Roy H Perlis - Publications

Affiliations: 
Massachusetts General Hospital & Harvard Medical School, Boston, MA, United States 
Area:
Patient-derived cellular models, microglia, drug discovery, mood disorders

156 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sharma A, Verhaak PF, McCoy TH, Perlis RH, Doshi-Velez F. Identifying data-driven subtypes of major depressive disorder with electronic health records. Journal of Affective Disorders. 356: 64-70. PMID 38565338 DOI: 10.1016/j.jad.2024.03.162  0.387
2023 Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH. Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-Like Cells Supports a Functional Role in Synaptic Engulfment. Biological Psychiatry. PMID 37573007 DOI: 10.1016/j.biopsych.2023.07.022  0.733
2023 Kim YR, Lauze MS, Slattery M, Perlis RH, Holsen LM, Breithaupt L, Stern CM, Fava M, Thomas JJ, Lawson EA, Misra M, Eddy KT. Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa. Jama Network Open. 6: e234625. PMID 36961462 DOI: 10.1001/jamanetworkopen.2023.4625  0.497
2022 Szmulewicz AG, Wanis KN, Perlis RH, Hernán MA, Öngür D, Hernández-Díaz S. Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR∗D Randomized Trial. Biological Psychiatry. PMID 36639294 DOI: 10.1016/j.biopsych.2022.09.028  0.342
2022 Gracias J, Orhan F, Hörbeck E, Holmén-Larsson J, Khanlarkani N, Malwade S, Goparaju SK, Schwieler L, Demirel İŞ, Fu T, Fatourus-Bergman H, Pelanis A, Goold CP, Goulding A, Annerbrink K, ... ... Perlis RH, et al. Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia. Nature Communications. 13: 6427. PMID 36329007 DOI: 10.1038/s41467-022-33797-6  0.592
2022 Oliveira AO, Malwade S, Rufino de Sousa N, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM. SARS-CoV-2 promotes microglial synapse elimination in human brain organoids. Molecular Psychiatry. PMID 36198765 DOI: 10.1038/s41380-022-01786-2  0.603
2022 Lee PH, Doyle AE, Silberstein M, Jung JY, Liu R, Perlis RH, Roffman J, Smoller JW, Fava M, Kessler RC. Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US. Jama Psychiatry. PMID 36044238 DOI: 10.1001/jamapsychiatry.2022.2379  0.448
2022 Lage I, McCoy TH, Perlis RH, Doshi-Velez F. Efficiently identifying individuals at high risk for treatment resistance in major depressive disorder using electronic health records. Journal of Affective Disorders. PMID 35181388 DOI: 10.1016/j.jad.2022.02.046  0.315
2022 Perlis RH, Fava M. Is It Time to Try Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Again? Jama Psychiatry. PMID 35138341 DOI: 10.1001/jamapsychiatry.2021.4281  0.506
2021 Lee PH, Doyle AE, Li X, Silberstein M, Jung JY, Gollub RL, Nierenberg AA, Liu RT, Kessler RC, Perlis RH, Fava M. Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study. Biological Psychiatry. PMID 35216811 DOI: 10.1016/j.biopsych.2021.11.026  0.508
2021 Miles AE, Dos Santos FC, Byrne EM, Renteria ME, McIntosh AM, Adams MJ, Pistis G, Castelao E, Preisig M, Baune BT, Schubert KO, Lewis CM, Jones LA, Jones I, Uher R, ... ... Perlis RH, et al. Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34588609 DOI: 10.1038/s41386-021-01189-x  0.306
2021 Perlis RH, Ognyanova K, Quintana A, Green J, Santillana M, Lin J, Druckman J, Lazer D, Simonson MD, Baum MA, Chwe H. Gender-specificity of resilience in major depressive disorder. Depression and Anxiety. PMID 34370885 DOI: 10.1002/da.23203  0.363
2021 Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, St Clair D, Lencz T, Mowry BJ, Periyasamy S, Cairns MJ, Tooney PA, Wu JQ, Kelly B, ... ... Perlis RH, et al. Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry. PMID 34099189 DOI: 10.1016/j.biopsych.2021.02.972  0.341
2021 Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, ... ... Perlis RH, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics. PMID 34002096 DOI: 10.1038/s41588-021-00857-4  0.333
2021 Sheridan SD, Thanos JM, De Guzman RM, McCrea LT, Horng JE, Fu T, Sellgren CM, Perlis RH, Edlow AG. Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Translational Psychiatry. 11: 179. PMID 33741894 DOI: 10.1038/s41398-021-01287-w  0.582
2021 Garvert L, Baune BT, Berger K, Boomsma DI, Breen G, Greinacher A, Hamilton SP, Levinson DF, Lewis CM, Lucae S, Magnusson PKE, Martin NG, McIntosh AM, Mors O, Müller-Myhsok B, ... ... Perlis RH, et al. The association between genetically determined ABO blood types and major depressive disorder. Psychiatry Research. 299: 113837. PMID 33721783 DOI: 10.1016/j.psychres.2021.113837  0.308
2020 Sheridan SD, Thanos JM, De Guzman RM, McCrea LT, Horng J, Fu T, Sellgren CM, Perlis RH, Edlow AG. Umbilical cord blood derived microglia-like cells to model COVID-19 exposure. Biorxiv : the Preprint Server For Biology. PMID 33052344 DOI: 10.1101/2020.10.07.329748  0.582
