Dinarello CA, Harris TB, Benjamin EJ, Au R, Kiel DP, Wolf PA, Seshadri S. Inflammatory markers and the risk of Alzheimer disease: the Framingham Study. Neurology. 68: 1902-8. PMID 17536046 DOI: 10.1212/01.Wnl.0000263217.36439.Da  0.366
2007 Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C. Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology. 68: 1032-8. PMID 17389308 DOI: 10.1212/01.Wnl.0000257815.20548.Df  0.378
2007 Elias MF, Sullivan LM, Elias PK, D'Agostino RB, Wolf PA, Seshadri S, Au R, Benjamin EJ, Vasan RS. Left ventricular mass, blood pressure, and lowered cognitive performance in the Framingham offspring. Hypertension. 49: 439-45. PMID 17224472 DOI: 10.1161/01.Hyp.0000256361.68158.24  0.345
2007 Carandang R, Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Kannel WB, Wolf PA. Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. Jama. 296: 2939-46. PMID 17190894 DOI: 10.1001/Jama.296.24.2939  0.338
2006 Elias MF, Sullivan LM, Elias PK, Vasan RS, D'Agostino RB, Seshadri S, Au R, Wolf PA, Benjamin EJ. Atrial fibrillation is associated with lower cognitive performance in the Framingham offspring men. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. 15: 214-22. PMID 17904078 DOI: 10.1016/J.Jstrokecerebrovasdis.2006.05.009  0.369
2006 Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S. Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Archives of Neurology. 63: 1551-5. PMID 17101823 DOI: 10.1001/Archneur.63.11.1551  0.322
2006 Seshadri S. Methodology for measuring cerebrovascular disease burden International Review of Psychiatry. 18: 409-422. PMID 17085360 DOI: 10.1080/09540260600935413  0.386
2006 Seshadri S. Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease? Journal of Alzheimer's Disease. 9: 393-398. PMID 16917147 DOI: 10.3233/Jad-2006-9404  0.423
2006 McKee AC, Au R, Cabral HJ, Kowall NW, Seshadri S, Kubilus CA, Drake J, Wolf PA. Visual association pathology in preclinical Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 621-30. PMID 16783172 DOI: 10.1097/00005072-200606000-00010  0.355
2006 Au R, Massaro JM, Wolf PA, Young ME, Beiser A, Seshadri S, D'Agostino RB, DeCarli C. Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study. Archives of Neurology. 63: 246-50. PMID 16476813 DOI: 10.1001/Archneur.63.2.246  0.311
2006 Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, Wolf PA. The lifetime risk of stroke: estimates from the Framingham Study. Stroke. 37: 345-50. PMID 16397184 DOI: 10.1161/01.Str.0000199613.38911.B2  0.329
2006 Bristow KQ, Au R, Massaro JM, Seshadri S, Wolf PA, Kelly-Hayes M, DeCarli C. Relationship of Silent Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham Offspring Study Alzheimer Disease & Associated Disorders. 20: S101. DOI: 10.1097/00002093-200607001-00020  0.304
2006 Peloso GM, Beiser AS, Destefano AL, Seshadri S. P2-111: INTERACTION BETWEEN ALZHEIMER'S DISEASE GENETIC RISK SCORE AND MIDLIFE PLASMA LIPID LEVELS ON ALZHEIMER ’S DISEASE IN THE FRAMINGHAM HEART STUDY Alzheimer's & Dementia. 14: P711-P711. DOI: 10.1016/J.Jalz.2018.06.797  0.364
2006 Satizabal CL, Himali JJ, Beiser AS, Vasan RS, DeCarli CS, Harris WS, Seshadri S. O2-10-01: OMEGA-3 FATTY ACID LEVELS ARE ASSOCIATED WITH BRAIN MRI MEASURES IN MIDDLE-AGED ADULTS FROM THE FRAMINGHAM HEART STUDY Alzheimer's & Dementia. 14: P644-P644. DOI: 10.1016/J.Jalz.2018.06.2694  0.301
2006 Pase MP, Davis-Plourde K, Beiser AS, Himali JJ, Satizabal CL, Aparicio HJ, Seshadri S, DeCarli CS. O2-05-02: IMPACT OF AGE ON THE ASSOCIATION BETWEEN VASCULAR RISK FACTOR BURDEN AND BRAIN VOLUME Alzheimer's & Dementia. 14: P627-P628. DOI: 10.1016/J.Jalz.2018.06.2664  0.349
2006 Himali JJ, Melo van Lent D, O'Donnell A, Jacques PF, Wagner M, Vasan RS, Beiser AS, Seshadri S, Pase MP. P3-561: ADHERENCE TO THE MIND DIET IS ASSOCIATED WITH BETTER COGNITION IN THE FRAMINGHAM HEART STUDY Alzheimer's & Dementia. 14: P1338-P1339. DOI: 10.1016/J.Jalz.2018.06.1927  0.307
2006 Li S, Teumer A, Knol MJ, Yang Q, Seshadri S. P1-004: GENOME-WIDE ASSOCIATION STUDY OF 11,785 INDIVIDUALS IDENTIFIES SEVEN LOCI ASSOCIATED WITH BRAIN-DERIVED NEUROTROPHIC FACTOR Alzheimer's & Dementia. 14: P262-P262. DOI: 10.1016/J.Jalz.2018.06.005  0.337
2006 Tan ZS, Seshadri S, Beiser A, Roubenoff R, Dinarello C, Harris T, Benjamin E, Au R, Kiel DP, Vasan RS, Wolf PA. P1-209: Relations of serum inflammatory markers and monocyte production of cytokines to the risk for Alzheimer's disease: The Framingham study Alzheimer's & Dementia. 2: S157-S157. DOI: 10.1016/J.Jalz.2006.05.586  0.324
2006 DeCarli C, Massaro J, Au R, Seshadri S, Wolf PA. P1-175: Stroke risk factors and brain atrophy among the original cohort of the Framingham Heart Study Alzheimer's & Dementia. 2: S147-S147. DOI: 10.1016/J.Jalz.2006.05.551  0.393
