Manuel Tena-Sempere - Publications

Affiliations: 
University of Cordoba, Córdoba, Andalucía, Spain 

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Anderson GM, Hill JW, Kaiser UB, Navarro VM, Ong KK, Perry JRB, Prevot V, Tena-Sempere M, Elias CF. Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work. Nature Reviews. Endocrinology. PMID 38049643 DOI: 10.1038/s41574-023-00919-z  0.503
2023 Rodríguez-Carrillo A, Remy S, Koppen G, Wauters N, Freire C, Olivas-Martínez A, Schillemans T, Åkesson A, Desalegn A, Iszatt N, den Hond E, Verheyen V, Fábelová L, Murinova LP, Pedraza-Díaz S, ... ... Tena-Sempere M, et al. PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies. Environmental Pollution (Barking, Essex : 1987). 335: 122214. PMID 37482334 DOI: 10.1016/j.envpol.2023.122214  0.306
2023 Prévot V, Tena-Sempere M, Pitteloud N. New Horizons: Gonadotropin-releasing hormone and cognition. The Journal of Clinical Endocrinology and Metabolism. PMID 37261390 DOI: 10.1210/clinem/dgad319  0.325
2022 Perdices-Lopez C, Avendaño MS, Barroso A, Gaytán F, Ruiz-Pino F, Vázquez MJ, Leon S, Song YB, Sobrino V, Heras V, Romero-Ruiz A, Roa J, Mayor F, Murga C, Pinilla L, ... ... Tena-Sempere M, et al. Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons. Metabolism: Clinical and Experimental. 129: 155141. PMID 35074314 DOI: 10.1016/j.metabol.2022.155141  0.317
2021 Pellegrino G, Martin M, Allet C, Lhomme T, Geller S, Franssen D, Mansuy V, Manfredi-Lozano M, Coutteau-Robles A, Delli V, Rasika S, Mazur D, Loyens A, Tena-Sempere M, Siepmann J, et al. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation. Nature Neuroscience. PMID 34795451 DOI: 10.1038/s41593-021-00960-z  0.319
2021 Soriano-Guillén L, Tena-Sempere M, Seraphim CE, Latronico AC, Argente J. Precocious sexual maturation: Unravelling the mechanisms of pubertal onset through clinical observations. Journal of Neuroendocrinology. e12979. PMID 33904190 DOI: 10.1111/jne.12979  0.306
2021 Torres E, Velasco I, Franssen D, Heras V, Gaytan F, Leon S, Navarro V, Pineda R, Candenas ML, Romero-Ruiz A, Tena-Sempere M. Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis. American Journal of Physiology. Endocrinology and Metabolism. PMID 33427049 DOI: 10.1152/ajpendo.00346.2020  0.603
2020 Vázquez MJ, Novelle MG, Rodríguez-Pacheco F, Lage R, Varela L, López M, Pinilla L, Tena-Sempere M, Diéguez C. AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin. Cells. 9. PMID 32839401 DOI: 10.3390/cells9091940  0.386
2020 Sanchez-Garrido MA, Ruiz-Pino F, Pozo-Salas AI, Castellano JM, Vazquez MJ, Luque RM, Tena-Sempere M. Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms. Scientific Reports. 10: 13898. PMID 32807904 DOI: 10.1038/s41598-020-70898-y  0.393
2020 Ruohonen ST, Poutanen M, Tena-Sempere M. Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges. Fertility and Sterility. 114: 465-474. PMID 32771258 DOI: 10.1016/J.Fertnstert.2020.06.038  0.525
2020 Barroso A, Santos-Marcos JA, Perdices-Lopez C, Vega-Rojas A, Sánchez-Garrido MA, Krylova Y, Molina-Abril H, Ohlsson C, Martinez PP, Poutanen M, Lopez-Miranda J, Tena-Sempere M, Camargo A. Neonatal exposure to androgens dynamically alters gut microbiota architecture. The Journal of Endocrinology. PMID 32755996 DOI: 10.1530/JOE-20-0277  0.302
2020 Bolze F, Williams H, Bhuwania R, Egecioglu E, Bloem E, Paulsson JF, Pedersen MØ, Broadmeadow A, Chesher CJ, Moore EL, Skydsgaard M, Galle PS, Dalgaard M, Wulff BS, Tena-Sempere M, et al. Kisspeptin-52 partially rescues the activity of the hypothalamus-pituitary-gonadal axis in underweight male rats dosed with an anti-obesity compound. Toxicology and Applied Pharmacology. 115152. PMID 32726590 DOI: 10.1016/j.taap.2020.115152  0.391
2020 Rodríguez-Vázquez E, Tena-Sempere M, Castellano JM. Mechanisms for the Metabolic Control of Puberty Current Opinion in Endocrine and Metabolic Research. 14: 78-84. DOI: 10.1016/J.Coemr.2020.06.003  0.385
2019 Herrera-Marcos LV, Sancho-Knapik S, Gabás-Rivera C, Barranquero C, Gascón S, Romanos E, Martínez-Beamonte R, Navarro MA, Surra JC, Arnal C, García-de-Jalón JA, Rodríguez-Yoldi MJ, Tena-Sempere M, Sánchez-Ramos C, Monsalve M, et al. Pgc1a is responsible for the sex differences in hepatic Cidec/Fsp27β mRNA expression in hepatic steatosis of mice fed a Western diet. American Journal of Physiology. Endocrinology and Metabolism. PMID 31846369 DOI: 10.1152/Ajpendo.00199.2019  0.358
2019 Ruiz-Pino F, Miceli D, Franssen D, Vazquez MJ, Farinetti A, Castellano JM, Panzica G, Tena-Sempere M. Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice. Environmental Health Perspectives. 127: 107011. PMID 31652106 DOI: 10.1289/Ehp5570  0.368
2019 Braxton TM, Sarpong DE, Dovey JL, Guillou A, Evans B, Castellano JM, Keenan BE, Baraghithy S, Evans SL, Tena-Sempere M, Mollard P, Tam J, Wells T. Thermoneutrality improves skeletal impairment in adult Prader-Willi syndrome mice. The Journal of Endocrinology. PMID 31454785 DOI: 10.1530/Joe-19-0279  0.359
2019 Velasco I, León S, Barroso A, Ruiz-Pino F, Heras V, Torres E, León M, Ruohonen ST, García-Galiano D, Romero-Ruiz A, Sánchez-Garrido MA, Olhsson C, Castellano JM, Roa J, Poutanen M, ... ... Tena-Sempere M, et al. Gonadal Hormone-Dependent vs. -Independent Effects of Kisspeptin Signaling in the Control of Body Weight and Metabolic Homeostasis. Metabolism: Clinical and Experimental. PMID 31226351 DOI: 10.1016/j.metabol.2019.06.007  0.335
2019 Blasco V, Pinto FM, Fernández-Atucha A, Prados N, Tena-Sempere M, Fernández-Sánchez M, Candenas L. Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome. Journal of Assisted Reproduction and Genetics. 36: 113-120. PMID 30382469 DOI: 10.1007/S10815-018-1338-7  0.325
2019 Sliwowska JH, Ziarniak K, Dudek M, Matuszewska J, Tena-Sempere M. Dangerous liaisons for pubertal maturation: the impact of alcohol consumption and obesity on the timing of puberty. Biology of Reproduction. 100: 25-40. PMID 30052777 DOI: 10.1093/Biolre/Ioy168  0.414
2018 Palomares B, Ruiz-Pino F, Navarrete C, Velasco I, Sánchez-Garrido MA, Jimenez-Jimenez C, Pavicic C, Vazquez MJ, Appendino G, Bellido ML, Calzado MA, Tena-Sempere M, Muñoz E. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. Scientific Reports. 8: 16092. PMID 30382123 DOI: 10.1038/S41598-018-34259-0  0.351
2018 Roa J, Barroso A, Ruiz-Pino F, Vázquez MJ, Seoane-Collazo P, Martínez-Sanchez N, García-Galiano D, Ilhan T, Pineda R, León S, Manfredi-Lozano M, Heras V, Poutanen M, Castellano JM, Gaytan F, ... ... Tena-Sempere M, et al. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348767 DOI: 10.1073/pnas.1802053115  0.342
2018 González-García I, Contreras C, Estévez-Salguero Á, Ruíz-Pino F, Colsh B, Pensado I, Liñares-Pose L, Rial-Pensado E, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, Le Stunff H, Magnan C, Tena-Sempere M, et al. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Reports. 25: 413-423.e5. PMID 30304681 DOI: 10.1016/J.Celrep.2018.09.038  0.38
2018 Leon S, Velasco I, Vázquez MJ, Barroso A, Beiroa D, Heras V, Ruiz-Pino F, Manfredi-Lozano M, Romero-Ruiz A, Sanchez-Garrido MA, Dieguez C, Pinilla L, Roa J, Nogueiras R, Tena-Sempere M. Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice. Metabolism: Clinical and Experimental. PMID 30075164 DOI: 10.1016/J.Metabol.2018.07.003  0.426
2018 Argente-Arizón P, Castro-González D, Díaz F, Fernández-Gómez MJ, Sánchez-Garrido MA, Tena-Sempere M, Argente J, Chowen JA. Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone β-Subunit in Peripubertal Male Rats. Frontiers in Endocrinology. 9: 168. PMID 29706935 DOI: 10.3389/Fendo.2018.00168  0.472
2018 Franssen D, Tena-Sempere M. The kisspeptin receptor: A key G-protein-coupled receptor in the control of the reproductive axis. Best Practice & Research. Clinical Endocrinology & Metabolism. 32: 107-123. PMID 29678280 DOI: 10.1016/J.Beem.2018.01.005  0.406
2018 Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, ... ... Tena-Sempere M, et al. The 3 World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field. Journal of Neuroendocrinology. e12600. PMID 29656508 DOI: 10.1111/Jne.12600  0.6
2017 Sanchez-Garrido MA, Ruiz-Pino F, Velasco I, Barroso A, Fernandois D, Heras V, Manfredi-Lozano M, Vazquez MJ, Castellano JM, Roa J, Pinilla L, Tena-Sempere M. Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways. Endocrinology. PMID 29309558 DOI: 10.1210/En.2017-00705  0.372
2017 Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge EJ, Tang C, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, ... ... Tena-Sempere M, et al. Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. Nature Communications. 8: 1289. PMID 29097701 DOI: 10.1038/S41467-017-01429-Z  0.375
2017 Argente-Arizón P, Díaz F, Ros P, Barrios V, Tena-Sempere M, García-Segura LM, Argente J, Chowen JA. The hypothalamic inflammatory/gliosis response to neonatal overnutrition is sex and age dependent. Endocrinology. PMID 29077836 DOI: 10.1210/En.2017-00539  0.41
