Bryan W. Lepore, Ph.D.

Affiliations: 
Brandeis University, Waltham, MA, United States 
Area:
relationship of protein three-dimensional structure to chemical function
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"Bryan Lepore"
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Parents

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Dagmar Ringe grad student 2005 Brandeis
 (Structural studies of pyridoxal-5'-phosphate dependent enzymes via X-ray crystallography.)
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Publications

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Lepore BW, Indic M, Pham H, et al. (2011) Ligand-gated diffusion across the bacterial outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 108: 10121-6
Lepore BW, Liu D, Peng Y, et al. (2010) Chiral discrimination among aminotransferases: Inactivation by 4-amino-4,5-dihydrothiophenecarboxylic Acid Biochemistry. 49: 3138-3147
Hearn EM, Patel DR, Lepore BW, et al. (2009) Transmembrane passage of hydrophobic compounds through a protein channel wall. Nature. 458: 367-70
Liu D, Pozharski E, Lepore BW, et al. (2007) Inactivation of Escherichia coli L-aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-thiophenecarboxylic acid reveals "a tale of two mechanisms". Biochemistry. 46: 10517-27
Chen D, Frey PA, Lepore BW, et al. (2006) Identification of structural and catalytic classes of highly conserved amino acid residues in lysine 2,3-aminomutase. Biochemistry. 45: 12647-53
Lepore BW, Ruzicka FJ, Frey PA, et al. (2005) The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Proceedings of the National Academy of Sciences of the United States of America. 102: 13819-24
Liu D, Lepore BW, Petsko GA, et al. (2005) Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proceedings of the National Academy of Sciences of the United States of America. 102: 11882-7
Taoka S, Lepore BW, Kabil O, et al. (2002) Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme. Biochemistry. 41: 10454-61
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