2020 Pradier MF, Hughes MC, McCoy TH, Barroilhet SA, Doshi-Velez F, Perlis RH. Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32927464 DOI: 10.1038/S41386-020-00838-X  0.359
2020 Haggarty SJ, Karmacharya R, Perlis RH. Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Molecular Psychiatry. PMID 32636474 DOI: 10.1038/S41380-020-0831-4  0.368
2020 Perlis RH, Dowd D, Fava M, Lencz T, Krause DS. Randomized, controlled, participant- and rater-blind trial of pharmacogenomic test-guided treatment versus treatment as usual for major depressive disorder. Depression and Anxiety. PMID 32383277 DOI: 10.1002/da.23029  0.54
2020 Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, ... ... Perlis RH, et al. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nature Genetics. PMID 32231276 DOI: 10.1038/S41588-020-0594-5  0.32
2020 Perlis RH. Abandoning personalization to get to precision in the pharmacotherapy of depression. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 15: 228-235. PMID 27717262 DOI: 10.1002/wps.20345  0.338
2019 Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, ... ... Perlis RH, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. PMID 31043756 DOI: 10.1038/S41588-019-0397-8  0.599
2019 Brown HE, Freudenreich O, Fan X, Heard SO, Goff D, Petrides G, Harrington AL, Kane JM, Judge H, Hoeppner B, Fava M, Perlis RH. Efficacy and Tolerability of Adjunctive Intravenous Sodium Nitroprusside Treatment for Outpatients With Schizophrenia: A Randomized Clinical Trial. Jama Psychiatry. PMID 30916714 DOI: 10.1001/Jamapsychiatry.2019.0151  0.47
2019 Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nature Neuroscience. PMID 30718903 DOI: 10.1038/S41593-018-0334-7  0.605
2019 Sellgren CM, Gracias J, Jungholm O, Perlis RH, Engberg G, Schwieler L, Landen M, Erhardt S. Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls. Translational Psychiatry. 9: 37. PMID 30696814 DOI: 10.1038/s41398-019-0378-9  0.633
2019 Hart KL, Brown HE, Roffman JL, Perlis RH. Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders. Neuropsychology. PMID 30688494 DOI: 10.1037/neu0000506  0.338
2019 Zwicker A, Fabbri C, Gaston D, Denovan-Wright EM, Aitchison K, Peter M, Lewis CM, Perlis R, Castro V, Uher R. GENETIC DETERMINANTS OF WEIGHT CHANGE DURING ANTIDEPRESSANT TREATMENT WITH SELECTIVE SEROTONIN RE-UPTAKE INHIBITORS: GENOME-WIDE STUDY AND META-ANALYSIS European Neuropsychopharmacology. 29: S1000. DOI: 10.1016/J.Euroneuro.2017.08.390  0.307
2018 Charney AW, Stahl EA, Green EK, Chen CY, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, ... ... Perlis R, et al. Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biological Psychiatry. PMID 30686506 DOI: 10.1016/J.Biopsych.2018.12.009  0.606
2018 Perlis RH, Fava M, McCoy TH. Can electronic health records revive central nervous system clinical trials? Molecular Psychiatry. PMID 30429581 DOI: 10.1038/s41380-018-0278-z  0.404
2018 Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH. Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders. Npj Schizophrenia. 4: 9. PMID 29808011 DOI: 10.1038/s41537-018-0050-z  0.31
2018 Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, ... ... Perlis RH, et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics. PMID 29700475 DOI: 10.1038/S41588-018-0090-3  0.369
2018 Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, ... Perlis RH, et al. Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Translational Psychiatry. 8: 86. PMID 29666432 DOI: 10.1038/S41398-018-0133-7  0.516
2017 García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, ... ... Perlis R, et al. Pharmacogenetics of antidepressant response: A polygenic approach. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28159590 DOI: 10.1016/J.Pnpbp.2017.01.011  0.319
2017 Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, ... ... Perlis RH, et al. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Translational Psychiatry. 7: e993. PMID 28072414 DOI: 10.1038/Tp.2016.242  0.597
2016 Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DH, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, ... ... Perlis R, et al. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biological Psychiatry. PMID 28049566 DOI: 10.1016/J.Biopsych.2016.11.013  0.363
2016 Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV. Tissue Type Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27585738 DOI: 10.1038/Npp.2016.180  0.519
2016 Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nature Genetics. PMID 27479909 DOI: 10.1038/Ng.3623  0.329
2016 Vöhringer PA, Perlis RH. Discriminating Between Bipolar Disorder and Major Depressive Disorder. The Psychiatric Clinics of North America. 39: 1-10. PMID 26876315 DOI: 10.1016/j.psc.2015.10.001  0.396
