Andre K. Isaacs, Ph.D.
Affiliations: | 2011 | University of Pennsylvania, Philadelphia, PA, United States |
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"Andre Isaacs"Mean distance: 7.73 | S | N | B | C | P |
Parents
Sign in to add mentor| Jeffrey D. Winkler | grad student | 2011 | Penn | |
| (The design and synthesis of novel steroid-derived inhibitors of hedgehog signaling based on the alkaloid cyclopamine.) | ||||
| Richmond Sarpong | post-doc | 2011-2012 | UC Berkeley | |
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Publications
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| Isaacs AK, Qi S, Sarpong R, et al. (2012) Insect ryanodine receptor: distinct but coupled insecticide binding sites for [N-C(3)H(3)]chlorantraniliprole, flubendiamide, and [(3)H]ryanodine. Chemical Research in Toxicology. 25: 1571-3 |
| Winkler JD, Isaacs AK, Xiang C, et al. (2011) Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors. Tetrahedron. 67: 10261-10266 |
| Isaacs AK, Xiang C, Baubet V, et al. (2011) Studies directed toward the elucidation of the pharmacophore of steroid-based Sonic Hedgehog signaling inhibitors. Organic Letters. 13: 5140-3 |
| Yano T, Kassovska-Bratinova S, Teh JS, et al. (2011) Reduction of clofazimine by mycobacterial type 2 NADH:quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen species. The Journal of Biological Chemistry. 286: 10276-87 |
| Winkler JD, Isaacs A, Holderbaum L, et al. (2009) Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine. Organic Letters. 11: 2824-7 |
| Choi S, Isaacs A, Clements D, et al. (2009) De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers. Proceedings of the National Academy of Sciences of the United States of America. 106: 6968-73 |
| Quinn KJ, Isaacs AK, DeChristopher BA, et al. (2005) Asymmetric total synthesis of rollicosin. Organic Letters. 7: 1243-5 |