Rodney A. Bednar, Ph.D.

Affiliations: 
Pennsylvania Drug Discovery Institute 
 Merck Research Laboratories, West Point, Pennsylvania, Lansdale, PA, United States 
 Stony Brook University, Stony Brook, NY, United States 
Area:
Drug Discovery, Enzymology
Website:
http://www.linkedin.com/in/rodneybednar
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"Rodney Bednar"
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Publications

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Garner R, Gopalakrishnan S, McCauley JA, et al. (2015) Preclinical pharmacology and pharmacokinetics of CERC-301, a GluN2B-selective N-methyl-D-aspartate receptor antagonist. Pharmacology Research & Perspectives. 3: e00198
Mercer SP, Roecker AJ, Garson S, et al. (2013) Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs). Bioorganic & Medicinal Chemistry Letters. 23: 6620-4
Coleman PJ, Schreier JD, Cox CD, et al. (2012) Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties. Chemmedchem. 7: 415-24, 337
Layton ME, Kelly MJ, Rodzinak KJ, et al. (2011) Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists. Acs Chemical Neuroscience. 2: 352-62
Hutson PH, Finger EN, Magliaro BC, et al. (2011) The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. Neuropharmacology. 61: 665-76
Wood MR, Schirripa KM, Kim JJ, et al. (2010) Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality. Bioorganic & Medicinal Chemistry Letters. 20: 6827-30
Cox CD, Breslin MJ, Whitman DB, et al. (2010) Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. Journal of Medicinal Chemistry. 53: 5320-32
Stump CA, Bell IM, Bednar RA, et al. (2010) Identification of potent, highly constrained CGRP receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2572-6
Wood MR, Schirripa KM, Kim JJ, et al. (2009) Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility. Bioorganic & Medicinal Chemistry Letters. 19: 5787-90
McIntyre CJ, McCauley JA, Bednar B, et al. (2009) Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 5132-5
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