2017 Skrede S, González-García I, Martins L, Berge RK, Nogueiras R, Tena-Sempere M, Mellgren G, Steen VM, López M, Fernø J. Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. The International Journal of Neuropsychopharmacology. PMID 29020342 DOI: 10.1093/Ijnp/Pyx073  0.477
2017 Avendaño MS, Vazquez MJ, Tena-Sempere M. Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty. Human Reproduction Update. 1-27. PMID 28961976 DOI: 10.1093/Humupd/Dmx025  0.392
2017 Manfredi-Lozano M, Roa J, Tena-Sempere M. Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility. Frontiers in Neuroendocrinology. 48: 37-49. PMID 28754629 DOI: 10.1016/j.yfrne.2017.07.008  0.309
2017 Gaytan F, Morales C, Leon S, Heras V, Barroso A, Avendaño MS, Vazquez MJ, Castellano JM, Roa J, Tena-Sempere M. Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score). Scientific Reports. 7: 46381. PMID 28401948 DOI: 10.1038/Srep46381  0.379
2017 Novelle MG, Vázquez MJ, Peinado JR, Martinello KD, López M, Luckman SM, Tena-Sempere M, Malagón MM, Nogueiras R, Diéguez C. Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue. Scientific Reports. 7: 46194. PMID 28387334 DOI: 10.1038/Srep46194  0.345
2017 López M, Tena-Sempere M. Estradiol effects on hypothalamic AMPK and BAT thermogenesis: a gateway for obesity treatment? Pharmacology & Therapeutics. PMID 28351720 DOI: 10.1016/J.Pharmthera.2017.03.014  0.376
2017 Tena-Sempere M. Neuroendocrinology in 2016: Neuroendocrine control of metabolism and reproduction. Nature Reviews. Endocrinology. 13: 67-68. PMID 28059155 DOI: 10.1038/Nrendo.2016.216  0.342
2016 Moreno-Indias I, Sánchez-Alcoholado L, Sánchez-Garrido MÁ, Martín-Núñez GM, Pérez-Jiménez F, Tena-Sempere M, Tinahones FJ, Queipo-Ortuño MI. Neonatal Androgen Exposure Causes Persistent Gut Microbiota Dysbiosis Related to Metabolic Disease in Adult Female Rats. Endocrinology. 157: 4888-4898. PMID 27700135 DOI: 10.1210/en.2016-1317  0.328
2016 López M, Tena-Sempere M. Estradiol and brown fat. Best Practice & Research. Clinical Endocrinology & Metabolism. 30: 527-536. PMID 27697213 DOI: 10.1016/J.Beem.2016.08.004  0.403
2016 Manfredi-Lozano M, Roa J, Ruiz-Pino F, Piet R, Garcia-Galiano D, Pineda R, Zamora A, Leon S, Sanchez-Garrido MA, Romero-Ruiz A, Dieguez C, Vazquez MJ, Herbison AE, Pinilla L, Tena-Sempere M. Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty. Molecular Metabolism. 5: 844-57. PMID 27688998 DOI: 10.1016/J.Molmet.2016.08.003  0.407
2016 Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F, Zalvide J, Gallego R, Diéguez C, Nogueiras R, Tena-Sempere M, López M. A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance. Cell Reports. PMID 27524625 DOI: 10.1016/J.Celrep.2016.07.045  0.392
2016 Gahete MD, Vázquez-Borrego MC, Martínez-Fuentes AJ, Tena-Sempere M, Castaño JP, Luque RM. Role of the Kiss1/Kiss1r system in the regulation of pituitary cell function. Molecular and Cellular Endocrinology. 438: 100-106. PMID 27477782 DOI: 10.1016/J.Mce.2016.07.039  0.514
2016 Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V. Corrigendum: A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nature Neuroscience. 19: 1115. PMID 27459406 DOI: 10.1038/Nn0816-1115A  0.353
2016 Castellano JM, Tena-Sempere M. Metabolic control of female puberty: potential therapeutic targets. Expert Opinion On Therapeutic Targets. PMID 27409160 DOI: 10.1080/14728222.2016.1212015  0.359
2016 Argente-Arizón P, Ros P, Díaz F, Fuente-Martin E, Castro-González D, Sánchez-Garrido MÁ, Barrios V, Tena-Sempere M, Argente J, Chowen JA. Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens. Biology of Sex Differences. 7: 26. PMID 27195103 DOI: 10.1186/S13293-016-0079-5  0.342
2016 Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V. A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nature Neuroscience. PMID 27135215 DOI: 10.1038/Nn.4298  0.45
2016 Mela V, Díaz F, Vázquez MJ, Argente J, Tena-Sempere M, Viveros MP, Chowen JA. Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats. Biology of Sex Differences. 7: 2. PMID 26759712 DOI: 10.1186/S13293-015-0054-6  0.41
2016 León S, Barroso A, Vázquez MJ, García-Galiano D, Manfredi-Lozano M, Ruiz-Pino F, Heras V, Romero-Ruiz A, Roa J, Schutz G, Kirilov M, Gaytan F, Pinilla L, Tena-Sempere M. Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Scientific Reports. 6: 19206. PMID 26755241 DOI: 10.1038/Srep19206  0.513
2016 Castellano JM, Tena-Sempere M. Animal Modeling of Early Programming and Disruption of Pubertal Maturation. Endocrine Development. 29: 87-121. PMID 26680574 DOI: 10.1159/000438877  0.441
2016 Leon S, Tena-Sempere M. Dissecting the roles of gonadotropin-inhibitory hormone in mammals: Studies using pharmacological tools and genetically modified mouse models Frontiers in Endocrinology. 6. DOI: 10.3389/fendo.2015.00189  0.407
2015 Leon S, Tena-Sempere M. Dissecting the Roles of Gonadotropin-Inhibitory Hormone in Mammals: Studies Using Pharmacological Tools and Genetically Modified Mouse Models. Frontiers in Endocrinology. 6: 189. PMID 26779117 DOI: 10.3389/Fendo.2015.00189  0.503
2015 Gaytan F, Morales C, Leon S, Garcia-Galiano D, Roa J, Tena-Sempere M. Crowding and Follicular Fate: Spatial Determinants of Follicular Reserve and Activation of Follicular Growth in the Mammalian Ovary. Plos One. 10: e0144099. PMID 26642206 DOI: 10.1371/Journal.Pone.0144099  0.326
2015 Min L, Leon S, Li H, Pinilla L, Carroll RS, Tena-Sempere M, Kaiser UB. RF9 acts as a KISS1R agonist in vivo and in vitro. Endocrinology. en20151635. PMID 26418326 DOI: 10.1210/En.2015-1635  0.316
2015 Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, et al. Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment. Nature Reviews. Endocrinology. 11: 547-64. PMID 26194704 DOI: 10.1038/Nrendo.2015.112  0.388
2015 Pinto FM, Bello AR, Gallardo-Castro M, Valladares F, Almeida TA, Tena-Sempere M, Candenas L. Analysis of the Expression of Tachykinins and Tachykinin Receptors in the Rat Uterus During Early Pregnancy. Biology of Reproduction. 93: 51. PMID 26157068 DOI: 10.1095/Biolreprod.115.130617  0.4
2015 Sánchez-Garrido MA, Ruiz-Pino F, Manfredi-Lozano M, Leon S, Heras V, Castellano JM, Castaño JP, Luque RM, Vázquez MJ, Roa J, Romero-Ruiz A, Diéguez C, Pinilla L, Tena-Sempere M. Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion. Endocrinology. 156: 2984-98. PMID 25984764 DOI: 10.1210/En.2014-1951  0.463
2015 Mela V, Díaz F, Lopez-Rodriguez AB, Vázquez MJ, Gertler A, Argente J, Tena-Sempere M, Viveros MP, Chowen JA. Blockage of the Neonatal Leptin Surge Affects the Gene Expression of Growth Factors, Glial Proteins, and Neuropeptides Involved in the Control of Metabolism and Reproduction in Peripubertal Male and Female Rats. Endocrinology. 156: 2571-81. PMID 25856428 DOI: 10.1210/En.2014-1981  0.471
2015 Castro-González D, Fuente-Martín E, Sánchez-Garrido MA, Argente-Arizón P, Tena-Sempere M, Barrios V, Chowen JA, Argente J. Increased prepubertal body weight enhances leptin sensitivity in proopiomelanocortin and neuropeptide y neurons before puberty onset in female rats. Endocrinology. 156: 1272-82. PMID 25574789 DOI: 10.1210/En.2014-1759  0.346
2015 Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, Sánchez-Garrido MA, Roa J, Pinilla L, Navarro VM, Tena-Sempere M. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology. 156: 576-88. PMID 25490143 DOI: 10.1210/En.2014-1026  0.698
2015 Vázquez MJ, Romero-Ruiz A, Tena-Sempere M. Roles of leptin in reproduction, pregnancy and polycystic ovary syndrome: consensus knowledge and recent developments. Metabolism: Clinical and Experimental. 64: 79-91. PMID 25467843 DOI: 10.1016/j.metabol.2014.10.013  0.336
2015 Navarro VM, Bosch MA, León S, Simavli S, True C, Pinilla L, Carroll RS, Seminara SB, Tena-Sempere M, Rønnekleiv OK, Kaiser UB. The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Endocrinology. 156: 627-37. PMID 25422875 DOI: 10.1210/En.2014-1651  0.659
2014 Overgaard A, Ruiz-Pino F, Castellano JM, Tena-Sempere M, Mikkelsen JD. Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats. Endocrinology. 155: 3945-55. PMID 25051440 DOI: 10.1210/En.2014-1200  0.481
2014 Gaytan F, Garcia-Galiano D, Dorfman MD, Manfredi-Lozano M, Castellano JM, Dissen GA, Ojeda SR, Tena-Sempere M. Kisspeptin receptor haplo-insufficiency causes premature ovarian failure despite preserved gonadotropin secretion. Endocrinology. 155: 3088-97. PMID 24885574 DOI: 10.1210/en.2014-1110  0.321
2014 León S, García-Galiano D, Ruiz-Pino F, Barroso A, Manfredi-Lozano M, Romero-Ruiz A, Roa J, Vázquez MJ, Gaytan F, Blomenrohr M, van Duin M, Pinilla L, Tena-Sempere M. Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse. Endocrinology. 155: 2953-65. PMID 24823392 DOI: 10.1210/En.2014-1030  0.485
2014 Novelle MG, Vázquez MJ, Martinello KD, Sanchez-Garrido MA, Tena-Sempere M, Diéguez C. Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin. Scientific Reports. 4: 4855. PMID 24798184 DOI: 10.1038/Srep04855  0.372
