Qian Xie, Ph.D.

Affiliations: 
2014 Biochemistry, Biophysics, and Molecular Biology Iowa State University, Ames, IA, United States 
Area:
Nuclear magnetic resonance, Macromolecular structure and recognition
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"Qian Xie"
Mean distance: 8.15
 
SNBCP

Parents

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Amy H. Andreotti grad student 2014 Iowa State
 (Mechanistic insight into the regulation of Tec family kinase activity -- substrate selection and conformational preferences.)
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Publications

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Xie Q, Wiedmann MM, Zhao A, et al. (2020) Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the Staphylococcus aureus receptor histidine kinase, AgrC. Chemical Communications (Cambridge, England)
Qin Y, Musket A, Kou J, et al. (2020) Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice. Neuro-Oncology Advances. 2: vdaa067
Xie Q, Zhao A, Jeffrey PD, et al. (2019) Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chemical Biology
Kou J, Musich PR, Staal B, et al. (2018) Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody. Journal of Translational Medicine. 16: 253
Wang B, Zhao A, Xie Q, et al. (2017) Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chemical Biology. 24: 76-86
Xie Q, Fulton DB, Andreotti AH. (2015) A selective NMR probe to monitor the conformational transition from inactive to active kinase. Acs Chemical Biology. 10: 262-8
Boyken SE, Chopra N, Xie Q, et al. (2014) A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. Journal of Molecular Biology. 426: 3656-69
Joseph RE, Kleino I, Wales TE, et al. (2013) Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases. Science Signaling. 6: ra76
Xie Q, Joseph RE, Fulton DB, et al. (2013) Substrate recognition of PLCγ1 via a specific docking surface on Itk. Journal of Molecular Biology. 425: 683-96
Joseph RE, Xie Q, Andreotti AH. (2010) Identification of an allosteric signaling network within Tec family kinases. Journal of Molecular Biology. 403: 231-42
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