M David Percival

Affiliations: 
Concordia University (Canada), Montreal, Canada 
 2009- Biochemistry and Molecular Biology Merck Frosst Centre for Therapeutic Research 
Area:
Biochemistry
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"Michael David Percival" OR "M David Percival"
Bio:

http://hdl.handle.net/2429/29058

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Parents

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Stephen G. Withers grad student 1988 UBC
 (Mechanistic studies on phosphoglucomutase.)
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Publications

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Zhuo Y, Gauthier JY, Black WC, et al. (2014) Inhibition of bone resorption by the cathepsin K inhibitor odanacatib is fully reversible. Bone. 67: 269-80
Fournier PA, Arbour M, Cauchon E, et al. (2012) Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2670-4
Chen A, Cauchon E, Chefson A, et al. (2011) Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorganic & Medicinal Chemistry Letters. 21: 3976-81
Chen A, Campeau LC, Cauchon E, et al. (2011) Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines. Bioorganic & Medicinal Chemistry Letters. 21: 3970-5
Baugh M, Black D, Westwood P, et al. (2011) Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity Journal of Autoimmunity. 36: 201-209
Aspiotis R, Chen A, Cauchon E, et al. (2011) The discovery and synthesis of potent zwitterionic inhibitors of renin. Bioorganic & Medicinal Chemistry Letters. 21: 2430-6
St-Jacques R, Toulmond S, Auger A, et al. (2011) Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors. Journal of the Renin-Angiotensin-Aldosterone System : Jraas. 12: 133-45
Samokhin AO, Gauthier JY, Percival MD, et al. (2011) Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis. Respiratory Research. 12: 13
Veilleux A, Black WC, Gauthier JY, et al. (2011) Probing cathepsin S activity in whole blood by the activity-based probe BIL-DMK: cellular distribution in human leukocyte populations and evidence of diurnal modulation. Analytical Biochemistry. 411: 43-9
Deschamps K, Cromlish W, Weicker S, et al. (2011) Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma. American Journal of Respiratory Cell and Molecular Biology. 45: 81-7
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