2014 Gaytán F, Morales C, Manfredi-Lozano M, Tena-Sempere M. Generation of multi-oocyte follicles in the peripubertal rat ovary: link to the invasive capacity of granulosa cells? Fertility and Sterility. 101: 1467-76. PMID 24581577 DOI: 10.1016/J.Fertnstert.2014.01.037  0.388
2014 Luque RM, Córdoba-Chaćon J, Ibań̃ez-Costa A, Gesmundo I, Grande C, Gracia-Navarro F, Tena-Sempere M, Ghigo E, Gahete MD, Granata R, Kineman RD, Castaño JP. Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice Endocrinology. 155: 1407-1417. PMID 24484169 DOI: 10.1210/En.2013-1728  0.536
2014 Sánchez-Garrido MA, Ruiz-Pino F, Manfredi-Lozano M, Leon S, Garcia-Galiano D, Castaño JP, Luque RM, Romero-Ruiz A, Castellano JM, Diéguez C, Pinilla L, Tena-Sempere M. Obesity-induced hypogonadism in the male: premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms. Endocrinology. 155: 1067-79. PMID 24424048 DOI: 10.1210/En.2013-1584  0.481
2013 Tena-Sempere M. Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 45: 919-27. PMID 24155252 DOI: 10.1055/s-0033-1355399  0.383
2013 Sanchez-Garrido MA, Tena-Sempere M. Metabolic control of puberty: roles of leptin and kisspeptins. Hormones and Behavior. 64: 187-94. PMID 23998663 DOI: 10.1016/j.yhbeh.2013.01.014  0.377
2013 Tena-Sempere M. Keeping puberty on time: novel signals and mechanisms involved. Current Topics in Developmental Biology. 105: 299-329. PMID 23962847 DOI: 10.1016/B978-0-12-396968-2.00011-7  0.42
2013 Álvarez-Crespo M, Martínez-Sánchez N, Ruíz-Pino F, Garcia-Lavandeira M, Alvarez CV, Tena-Sempere M, Nogueiras R, Diéguez C, López M. The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis. Endocrinology. 154: 3589-98. PMID 23861376 DOI: 10.1210/En.2013-1251  0.519
2013 Witchel SF, Tena-Sempere M. The Kiss1 system and polycystic ovary syndrome: lessons from physiology and putative pathophysiologic implications. Fertility and Sterility. 100: 12-22. PMID 23809625 DOI: 10.1016/j.fertnstert.2013.05.024  0.39
2013 Sánchez-Garrido MA, Castellano JM, Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, Romero-Ruiz A, Diéguez C, Pinilla L, Tena-Sempere M. Metabolic programming of puberty: sexually dimorphic responses to early nutritional challenges. Endocrinology. 154: 3387-400. PMID 23751873 DOI: 10.1210/En.2012-2157  0.423
2013 Tena-Sempere M. Ghrelin, the gonadal axis and the onset of puberty. Endocrine Development. 25: 69-82. PMID 23652393 DOI: 10.1159/000346055  0.476
2013 Overgaard A, Tena-Sempere M, Franceschini I, Desroziers E, Simonneaux V, Mikkelsen JD. Comparative analysis of kisspeptin-immunoreactivity reveals genuine differences in the hypothalamic Kiss1 systems between rats and mice. Peptides. 45: 85-90. PMID 23651990 DOI: 10.1016/J.Peptides.2013.04.013  0.434
2013 Castellano JM, Tena-Sempere M. Metabolic regulation of kisspeptin. Advances in Experimental Medicine and Biology. 784: 363-83. PMID 23550015 DOI: 10.1007/978-1-4614-6199-9_17  0.421
2013 García-Galiano D, Tena-Sempere M. Emerging roles of NUCB2/nesfatin-1 in the metabolic control of reproduction. Current Pharmaceutical Design. 19: 6966-6972. PMID 23537080 DOI: 10.2174/138161281939131127142531  0.512
2013 Aguilar E, Pineda R, Gaytán F, Sánchez-Garrido MA, Romero M, Romero-Ruiz A, Ruiz-Pino F, Tena-Sempere M, Pinilla L. Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies. Neuroendocrinology. 98: 38-50. PMID 23485923 DOI: 10.1159/000350323  0.529
2013 Gaytan F, Sangiao-Alvarellos S, Manfredi-Lozano M, García-Galiano D, Ruiz-Pino F, Romero-Ruiz A, León S, Morales C, Cordido F, Pinilla L, Tena-Sempere M. Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism. Endocrinology. 154: 1321-36. PMID 23337528 DOI: 10.1210/En.2012-1745  0.339
2013 Sangiao-Alvarellos S, Manfredi-Lozano M, Ruiz-Pino F, Navarro VM, Sánchez-Garrido MA, Leon S, Dieguez C, Cordido F, Matagne V, Dissen GA, Ojeda SR, Pinilla L, Tena-Sempere M. Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty. Endocrinology. 154: 942-55. PMID 23291449 DOI: 10.1210/En.2012-2006  0.531
2013 Sirotkin AV, Pavlova S, Tena-Sempere M, Grossmann R, Jiménez MR, Rodriguez JM, Valenzuela F. Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 164: 141-53. PMID 22877785 DOI: 10.1016/J.Cbpa.2012.07.010  0.401
2012 Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. The Journal of Clinical Investigation. 122: 3900-13. PMID 23064363 DOI: 10.1172/Jci64102  0.333
2012 García-Galiano D, Pineda R, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, Castellano JM, Aguilar E, Navarro VM, Pinilla L, Tena-Sempere M. Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission. American Journal of Physiology. Endocrinology and Metabolism. 303: E1252-63. PMID 23011064 DOI: 10.1152/Ajpendo.00250.2012  0.644
2012 Tena-Sempere M. ENDOCRINOLOGY AND ADOLESCENCE: Deciphering puberty: novel partners, novel mechanisms European Journal of Endocrinology. 167: 733-747. PMID 22989465 DOI: 10.1530/Eje-12-0669  0.408
2012 Ruiz-Pino F, Navarro VM, Bentsen AH, Garcia-Galiano D, Sanchez-Garrido MA, Ciofi P, Steiner RA, Mikkelsen JD, Pinilla L, Tena-Sempere M. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology. 153: 4818-29. PMID 22822161 DOI: 10.1210/En.2012-1287  0.775
2012 Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews. 92: 1235-316. PMID 22811428 DOI: 10.1152/Physrev.00037.2010  0.485
2012 Codner E, Merino PM, Tena-Sempere M. Female reproduction and type 1 diabetes: from mechanisms to clinical findings Human Reproduction Update. 18: 568-585. PMID 22709979 DOI: 10.1093/Humupd/Dms024  0.361
2012 Wahab F, Salahuddin H, Anees M, Leprince J, Vaudry H, Tena-Sempere M, Shahab M. Study of the effect of 26RF- and 43RF-amides on Testosterone and Prolactin secretion in the adult male rhesus monkey (Macaca mulatta) Peptides. 36: 23-28. PMID 22531487 DOI: 10.1016/J.Peptides.2012.04.009  0.399
2012 Qaiser F, Wahab F, Wiqar MA, Hashim R, Leprince J, Vaudry H, Tena-Sempere M, Shahab M. Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta). Endocrine. 42: 658-663. PMID 22527890 DOI: 10.1007/S12020-012-9672-5  0.43
2012 Cejudo Roman A, Pinto FM, Dorta I, Almeida TA, Hernández M, Illanes M, Tena-Sempere M, Candenas L. Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract. Fertility and Sterility. 97: 1213-9. PMID 22424618 DOI: 10.1016/J.Fertnstert.2012.02.021  0.354
2012 Navarro VM, Ruiz-Pino F, Sánchez-Garrido MA, García-Galiano D, Hobbs SJ, Manfredi-Lozano M, León S, Sangiao-Alvarellos S, Castellano JM, Clifton DK, Pinilla L, Steiner RA, Tena-Sempere M. Role of neurokinin B in the control of female puberty and its modulation by metabolic status. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2388-97. PMID 22396413 DOI: 10.1523/Jneurosci.4288-11.2012  0.786
2012 García-Galiano D, Pineda R, Ilhan T, Castellano JM, Ruiz-Pino F, Sánchez-Garrido MA, Vazquez MJ, Sangiao-Alvarellos S, Romero-Ruiz A, Pinilla L, Diéguez C, Gaytán F, Tena-Sempere M. Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis. Endocrinology. 153: 1959-71. PMID 22334726 DOI: 10.1210/En.2011-2032  0.437
2012 Varela L, Martínez-Sánchez N, Gallego R, Vázquez MJ, Roa J, Gándara M, Schoenmakers E, Nogueiras R, Chatterjee K, Tena-Sempere M, Diéguez C, López M. Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. The Journal of Pathology. 227: 209-22. PMID 22294347 DOI: 10.1002/path.3984  0.376
2012 Ancel C, Bentsen AH, Sébert ME, Tena-Sempere M, Mikkelsen JD, Simonneaux V. Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule. Endocrinology. 153: 1352-63. PMID 22275511 DOI: 10.1210/En.2011-1622  0.519
2012 Fuente-Martín E, Granado M, García-Cáceres C, Sanchez-Garrido MA, Frago LM, Tena-Sempere M, Argente J, Chowen JA. Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats Metabolism-Clinical and Experimental. 61: 812-822. PMID 22209665 DOI: 10.1016/J.Metabol.2011.11.003  0.361
2012 Tena-Sempere M, Felip A, Gómez A, Zanuy S, Carrillo M. Comparative insights of the kisspeptin/kisspeptin receptor system: lessons from non-mammalian vertebrates. General and Comparative Endocrinology. 175: 234-43. PMID 22137912 DOI: 10.1016/J.Ygcen.2011.11.015  0.463
2012 García-Galiano D, van Ingen Schenau D, Leon S, Krajnc-Franken MA, Manfredi-Lozano M, Romero-Ruiz A, Navarro VM, Gaytan F, van Noort PI, Pinilla L, Blomenröhr M, Tena-Sempere M. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 153: 316-28. PMID 22067321 DOI: 10.1210/En.2011-1260  0.672
2012 García-Galiano D, Pinilla L, Tena-Sempere M. Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions. Journal of Neuroendocrinology. 24: 22-33. PMID 21951227 DOI: 10.1111/J.1365-2826.2011.02230.X  0.53
2012 Pinto FM, Cejudo-Román A, Ravina CG, Fernández-Sánchez M, Martín-Lozano D, Illanes M, Tena-Sempere M, Candenas ML. Characterization of the kisspeptin system in human spermatozoa. International Journal of Andrology. 35: 63-73. PMID 21651574 DOI: 10.1111/J.1365-2605.2011.01177.X  0.352
