| Year |
Citation |
Score |
| 2008 |
Varty GB, Lu SX, Morgan CA, Cohen-Williams ME, Hodgson RA, Smith-Torhan A, Zhang H, Fawzi AB, Graziano MP, Ho GD, Matasi J, Tulshian D, Coffin VL, Carey GJ. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). The Journal of Pharmacology and Experimental Therapeutics. 326: 672-82. PMID 18492950 DOI: 10.1124/Jpet.108.136937 |
0.48 |
|
| 2006 |
Shue HJ, Chen X, Schwerdt JH, Paliwal S, Blythin DJ, Lin L, Gu D, Wang C, Reichard GA, Wang H, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Nomeir AA, et al. Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions. Bioorganic & Medicinal Chemistry Letters. 16: 1065-9. PMID 16290143 DOI: 10.1016/J.Bmcl.2005.10.072 |
0.354 |
|
| 2005 |
Shue HJ, Chen X, Shih NY, Blythin DJ, Paliwal S, Lin L, Gu D, Schwerdt JH, Shah S, Reichard GA, Piwinski JJ, Duffy RA, Lachowicz JE, Coffin VL, Liu F, et al. Cyclic urea derivatives as potent NK1 selective antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 3896-9. PMID 16019209 DOI: 10.1016/J.Bmcl.2005.05.111 |
0.349 |
|
| 2002 |
Wang Y, Chackalamannil S, Hu Z, Greenlee WJ, Clader J, Boyle CD, Kaminski JJ, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, Cohen-Williams M, Coffin VL, Cox KA, et al. Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists. Journal of Medicinal Chemistry. 45: 5415-8. PMID 12459007 DOI: 10.1021/Jm0255163 |
0.341 |
|
| 2002 |
Boyle CD, Vice SF, Campion J, Chackalamannil S, Lankin CM, McCombie SW, Billard W, Binch H, Crosby G, Williams MC, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, et al. Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification. Bioorganic & Medicinal Chemistry Letters. 12: 3479-82. PMID 12419388 DOI: 10.1016/S0960-894X(02)00742-4 |
0.385 |
|
| 2002 |
Varty GB, Cohen-Williams ME, Morgan CA, Pylak U, Duffy RA, Lachowicz JE, Carey GJ, Coffin VL. The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 371-9. PMID 12225694 DOI: 10.1016/S0893-133X(02)00313-5 |
0.452 |
|
| 2002 |
Varty GB, Morgan CA, Cohen-Williams ME, Coffin VL, Carey GJ. The gerbil elevated plus-maze I: behavioral characterization and pharmacological validation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 357-70. PMID 12225693 DOI: 10.1016/S0893-133X(02)00312-3 |
0.425 |
|
| 2001 |
Carey GJ, Billard W, Binch H, Cohen-Williams M, Crosby G, Grzelak M, Guzik H, Kozlowski JA, Lowe DB, Pond AJ, Tedesco RP, Watkins RW, Coffin VL. SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals. European Journal of Pharmacology. 431: 189-200. PMID 11728425 DOI: 10.1016/S0014-2999(01)01440-6 |
0.444 |
|
| 2001 |
Boyle CD, Chackalamannil S, Clader JW, Greenlee WJ, Josien HB, Kaminski JJ, Kozlowski JA, McCombie SW, Nazareno DV, Tagat JR, Wang Y, Zhou G, Billard W, Binch H, Crosby G, ... ... Coffin VL, et al. Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution. Bioorganic & Medicinal Chemistry Letters. 11: 2311-4. PMID 11527721 DOI: 10.1016/S0960-894X(01)00435-8 |
0.326 |
|
| 2001 |
Greenlee W, Clader J, Asberom T, McCombie S, Ford J, Guzik H, Kozlowski J, Li S, Liu C, Lowe D, Vice S, Zhao H, Zhou G, Billard W, Binch H, ... ... Coffin V, et al. Muscarinic agonists and antagonists in the treatment of Alzheimer's disease. Farmaco (Societã Chimica Italiana : 1989). 56: 247-50. PMID 11421251 DOI: 10.1016/S0014-827X(01)01102-8 |
0.358 |
|
| 2000 |
Boyle CD, Chackalamannil S, Chen LY, Dugar S, Pushpavanam P, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Duffy RA, Ruperto V, Lachowicz JE. Benzylidene ketal derivatives as M2 muscarinic receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 10: 2727-30. PMID 11133078 DOI: 10.1016/S0960-894X(00)00553-9 |
0.388 |
|
| 2000 |