2015 Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, ... ... Perlis RH, et al. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Molecular Psychiatry. PMID 26503763 DOI: 10.1038/Mp.2015.165  0.569
2015 Brennan FX, Gardner KR, Lombard J, Perlis RH, Fava M, Harris HW, Scott R. A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders. The Primary Care Companion For Cns Disorders. 17. PMID 26445691 DOI: 10.4088/Pcc.14M01717  0.527
2015 Ostacher MJ, Perlis RH, Geddes J. Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder The American Journal of Psychiatry. 172: 586. PMID 26029807 DOI: 10.1176/appi.ajp.2015.14111443  0.356
2015 Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, ... ... Perlis RH, et al. Validation of electronic health record phenotyping of bipolar disorder cases and controls. The American Journal of Psychiatry. 172: 363-72. PMID 25827034 DOI: 10.1176/Appi.Ajp.2014.14030423  0.522
2015 Madison JM, Zhou F, Nigam A, Hussain A, Barker DD, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau FH, Ahfeldt T, ... ... Perlis RH, et al. Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities. Molecular Psychiatry. 20: 703-17. PMID 25733313 DOI: 10.1038/Mp.2015.7  0.557
2015 Ramos EM, Gillis T, Mysore JS, Lee JM, Alonso I, Gusella JF, Smoller JW, Sklar P, MacDonald ME, Perlis RH. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder. Bipolar Disorders. 17: 403-8. PMID 25726852 DOI: 10.1111/Bdi.12289  0.589
2015 Clements CC, Castro VM, Blumenthal SR, Rosenfield HR, Murphy SN, Fava M, Erb JL, Churchill SE, Kaimal AJ, Doyle AE, Robinson EB, Smoller JW, Kohane IS, Perlis RH. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Molecular Psychiatry. 20: 727-34. PMID 25155880 DOI: 10.1038/mp.2014.90  0.52
2014 Fagerness J, Fonseca E, Hess GP, Scott R, Gardner KR, Koffler M, Fava M, Perlis R, Brennan FX, Lombard J. Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings. The American Journal of Managed Care. 20: e146-56. PMID 25326929  0.447
2014 Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH. An electronic health records study of long-term weight gain following antidepressant use. Jama Psychiatry. 71: 889-96. PMID 24898363 DOI: 10.1001/jamapsychiatry.2014.414  0.439
2014 Wiste A, Robinson EB, Milaneschi Y, Meier S, Ripke S, Clements CC, Fitzmaurice GM, Rietschel M, Penninx BW, Smoller JW, Perlis RH. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder. Bipolar Disorders. 16: 608-16. PMID 24725193 DOI: 10.1111/Bdi.12201  0.377
2014 O'Dushlaine C, Ripke S, Ruderfer DM, Hamilton SP, Fava M, Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, Perlis RH. Rare copy number variation in treatment-resistant major depressive disorder. Biological Psychiatry. 76: 536-41. PMID 24529801 DOI: 10.1016/j.biopsych.2013.10.028  0.586
2014 Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P, Perlis RH. Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disorders. 16: 199-203. PMID 24372835 DOI: 10.1111/bdi.12143  0.627
2014 Uher R, Payne JL, Pavlova B, Perlis RH. Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV. Depression and Anxiety. 31: 459-71. PMID 24272961 DOI: 10.1002/da.22217  0.386
2014 Hoogenboom WS, Perlis RH, Smoller JW, Zeng-Treitler Q, Gainer VS, Murphy SN, Churchill SE, Kohane IS, Shenton ME, Iosifescu DV. Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: a diffusion tensor imaging study using legacy data. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 15: 122-34. PMID 22540406 DOI: 10.3109/15622975.2012.669499  0.359
2014 Perlis RH, Cusin C, Fava M. Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder. Psychological Medicine. 44: 1361-7. PMID 22417535 DOI: 10.1017/S0033291712000281  0.598
2013 Perlis RH. Pharmacogenomic testing and personalized treatment of depression. Clinical Chemistry. 60: 53-9. PMID 24281779 DOI: 10.1373/clinchem.2013.204446  0.351
2013 McGrath LM, Cornelis MC, Lee PH, Robinson EB, Duncan LE, Barnett JH, Huang J, Gerber G, Sklar P, Sullivan P, Perlis RH, Smoller JW. Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 162: 779-88. PMID 24039173 DOI: 10.1002/Ajmg.B.32190  0.609
2013 Pacchiarotti I, Bond DJ, Baldessarini RJ, Nolen WA, Grunze H, Licht RW, Post RM, Berk M, Goodwin GM, Sachs GS, Tondo L, Findling RL, Youngstrom EA, Tohen M, Undurraga J, ... ... Perlis RH, et al. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. The American Journal of Psychiatry. 170: 1249-62. PMID 24030475 DOI: 10.1176/Appi.Ajp.2013.13020185  0.316
2013 Cusin C, Iovieno N, Iosifescu DV, Nierenberg AA, Fava M, Rush AJ, Perlis RH. A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder. The Journal of Clinical Psychiatry. 74: e636-41. PMID 23945458 DOI: 10.4088/Jcp.12M08093  0.582
2013 Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics. 45: 984-94. PMID 23933821 DOI: 10.1038/Ng.2711  0.601
