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Rance Nault, Ph.D., MSc. - Publications

Affiliations: 
2011 Biology University of Ottawa, Ottawa, ON, Canada 
 2011- Biochemistry and Molecular Biology Michigan State University, East Lansing, MI 
Website:
https://iit.msu.edu/directory/nault_rance.html
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Orlowska K, Nault R, Ara J, LaPres JJ, Harkema J, Demireva EY, Xie H, Wilson RH, Bradfield CA, Yap D, Joshi A, Elferink CJ, Zacharewski T. Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity. Redox Biology. 77: 103405. PMID 39490313 DOI: 10.1016/j.redox.2024.103405  0.823
2024 Sink WJ, Fling R, Yilmaz A, Nault R, Goniwiecha D, Harkema JR, Graham SF, Zacharewski T. 2,3,7,8-Tetrachlorodibenzo- -dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression. Biorxiv : the Preprint Server For Biology. PMID 39484576 DOI: 10.1101/2024.10.22.619714  0.829
2024 Cholico GN, Nault R, Zacharewski T. Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure. Bmc Genomics. 25: 809. PMID 39198768 DOI: 10.1186/s12864-024-10730-3  0.837
2023 Cholico GN, Fling RR, Sink WJ, Nault R, Zacharewski T. Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice. The Journal of Biological Chemistry. 105500. PMID 38013089 DOI: 10.1016/j.jbc.2023.105500  0.795
2023 Jurgelewicz A, Nault R, Harkema J, Zacharewski TR, LaPres JJ. Characterizing the impact of simvastatin co-treatment of cell specific TCDD-induced gene expression and systemic toxicity. Scientific Reports. 13: 16598. PMID 37789023 DOI: 10.1038/s41598-023-42972-8  0.725
2023 Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. Cystine/Glutamate Xc Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo--dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis. Chemical Research in Toxicology. PMID 37184393 DOI: 10.1021/acs.chemrestox.3c00017  0.836
2023 Cholico GN, Orlowska K, Fling RR, Sink WJ, Zacharewski NA, Fader KA, Nault R, Zacharewski T. Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver. Scientific Reports. 13: 4138. PMID 36914879 DOI: 10.1038/s41598-023-31087-9  0.767
2022 Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski T. Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 36222588 DOI: 10.1093/toxsci/kfac109  0.497
2022 Orlowska K, Fling RR, Nault R, Sink WJ, Schilmiller AL, Zacharewski T. Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway, resulting in acrylyl-CoA conjugate buildup. The Journal of Biological Chemistry. 102301. PMID 35931118 DOI: 10.1016/j.jbc.2022.102301  0.833
2022 Cholico GN, Nault R, Zacharewski TR. Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver. International Journal of Molecular Sciences. 23. PMID 35163483 DOI: 10.3390/ijms23031558  0.834
2021 Cholico GN, Fling RR, Zacharewski NA, Fader KA, Nault R, Zacharewski TR. Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation. Scientific Reports. 11: 15689. PMID 34344994 DOI: 10.1038/s41598-021-95214-0  0.806
2021 Jurgelewicz A, Dornbos P, Warren M, Nault R, Arkatkar A, Lin H, Threadgill DW, Zacharewski T, LaPres JJ. Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor (AHR) in Mice Liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33720361 DOI: 10.1093/toxsci/kfab032  0.345
2020 Fling RR, Doskey CM, Fader KA, Nault R, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice. Scientific Reports. 10: 14831. PMID 32908189 DOI: 10.1038/S41598-020-71795-0  0.846
2020 Nault R, Fader KA, Bhattacharya S, Zacharewski TR. Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Cellular and Molecular Gastroenterology and Hepatology. PMID 32791302 DOI: 10.1016/J.Jcmgh.2020.07.012  0.751
2020 Doskey CM, Fader KA, Nault R, Lydic T, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski T. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicology and Applied Pharmacology. 115034. PMID 32387183 DOI: 10.1016/J.Taap.2020.115034  0.852
2019 Nault R, Bals B, Teymouri F, Black MB, Andersen ME, McMullen PD, Krishnan S, Kuravadi N, Paul N, Kumar S, Kannan K, Jayachandra KC, Alagappan L, Patel BD, Bogen KT, et al. A toxicogenomic approach for the risk assessment of the food contaminant acetamide. Toxicology and Applied Pharmacology. 114872. PMID 31881176 DOI: 10.1016/J.Taap.2019.114872  0.643