2011 Navarro VM, Gottsch ML, Wu M, García-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA. Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology. 152: 4265-75. PMID 21914775 DOI: 10.1210/En.2011-1143  0.729
2011 Navarro VM, Tena-Sempere M. Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nature Reviews. Endocrinology. 8: 40-53. PMID 21912400 DOI: 10.1038/Nrendo.2011.147  0.664
2011 Castellano JM, Bentsen AH, Sánchez-Garrido MA, Ruiz-Pino F, Romero M, Garcia-Galiano D, Aguilar E, Pinilla L, Diéguez C, Mikkelsen JD, Tena-Sempere M. Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology. 152: 3396-408. PMID 21712362 DOI: 10.1210/En.2010-1415  0.465
2011 Ruscica M, Dozio E, Steffani L, Passafaro L, Mazzer M, Castellano JM, Motta M, Tena-Sempere M, Magni P. Role of the energy sensor adenosine monophosphate-activated protein kinase in the regulation of immature gonadotropin-releasing hormone neuron migration. Journal of Endocrinological Investigation. 34: e362-8. PMID 21697647 DOI: 10.3275/7803  0.381
2011 Roa J, Navarro VM, Tena-Sempere M. Kisspeptins in reproductive biology: consensus knowledge and recent developments. Biology of Reproduction. 85: 650-60. PMID 21677307 DOI: 10.1095/Biolreprod.111.091538  0.655
2011 Tapia-González S, García-Segura LM, Tena-Sempere M, Frago LM, Castellano JM, Fuente-Martín E, García-Cáceres C, Argente J, Chowen JA. Activation of microglia in specific hypothalamic nuclei and the cerebellum of adult rats exposed to neonatal overnutrition. Journal of Neuroendocrinology. 23: 365-70. PMID 21314736 DOI: 10.1111/J.1365-2826.2011.02113.X  0.379
2011 Pinilla L, Pineda R, Gaytán F, Romero M, García-Galiano D, Sánchez-Garrido MA, Ruiz-Pino F, Tena-Sempere M, Aguilar E. Characterization of the reproductive effects of the anorexigenic VGF-derived peptide TLQP-21: in vivo and in vitro studies in male rats. American Journal of Physiology. Endocrinology and Metabolism. 300: E837-47. PMID 21304062 DOI: 10.1152/Ajpendo.00598.2010  0.522
2011 Luque RM, Córdoba-Chacón J, Gahete MD, Navarro VM, Tena-Sempere M, Kineman RD, Castaño JP. Kisspeptin regulates gonadotroph and somatotroph function in nonhuman primate pituitary via common and distinct signaling mechanisms. Endocrinology. 152: 957-66. PMID 21209013 DOI: 10.1210/En.2010-1142  0.662
2011 Navarro VM, Tena-Sempere M. Kisspeptins and the neuroendocrine control of reproduction. Frontiers in Bioscience (Scholar Edition). 3: 267-75. PMID 21196375 DOI: 10.2741/S150  0.644
2011 Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA. Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. American Journal of Physiology. Endocrinology and Metabolism. 300: E202-10. PMID 21045176 DOI: 10.1152/Ajpendo.00517.2010  0.757
2011 Tena-Sempere M. Neuroendocrine Mechanisms for the Metabolic Control of Puberty. Biology of Reproduction. 85: 19-19. DOI: 10.1093/Biolreprod/85.S1.19  0.309
2010 Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M. Kisspeptins: bridging energy homeostasis and reproduction. Brain Research. 1364: 129-38. PMID 20800054 DOI: 10.1016/J.Brainres.2010.08.057  0.457
2010 García-Galiano D, Navarro VM, Gaytan F, Tena-Sempere M. Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation. Journal of Molecular Endocrinology. 45: 281-90. PMID 20682642 DOI: 10.1677/Jme-10-0059  0.609
2010 Roa J, Tena-Sempere M. Energy balance and puberty onset: emerging role of central mTOR signaling. Trends in Endocrinology and Metabolism. 21: 519-528. PMID 20554449 DOI: 10.1016/J.Tem.2010.05.003  0.403
2010 García-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Gaytán F, Diéguez C, Pinilla L, Tena-Sempere M. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7783-92. PMID 20534827 DOI: 10.1523/Jneurosci.5828-09.2010  0.7
2010 Pineda R, Aguilar E, Pinilla L, Tena-Sempere M. Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction. Progress in Brain Research. 181: 55-77. PMID 20478433 DOI: 10.1016/S0079-6123(08)81005-9  0.475
2010 Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, Noort PIv, Tena-Sempere M. Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies American Journal of Physiology-Endocrinology and Metabolism. 299. PMID 20424142 DOI: 10.1152/Ajpendo.00108.2010  0.481
2010 Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sánchez-Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M. Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. American Journal of Physiology. Endocrinology and Metabolism. 299: E54-61. PMID 20407007 DOI: 10.1152/Ajpendo.00081.2010  0.32
2010 Tena-Sempere M. Kisspeptins and the metabolic control of reproduction: physiologic roles and physiopathological implications. Annales D'Endocrinologie. 71: 201-2. PMID 20362974 DOI: 10.1016/j.ando.2010.02.018  0.309
2010 Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, Romero M, Ruiz-Pino F, Aguilar E, Dijcks FA, Blomenröhr M, Pinilla L, Noort PIv, Tena-Sempere M. Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. Endocrinology. 151: 1902-1913. PMID 20160130 DOI: 10.1210/En.2009-1259  0.513
2010 Roa J, García-Galiano D, Castellano JM, Gaytan F, Pinilla L, Tena-Sempere M. Metabolic control of puberty onset: new players, new mechanisms. Molecular and Cellular Endocrinology. 324: 87-94. PMID 20026241 DOI: 10.1016/J.Mce.2009.12.018  0.426
2010 Tena-Sempere M. Roles of kisspeptins in the control of hypothalamic-gonadotropic function: focus on sexual differentiation and puberty onset. Endocrine Development. 17: 52-62. PMID 19955756 DOI: 10.1159/000262528  0.47
2010 Bentsen AH, Ansel L, Simonneaux V, Tena-Sempere M, Juul A, Mikkelsen JD. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides. 31: 275-83. PMID 19944729 DOI: 10.1016/J.Peptides.2009.11.017  0.511
2010 Tena-Sempere M. Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function. International Journal of Andrology. 33: 360-368. PMID 19906185 DOI: 10.1111/J.1365-2605.2009.01012.X  0.509
2010 Nurmio M, Tena-Sempere M, Toppari J. Orexins and the regulation of the hypothalamic-pituitary-testicular axis Acta Physiologica. 198: 349-354. PMID 19476455 DOI: 10.1111/J.1748-1716.2009.02006.X  0.476
2010 Tena-Sempere M. Metabolic Regulation of Reproduction: Roles of the Hypothalamic Kiss1 System. Biology of Reproduction. 83: 197-197. DOI: 10.1093/Biolreprod/83.S1.197  0.393
2009 Pineda R, Garcia-Galiano D, Roseweir A, Romero M, Sanchez-Garrido MA, Pino FR, Morgan K, Pinilla L, Millar RP, Tena-Sempere M. Critical Roles of Kisspeptin in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist. Endocrine Reviews. 30: 928-929. PMID 28199591 DOI: 10.1210/edrv.30.7.9994  0.328
2009 Pineda R, Garcia-Galiano D, Roseweir A, Romero M, Sanchez-Garrido MA, Ruiz-Pino F, Morgan K, Pinilla L, Millar RP, Tena-Sempere M. Critical roles of kisspeptins in female puberty and preovulatory gonadotropin surges as revealed by a novel antagonist. Endocrinology. 151: 722-30. PMID 19952274 DOI: 10.1210/en.2009-0803  0.365
2009 López M, Nogueiras R, Tena-Sempere M, Diéguez C. Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis. Acta Physiologica (Oxford, England). 198: 325-34. PMID 19769635 DOI: 10.1111/j.1748-1716.2009.02042.x  0.336
2009 Roa J, Garcia-Galiano D, Varela L, Sánchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, López M, Gaytan F, Diéguez C, Pinilla L, Tena-Sempere M. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology. 150: 5016-26. PMID 19734277 DOI: 10.1210/En.2009-0096  0.467
2009 Gutiérrez-Pascual E, Leprince J, Martínez-Fuentes AJ, Ségalas-Milazzo I, Pineda R, Roa J, Duran-Prado M, Guilhaudis L, Desperrois E, Lebreton A, Pinilla L, Tonon MC, Malagón MM, Vaudry H, Tena-Sempere M, et al. In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides. Molecular Pharmacology. 76: 58-67. PMID 19389922 DOI: 10.1124/Mol.108.053751  0.404
2009 Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP. Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3920-9. PMID 19321788 DOI: 10.1523/Jneurosci.5740-08.2009  0.697
2009 Pinilla L, Castellano JM, Romero M, Tena-Sempere M, Gaytán F, Aguilar E. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Endocrinology. 150: 2889-97. PMID 19228890 DOI: 10.1210/en.2008-1381  0.455
2009 Gaytán F, Gaytán M, Castellano JM, Romero M, Roa J, Aparicio B, Garrido N, Sánchez-Criado JE, Millar RP, Pellicer A, Fraser HM, Tena-Sempere M. KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction. American Journal of Physiology. Endocrinology and Metabolism. 296: E520-31. PMID 19141682 DOI: 10.1152/Ajpendo.90895.2008  0.394
2009 Navarro VM, Sánchez-Garrido MA, Castellano JM, Roa J, García-Galiano D, Pineda R, Aguilar E, Pinilla L, Tena-Sempere M. Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation. Endocrinology. 150: 2359-67. PMID 19106226 DOI: 10.1210/En.2008-0580  0.654
2009 Felip A, Zanuy S, Pineda R, Pinilla L, Carrillo M, Tena-Sempere M, Gómez A. Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals. Molecular and Cellular Endocrinology. 312: 61-71. PMID 19084576 DOI: 10.1016/J.Mce.2008.11.017  0.392