2013 Castro VM, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH. QT interval and antidepressant use: a cross sectional study of electronic health records. Bmj (Clinical Research Ed.). 346: f288. PMID 23360890 DOI: 10.1136/bmj.f288  0.47
2013 Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, et al. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Alimentary Pharmacology & Therapeutics. 37: 445-54. PMID 23289600 DOI: 10.1111/Apt.12195  0.301
2013 Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 653-62. PMID 23026132 DOI: 10.1016/J.Euroneuro.2012.08.010  0.304
2013 Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, ... ... Perlis RH, et al. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry. 18: 497-511. PMID 22472876 DOI: 10.1038/Mp.2012.21  0.579
2013 Perlis RH, Fijal B, Dharia S, Houston JP. Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder. The Pharmacogenomics Journal. 13: 280-5. PMID 22249355 DOI: 10.1038/tpj.2011.62  0.349
2013 Uher R, Tansey KE, Rietschel M, Henigsberg N, Maier W, Mors O, Hauser J, Placentino A, Souery D, Farmer A, Aitchison KJ, Craig I, McGuffin P, Lewis CM, Ising M, ... ... Perlis RH, et al. Common genetic variation and antidepressant efficacy in major depressive disorder: A meta-analysis of three genome-wide pharmacogenetic studies American Journal of Psychiatry. 170: 207-217. DOI: 10.1176/Appi.Ajp.2012.12020237  0.605
2012 Lee PH, Perlis RH, Jung JY, Byrne EM, Rueckert E, Siburian R, Haddad S, Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P, Martin NG, et al. Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Translational Psychiatry. 2: e184. PMID 23149448 DOI: 10.1038/Tp.2012.95  0.607
2012 Perlis RH, Uher R, Perroud N, Fava M. Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial? The Journal of Clinical Psychiatry. 73: 1439-42. PMID 23059018 DOI: 10.4088/JCP.12m07777  0.542
2012 Gallagher PJ, Castro V, Fava M, Weilburg JB, Murphy SN, Gainer VS, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH. Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study. The American Journal of Psychiatry. 169: 1065-72. PMID 23032386 DOI: 10.1176/appi.ajp.2012.11091325  0.56
2012 Perlis RH, Ruderfer D, Hamilton SP, Ernst C. Copy number variation in subjects with major depressive disorder who attempted suicide. Plos One. 7: e46315. PMID 23029476 DOI: 10.1371/journal.pone.0046315  0.316
2012 Farabaugh A, Alpert J, Wisniewski SR, Otto MW, Fava M, Baer L, Perlis R, Friedman E, Nyer M, Bitran S, Balasubramani GK, Inamori A, Trivedi M, Thase ME. Cognitive therapy for anxious depression in STAR(*) D: what have we learned? Journal of Affective Disorders. 142: 213-8. PMID 22877961 DOI: 10.1016/J.Jad.2012.04.029  0.552
2012 Castro VM, Gallagher PJ, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH. Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants. Bmj Open. 2: e000544. PMID 22466034 DOI: 10.1136/bmjopen-2011-000544  0.507
2012 Gilman SE, Dupuy JM, Perlis RH. Risks for the transition from major depressive disorder to bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions. The Journal of Clinical Psychiatry. 73: 829-36. PMID 22394428 DOI: 10.4088/JCP.11m06912  0.387
2012 Bowden CL, Perlis RH, Thase ME, Ketter TA, Ostacher MM, Calabrese JR, Reilly-Harrington NA, Gonzalez JM, Singh V, Nierenberg AA, Sachs GS. Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD). Cns Neuroscience & Therapeutics. 18: 243-9. PMID 22070541 DOI: 10.1111/j.1755-5949.2011.00257.x  0.381
2012 Uher R, Perlis RH, Henigsberg N, Zobel A, Rietschel M, Mors O, Hauser J, Dernovsek MZ, Souery D, Bajs M, Maier W, Aitchison KJ, Farmer A, McGuffin P. Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms. Psychological Medicine. 42: 967-80. PMID 21929846 DOI: 10.1017/S0033291711001905  0.308
2012 Perlis RH, Iosifescu DV, Castro VM, Murphy SN, Gainer VS, Minnier J, Cai T, Goryachev S, Zeng Q, Gallagher PJ, Fava M, Weilburg JB, Churchill SE, Kohane IS, Smoller JW. Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model. Psychological Medicine. 42: 41-50. PMID 21682950 DOI: 10.1017/S0033291711000997  0.52
2012 Dupuy JM, Ostacher MJ, Huffman J, Perlis RH, Nierenberg AA. Evidence-based pharmacotherapy of major depressive disorder Essential Evidence-Based Psychopharmacology, Second Edition. 53-72. DOI: 10.1017/CBO9780511910395.005  0.387
2011 Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, ... ... Perlis R, et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 Nature Genetics. 43: 977-985. PMID 21926972 DOI: 10.1038/Ng.943  0.588
2011 Lee PH, Bergen SE, Perlis RH, Sullivan PF, Sklar P, Smoller JW, Purcell SM. Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework. Human Heredity. 72: 10-20. PMID 21849790 DOI: 10.1159/000327158  0.485
