John R. Jalas, Ph.D.

Affiliations: 
2003 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
protein engineering, protein prenylation and cellular patterning
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"John Jalas"
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Mark D. Distefano grad student 2003 UMN
 (Stereo- and regioselectivity in the cytochrome P450-mediated metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).)
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Jalas JR, Hecht SS, Murphy SE. (2005) Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen. Chemical Research in Toxicology. 18: 95-110
Jalas JR, Seetharaman M, Hecht SS, et al. (2004) Molecular modelling of CYP2A enzymes: application to metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 34: 515-33
Jalas JR, Ding X, Murphy SE. (2003) Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1199-202
Jalas JR, McIntee EJ, Kenney PM, et al. (2003) Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Chemical Research in Toxicology. 16: 794-806
Jalas JR, Hecht SS. (2003) Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5. Chemical Research in Toxicology. 16: 782-93
Cheng G, Shi Y, Sturla SJ, et al. (2003) Reactions of formaldehyde plus acetaldehyde with deoxyguanosine and DNA: formation of cyclic deoxyguanosine adducts and formaldehyde cross-links. Chemical Research in Toxicology. 16: 145-52
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