2009 Castellano JM, Navarro VM, Roa J, Pineda R, Sánchez-Garrido MA, García-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology. 150: 784-94. PMID 18845637 DOI: 10.1210/En.2008-0849  0.601
2009 Roa J, Castellano JM, Navarro VM, Handelsman DJ, Pinilla L, Tena-Sempere M. Kisspeptins and the control of gonadotropin secretion in male and female rodents. Peptides. 30: 57-66. PMID 18793689 DOI: 10.1016/J.Peptides.2008.08.009  0.682
2009 Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides. 30: 139-45. PMID 18634841 DOI: 10.1016/j.peptides.2008.06.007  0.336
2009 Tena-Sempere M, Huhtaniemi I. Sex in the brain: How the brain regulates reproductive function The Biochemist. 31: 4-7. DOI: 10.1042/bio03102004  0.43
2008 Tena-Sempere M. Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nature Clinical Practice. Endocrinology & Metabolism. 4: 666-74. PMID 18981992 DOI: 10.1038/ncpendmet1003  0.392
2008 Roa J, Vigo E, Castellano JM, Gaytan F, García-Galiano D, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M. Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors. Endocrinology. 149: 5783-90. PMID 18635654 DOI: 10.1210/En.2008-0604  0.698
2008 Sirotkin AV, Chrenková M, Nitrayová S, Patraš P, Darlak K, Valenzuela F, Pinilla L, Tena-Sempere M. Effects of chronic food restriction and treatments with leptin or ghrelin on different reproductive parameters of male rats. Peptides. 29: 1362-1368. PMID 18455268 DOI: 10.1016/J.Peptides.2008.03.011  0.489
2008 Roa J, Vigo E, García-Galiano D, Castellano JM, Navarro VM, Pineda R, Diéguez C, Aguilar E, Pinilla L, Tena-Sempere M. Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. American Journal of Physiology. Endocrinology and Metabolism. 294: E1088-96. PMID 18413669 DOI: 10.1152/Ajpendo.90240.2008  0.689
2008 Caminos JE, Nogueiras R, Gaytán F, Pineda R, González CR, Barreiro ML, Castaño JP, Malagón MM, Pinilla L, Toppari J, Diéguez C, Tena-Sempere M. Novel expression and direct effects of adiponectin in the rat testis. Endocrinology. 149: 3390-402. PMID 18403483 DOI: 10.1210/en.2007-1582  0.448
2008 Gordon A, Garrido-Gracia JC, Aguilar R, Bellido C, Velasco JA, Millan Y, Tena-Sempere M, Martín de Las Mulas J, Sánchez-Criado JE. The ovary-mediated FSH attenuation of the LH surge in the rat involves a decreased gonadotroph progesterone receptor (PR) action but not PR expression. The Journal of Endocrinology. 196: 583-92. PMID 18310454 DOI: 10.1677/Joe-07-0223  0.513
2008 Vidal C, Roa J, Pinilla L, Pellicer A, Tena-Sempere M. Maternal serum ghrelin levels in early IVF pregnancies: lack of prognostic value for viable pregnancy and altered post-prandial responses Human Reproduction. 23: 958-963. PMID 18281683 DOI: 10.1093/Humrep/Den020  0.332
2008 Rodríguez-Pacheco F, Luque RM, Tena-Sempere M, Malagón MM, Castaño JP. Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway. Journal of Neuroendocrinology. 20: 406-12. PMID 18208548 DOI: 10.1111/j.1365-2826.2008.01645.x  0.354
2008 Roa J, Vigo E, Castellano JM, Gaytan F, Navarro VM, Aguilar E, Dijcks FA, Ederveen AG, Pinilla L, van Noort PI, Tena-Sempere M. Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge. Endocrinology. 149: 1627-37. PMID 18174277 DOI: 10.1210/En.2007-1540  0.698
2008 Navarro VM, Tena-Sempere M. The KiSS-1/GPR54 system: putative target for endocrine disruption of reproduction at hypothalamic-pituitary unit? International Journal of Andrology. 31: 224-32. PMID 17971159 DOI: 10.1111/J.1365-2605.2007.00833.X  0.648
2008 Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Frontiers in Neuroendocrinology. 29: 48-69. PMID 17870152 DOI: 10.1016/J.Yfrne.2007.07.002  0.422
2007 Tena-Sempere M, Barreiro M, Lage M, Dieguez C, Casanueva F. Role of leptin and ghrelin in the regulation of gonadal function Expert Review of Endocrinology & Metabolism. 2: 239-249. PMID 30754186 DOI: 10.1586/17446651.2.2.239  0.461
2007 Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitamins and Hormones Series. 77: 285-300. PMID 17983861 DOI: 10.1016/S0083-6729(06)77012-1  0.508
2007 Tena-Sempere M. Roles of ghrelin and leptin in the control of reproductive function Neuroendocrinology. 86: 229-241. PMID 17851226 DOI: 10.1159/000108410  0.505
2007 Pinilla L, Fernández-Fernández R, Roa J, Castellano JM, Tena-Sempere M, Aguilar E. Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat. American Journal of Physiology. Endocrinology and Metabolism. 293: E1385-92. PMID 17785504 DOI: 10.1152/Ajpendo.00274.2007  0.424
2007 Vigo E, Roa J, Pineda R, Castellano JM, Navarro VM, Aguilar E, Pinilla L, Tena-Sempere M. Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod. American Journal of Physiology. Endocrinology and Metabolism. 293: E1265-73. PMID 17726140 DOI: 10.1152/Ajpendo.00425.2007  0.716
2007 Fernández-Fernández R, Tena-Sempere M, Roa J, Castellano JM, Navarro VM, Aguilar E, Pinilla L. Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen. Reproduction (Cambridge, England). 133: 1223-32. PMID 17636176 DOI: 10.1530/Rep-06-0227  0.708
2007 Luque RM, Kineman RD, Tena-Sempere M. Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology. 148: 4601-4611. PMID 17595226 DOI: 10.1210/En.2007-0500  0.465
2007 Archanco M, Gómez-Ambrosi J, Tena-Sempere M, Frühbeck G, Burrell MA. Expression of leptin and adiponectin in the rat oviduct. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 55: 1027-37. PMID 17565119 DOI: 10.1369/jhc.6A7128.2007  0.374
2007 Gutiérrez-Pascual E, Martínez-Fuentes AJ, Pinilla L, Tena-Sempere M, Malagón MM, Castaño JP. Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. Journal of Neuroendocrinology. 19: 521-530. PMID 17532794 DOI: 10.1111/J.1365-2826.2007.01558.X  0.551
2007 Gaytán M, Castellano JM, Roa J, Sánchez-Criado JE, Tena-Sempere M, Gaytán F. Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation? Cell and Tissue Research. 329: 571-9. PMID 17503086 DOI: 10.1007/S00441-007-0426-2  0.382
2007 García MC, López M, Alvarez CV, Casanueva F, Tena-Sempere M, Diéguez C. Role of ghrelin in reproduction. Reproduction (Cambridge, England). 133: 531-40. PMID 17379649 DOI: 10.1530/REP-06-0249  0.341
2007 Navarro VM, Castellano JM, García-Galiano D, Tena-Sempere M. Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin. Reviews in Endocrine & Metabolic Disorders. 8: 11-20. PMID 17340172 DOI: 10.1007/S11154-007-9028-2  0.613
2007 Roa J, Tena-Sempere M. KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals. General and Comparative Endocrinology. 153: 132-140. PMID 17324425 DOI: 10.1016/J.Ygcen.2007.01.026  0.514
2007 Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M. Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology. 148: 1774-83. PMID 17204549 DOI: 10.1210/En.2006-1540  0.67
2007 Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M. Neuromedin s as novel putative regulator of luteinizing hormone secretion. Endocrinology. 148: 813-23. PMID 17110433 DOI: 10.1210/En.2006-0636  0.662
2007 Rodriguez-Pacheco F, Martinez-Fuentes AJ, Tovar S, Pinilla L, Tena-Sempere M, Dieguez C, Castaño JP, Malagon MM. Regulation of pituitary cell function by adiponectin. Endocrinology. 148: 401-10. PMID 17038552 DOI: 10.1210/En.2006-1019  0.483
2007 Navarro VM, Castellano JM, Tena-Sempere M. New signals in puberty: The KiSS-1/GPR54 system | Nuevas señales en pubertad: Sistema KiSS-1/GPR54 Endocrinologia Y Nutricion. 54: 299-306. DOI: 10.1016/S1575-0922(07)71454-7  0.497
2006 Davies JS, Thompson NM, Christian HC, Pinilla L, Ebling FJ, Tena-Sempere M, Wells T. Hypothalamic expression of human growth hormone induces post-pubertal hypergonadotrophism in male transgenic growth retarded rats. Journal of Neuroendocrinology. 18: 719-31. PMID 16965290 DOI: 10.1111/J.1365-2826.2006.01467.X  0.526
2006 Tena-Sempere M. KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology. 83: 275-281. PMID 16940711 DOI: 10.1159/000095549  0.407
2006 Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes. 55: 2602-10. PMID 16936210 DOI: 10.2337/Db05-1584  0.615
2006 Castellano JM, Navarro VM, Fernández-Fernández R, Castaño JP, Malagón MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M. Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat. Molecular and Cellular Endocrinology. 257: 75-83. PMID 16930819 DOI: 10.1016/J.Mce.2006.07.002  0.684
2006 Tena-Sempere M. The roles of kisspeptins and G protein-coupled receptor-54 in pubertal development. Current Opinion in Pediatrics. 18: 442-447. PMID 16915001 DOI: 10.1097/01.Mop.0000236396.79580.Cc  0.496
2006 Sirotkin AV, Grossmann R, María-Peon MT, Roa J, Tena-Sempere M, Klein S. Novel expression and functional role of ghrelin in chicken ovary. Molecular and Cellular Endocrinology. 257: 15-25. PMID 16891055 DOI: 10.1016/J.Mce.2006.06.004  0.458