2011 Houston JP, Kohler J, Ostbye KM, Heinloth A, Perlis RH. Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder. Psychiatry Research. 189: 475-7. PMID 21788083 DOI: 10.1016/j.psychres.2011.07.002  0.324
2011 Perlis RH, Uher R, Ostacher M, Goldberg JF, Trivedi MH, Rush AJ, Fava M. Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder. Archives of General Psychiatry. 68: 351-60. PMID 21135313 DOI: 10.1001/Archgenpsychiatry.2010.179  0.604
2011 Barnett JH, Huang J, Perlis RH, Young MM, Rosenbaum JF, Nierenberg AA, Sachs G, Nimgaonkar VL, Miklowitz DJ, Smoller JW. Personality and bipolar disorder: dissecting state and trait associations between mood and personality. Psychological Medicine. 41: 1593-604. PMID 21134316 DOI: 10.1017/S0033291710002333  0.325
2011 Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, ... ... Perlis RH, et al. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Molecular Psychiatry. 16: 2-4. PMID 20351715 DOI: 10.1038/Mp.2009.107  0.621
2010 Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, Dougherty DD, Kim BW, Lee MJ, Wu S, Lee S, Calhoun J, Hodge SM, Fava M, Rosen BR, Smoller JW, et al. Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. Plos One. 5: e13945. PMID 21124764 DOI: 10.1371/Journal.Pone.0013945  0.559
2010 Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, Hamilton SP, McMahon FJ, Schulze TG, Schulze T, Potash JB, Zandi PP, Willour VL, Penninx BW, Boomsma DI, et al. Genome-wide association study of suicide attempts in mood disorder patients. The American Journal of Psychiatry. 167: 1499-507. PMID 21041247 DOI: 10.1176/Appi.Ajp.2010.10040541  0.736
2010 Simon GE, Perlis RH. Personalized medicine for depression: can we match patients with treatments? The American Journal of Psychiatry. 167: 1445-55. PMID 20843873 DOI: 10.1176/appi.ajp.2010.09111680  0.305
2010 Perlis RH, Ostacher MJ, Goldberg JF, Miklowitz DJ, Friedman E, Calabrese J, Thase ME, Sachs GS. Transition to mania during treatment of bipolar depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 2545-52. PMID 20827274 DOI: 10.1038/npp.2010.122  0.36
2010 Huang J, Perlis RH, Lee PH, Rush AJ, Fava M, Sachs GS, Lieberman J, Hamilton SP, Sullivan P, Sklar P, Purcell S, Smoller JW. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. The American Journal of Psychiatry. 167: 1254-63. PMID 20713499 DOI: 10.1176/Appi.Ajp.2010.09091335  0.714
2010 Kim BW, Kennedy DN, Lehár J, Lee MJ, Blood AJ, Lee S, Perlis RH, Smoller JW, Morris R, Fava M, Breiter HC. Recurrent, robust and scalable patterns underlie human approach and avoidance. Plos One. 5: e10613. PMID 20532247 DOI: 10.1371/Journal.Pone.0010613  0.431
2010 Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, ... ... Perlis RH, et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 62: 72-8. PMID 20453537 DOI: 10.1159/000314708  0.344
2010 Perlis RH, Smoller JW, Mysore J, Sun M, Gillis T, Purcell S, Rietschel M, Nöthen MM, Witt S, Maier W, Iosifescu DV, Sullivan P, Rush AJ, Fava M, Breiter H, et al. Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder. The American Journal of Psychiatry. 167: 574-9. PMID 20360314 DOI: 10.1176/Appi.Ajp.2009.09070973  0.579
2010 Perlis RH, Ostacher MJ, Miklowitz DJ, Hay A, Nierenberg AA, Thase ME, Sachs GS. Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. The Journal of Clinical Psychiatry. 71: 296-303. PMID 20331931 DOI: 10.4088/JCP.09m05514yel  0.304
2010 Perlis RH, Ostacher M, Fava M, Nierenberg AA, Sachs GS, Rosenbaum JF. Assuring that double-blind is blind. The American Journal of Psychiatry. 167: 250-2. PMID 20194487 DOI: 10.1176/appi.ajp.2009.09060820  0.397
2010 Perlis RH, Ostacher MJ, Miklowitz DJ, Smoller JW, Dennehy EB, Cowperthwait C, Nierenberg AA, Thase ME, Sachs GS. Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report. The Journal of Clinical Psychiatry. 71: 194-200. PMID 20193647 DOI: 10.4088/Jcp.09M05019Yel  0.319
2010 Perlis RH, Adams DH, Fijal B, Sutton VK, Farmen M, Breier A, Houston JP. Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression. The Journal of Clinical Psychiatry. 71: 599-605. PMID 20021991 DOI: 10.4088/JCP.08m04632gre  0.34
2010 Ostacher MJ, Perlis RH, Nierenberg AA, Calabrese J, Stange JP, Salloum I, Weiss RD, Sachs GS. Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). The American Journal of Psychiatry. 167: 289-97. PMID 20008948 DOI: 10.1176/Appi.Ajp.2009.09020299  0.36
2010 Casamassima F, Huang J, Fava M, Sachs GS, Smoller JW, Cassano GB, Lattanzi L, Fagerness J, Stange JP, Perlis RH. Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 303-9. PMID 19388002 DOI: 10.1002/ajmg.b.30962  0.599
2009 Miller KK, Perlis RH, Papakostas GI, Mischoulon D, Losifescu DV, Brick DJ, Fava M. Low-dose transdermal testosterone augmentation therapy improves depression severity in women. Cns Spectrums. 14: 688-94. PMID 20394176 DOI: 10.1017/S1092852900023944  0.54
