Mitchell R. Seim, Ph.D.
Affiliations: | University of Kansas, Lawrence, KS, United States |
Area:
neurotransmitters and drugs affecting them in the central nervous systemGoogle:
"Mitchell Seim"Mean distance: 9.57 | S | N | B | C | P |
Parents
Sign in to add mentor| Gary L. Grunewald | grad student | 2007 | University of Kansas | |
| (Structure-based design and synthesis of inhibitors of phenylethanolamine N-methyltransferase.) | ||||
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| Grunewald GL, Seim MR, Bhat SR, et al. (2008) Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorganic & Medicinal Chemistry. 16: 542-59 |
| Grunewald GL, Seim MR, Regier RC, et al. (2007) Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors. Bioorganic & Medicinal Chemistry. 15: 1298-310 |
| Grunewald GL, Seim MR, Regier RC, et al. (2006) Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry. 49: 5424-33 |
| Grunewald GL, Seim MR, Lu J, et al. (2006) Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination. Journal of Medicinal Chemistry. 49: 2939-52 |
| Grunewald GL, Romero FA, Seim MR, et al. (2005) Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines. Bioorganic & Medicinal Chemistry Letters. 15: 1143-7 |