2006 Castellano JM, Navarro VM, Fernández-Fernández R, Roa J, Vigo E, Pineda R, Steiner RA, Aguilar E, Pinilla L, Tena-Sempere M. Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty. American Journal of Physiology. Endocrinology and Metabolism. 291: E1281-9. PMID 16849629 DOI: 10.1152/Ajpendo.00130.2006  0.767
2006 Castellano JM, Gaytan M, Roa J, Vigo E, Navarro VM, Bellido C, Dieguez C, Aguilar E, Sánchez-Criado JE, Pellicer A, Pinilla L, Gaytan F, Tena-Sempere M. Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology. 147: 4852-62. PMID 16825322 DOI: 10.1210/En.2006-0117  0.682
2006 Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Novel signals for the integration of energy balance and reproduction. Molecular and Cellular Endocrinology. 254: 127-32. PMID 16759792 DOI: 10.1016/J.Mce.2006.04.026  0.659
2006 Tena-Sempere M. GPR54 and kisspeptin in reproduction Human Reproduction Update. 12: 631-639. PMID 16731583 DOI: 10.1093/Humupd/Dml023  0.468
2006 Martínez-Fuentes AJ, Moreno-Fernández J, Vázquez-Martínez R, Durán-Prado M, de la Riva A, Tena-Sempere M, Diéguez C, Jiménez-Reina L, Webb SM, Pumar A, Leal-Cerro A, Benito-López P, Malagón MM, Castaño JP. Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas. The Journal of Clinical Endocrinology and Metabolism. 91: 2225-31. PMID 16551736 DOI: 10.1210/Jc.2006-0235  0.407
2006 Navarro VM, Fernández-Fernández R, Nogueiras R, Vigo E, Tovar S, Chartrel N, Le Marec O, Leprince J, Aguilar E, Pinilla L, Dieguez C, Vaudry H, Tena-Sempere M. Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis. The Journal of Physiology. 573: 237-49. PMID 16543265 DOI: 10.1113/Jphysiol.2006.106856  0.695
2006 Roa J, Vigo E, Castellano JM, Navarro VM, Fernández-Fernández R, Casanueva FF, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M. Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat. Endocrinology. 147: 2864-78. PMID 16527840 DOI: 10.1210/En.2005-1463  0.698
2006 Leffers H, Navarro VM, Nielsen JE, Mayen A, Pinilla L, Dalgaard M, Malagon MM, Castaño JP, Skakkebaek NE, Aguilar E, Tena-Sempere M. Increased expression of α- and β-globin mRNAs at the pituitary following exposure to estrogen during the critical period of neonatal sex differentiation in the rat Journal of Steroid Biochemistry and Molecular Biology. 99: 33-43. PMID 16520034 DOI: 10.1016/J.Jsbmb.2005.11.012  0.602
2006 Tovar S, Vázquez MJ, Navarro VM, Fernández-Fernández R, Castellano JM, Vigo E, Roa J, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M. Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats. Endocrinology. 147: 2696-704. PMID 16513831 DOI: 10.1210/En.2005-1397  0.661
2006 Sánchez-Criado JE, de Las Mulas JM, Bellido C, Navarro VM, Aguilar R, Garrido-Gracia JC, Malagón MM, Tena-Sempere M, Blanco A. Gonadotropin-secreting cells in ovariectomized rats treated with different oestrogen receptor ligands: a modulatory role for ERbeta in the gonadotrope? The Journal of Endocrinology. 188: 167-77. PMID 16461544 DOI: 10.1677/Joe.1.06377  0.668
2006 Martini AC, Fernández-Fernández R, Tovar S, Navarro VM, Vigo E, Vazquez MJ, Davies JS, Thompson NM, Aguilar E, Pinilla L, Wells T, Dieguez C, Tena-Sempere M. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology. 147: 2374-82. PMID 16455774 DOI: 10.1210/En.2005-1422  0.702
2006 Pinilla L, Fernández-Fernández R, Vigo E, Navarro VM, Roa J, Castellano JM, Pineda R, Tena-Sempere M, Aguilar E. Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats. American Journal of Physiology. Endocrinology and Metabolism. 290: E1162-71. PMID 16390861 DOI: 10.1152/Ajpendo.00469.2005  0.667
2006 Lavaque E, Mayen A, Azcoitia I, Tena-Sempere M, Garcia-Segura LM. Sex differences, developmental changes, response to injury and cAMP regulation of the mRNA levels of steroidogenic acute regulatory protein, cytochrome P450scc, and aromatase in the olivocerebellar system Journal of Neurobiology. 66: 308-318. PMID 16329132 DOI: 10.1002/Neu.20221  0.444
2006 Tena-Sempere M, Kauffman A, Roa J, Navarro V, Gottsch M, Clifton D, Steiner R. Sexual differentiation of Kiss1 expression in the brain of the rat Frontiers in Neuroendocrinology. 27: 97. DOI: 10.1016/J.Yfrne.2006.03.222  0.552
2006 Malagón MM, Rodríguez-Pacheco F, Martínez-Fuentes AJ, Tovar S, Pinilla L, Tena-Sempere M, Diéguez C, Castaño JP. Regulation of pituitary cell function by the adipokine adiponectin Frontiers in Neuroendocrinology. 27: 35. DOI: 10.1016/J.Yfrne.2006.03.071  0.369
2005 Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, Aguilar E, Pinilla L. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology. 82: 245-55. PMID 16721030 DOI: 10.1159/000092753  0.712
2005 Aguilar E, Tena-Sempere M, Pinilla L. Role of excitatory amino acids in the control of growth hormone secretion. Endocrine. 28: 295-302. PMID 16388119 DOI: 10.1385/Endo:28:3:295  0.442
2005 Barreiro ML, Pineda R, Gaytan F, Archanco M, Burrell MA, Castellano JM, Hakovirta H, Nurmio M, Pinilla L, Aguilar E, Toppari J, Dieguez C, Tena-Sempere M. Pattern of orexin expression and direct biological actions of orexin-a in rat testis. Endocrinology. 146: 5164-75. PMID 16141395 DOI: 10.1210/En.2005-0455  0.459
2005 Tena-Sempere M. Hypothalamic KiSS-1: the missing link in gonadotropin feedback control? Endocrinology. 146: 3683-3685. PMID 16105827 DOI: 10.1210/En.2005-0652  0.34
2005 Castellano JM, Navarro VM, Fernández-Fernández R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M. Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology. 146: 3917-25. PMID 15932928 DOI: 10.1210/En.2005-0337  0.652
2005 Nogueiras R, Caminos JE, Gallego R, Raghay K, Bravo S, Tovar S, Pombo C, López M, Tena-Sempere M, García-Caballero T, Diéguez C. Regulation of peroxisome proliferator activated receptor-gamma in rat pituitary. Journal of Neuroendocrinology. 17: 292-7. PMID 15869564 DOI: 10.1111/j.1365-2826.2005.01304.x  0.399
2005 Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function Growth Hormone & Igf Research. 15: 83-88. PMID 15809012 DOI: 10.1016/J.Ghir.2005.02.001  0.5
2005 Fernández-Fernández R, Navarro VM, Barreiro ML, Vigo EM, Tovar S, Sirotkin AV, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology. 146: 3018-25. PMID 15790726 DOI: 10.1210/En.2004-1622  0.643
2005 Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology. 146: 1689-97. PMID 15637288 DOI: 10.1210/En.2004-1353  0.683
2005 Gaytan F, Morales C, Barreiro M, Jeffery P, Chopin L, Herington A, Casanueva F, Aguilar E, Dieguez C, Tena-Sempere M. Expression of Growth Hormone Secretagogue Receptor Type 1a, the Functional Ghrelin Receptor, in Human Ovarian Surface Epithelium, Mullerian Duct Derivatives, and Ovarian Tumors The Journal of Clinical Endocrinology and Metabolism. 90: 1798-1804. PMID 15585554 DOI: 10.1210/Jc.2004-1532  0.371
2005 Fernandez-Fernandez R, Aguilar E, Tena-Sempere M, Pinilla L. Effects of Polypeptide YY3–36 upon Luteinizing Hormone-Releasing Hormone and Gonadotropin Secretion in Prepubertal Rats: In Vivo and in Vitro Studies Endocrinology. 146: 1403-1410. PMID 15564330 DOI: 10.1210/En.2004-0858  0.542
2005 Barreiro ML, Tena-Sempere M. Ghrelin and reproduction: a novel signal linking energy status and fertility? Molecular and Cellular Endocrinology. 226: 1-9. PMID 15488999 DOI: 10.1016/j.mce.2004.07.015  0.449
2005 Navarro VM, Castellano JM, Fernández-Fernández R, Tovar S, Roa J, Mayen A, Nogueiras R, Vazquez MJ, Barreiro ML, Magni P, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54. Endocrinology. 146: 156-63. PMID 15375028 DOI: 10.1210/En.2004-0836  0.673
2005 Aguilar-Valles A, Sánchez E, Gortari Pd, Balderas I, Ramírez-Amaya V, Bermúdez-Rattoni F, Joseph-Bravo P, Fernández-Fernández R, Bornstein SR, Jasoni CL, Todman MG, Han S, Herbison AE, Smallwood S, Castellano JM, ... ... Tena-Sempere M, et al. Contents Vol. 82, 2005 Neuroendocrinology. 82: 331-332. DOI: 10.1159/000093617  0.453
2005 Aguilar-Valles A, Sánchez E, Gortari Pd, Balderas I, Ramírez-Amaya V, Bermúdez-Rattoni F, Joseph-Bravo P, Fernández-Fernández R, Bornstein SR, Jasoni CL, Todman MG, Han S, Herbison AE, Smallwood S, Castellano JM, ... ... Tena-Sempere M, et al. Subject Index Vol. 82, 2005 Neuroendocrinology. 82: 330-330. DOI: 10.1159/000093616  0.442
2004 Navarro VM, Fernández-Fernández R, Castellano JM, Roa J, Mayen A, Barreiro ML, Gaytan F, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. The Journal of Physiology. 561: 379-86. PMID 15486019 DOI: 10.1113/Jphysiol.2004.072298  0.655
2004 Barreiro ML, Gaytan F, Castellano JM, Suominen JS, Roa J, Gaytan M, Aguilar E, Dieguez C, Toppari J, Tena-Sempere M. Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis. Endocrinology. 145: 4825-34. PMID 15284210 DOI: 10.1210/En.2004-0732  0.39
2004 Aguilar E, Fernandez-Fernandez R, Tena-Sempere M, Pinilla L. Effects of peptide YY3–36 on PRL secretion: pituitary and extra-pituitary actions in the rat Peptides. 25: 1147-1152. PMID 15245874 DOI: 10.1016/J.Peptides.2004.04.002  0.517
2004 Navarro VM, Castellano JM, Fernández-Fernández R, Barreiro ML, Roa J, Sanchez-Criado JE, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology. 145: 4565-74. PMID 15242985 DOI: 10.1210/En.2004-0413  0.706