2009 Perlis RH, Ostacher MJ, Uher R, Nierenberg AA, Casamassima F, Kansky C, Calabrese JR, Thase M, Sachs GS. Stability of symptoms across major depressive episodes in bipolar disorder. Bipolar Disorders. 11: 867-75. PMID 19922555 DOI: 10.1111/j.1399-5618.2009.00764.x  0.327
2009 Laje G, Perlis RH, Rush AJ, McMahon FJ. Pharmacogenetics studies in STAR*D: Strengths, limitations, and results Psychiatric Services. 60: 1446-1457. PMID 19880459 DOI: 10.1176/Appi.Ps.60.11.1446  0.347
2009 Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. The American Journal of Psychiatry. 166: 718-25. PMID 19448189 DOI: 10.1176/Appi.Ajp.2009.08111633  0.598
2009 Gasic GP, Smoller JW, Perlis RH, Sun M, Lee S, Kim BW, Lee MJ, Holt DJ, Blood AJ, Makris N, Kennedy DK, Hoge RD, Calhoun J, Fava M, Gusella JF, et al. BDNF, relative preference, and reward circuitry responses to emotional communication. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 762-81. PMID 19388013 DOI: 10.1002/Ajmg.B.30944  0.432
2009 Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ. Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1819-28. PMID 19295509 DOI: 10.1038/npp.2009.4  0.577
2009 Goldberg JF, Brooks JO, Kurita K, Hoblyn JC, Ghaemi SN, Perlis RH, Miklowitz DJ, Ketter TA, Sachs GS, Thase ME. Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD. The Journal of Clinical Psychiatry. 70: 155-62. PMID 19210946 DOI: 10.4088/JCP.08m04301  0.368
2009 Perlis RH, Fava M, Trivedi MH, Alpert J, Luther JF, Wisniewski SR, Rush AJ. Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder. Acta Psychiatrica Scandinavica. 119: 282-9. PMID 19207123 DOI: 10.1111/J.1600-0447.2008.01298.X  0.617
2009 Goldberg JF, Perlis RH, Bowden CL, Thase ME, Miklowitz DJ, Marangell LB, Calabrese JR, Nierenberg AA, Sachs GS. Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. The American Journal of Psychiatry. 166: 173-81. PMID 19122008 DOI: 10.1176/appi.ajp.2008.08050746  0.368
2009 Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, ... ... Perlis RH, et al. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Molecular Psychiatry. 14: 359-75. PMID 19065144 DOI: 10.1038/Mp.2008.125  0.539
2008 Perlis RH, Fijal B, Adams DH, Sutton VK, Trivedi MH, Houston JP. Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder. Biological Psychiatry. 65: 785-91. PMID 19095219 DOI: 10.1016/j.biopsych.2008.10.002  0.397
2008 Makris N, Gasic GP, Kennedy DN, Hodge SM, Kaiser JR, Lee MJ, Kim BW, Blood AJ, Evins AE, Seidman LJ, Iosifescu DV, Lee S, Baxter C, Perlis RH, Smoller JW, et al. Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse? Neuron. 60: 174-88. PMID 18940597 DOI: 10.1016/J.Neuron.2008.08.011  0.409
2008 Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics. 40: 1056-8. PMID 18711365 DOI: 10.1038/Ng.209  0.554
2008 Perlis RH. A roadmap to key pharmacologic principles in using antipsychotics in the treatment of bipolar disorder. The Journal of Clinical Psychiatry. 69: 1176-83. PMID 18687017 DOI: 10.4088/jcp.v69n0718  0.302
2008 Perlis RH, Holt DJ, Smoller JW, Blood AJ, Lee S, Kim BW, Lee MJ, Sun M, Makris N, Kennedy DK, Rooney K, Dougherty DD, Hoge R, Rosenbaum JF, Fava M, et al. Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. Archives of General Psychiatry. 65: 882-92. PMID 18678793 DOI: 10.1001/Archgenpsychiatry.2008.3  0.524
2008 Candrian M, Schwartz F, Farabaugh A, Perlis RH, Ehlert U, Fava M. Personality disorders and perceived stress in major depressive disorder. Psychiatry Research. 160: 184-91. PMID 18573540 DOI: 10.1016/J.Psychres.2007.06.014  0.538
2008 Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH. A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder. Journal of Occupational and Environmental Medicine. 50: 428-36. PMID 18404015 DOI: 10.1097/JOM.0b013e31816b5034  0.598
2008 Petersen T, Perlis RH, Ticknor C, Lohr J, Solvason HB, O'Reardon JP, Wohlreich MM, Andreotti C, Wilson M, Fava M. Efficacy of duloxetine for the treatment of depression: relationship to most recent antidepressant trial. Psychopharmacology Bulletin. 41: 34-45. PMID 18362869  0.542
2008 Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, et al. Whole-genome association study of bipolar disorder. Molecular Psychiatry. 13: 558-69. PMID 18317468 DOI: 10.1038/Sj.Mp.4002151  0.546
2008 Iosifescu DV, Greenwald S, Devlin P, Perlis RH, Denninger JW, Alpert JE, Fava M. Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Acta Psychiatrica Scandinavica. 117: 271-6. PMID 18307587 DOI: 10.1111/J.1600-0447.2008.01156.X  0.54
2008 Perlis RH, Moorjani P, Fagerness J, Purcell S, Trivedi MH, Fava M, Rush AJ, Smoller JW. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2810-9. PMID 18288090 DOI: 10.1038/Npp.2008.6  0.578
