Corey P. Causey, Ph.D.

Affiliations: 
2007 Duke University, Durham, NC 
Area:
biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide
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"Corey Causey"
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Parents

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Eric J. Toone grad student 2007 Duke
 (Expanding the synthetic utility of KDPG aldolase.)
Paul R. Thompson post-doc 2010 University of North Florida
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Publications

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Witalison EE, Cui X, Causey CP, et al. (2015) Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget
Witalison EE, Cui X, Hofseth AB, et al. (2015) Inhibiting protein arginine deiminases has antioxidant consequences. The Journal of Pharmacology and Experimental Therapeutics. 353: 64-70
McElwee JL, Mohanan S, Griffith OL, et al. (2012) Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. Bmc Cancer. 12: 500
Kan R, Jin M, Subramanian V, et al. (2012) Potential role for PADI-mediated histone citrullination in preimplantation development. Bmc Developmental Biology. 12: 19
Mohamed BM, Verma NK, Davies AM, et al. (2012) Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (London, England). 7: 1181-95
Jones JE, Slack JL, Fang P, et al. (2012) Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. Acs Chemical Biology. 7: 160-5
Causey CP, Jones JE, Slack JL, et al. (2011) The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. Journal of Medicinal Chemistry. 54: 6919-35
Obianyo O, Causey CP, Jones JE, et al. (2011) Activity-based protein profiling of protein arginine methyltransferase 1. Acs Chemical Biology. 6: 1127-35
Zhang X, Gamble MJ, Stadler S, et al. (2011) Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. Plos Genetics. 7: e1002112
Chumanevich AA, Causey CP, Knuckley BA, et al. (2011) Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G929-38
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