Sharmila Sivendran, Ph.D.
Affiliations: | 2008 | Chemistry and Biochemistry | University of Delaware, Newark, DE, United States |
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"Sharmila Sivendran"Mean distance: 8.69
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Sign in to add mentor| Roberta F. Colman | grad student | 2008 | University of Delaware | |
| (Bacillus subtilis and human adenylosuccinate lyase: I. Studies of two novel point mutations of ASL deficiency II. Effect of adjacent amino acids on the pK of His68 III. Studies with a new substrate analogue.) | ||||
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| Sivendran S, Jones V, Sun D, et al. (2010) Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorganic & Medicinal Chemistry. 18: 896-908 |
| Sivendran S, Colman RF. (2008) Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens. Protein Science : a Publication of the Protein Society. 17: 1162-74 |
| Hung SH, Liu AH, Pixley RA, et al. (2008) A new nonhydrolyzable reactive cGMP analogue, (Rp)-guanosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A. Bioorganic Chemistry. 36: 141-7 |
| Sivendran S, Segall ML, Rancy PC, et al. (2007) Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase. Protein Science : a Publication of the Protein Society. 16: 1700-7 |
| Sivendran S, Patterson D, Spiegel E, et al. (2004) Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL. The Journal of Biological Chemistry. 279: 53789-97 |