Haile CN, Carey G, Varty GB, Coffin VL. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. European Journal of Pharmacology. 388: 125-31. PMID 10666503 DOI: 10.1016/S0014-2999(99)00864-X |
0.468 |
|
| 1999 |
Romach MK, Glue P, Kampman K, Kaplan HL, Somer GR, Poole S, Clarke L, Coffin V, Cornish J, O'Brien CP, Sellers EM. Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166) Archives of General Psychiatry. 56: 1101-1106. PMID 10591286 DOI: 10.1001/Archpsyc.56.12.1101 |
0.344 |
|
| 1997 |
Smith RD, Grzelak ME, Coffin VL. Reduction of dizocilpine and scopolamine-induced deficits in avoidance responding by SCH 54388, a metabolite of felbamate. Pharmacology, Biochemistry, and Behavior. 58: 657-64. PMID 9329055 DOI: 10.1016/S0091-3057(97)00027-0 |
0.44 |
|
| 1997 |
Howell LL, Coffin VL, Spealman RD. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology. 129: 1-14. PMID 9122357 DOI: 10.1007/S002130050155 |
0.62 |
|
| 1996 |
Smith RD, Kistler MK, Cohen-Williams M, Coffin VL. Cholinergic improvement of a naturally-occurring memory deficit in the young rat. Brain Research. 707: 13-21. PMID 8866709 DOI: 10.1016/0006-8993(95)01207-9 |
0.433 |
|
| 1995 |
Caine SB, Heinrichs SC, Coffin VL, Koob GF. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Research. 692: 47-56. PMID 8548319 DOI: 10.1016/0006-8993(95)00598-K |
0.369 |
|
| 1994 |
Smith RD, Grzelak ME, Coffin VL. Methylatropine blocks the central effects of cholinergic antagonists. Behavioural Pharmacology. 5: 167-175. PMID 11224265 |
0.338 |
|
| 1993 |
Tedford CE, Coffin VL, Ruperto V, Cohen M, McQuade RD, Johnson R, Kim HK, Lin CC. Determination of plasma and brain concentrations of SCH 39166 and their correlation to conditioned avoidance behavior in rats. Psychopharmacology. 113: 199-204. PMID 7855181 DOI: 10.1007/Bf02245697 |
0.36 |
|
| 1993 |
Coffin VL, McHugh DT, Casey DE, Barnett A. A novel dopamine D1 antagonist can prevent sensitization to abnormal movements by haloperidol Schizophrenia Research. 9: 276. DOI: 10.1016/0920-9964(93)90645-Y |
0.34 |
|
| 1992 |
Coffin VL, McHuch D, Chipkin RE, Barnett A. SCH 39166, a potential antipsychotic drug, does not evoke movement disorders in cebus monkeys. Neurochemistry International. 20: 141S-145S. PMID 1365413 DOI: 10.1016/0197-0186(92)90227-I |
0.408 |
|
| 1992 |
McQuade RD, Duffy RA, Coffin VL, Barnett A. In vivo binding to dopamine receptors: a correlate of potential antipsychotic activity. European Journal of Pharmacology. 215: 29-34. PMID 1355442 DOI: 10.1016/0014-2999(92)90604-3 |
0.433 |
|
| 1992 |
Chang WK, Peters M, Fevig VP, Kozlowski JA, Zhou G, Lowe DB, Guzik H, McQuade RD, Duffy R, Coffin VL, Berger JG. Dopamine receptor binding properties of some 2,3,4,5-tetrahydro-1H-3-benzazepine-7-ols with non-aromatic substituents in the 5-position Bioorganic and Medicinal Chemistry Letters. 2: 399-402. DOI: 10.1016/S0960-894X(00)80155-9 |
0.398 |
|
| 1992 |
Tedford CE, Ruperto VB, Coffin VL, Cohen M, Libonati M, Barnett A. SCH 39166, a novel dopamine D1 receptor antagonist: In vitro investigation of its glucuronidation and potential species differences Drug Development Research. 26: 389-403. DOI: 10.1002/Ddr.430260403 |
0.478 |
|
| 1991 |
Chipkin RE, Coffin VL. Analgesic and acute central nervous system side effects of the intravenously administered enkephalinase inhibitor SCH 32615. Pharmacology, Biochemistry, and Behavior. 38: 21-7. PMID 2017447 DOI: 10.1016/0091-3057(91)90584-O |
0.435 |
|
| 1991 |
McQuade RD, Duffy RA, Anderson CC, Crosby G, Coffin VL, Chipkin RE, Barnett A. [3H]SCH 39166, a new D1-selective radioligand: in vitro and in vivo binding analyses. Journal of Neurochemistry. 57: 2001-10. PMID 1834801 DOI: 10.1111/J.1471-4159.1991.Tb06415.X |
0.419 |
|
| 1991 |
