William B. Pratt

Affiliations: 
1973-2006 Pharmacology University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacology, Biochemistry
Website:
https://www.lib.umich.edu/faculty-history/faculty/william-b-pratt
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"William Pratt"
Bio:

Pratt, William Brewster, The Y-glutamyl bond in chick embryo collagen (1964). Yale Medicine Thesis Digital Library. 3042.
https://elischolar.library.yale.edu/ymtdl/3042

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Parents

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Lewis Nelson Lukens grad student 1964 Yale
 (M.D. thesis: The Y-glutamyl bond in chick embryo collagen.)
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Publications

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Mehta RK, Pal S, Kondapi K, et al. (2020) Low dose Hsp90 inhibitor selectively radiosensitizes HNSCC and Pancreatic xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Morishima Y, Mehta RK, Yoshimura M, et al. (2018) Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery. Molecular Pharmacology
Pratt WB, Gestwicki JE, Osawa Y, et al. (2015) Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 55: 353-71
Pratt WB, Morishima Y, Gestwicki JE, et al. (2014) A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1405-13
Ahsan A, Ray D, Ramanand SG, et al. (2013) Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization. The Journal of Biological Chemistry. 288: 26879-86
Wang AM, Miyata Y, Klinedinst S, et al. (2013) Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature Chemical Biology. 9: 112-8
Ahsan A, Ramanand SG, Whitehead C, et al. (2012) Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia (New York, N.Y.). 14: 670-7
Peng HM, Morishima Y, Pratt WB, et al. (2012) Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. The Journal of Biological Chemistry. 287: 1556-65
Morishima Y, Lau M, Peng HM, et al. (2011) Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry. 50: 7146-56
Lieberman AP, Pratt WB. (2011) Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery Protein Chaperones and Protection From Neurodegenerative Diseases. 211-233
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