John R. Murphy, PhD

Affiliations: 
1984 Microbiology and Molecular Genetics Harvard Medical School, Boston, MA, United States 
 1984- Microbiology Boston University School of Medicine, Boston, MA 
Area:
molecular biology and molecular genetics of bacterial protein toxins
Website:
http://www.bu.edu/neidl/research/researchers/john-r-murphy-ph-d/
Google:
"John Richard Murphy"
Bio:

http://aem.asm.org/content/24/2/283.short
DOI: 10.1099/00221287-73-2-339
http://www.pnas.org/content/71/1/11.short

Mean distance: 8.65
 
SNBCP
Cross-listing: ID Tree

Parents

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Richard C. Tilton grad student 1972 University of Connecticut Health Center
 (Purification and characterization of thiosulfate : cyanide sulfur transferase from Thiobacillus sp. strain IV-85)
Alwin M. Pappenheimer, Jr post-doc 1972-1974 Harvard
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Publications

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Kumar P, Kumar A, Parveen S, et al. (2019) Recent advances with Treg depleting fusion protein toxins for cancer immunotherapy. Immunotherapy
Parveen S, Bishai WR, Murphy JR. (2019) : Diphtheria Toxin, the Operon, and Its Regulation by Fe2 Activation of apo-DtxR. Microbiology Spectrum. 7
Cheung LS, Fu J, Kumar P, et al. (2019) Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma. Proceedings of the National Academy of Sciences of the United States of America
Gupta S, Cheung L, Pokkali S, et al. (2017) Suppressor Cell-Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis. The Journal of Infectious Diseases. 215: 1883-1887
Fogg M, Murphy JR, Lorch J, et al. (2013) Therapeutic targeting of regulatory T cells enhances tumor-specific CD8+ T cell responses in Epstein-Barr virus associated nasopharyngeal carcinoma. Virology. 441: 107-13
Murphy JR, Stevens JL, Kohl BC, et al. (2013) Advanced seismic analyses of the source characteristics of the 2006 and 2009 North Korean nuclear tests Bulletin of the Seismological Society of America. 103: 1640-1661
Murphy JR. (2011) Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. Toxins. 3: 294-308
Tamayo AG, Slater L, Taylor-Parker J, et al. (2011) GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Molecular Microbiology. 81: 1390-401
Trujillo C, Taylor-Parker J, Harrison R, et al. (2010) Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry. Molecular Microbiology. 76: 1010-9
Chiavolini D, Weir S, Murphy JR, et al. (2008) Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clinical and Vaccine Immunology : Cvi. 15: 1322-9
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