Iorio LC, Cohen M, Coffin VL. Anticholinergic drugs potentiate dopamine D1 but not D2 antagonists on a conditioned avoidance task in rats. The Journal of Pharmacology and Experimental Therapeutics. 258: 118-23. PMID 1830098 |
0.35 |
|
| 1991 |
McQuade RD, Duffy RA, Coffin VL, Chipkin RE, Barnett A. In vivo binding of SCH 39166: a D-1 selective antagonist. The Journal of Pharmacology and Experimental Therapeutics. 257: 42-9. PMID 1826927 |
0.37 |
|
| 1991 |
McHugh D, Coffin V. The reversal of extrapyramidal side effects with SCH 39166, a dopamine D1 receptor antagonist. European Journal of Pharmacology. 202: 133-4. PMID 1686252 DOI: 10.1016/0014-2999(91)90268-U |
0.419 |
|
| 1990 |
Barnett A, McQuade RD, Coffin VL. Effects of repeated administration of D1 specific dopamine antagonists on dopamine receptor function European Journal of Pharmacology. 183: 744-745. DOI: 10.1016/0014-2999(90)92545-T |
0.393 |
|
| 1989 |
Coffin VL, Latranyi MB, Chipkin RE. Acute extrapyramidal syndrome in Cebus monkeys: development mediated by dopamine D2 but not D1 receptors. The Journal of Pharmacology and Experimental Therapeutics. 249: 769-74. PMID 2567351 |
0.365 |
|
| 1989 |
Coffin VL, Spealman RD. Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: comparison with caffeine and 7-(2-chloroethyl) theophylline. European Journal of Pharmacology. 170: 35-40. PMID 2482186 DOI: 10.1016/0014-2999(89)90130-1 |
0.647 |
|
| 1989 |
Coffin VL, Latranyi MB, Chipkin RE. Dopamine D1 antagonists do not produce extrapyramidal side effects (EPS) in cebus monkeys Schizophrenia Research. 2: 180. DOI: 10.1016/0920-9964(89)90216-8 |
0.389 |
|
| 1988 |
Spealman RD, Coffin VL. Discriminative-stimulus effects of adenosine analogs: mediation by adenosine A2 receptors. The Journal of Pharmacology and Experimental Therapeutics. 246: 610-8. PMID 3404449 |
0.611 |
|
| 1988 |
Chipkin RE, Iorio LC, Coffin VL, McQuade RD, Berger JG, Barnett A. Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. The Journal of Pharmacology and Experimental Therapeutics. 247: 1093-102. PMID 2905002 |
0.41 |
|
| 1987 |
Coffin VL, Spealman RD. Behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 241: 76-83. PMID 3572798 |
0.584 |
|
| 1986 |
Coffin VL, Carney JM. Effects of selected analogs of adenosine on schedule-controlled behavior in rats. Neuropharmacology. 25: 1141-7. PMID 3785582 DOI: 10.1016/0028-3908(86)90162-0 |
0.34 |
|
| 1986 |
Spealman RD, Coffin VL. Behavioral effects of adenosine analogs in squirrel monkeys: relation to adenosine A2 receptors. Psychopharmacology. 90: 419-21. PMID 3097732 DOI: 10.1007/Bf00179203 |
0.633 |
|
| 1985 |
Coffin VL, Spealman RD. Modulation of the behavioral effects of chlordiazepoxide by methylxanthines and analogs of adenosine in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics. 235: 724-8. PMID 2416907 |
0.586 |
|
| 1985 |
Coffin VL, Spealman RD. Behavioral and cardiovascular effects of some adenosine analogs in cynomolgus monkeys Federation Proceedings. 44: No. 1827. |
0.555 |
|
| 1984 |
Coffin VL, Taylor JA, Phillis JW, Altman HJ, Barraco RA. Behavioral interaction of adenosine and methylxanthines on central purinergic systems. Neuroscience Letters. 47: 91-8. PMID 6205333 DOI: 10.1016/0304-3940(84)90412-9 |
0.439 |
|
| 1983 |
Wu PH, Phillis JW, Coffin VL. Calmodulin antagonists inhibit adenosine uptake by rat brain cortical synaptosomes. Neuroscience Letters. 37: 187-92. PMID 6877667 DOI: 10.1016/0304-3940(83)90151-9 |
0.315 |
|
| 1983 |
Barraco RA, Coffin VL, Altman HJ, Phillis JW. Central effects of adenosine analogs on locomotor activity in mice and antagonism of caffeine. Brain Research. 272: 392-5. PMID 6616215 DOI: 10.1016/0006-8993(83)90591-7 |
0.445 |
|
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