Michael J. Rozema
Affiliations: | AbbVie |
Area:
Process R&DGoogle:
"Michael Rozema"Mean distance: 8.83 | S | N | B | C | P |
Parents
Sign in to add mentor| Paul Knochel | grad student | 1988-1992 | University of Michigan |
| Stephen Hanessian | post-doc | 1993-1995 | Université de Montréal |
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Publications
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| Wang Z, Richter SM, Rozema MJ, et al. (2017) Potential Safety Hazards Associated with Using Acetonitrile and a Strong Aqueous Base Organic Process Research & Development. 21: 1501-1508 |
| Wang Z, Richter SM, Gandarilla J, et al. (2013) Safe Scale-Up of a Hydrazine Condensation by the Addition of a Base Organic Process Research and Development. 17: 1603-1610 |
| McDermott TS, Bhagavatula L, Borchardt TB, et al. (2009) Development of a scalable synthesis of dipeptidyl peptidase-4 inhibitor ABT-279 Organic Process Research and Development. 13: 1145-1155 |
| Rozema MJ, Fickes M, McLaughlin M, et al. (2006) Enantioselective synthesis of the farnesyltransferase inhibitor, A-345665.0 Tetrahedron Letters. 47: 8765-8768 |
| Rozema MJ, Kruger AW, Rohde BD, et al. (2005) Synthesis of a novel farnesyl transferase inhibitor, ABT-100; Selective preparation of a stereogenic tertiary carbinol Tetrahedron. 61: 4419-4425 |
| Ku YY, Grieme T, Raje P, et al. (2003) A practical and scaleable synthesis of A-224817.0, a novel nonsteroidal ligand for the glucocorticoid receptor. The Journal of Organic Chemistry. 68: 3238-40 |
| Hanessian S, Griffin AM, Rozema MJ. (1997) Tricyclic β-lactams: Total synthesis and antibacterial activity of 5α-methoxyethyl and 5α-hydroxyethyl trinems Bioorganic and Medicinal Chemistry Letters. 7: 1857-1862 |
| Hanessian S, Rozema MJ. (1996) A highly stereoselective and practical total synthesis of the tricyclic β-lactam antibiotic GV104326 (4-methoxytrinem) Journal of the American Chemical Society. 118: 9884-9891 |
| Hanessian S, Rozema MJ, Reddy GB, et al. (1995) Tricyclic β-lactams: total synthesis and antibacterial activity of 5α- and 5β-methoxy-tribactams Bioorganic and Medicinal Chemistry Letters. 5: 2535-2540 |
| Hanessian S, Rozema MJ. (1994) Synthesis and biological evaluation of 1-substituted-7-(1-hydroxyethyl) carbacephems - a class of "hybrid" bicyclic β-lactams Bioorganic and Medicinal Chemistry Letters. 4: 2279-2284 |