2004 Nogueiras R, Barreiro ML, Caminos JE, Gaytán F, Suominen JS, Navarro VM, Casanueva FF, Aguilar E, Toppari J, Diéguez C, Tena-Sempere M. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. Journal of Cell Science. 117: 3247-57. PMID 15226398 DOI: 10.1242/Jcs.01196  0.672
2004 Sánchez-Criado JE, Martín De Las Mulas J, Bellido C, Tena-Sempere M, Aguilar R, Blanco A. Biological role of pituitary estrogen receptors ERalpha and ERbeta on progesterone receptor expression and action and on gonadotropin and prolactin secretion in the rat. Neuroendocrinology. 79: 247-58. PMID 15205556 DOI: 10.1159/000079100  0.492
2004 Fernández-Fernández R, Tena-Sempere M, Aguilar E, Pinilla L. Ghrelin effects on gonadotropin secretion in male and female rats. Neuroscience Letters. 362: 103-7. PMID 15193764 DOI: 10.1016/j.neulet.2004.03.003  0.461
2004 Tena-Sempere M, Aguilar E, Fernandez-Fernandez R, Pinilla L. Ghrelin inhibits prolactin secretion in prepubertal rats. Neuroendocrinology. 79: 133-141. PMID 15103226 DOI: 10.1159/000077271  0.429
2004 Tena-Sempere M, Barreiro M, Aguilar E, Pinilla L. Mechanisms for altered reproductive function in female rats following neonatal administration of raloxifene European Journal of Endocrinology. 150: 397-403. PMID 15012627 DOI: 10.1530/Eje.0.1500397  0.564
2004 Barreiro ML, Pineda R, Navarro VM, Lopez M, Suominen JS, Pinilla L, Señaris R, Toppari J, Aguilar E, Diéguez C, Tena-Sempere M. Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. Endocrinology. 145: 2297-306. PMID 14764632 DOI: 10.1210/En.2003-1405  0.648
2004 Gaytan F, Barreiro M, Caminos J, Chopin L, Herington A, Morales C, Pinilla L, Paniagua R, Nistal M, Casanueva F, Aguilar E, Dieguez C, Tena-Sempere M. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. The Journal of Clinical Endocrinology and Metabolism. 89: 400-409. PMID 14715878 DOI: 10.1210/Jc.2003-031375  0.434
2004 Tena-Sempere M, Navarro VM, Mayen A, Bellido C, Sánchez-Criado JE. Regulation of Estrogen Receptor (ER) Isoform Messenger RNA Expression by Different ER Ligands in Female Rat Pituitary Biology of Reproduction. 70: 671-678. PMID 14613904 DOI: 10.1095/Biolreprod.103.021378  0.641
2003 Bellido C, Martín de las Mulas J, Tena-Sempere M, Aguilar R, Alonso R, Sánchez-Criado JE. Tamoxifen induces gonadotropin-releasing hormone self-priming through an estrogen-dependent progesterone receptor expression in the gonadotrope of the rat. Neuroendocrinology. 77: 425-35. PMID 12845228 DOI: 10.1159/000071314  0.475
2003 Caminos JE, Tena-Sempere M, Gaytán F, Sanchez-Criado JE, Barreiro ML, Nogueiras R, Casanueva FF, Aguilar E, Diéguez C. Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology. 144: 1594-1602. PMID 12639944 DOI: 10.1210/En.2002-221058  0.457
2003 Pinilla L, Barreiro ML, Tena-Sempere M, Aguilar E. Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology. 77: 83-90. PMID 12624529 DOI: 10.1159/000068652  0.416
2003 Gaytan F, Barreiro ML, Chopin LK, Herington AC, Morales C, Pinilla L, Casanueva FF, Aguilar E, Diéguez C, Tena-Sempere M. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. The Journal of Clinical Endocrinology and Metabolism. 88: 879-87. PMID 12574228 DOI: 10.1210/JC.2002-021196  0.324
2003 Pinilla L, Gonzalez LC, Tena-Sempere M, Aguilar E. 5-HT1 and 5-HT2 receptor activation reduces N-methyl-D-aspartate (NMDA)-stimulated LH secretion in prepubertal male and female rats. European Journal of Endocrinology. 148: 121-127. PMID 12534365 DOI: 10.1530/Eje.0.1480121  0.352
2003 Barreiro ML, Gaytán F, Caminos JE, Pinilla L, Casanueva FF, Aguilar E, Diéguez C, Tena-Sempere M. Cellular location and hormonal regulation of ghrelin expression in rat testis. Biology of Reproduction. 67: 1768-76. PMID 12444052 DOI: 10.1095/biolreprod.102.006965  0.41
2002 Barreiro ML, Suominen JS, Gaytán F, Pinilla L, Chopin LK, Casanueva FF, Diéguez C, Aguilar E, Toppari J, Tena-Sempere M. Developmental, stage-specific, and hormonally regulated expression of growth hormone secretagogue receptor messenger RNA in rat testis. Biology of Reproduction. 68: 1631-40. PMID 12606422 DOI: 10.1095/biolreprod.102.008862  0.319
2002 Barreiro M, Pinilla L, Aguilar E, Tena-Sempere M. Expression and homologous regulation of GH secretagogue receptor mRNA in rat adrenal gland. European Journal of Endocrinology. 147: 677-688. PMID 12444901 DOI: 10.1530/Eje.0.1470677  0.452
2002 Pinilla L, Barreiro ML, Tena-Sempere M, Aguilar E. Raloxifene effects upon the neuronal system controlling sexual receptivity in female rats. Neuroscience Letters. 329: 285-8. PMID 12183032 DOI: 10.1016/S0304-3940(02)00685-7  0.36
2002 Tena-Sempere M, Barreiro ML. Leptin in male reproduction: the testis paradigm. Molecular and Cellular Endocrinology. 188: 9-13. PMID 11911940 DOI: 10.1016/S0303-7207(02)00008-4  0.536
2002 Pinilla L, Barreiro M, Gonzalez L, Tena-Sempere M, Aguilar E. Comparative effects of testosterone propionate, oestradiol benzoate, ICI 182,780, tamoxifen and raloxifene on hypothalamic differentiation in the female rat. Journal of Endocrinology. 172: 441-448. PMID 11874692 DOI: 10.1677/Joe.0.1720441  0.472
2001 Manna PR, Kero J, Tena-Sempere M, Pakarinen P, Stocco DM, Huhtaniemi IT. Assessment of Mechanisms of Thyroid Hormone Action in Mouse Leydig Cells: Regulation of the Steroidogenic Acute Regulatory Protein, Steroidogenesis, and Luteinizing Hormone Receptor Function* * This investigation was supported in part by grants from the Sigrid Jusélius Foundation, Academy of Finland, Foundation for the Finnish Cancer Societies (to I.T.H.), and NIH Grant (HD-1-7481) (to D.M.S.). Endocrinology. 142: 319-331. PMID 28201390 DOI: 10.1210/Endo.142.1.7900  0.386
2001 Pinilla L, González LC, Tena-Sempere M, Bellido C, Aguilar E. Effects of systemic blockade of nitric oxide synthases on pulsatile LH, prolactin, and GH secretion in adult male rats. Hormone Research in Paediatrics. 55: 229-235. PMID 11740144 DOI: 10.1159/000050001  0.43
2001 Tena-Sempere M, Barreiro ML, González LC, Pinilla L, Aguilar E. Differential neonatal imprinting and regulation by estrogen of estrogen receptor subtypes alpha and beta and of the truncated estrogen receptor product (TERP-1) mRNA expression in the male rat pituitary. Neuroendocrinology. 74: 347-58. PMID 11694766 DOI: 10.1159/000054701  0.408
2001 Pinilla L, Gonzalez LC, Tena-Sempere M, Aguilar E. Evidence for an estrogen-like action of raloxifene upon the hypothalamic-pituitary unit: raloxifene inhibits luteinizing hormone secretion and stimulates prolactin secretion in ovariectomized female rats. Neuroscience Letters. 311: 149-152. PMID 11578816 DOI: 10.1016/S0304-3940(01)02104-8  0.494
2001 Tena-Sempere M, Manna P, Zhang F, Pinilla L, Gonzalez L, Dieguez C, Huhtaniemi I, Aguilar E. Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression Journal of Endocrinology. 170: 413-423. PMID 11479137 DOI: 10.1677/Joe.0.1700413  0.455
2001 Pinilla L, González LC, Gaytán F, Tena-Sempere M, Aguilar E. Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats. Reproduction (Cambridge, England). 121: 915-24. PMID 11373178 DOI: 10.1530/REP.0.1210915  0.37
2001 Pinilla L, Gonzalez LC, Tena-Sempere M, Aguilar E. 5-HT1 and 5-HT2 receptor agonists blunt +/- -alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-stimulated GH secretion in prepubertal male rats European Journal of Endocrinology. 144: 535-541. PMID 11331221 DOI: 10.1530/Eje.0.1440535  0.334
2001 Pinilla L, Gonzalez L, Tena-Sempere M, Aguilar E. Activation of AMPA receptors inhibits prolactin and estradiol secretion and delays the onset of puberty in female rats. The Journal of Steroid Biochemistry and Molecular Biology. 75: 277-81. PMID 11282283 DOI: 10.1016/S0960-0760(00)00191-6  0.332
2001 Pinilla L, Gonzalez LC, Tena-Sempere M, Aguilar E. Cross-talk between excitatory and inhibitory amino acids in the regulation of growth hormone secretion in neonatal rats. Neuroendocrinology. 73: 62-67. PMID 11174018 DOI: 10.1159/000054621  0.443
2001 Tena-Sempere M, González LC, Pinilla L, Huhtaniemi I, Aguilar E. Neonatal imprinting and regulation of estrogen receptor alpha and beta mRNA expression by estrogen in the pituitary and hypothalamus of the male rat. Neuroendocrinology. 73: 12-25. PMID 11174013 DOI: 10.1159/000054616  0.508
2001 Tena-Sempere M, Pinilla L, Zhang F, González LC, Huhtaniemi I, Casanueva FF, Dieguez C, Aguilar E. Developmental and Hormonal Regulation of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid Expression in Rat Testis Biology of Reproduction. 64: 634-643. PMID 11159367 DOI: 10.1095/Biolreprod64.2.634  0.411
2000 Tena-Sempere M, Pinilla L, Gonzalez L, Casanueva F, Dieguez C, Aguilar E. Homologous and heterologous down-regulation of leptin receptor messenger ribonucleic acid in rat adrenal gland. Journal of Endocrinology. 167: 479-486. PMID 11115775 DOI: 10.1677/Joe.0.1670479  0.491
