Sofiya Yashchuk, Ph.D.
Affiliations: | 2010 | Chemistry | Purdue University, West Lafayette, IN, United States |
Area:
HIV-1 protease inhibitorsGoogle:
"Sofiya Yashchuk"Mean distance: 8.51 | S | N | B | C | P |
Parents
Sign in to add mentor| Arun K. Ghosh | grad student | 2010 | Purdue | |
| (Asymmetric synthesis of bis-tetrahydrofuran and its conversion to darunavir and design of novel HIV-1 protease inhibitors based upon the 'backbone binding concept'.) | ||||
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Publications
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| Ghosh AK, Brindisi M, Nyalapatla PR, et al. (2017) Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex. Bioorganic & Medicinal Chemistry |
| Ghosh AK, Takayama J, Kassekert LA, et al. (2015) Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands. Bioorganic & Medicinal Chemistry Letters |
| Agniswamy J, Louis JM, Shen CH, et al. (2015) Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. Journal of Medicinal Chemistry. 58: 5088-95 |
| Ghosh AK, Yashchuk S, Mizuno A, et al. (2015) Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation. Chemmedchem. 10: 107-15 |
| Salcedo Gómez PM, Amano M, Yashchuk S, et al. (2013) GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration. Antimicrobial Agents and Chemotherapy. 57: 6110-21 |
| Chang YC, Yu X, Zhang Y, et al. (2012) Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring. Journal of Medicinal Chemistry. 55: 3387-97 |