Binqing Wei, Ph.D.
Affiliations: | 2003 | Northwestern University, Evanston, IL |
Area:
GPCR, computational chemistryGoogle:
"Binqing Wei"Mean distance: 9.91
Parents
Sign in to add mentor| Brian K. Shoichet | grad student | 2003 | Northwestern | |
| (Solvation and receptor flexibility in molecular docking: Algorithm development and application to drug design.) | ||||
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Publications
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| Staben LR, Chen J, Cruz-Chuh JD, et al. (2020) Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates. Journal of Medicinal Chemistry |
| Dragovich PS, Adhikari P, Blake RA, et al. (2019) Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Bioorganic & Medicinal Chemistry Letters. 126907 |
| Su D, Chen J, Cosino E, et al. (2019) Antibody-drug Conjugates Derived From Cytotoxic seco-CBI-Dimer Payloads are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjugate Chemistry |
| Ohri R, Bhakta S, Fourie-O'Donohue A, et al. (2018) High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers. Bioconjugate Chemistry |
| Zhang D, Le H, Cruz-Chuh JD, et al. (2018) Immolation of p-aminobenzyl ether linker and payload potency and stability determine the cell killing activity of antibody-drug conjugates with phenol-containing payloads. Bioconjugate Chemistry |
| Wei B, Gunzner-Toste J, Yao H, et al. (2017) Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. Journal of Medicinal Chemistry |
| Gregson SJ, Masterson LA, Wei B, et al. (2017) Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Non-Cleavable Drug-Linkers. Journal of Medicinal Chemistry |
| Safina BS, Elliott RL, Forrest AK, et al. (2017) Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles. Acs Medicinal Chemistry Letters. 8: 936-940 |
| Vollmar BS, Wei B, Ohri R, et al. (2017) Attachment site cysteine thiol pKa is a key driver for site-dependent stability of THIOMAB(TM) antibody-drug conjugates. Bioconjugate Chemistry |
| Staben LR, Koenig SG, Lehar SM, et al. (2016) Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119 |