2008 Perlis RH, Purcell S, Fagerness J, Kirby A, Petryshen TL, Fan J, Sklar P. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Archives of General Psychiatry. 65: 53-61. PMID 18180429 DOI: 10.1001/archgenpsychiatry.2007.15  0.574
2007 Goldberg JF, Perlis RH, Ghaemi SN, Calabrese JR, Bowden CL, Wisniewski S, Miklowitz DJ, Sachs GS, Thase ME. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. The American Journal of Psychiatry. 164: 1348-55. PMID 17728419 DOI: 10.1176/Appi.Ajp.2007.05122032  0.354
2007 Papakostas GI, Perlis RH, Seifert C, Fava M. Antidepressant dose reduction and the risk of relapse in major depressive disorder. Psychotherapy and Psychosomatics. 76: 266-70. PMID 17700046 DOI: 10.1159/000104702  0.585
2007 Fraguas R, Iosifescu DV, Bankier B, Perlis R, Clementi-Craven N, Alpert J, Fava M. Major depressive disorder with anger attacks and cardiovascular risk factors. International Journal of Psychiatry in Medicine. 37: 99-111. PMID 17645202 DOI: 10.2190/Y361-2W83-268H-5W7V  0.576
2007 Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW. Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Archives of General Psychiatry. 64: 689-97. PMID 17548750 DOI: 10.1001/ARCHPSYC.64.6.689  0.51
2007 Kim JW, Biederman J, Arbeitman L, Fagerness J, Doyle AE, Petty C, Perlis RH, Purcell S, Smoller JW, Faraone SV, Sklar P. Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 781-90. PMID 17455213 DOI: 10.1002/Ajmg.B.30522  0.53
2007 Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki L, Fava M, Smoller JW. Clinical and Genetic Dissection of Anger Expression and CREB1 Polymorphisms in Major Depressive Disorder Biological Psychiatry. 62: 536-540. PMID 17300755 DOI: 10.1016/J.Biopsych.2006.10.034  0.548
2007 Cusin C, Fava M, Amsterdam JD, Quitkin FM, Reimherr FW, Beasley CM, Rosenbaum JF, Perlis RH. Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications. The Journal of Clinical Psychiatry. 68: 52-57. PMID 17284130 DOI: 10.4088/Jcp.V68N0107  0.583
2007 Perlis RH, Beasley CM, Wines JD, Tamura RN, Cusin C, Shear D, Amsterdam J, Quitkin F, Strong RE, Rosenbaum JF, Fava M. Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes. Psychotherapy and Psychosomatics. 76: 40-6. PMID 17170562 DOI: 10.1159/000096363  0.534
2006 Marangell LB, Bauer MS, Dennehy EB, Wisniewski SR, Allen MH, Miklowitz DJ, Oquendo MA, Frank E, Perlis RH, Martinez JM, Fagiolini A, Otto MW, Chessick CA, Zboyan HA, Miyahara S, et al. Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years. Bipolar Disorders. 8: 566-75. PMID 17042830 DOI: 10.1111/J.1399-5618.2006.00369.X  0.303
2006 Corya SA, Perlis RH, Keck PE, Lin DY, Case MG, Williamson DJ, Tohen MF. A 24-week open-label extension study of olanzapine-fluoxetine combination and olanzapine monotherapy in the treatment of bipolar depression. The Journal of Clinical Psychiatry. 67: 798-806. PMID 16841630 DOI: 10.4088/JCP.V67N0514  0.331
2006 Papakostas GI, Petersen TJ, Perlis RH, Judy AE, Burns AM, Alpert JE, Birnbaum RJ, Fava M. A survey of antidepressant prescribing practices in major depression with comorbid attention-deficit hyperactivity disorder. Journal of Clinical Psychopharmacology. 26: 216-8. PMID 16633159 DOI: 10.1097/01.Jcp.0000203226.79364.5E  0.574
2006 Iosifescu DV, Renshaw PF, Lyoo IK, Lee HK, Perlis RH, Papakostas GI, Nierenberg AA, Fava M. Brain white-matter hyperintensities and treatment outcome in major depressive disorder. The British Journal of Psychiatry : the Journal of Mental Science. 188: 180-5. PMID 16449707 DOI: 10.1192/bjp.188.2.180  0.569
2006 Perlis RH, Brown E, Baker RW, Nierenberg AA. Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. The American Journal of Psychiatry. 163: 225-31. PMID 16449475 DOI: 10.1176/APPI.AJP.163.2.225  0.383
2006 Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang H, Wisniewski SR, Ketter TA, Miklowitz DJ, Otto MW, Gyulai L, Reilly-Harrington NA, Nierenberg AA, Sachs GS, Thase ME. Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). The American Journal of Psychiatry. 163: 217-24. PMID 16449474 DOI: 10.1176/appi.ajp.163.2.217  0.383
2006 Papakostas GI, Perlis RH, Scalia MJ, Petersen TJ, Fava M. A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder Journal of Clinical Psychopharmacology. 26: 56-60. PMID 16415707 DOI: 10.1097/01.jcp.0000195042.62724.76  0.538
2006 Perlis RH. Misdiagnosis of bipolar disorder. The American Journal of Managed Care. 11: S271-4. PMID 16232009  0.36
2005 Perlis RH, Delbello MP, Miyahara S, Wisniewski SR, Sachs GS, Nierenberg AA. Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants. Biological Psychiatry. 58: 549-53. PMID 16197928 DOI: 10.1016/J.Biopsych.2005.07.029  0.401
2005 Smoller JW, Biederman J, Arbeitman L, Doyle AE, Fagerness J, Perlis RH, Sklar P, Faraone SV. Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. Biological Psychiatry. 59: 460-7. PMID 16197923 DOI: 10.1016/J.Biopsych.2005.07.017  0.506