2000 El-Gehani F, Tena-Sempere M, Huhtaniemi I. Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis. Biology of Reproduction. 63: 1482-9. PMID 11058555 DOI: 10.1095/biolreprod63.5.1482  0.354
2000 Gonzalez L, Pinilla L, Tena-Sempere M, Aguilar E. Regulation of prolactin secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in male rats. Journal of Endocrinology. 166: 669-675. PMID 10974660 DOI: 10.1677/Joe.0.1660669  0.474
2000 Tena-Sempere M, Navarro J, Pinilla L, Gonzalez L, Huhtaniemi I, Aguilar E. Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development. Journal of Endocrinology. 165: 345-357. PMID 10810299 DOI: 10.1677/Joe.0.1650345  0.482
2000 Tena-Sempere M, Pinilla L, González LC, Aguilar E. Regulation of growth hormone (GH) secretion by different glutamate receptor subtypes in the rat. Amino Acids. 18: 1-16. PMID 10794128 DOI: 10.1007/S007260050001  0.459
2000 Gonzalez LC, Pinilla L, Tena-Sempere M, Dieguez C, Casanueva FF, Aguilar E. Effect of acute immunoneutralization of endogenous leptin on prolactin and LH secretion during the afternoon of pro-oestrus or in steroid-treated ovariectomized female rats. Journal of Reproduction and Fertility. 118: 39-45. PMID 10793624 DOI: 10.1530/JRF.0.1180039  0.366
2000 Tena-Sempere M, Pinilla L, Gonzalez L, Navarro J, Dieguez C, Casanueva F, Aguilar E. In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat. European Journal of Endocrinology. 142: 406-410. PMID 10754484 DOI: 10.1530/Eje.0.1420406  0.488
1999 Pinilla L, Tena-Sempere M, Aguilar E. Nitric oxide stimulates growth hormone secretion in vitro through a calcium- and cyclic guanosine monophosphate-independent mechanism. Hormone Research in Paediatrics. 51: 242-247. PMID 10559669 DOI: 10.1159/000023378  0.358
1999 Gonzalez LC, Pinilla L, Tena-Sempere M, Aguilar E. Leptin116–130 Stimulates Prolactin and Luteinizing Hormone Secretion in Fasted Adult Male Rats Neuroendocrinology. 70: 213-220. PMID 10516485 DOI: 10.1159/000054479  0.524
1999 Gonzalez L, Pinilla L, Tena-Sempere M, Aguilar E. Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the control of prolactin, growth hormone and gonadotropin secretion in prepubertal rats. Journal of Endocrinology. 162: 417-424. PMID 10467233 DOI: 10.1677/Joe.0.1620417  0.532
1999 Pinilla L, Tena-Sempere M, Gonzalez D, Aguilar E. The role of nitric oxide in the control of basal and LHRH-stimulated LH secretion. Journal of Endocrinological Investigation. 22: 340-8. PMID 10401707 DOI: 10.1007/BF03343571  0.42
1999 Tena-Sempere M, Pinilla L, Gonzalez L, Dieguez C, Casanueva F, Aguilar E. Leptin inhibits testosterone secretion from adult rat testis in vitro Journal of Endocrinology. 161: 211-218. PMID 10320818 DOI: 10.1677/Joe.0.1610211  0.523
1999 González LC, Pinilla L, Tena-Sempere M, Aguilar E. Regulation of growth hormone secretion by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in infantile, prepubertal, and adult male rats. Endocrinology. 140: 1279-84. PMID 10067854 DOI: 10.1210/endo.140.3.6568  0.371
1999 Pinilla L, Gonzalez L, Tena-Sempere M, Dieguez C, Aguilar E. Gonadal and age-related influences on NMDA-induced growth hormone secretion in male rats. Neuroendocrinology. 69: 11-19. PMID 9892846 DOI: 10.1159/000054398  0.409
1999 Pinilla L, Tena-Sempere M, Aguilar E. Sexual differences in the role of kainate receptors in controlling gonadotrophin secretion in prepubertal rats. Journal of Reproduction and Fertility. 113: 269-73. PMID 9861167 DOI: 10.1530/JRF.0.1130269  0.336
1998 Pinilla L, González D, Tena-Sempere M, Aguilar E. Nitric Oxide (NO) Stimulates Gonadotropin Secretion in vitro through a Calcium-Dependent, cGMP-Independent Mechanism Neuroendocrinology. 68: 180-186. PMID 9734002 DOI: 10.1159/000054364  0.329
1998 Pinilla L, Tena-Sempere M, Aguilar E. Role of excitatory amino acid pathways in control of gonadotrophin secretion in adult female rats sterilized by neonatal administration of oestradiol or testosterone. Journal of Reproduction and Fertility. 113: 53-9. PMID 9713376 DOI: 10.1530/JRF.0.1130053  0.323
1998 Pinilla L, Tena-Sempere M, Aguilar R, Aguilar E. Effects of N-methyl-D-aspartic acid and kainic acid on prolactin secretion in hyper- and hypoprolactinaemic conditions. European Journal of Endocrinology. 138: 460-466. PMID 9578517 DOI: 10.1530/Eje.0.1380460  0.361
1997 Aguilar E, Tena-Sempere M, Aguilar R, Gonzalez D, Pinilla L. Interactions between N-methyl-D-aspartate, nitric oxide and serotonin in the control of prolactin secretion in prepubertal male rats European Journal of Endocrinology. 137: 99-106. PMID 9242209 DOI: 10.1530/Eje.0.1370099  0.398
1997 Tena-Sempere M, Rannikko A, Kero J, Zhang FP, Huhtaniemi IT. Molecular mechanisms of reappearance of luteinizing hormone receptor expression and function in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate. Endocrinology. 138: 3340-8. PMID 9231786 DOI: 10.1210/ENDO.138.8.5325  0.367
1997 Tena-Sempere M, Pinilla L, Aguilar E. The pattern of testosterone replacement influences the recovery of the stimulatory effect of clonidine on growth hormone (GH) secretion in orchidectomized rats. The Journal of Steroid Biochemistry and Molecular Biology. 58: 533-8. PMID 8918979 DOI: 10.1016/0960-0760(96)00067-2  0.311
1996 Pinilla L, Gonzalez D, Tena-Sempere M, Aguilar R, Aguilar E. Mechanisms of inhibitory action of kainic acid on prolactin secretion in male rats. Journal of Endocrinology. 151: 159-167. PMID 8943780 DOI: 10.1677/Joe.0.1510159  0.496
1996 Pinilla L, González D, Tena-Sempere M, Aguilar R, Aguilar E. Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats. European Journal of Endocrinology. 135: 464-468. PMID 8921830 DOI: 10.1530/Eje.0.1350464  0.368
1996 Tena-Sempere M, Pinilla L, González D, Aguilar E. Involvement of Endogenous Nitric Oxide in the Control of Pituitary Responsiveness to Different Elicitors of Growth Hormone Release in Prepubertal Rats Neuroendocrinology. 64: 146-152. PMID 8857609 DOI: 10.1159/000127112  0.388
1996 Pinilla L, Tena-Sempere M, Gonzalez D, Aguilar E. Positive role of non-N-methyl-D-aspartate receptors in the control of growth hormone secretion in male rats Journal of Endocrinological Investigation. 19: 353-358. PMID 8844454 DOI: 10.1007/Bf03344969  0.485
1996 Tena-Sempere M, Pinilla L, Aguilar E. In vitro pituitary GH secretion after GHRH, forskolin, dibutyryl cyclic-adenosine 3',5'-monophosphate and phorbol 12-myristate 13-acetate stimulation in long-term orchidectomized rats. Journal of Molecular Endocrinology. 16: 81-88. PMID 8672236 DOI: 10.1677/Jme.0.0160081  0.501
1995 Tena-Sempere M, Pinilla L, Aguilar E. Orchidectomy selectively increases follicle-stimulating hormone secretion in gonadotropin-releasing hormone antagonist-treated male rats European Journal of Endocrinology. 132: 357-362. PMID 7889186 DOI: 10.1530/Eje.0.1320357  0.522
1995 Pinilla L, Tena-Sempere M, Aguilar E. The role of excitatory amino acid pathways in the control of pituitary function in neonatally oestrogenized male rats Journal of Endocrinology. 147: 51-57. PMID 7490537 DOI: 10.1677/Joe.0.1470051  0.476
1995 Pinilla L, Tena-Sempere M, Gonzalez D, Aguilar E. Mechanisms of altered LH secretion in neonatally oestrogenized male rats. Journal of Endocrinology. 147: 43-50. PMID 7490535 DOI: 10.1677/Joe.0.1470043  0.532
1994 Pinilla L, Garnelo P, Tena-Sempere M, Gaytan F, Aguilar E. Mechanisms of reproductive deficiency in male rats treated neonatally with a gonadotrophin-releasing hormone antagonist. Journal of Endocrinology. 142: 517-525. PMID 7964302 DOI: 10.1677/Joe.0.1420517  0.516
1994 Aguilar E, Ranchal A, Tena-Sempere M, Pinilla L. Serotoninergic control of prolactin secretion in prepubertal male rats. European Journal of Endocrinology. 131: 547-554. PMID 7524955 DOI: 10.1530/Eje.0.1310547  0.413
1993 Tena-Sempere M, Pinilla L, Aguilar E. Follicle-stimulating hormone and luteinizing hormone secretion in male rats orchidectomized or injected with ethylene dimethane sulfonate. Endocrinology. 133: 1173-1181. PMID 8396013 DOI: 10.1210/Endo.133.3.8396013  0.489
1993 Aguilar E, Pinilla L, Tena-Sempere M. Growth Hormone-Releasing Hormone-Induced Growth Hormone Secretion in Adult Rats Orchidectomized or Injected with Ethylene Dimethane Sulphonate Neuroendocrinology. 57: 132-134. PMID 8386817 DOI: 10.1159/000126352  0.483
1992 Aguilar E, Padilla MLR, Bellido C, Tena-Sempere M, Pinilla L. Changes in follicle-stimulating hormone secretion in spontaneously hypertensive rats. Neuroendocrinology. 56: 85-93. PMID 1641077 DOI: 10.1159/000126212  0.408
1992 Aguilar E, Tena-Sempere M, Pinilla L. 5-α androstane diol stimulates the pituitary growth hormone responsiveness to growth hormone releasing hormone more effectively than testosterone or dihydrotestosterone in rats European Journal of Endocrinology. 126: 162-166. PMID 1543022 DOI: 10.1530/Acta.0.1260162  0.457
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