Victoria V. Hargreaves, Ph.D.

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
biochemical and biophysical principles involved in protein function
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"Victoria Hargreaves"
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Parents

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Robert F. Schleif grad student 2008 Johns Hopkins
 (Electrostatics of the DNA binding domain of interferon regulatory factor 1.)
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Publications

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Liu N, Hargreaves VV, Zhu Q, et al. (2018) Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch. Cell
Hargreaves VV, Putnam CD, Kolodner RD. (2012) Engineered disulfide-forming amino acid substitutions interfere with a conformational change in the mismatch recognition complex Msh2-Msh6 required for mismatch repair Journal of Biological Chemistry. 287: 41232-41244
Hargreaves VV, Shell SS, Mazur DJ, et al. (2010) Interaction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complex Journal of Biological Chemistry. 285: 9301-9310
Mendillo ML, Hargreaves VV, Jamison JW, et al. (2009) A conserved MutS homolog connector domain interface interacts with MutL homologs Proceedings of the National Academy of Sciences of the United States of America. 106: 22223-22228
Hargreaves VV, Schleif RF. (2008) The salt dependence of the interferon regulatory factor 1 DNA binding domain binding to DNA reveals ions are localized around protein and DNA. Biochemistry. 47: 4119-28
Dragan AI, Hargreaves VV, Makeyeva EN, et al. (2007) Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding. Nucleic Acids Research. 35: 3525-34
Hargreaves VV, Makeyeva EN, Dragan AI, et al. (2005) Stability and DNA binding ability of the DNA binding domains of interferon regulatory factors 1 and 3. Biochemistry. 44: 14202-9
Larkin C, Datta S, Harley MJ, et al. (2005) Inter- and intramolecular determinants of the specificity of single-stranded DNA binding and cleavage by the F factor relaxase Structure. 13: 1533-1544
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