2005 Iosifescu DV, Nierenberg AA, Mischoulon D, Perlis RH, Papakostas GI, Ryan JL, Alpert JE, Fava M. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. The Journal of Clinical Psychiatry. 66: 1038-42. PMID 16086620 DOI: 10.4088/Jcp.V66N0812  0.573
2005 Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P. Molecular genetics of attention-deficit/hyperactivity disorder. Biological Psychiatry. 57: 1313-23. PMID 15950004 DOI: 10.1016/J.Biopsych.2004.11.024  0.509
2005 Ongur D, Farabaugh A, Iosifescu DV, Perlis R, Fava M. Tridimensional personality questionnaire factors in major depressive disorder: relationship to anxiety disorder comorbidity and age of onset. Psychotherapy and Psychosomatics. 74: 173-8. PMID 15832068 DOI: 10.1159/000084002  0.582
2005 Perlis RH, Fraguas R, Fava M, Trivedi MH, Luther JF, Wisniewski SR, Rush AJ. Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study. The Journal of Clinical Psychiatry. 66: 159-66; quiz 147, 27. PMID 15705000  0.604
2005 Perlis RH, Fava M, Rush AJ. Reply to Possible Bipolar Nature of Irritability in Major Depressive Disorder The Journal of Clinical Psychiatry. 66: 1073. DOI: 10.4088/JCP.V66N0818B  0.61
2005 Perlis RH, Fraguas R, Fava M, Trivedi MH, Luther JF, Wisniewski SR, Rush AJ. Prevalence and Clinical Correlates of Irritability in Major Depressive Disorder The Journal of Clinical Psychiatry. 66: 159-166. DOI: 10.4088/Jcp.V66N0202  0.596
2004 Iosifescu DV, Nierenberg AA, Alpert JE, Papakostas GI, Perlis RH, Sonawalla S, Fava M. Comorbid medical illness and relapse of major depressive disorder in the continuation phase of treatment. Psychosomatics. 45: 419-25. PMID 15345787 DOI: 10.1176/Appi.Psy.45.5.419  0.59
2004 Perlis RH, Iosifescu DV, Alpert J, Nierenberg AA, Rosenbaum JF, Fava M. Effect of medical comorbidity on response to fluoxetine augmentation or dose increase in outpatients with treatment-resistant depression. Psychosomatics. 45: 224-9. PMID 15123848 DOI: 10.1176/Appi.Psy.45.3.224  0.585
2004 Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biological Psychiatry. 55: 875-81. PMID 15110730 DOI: 10.1016/J.Biopsych.2004.01.022  0.319
2004 Perlis RH, Smoller JW, Fava M, Rosenbaum JF, Nierenberg AA, Sachs GS. The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder. Journal of Affective Disorders. 79: 291-5. PMID 15023510 DOI: 10.1016/S0165-0327(02)00451-2  0.603
2004 Deckersbach T, Perlis RH, Frankle WG, Gray SM, Grandin L, Dougherty DD, Nierenberg AA, Sachs GS. Presence of irritability during depressive episodes in bipolar disorder. Cns Spectrums. 9: 227-31. PMID 14999163  0.384
2004 Perlis RH, Alpert J, Nierenberg AA, Mischoulon D, Yeung A, Rosenbaum JF, Fava M. Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day. Acta Psychiatrica Scandinavica. 108: 432-8. PMID 14616224 DOI: 10.1046/J.0001-690X.2003.00168.X  0.534
2003 Post RM, Baldassano CF, Perlis RH, Ginsberg DL. Treatment of bipolar depression. Cns Spectrums. 8: 1-10; quiz 11. PMID 14986671 DOI: 10.1007/978-1-60327-435-7_5  0.399
2003 Perlis RH, Mischoulon D, Smoller JW, Wan YJ, Lamon-Fava S, Lin KM, Rosenbaum JF, Fava M. Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment. Biological Psychiatry. 54: 879-83. PMID 14573314 DOI: 10.1016/S0006-3223(03)00424-4  0.577
2003 Simon NM, Smoller JW, Fava M, Sachs G, Racette SR, Perlis R, Sonawalla S, Rosenbaum JF. Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression. Journal of Psychiatric Research. 37: 187-92. PMID 12650739 DOI: 10.1016/S0022-3956(03)00021-9  0.583
2003 Perlis RH. Antidepressant Effects of Atypical Antipsychotics Cns Spectrums. 8: 6-8. DOI: 10.1017/S1092852900028789  0.387
2002 Frankle WG, Perlis RH, Deckersbach T, Grandin LD, Gray SM, Sachs GS, Nierenberg AA. Bipolar depression: relationship between episode length and antidepressant treatment. Psychological Medicine. 32: 1417-23. PMID 12455940 DOI: 10.1017/S0033291702006165  0.327
2002 Perlis RH, Nierenberg AA, Alpert JE, Pava J, Matthews JD, Buchin J, Sickinger AH, Fava M. Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder. Journal of Clinical Psychopharmacology. 22: 474-80. PMID 12352270 DOI: 10.1097/00004714-200210000-00006  0.573
2002 Perlis RH, Fava M, Nierenberg AA, Pollack MH, Falk WE, Kienke AS, Rosenbaum JF. Strategies for treatment of SSRI-associated sexual dysfunction: a survey of an academic psychopharmacology practice. Harvard Review of Psychiatry. 10: 109-14. PMID 11897751  0.433
2002 Perlis RH, Fava M, Nierenberg AA, Pollack MH, Falk WE, Kienke AS, Rosenbaum JF. Strategies for Treatment of SSRI-Associated Sexual Dysfunction: A Survey of an Academic Psychopharmacology Practice Harvard Review of Psychiatry. 10: 109-114. DOI: 10.1080/10673220216211  0.433
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