2019 Fader KA, Nault R, Doskey CM, Fling RR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice. Scientific Reports. 9: 6514. PMID 31015483 DOI: 10.1038/S41598-019-42760-3  0.835
2018 Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski TR. Comparison of hepatic NRF2 and AHR binding in 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) treated mice demonstrates NRF2-independent PKM2 induction. Molecular Pharmacology. PMID 29752288 DOI: 10.1124/Mol.118.112144  0.827
2018 Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicology and Applied Pharmacology. PMID 29673856 DOI: 10.1016/J.Taap.2018.04.013  0.765
2018 Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol Appl Pharmacol. 321 (2017) 1-17]. Toxicology and Applied Pharmacology. PMID 29501526 DOI: 10.1016/J.Taap.2018.03.001  0.754
2017 Nault R, Fader KA, Harkema JR, Zacharewski T. Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice. Plos One. 12. PMID 28922406 DOI: 10.1371/Journal.Pone.0184842  0.823
2017 Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism. Scientific Reports. 7: 5921. PMID 28725001 DOI: 10.1038/S41598-017-05656-8  0.815
2017 Nault R, Fader KA, Lydic TA, Zacharewski TR. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemical Research in Toxicology. PMID 28238261 DOI: 10.1021/Acs.Chemrestox.6B00430  0.822
2017 Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicology and Applied Pharmacology. PMID 28213091 DOI: 10.1016/J.Taap.2017.02.006  0.826
2016 Kovalova N, Nault R, Crawford R, Zacharewski TR, Kaminski NE. Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicology and Applied Pharmacology. PMID 27913140 DOI: 10.1016/J.Taap.2016.11.009  0.606
2016 Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP. Coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27613713 DOI: 10.1093/Toxsci/Kfw175  0.834
2016 Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski T. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27562557 DOI: 10.1093/Toxsci/Kfw163  0.841
2016 Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP. Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism. Blood. PMID 26921287 DOI: 10.1182/Blood-2015-09-670703  0.797
2015 Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26582802 DOI: 10.1093/Toxsci/Kfv245  0.847
2015 Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26377647 DOI: 10.1093/Toxsci/Kfv206  0.855
2015 Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice. American Journal of Respiratory Cell and Molecular Biology. PMID 26203683 DOI: 10.1165/Rcmb.2015-0165Oc  0.561
2015 Nault R, Fader KA, Zacharewski T. RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice Bmc Genomics. 16: 373-373. PMID 25958198 DOI: 10.1186/S12864-015-1527-Z  0.797
2015 Nault R, Colbry D, Brandenberger C, Harkema JR, Zacharewski TR. Development of a computational high-throughput tool for the quantitative examination of dose-dependent histological features. Toxicologic Pathology. 43: 366-75. PMID 25274660 DOI: 10.1177/0192623314544379  0.562
2013 Nault R, Forgacs AL, Dere E, Zacharewski TR. Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver. Toxicology Letters. 223: 52-9. PMID 23994337 DOI: 10.1016/J.Toxlet.2013.08.013  0.816
2013 Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 465-75. PMID 23864506 DOI: 10.1093/Toxsci/Kft156  0.847
2013 Nault R, Abdul-Fattah H, Mironov GG, Berezovski MV, Moon TW. Assessment of energetic costs of AhR activation by β-naphthoflavone in rainbow trout (Oncorhynchus mykiss) hepatocytes using metabolic flux analysis. Toxicology and Applied Pharmacology. 271: 86-94. PMID 23639520 DOI: 10.1016/j.taap.2013.04.017  0.559
2013 Nault R, Kim S, Zacharewski TR. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicology and Applied Pharmacology. 267: 184-91. PMID 23238561 DOI: 10.1016/J.Taap.2012.11.028  0.741
2012 Nault R, Al-Hameedi S, Moon TW. Effects of polychlorinated biphenyls on whole animal energy mobilization and hepatic cellular respiration in rainbow trout, Oncorhynchus mykiss. Chemosphere. 87: 1057-62. PMID 22410624 DOI: 10.1016/j.chemosphere.2012.02.012  0.515
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