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Laura H. Lucas, Ph.D.

Affiliations: 
2004 University of Kansas, Lawrence, KS, United States 
Area:
Analytical Chemistry, Biochemistry
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"Laura Lucas"
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Cynthia Larive grad student 2004 University of Kansas
 (Development and application of state-of-the-art nuclear magnetic resonance (NMR) spectroscopic methodologies to analytical challenges relevant to the drug development process.)

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Publications

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Lucas LH, Ersoy BA, Kueltzo LA, et al. (2006) Probing protein structure and dynamics by second-derivative ultraviolet absorption analysis of cation-{pi} interactions. Protein Science : a Publication of the Protein Society. 15: 2228-43
Lucas LH, Larive CK, Wilkinson PS, et al. (2005) Progress toward automated metabolic profiling of human serum: comparison of CPMG and gradient-filtered NMR analytical methods. Journal of Pharmaceutical and Biomedical Analysis. 39: 156-63
Lucas LH, Wilson SF, Lunte CE, et al. (2005) Concentration profiling in rat tissue by high-resolution magic-angle spinning NMR spectroscopy: investigation of a model drug. Analytical Chemistry. 77: 2978-84
Lucas LH, Price KE, Larive CK. (2004) Epitope mapping and competitive binding of HSA drug site II ligands by NMR diffusion measurements. Journal of the American Chemical Society. 126: 14258-66
Lucas LH, Cerny MA, Koen YM, et al. (2004) 1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard. Analytical and Bioanalytical Chemistry. 380: 627-31
Price KE, Lucas LH, Larive CK. (2004) Analytical applications of NMR diffusion measurements. Analytical and Bioanalytical Chemistry. 378: 1405-7
Lucas LH, Larive CK. (2004) Measuring ligand-protein binding using NMR diffusion experiments Concepts in Magnetic Resonance Part a: Bridging Education and Research. 20: 24-41
Lucas LH, Yan J, Larive CK, et al. (2003) Transferred nuclear overhauser effect in nuclear magnetic resonance diffusion measurements of ligand-protein binding. Analytical Chemistry. 75: 627-34
Lucas LH, Otto WH, Larive CK. (2002) The 2D-J-DOSY experiment: resolving diffusion coefficients in mixtures. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 156: 138-45
Derrick TS, Lucas LH, Dimicoli JL, et al. (2002) 19F diffusion NMR analysis of enzyme-inhibitor binding Magnetic Resonance in Chemistry. 40
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