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Spencer C. Peck, Ph.D. - Publications

Affiliations: 
2015- Chemical Biology Harvard University, Cambridge, MA, United States 
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17 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D. A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium . Proceedings of the National Academy of Sciences of the United States of America. PMID 30718429 DOI: 10.1073/Pnas.1815661116  0.678
2019 Bougioukou DJ, Ting CP, Peck SC, Mukherjee S, van der Donk WA. Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin. Organic & Biomolecular Chemistry. PMID 30608108 DOI: 10.1039/C8Ob02860E  0.733
2017 Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL. Structural basis for methylphosphonate biosynthesis. Science (New York, N.Y.). 358: 1336-1339. PMID 29217579 DOI: 10.1126/Science.Aao3435  0.581
2017 Levin BJ, Huang YY, Peck SC, Wei Y, Martínez-Del Campo A, Marks JA, Franzosa EA, Huttenhower C, Balskus EP. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline. Science (New York, N.Y.). 355. PMID 28183913 DOI: 10.1126/Science.Aai8386  0.624
2017 Peck SC, Wang C, Dassama LM, Zhang B, Guo Y, Rajakovich LJ, Bollinger JM, Krebs C, van der Donk WA. O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase. Journal of the American Chemical Society. 139: 2045-2052. PMID 28092705 DOI: 10.1021/Jacs.6B12147  0.734
2016 Peck SC, van der Donk WA. Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 27783267 DOI: 10.1007/S00775-016-1399-Y  0.612
2015 Zhu H, Peck SC, Bonnot F, van der Donk WA, Klinman JP. Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species. Journal of the American Chemical Society. PMID 26267117 DOI: 10.1021/Jacs.5B03907  0.607
2015 Peck SC, Chekan JR, Ulrich EC, Nair SK, van der Donk WA. A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase. Journal of the American Chemical Society. 137: 3217-20. PMID 25699631 DOI: 10.1021/Jacs.5B00282  0.602
2014 Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK. Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. Chemistry & Biology. 21: 125-35. PMID 24361046 DOI: 10.1016/J.Chembiol.2013.11.006  0.742
2013 Wang C, Chang WC, Guo Y, Huang H, Peck SC, Pandelia ME, Lin GM, Liu HW, Krebs C, Bollinger JM. Evidence that the fosfomycin-producing epoxidase, HppE, is a non-heme-iron peroxidase. Science (New York, N.Y.). 342: 991-5. PMID 24114783 DOI: 10.1126/Science.1240373  0.437
2013 Peck SC, van der Donk WA. Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Current Opinion in Chemical Biology. 17: 580-8. PMID 23870698 DOI: 10.1016/J.Cbpa.2013.06.018  0.586
2013 Peck SC, van der Donk WA. Biochemistry: Positive and radical. Nature. 496: 34-5. PMID 23552937 DOI: 10.1038/496034A  0.582
2012 Peck SC, Kim SY, Evans BS, van der Donk WA. Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis. Medchemcomm. 3: 967-970. PMID 25400901 DOI: 10.1039/C2Md20009K  0.527
2012 Peck SC, Gao J, van der Donk WA. Discovery and biosynthesis of phosphonate and phosphinate natural products. Methods in Enzymology. 516: 101-23. PMID 23034226 DOI: 10.1016/B978-0-12-394291-3.00029-0  0.56
2012 Cooke HA, Peck SC, Evans BS, van der Donk WA. Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase. Journal of the American Chemical Society. 134: 15660-3. PMID 22957470 DOI: 10.1021/Ja306777W  0.725
2011 Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA. Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase. Biochemistry. 50: 6598-605. PMID 21711001 DOI: 10.1021/Bi200804R  0.734
2011 Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA. On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. Journal of the American Chemical Society. 133: 4236-9. PMID 21381767 DOI: 10.1021/Ja1113326  0.633
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