Angie R. Angeles, Ph.D.

Affiliations: 
2005 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Natural product synthesis
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Parents

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Amos B. Smith, III grad student 2005 Penn
 (The design and synthesis of novel ligands for the somatostatin and NK1 receptors incorporating the beta-D-glucoside scaffold and related mimetics of peptidal beta-turns.)
Samuel J. Danishefsky post-doc Columbia
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Publications

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Mansoor UF, Angeles AR, Dai C, et al. (2015) Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors. Bioorganic & Medicinal Chemistry. 23: 2424-34
Angeles AR, Yang L, Dai C, et al. (2010) Synthesis, determination of absolute configuration, and biological evaluation of spiro-fused thiadiazoline inhibitors of kinesin spindle protein (KSP) Tetrahedron Letters. 51: 6236-6239
Hirschmann RF, Nicolaou KC, Angeles AR, et al. (2009) The beta-D-glucose scaffold as a beta-turn mimetic. Accounts of Chemical Research. 42: 1511-20
Mowery BP, Prasad V, Kenesky CS, et al. (2006) Catechol: A minimal scaffold for non-peptide peptidomimetics of the i + 1 and i + 2 positions of the beta-turn of somatostatin. Organic Letters. 8: 4397-400
Angeles AR, Neagu I, Birzin ET, et al. (2005) Synthesis and binding affinities of novel SRIF-mimicking beta-D-glucosides satisfying the requirement for a pi-cloud at C1. Organic Letters. 7: 1121-4
Kaul R, Angeles AR, Jäger M, et al. (2001) Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets. Journal of the American Chemical Society. 123: 5206-12
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