2005 Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Jacques PF, Selhub J, Seshadri S, Au R, Beiser A, Wolf PA. Homocysteine and cognitive performance in the Framingham offspring study: age is important. American Journal of Epidemiology. 162: 644-53. PMID 16107567 DOI: 10.1093/Aje/Kwi259  0.39
2005 Tan ZS, Seshadri S, Beiser A, Zhang Y, Felson D, Hannan MT, Au R, Wolf PA, Kiel DP. Bone mineral density and the risk of Alzheimer disease. Archives of Neurology. 62: 107-11. PMID 15642856 DOI: 10.1001/Archneur.62.1.107  0.312
2004 Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C. Stroke risk profile, brain volume, and cognitive function: The Framingham Offspring Study Neurology. 63: 1591-1599. PMID 15534241 DOI: 10.1212/01.Wnl.0000142968.22691.70  0.428
2004 Au R, Seshadri S, Wolf PA, Elias MF, Elias PK, Sullivan L, Beiser A, D'Agostino RB. New norms for a new generation: Cognitive performance in the Framingham Offspring Cohort Experimental Aging Research. 30: 333-358. PMID 15371099 DOI: 10.1080/03610730490484380  0.306
2004 Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke. 35: 1857-61. PMID 15218158 DOI: 10.1161/01.Str.0000135226.53499.85  0.416
2004 Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke: the Framingham Study. Stroke. 35: 1264-8. PMID 15118167 DOI: 10.1161/01.Str.0000127810.92616.78  0.38
2004 Elias MF, Sullivan LM, D'Agostino RB, Elias PK, Beiser A, Au R, Seshadri S, DeCarli C, Wolf PA. Framingham stroke risk profile and lowered cognitive performance. Stroke; a Journal of Cerebral Circulation. 35: 404-9. PMID 14726556 DOI: 10.1161/01.Str.0000103141.82869.77  0.393
2003 Seshadri S, Wolf PA. Homocysteine and the brain: vascular risk factor or neurotoxin? The Lancet. Neurology. 2: 11. PMID 12849292 DOI: 10.1016/S1474-4422(03)00258-8  0.329
2003 Tan ZS, Seshadri S, Beiser A, Wilson PW, Kiel DP, Tocco M, D'Agostino RB, Wolf PA. Plasma total cholesterol level as a risk factor for Alzheimer disease: the Framingham Study. Archives of Internal Medicine. 163: 1053-7. PMID 12742802 DOI: 10.1001/Archinte.163.9.1053  0.348
2002 Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D'Agostino RB, Levy D. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. Jama. 287: 1003-10. PMID 11866648 DOI: 10.1001/Jama.287.8.1003  0.304
2002 Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PWF, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease New England Journal of Medicine. 346: 476-483. PMID 11844848 DOI: 10.1056/Nejmoa011613  0.392
2002 Vasan RS, Massaro JM, Wilson PW, Seshadri S, Wolf PA, Levy D, D'Agostino RB. Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study . Circulation. 105: 48-53. PMID 11772875 DOI: 10.1161/Hc0102.101774  0.319
2001 Seshadri S, Wolf PA, Beiser A, Vasan RS, Wilson PW, Kase CS, Kelly-Hayes M, Kannel WB, D'Agostino RB. Elevated midlife blood pressure increases stroke risk in elderly persons: the Framingham Study. Archives of Internal Medicine. 161: 2343-50. PMID 11606150 DOI: 10.1001/Archinte.161.19.2343  0.343
2001 Seshadri S, Zornberg GL, Derby LE, Myers MW, Jick H, Drachman DA. Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer Disease Jama Neurology. 58: 435-440. PMID 11255447 DOI: 10.1001/Archneur.58.3.435  0.315
2001 Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D’Agostino RB, DeCarli C. Stroke Risk Profile Predicts Brain Volume and Cognitive Function in Stroke-free Subjects: The Framingham Study Stroke. 32: 321-321. DOI: 10.1161/01.Str.32.Suppl_1.321-C  0.428
2001 Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Dementia and statins The Lancet. 357: 880-881. DOI: 10.1016/S0140-6736(05)71807-9  0.319
2000 Jick H, Zornberg GL, Jick SS, Seshadri S, Drachman DA. Statins and the risk of dementia Lancet. 356: 1627-1631. PMID 11089820 DOI: 10.1097/00006254-200104000-00019  0.371
2000 Beiser A, D'Agostino RB, Seshadri S, Sullivan LM, Wolf PA. Computing estimates of incidence, including lifetime risk: Alzheimer's disease in the Framingham Study. The Practical Incidence Estimators (PIE) macro. Statistics in Medicine. 19: 1495-522. PMID 10844714 DOI: 10.1002/(Sici)1097-0258(20000615/30)19:11/12<1495::Aid-Sim441>3.0.Co;2-E  0.323
2000 DeCarli C, Beiser A, Seshadri S, D’Agostino RB, Kase CS, Au R, Kelly-Hayes M, Wolf PA. Abnormalities of cerebral white matter and stroke risk in the Framingham Offspring Study Stroke. 32: 362-362. DOI: 10.1161/01.Str.32.Suppl_1.362-D  0.387
1998 Seshadri S, Wolf PA, Beiser A, Au R, McNulty K, White R, D'Agostino RB. Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study. Neurology. 49: 1498-504. PMID 9409336 DOI: 10.1212/Wnl.49.6.1498  0.369
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