Lata T. Gooljarsingh, Ph.D.
Affiliations: | 2000 | Pennsylvania State University, State College, PA, United States |
Area:
mechanistic enzymologyGoogle:
"Lata Gooljarsingh"Mean distance: 8.46
Parents
Sign in to add mentor| Stephen J. Benkovic | grad student | 2000 | Penn State | |
| (Mode of operation of the de novo purine biosynthetic pathway.) | ||||
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| Gooljarsingh LT, Fernandes C, Yan K, et al. (2006) A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues. Proceedings of the National Academy of Sciences of the United States of America. 103: 7625-30 |
| Zhang Y, Desharnais J, Marsilje TH, et al. (2003) Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 42: 6043-56 |
| Marsilje TH, Labroli MA, Hedrick MP, et al. (2002) 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 10: 2739-49 |
| Gooljarsingh LT, Ramcharan J, Gilroy S, et al. (2001) Localization of GAR transformylase in Escherichia coli and mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 6565-70 |
| Benkovic SJ, Gooljarsingh L, Ramcharan J, et al. (2000) The Transformylase Enzymes in de Novo Purine Biosynthesis Biochemical Society Transactions. 28: A122-A122 |
| Boger DL, Kochanny MJ, Cai H, et al. (1998) Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. Bioorganic & Medicinal Chemistry. 6: 643-59 |
| Boger DL, Haynes NE, Warren MS, et al. (1997) Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1831-8 |